<html> <head> <meta http-equiv=Content-Type
content="text/html; charset=windows-1252"> <meta
name=Generator content="Microsoft Word 11 (filtered)">
<title>he Cancer Council Australia/Australian Cancer Network
2005</title> <style> <!-- /* Font Definitions */
@font-face {font-family:Verdana; panose-1:2 11 6 4 3 5 4 4 2 4;} @font-face
{font-family:TimesNewRomanPSMT; panose-1:0 0 0 0 0 0 0 0 0 0;} /* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal {margin:0in; margin-bottom:.0001pt;
font-size:12.0pt; font-family:"Times New Roman";} p.MsoHeader,
li.MsoHeader, div.MsoHeader {margin:0in; margin-bottom:.0001pt; font-size:12.0pt;
font-family:"Times New Roman";} p.MsoFooter, li.MsoFooter,
div.MsoFooter {margin:0in; margin-bottom:.0001pt; font-size:12.0pt;
font-family:"Times New Roman";} a:link, span.MsoHyperlink {color:blue;
text-decoration:underline;} a:visited, span.MsoHyperlinkFollowed {color:purple;
text-decoration:underline;} /* Page Definitions */ @page Section1 {size:595.3pt 841.9pt;
margin:1.0in 1.25in 1.0in 1.25in;} div.Section1 {page:Section1;} -->
</style> </head> <body lang=EN-US link=blue
vlink=purple> <div class=Section1> <p class=MsoNormal
style='text-autospace:none'><b><span
style='font-size:9.0pt; font-family:Verdana'>The Cancer Council
Australia/Australian Cancer Network
2005</span></b></p> <p class=MsoNormal
style='text-autospace:none'><span
style='font-size:11.0pt; font-family:TimesNewRomanPSMT'>ISBN:
0-9775060-0-2</span></p> <p class=MsoNormal
style='text-autospace:none'><span
style='font-size:11.0pt;
font-family:TimesNewRomanPSMT'> </span></p>
<p class=MsoNormal
style='text-autospace:none'><span
style='font-size:11.0pt; font-family:TimesNewRomanPSMT'>This
work is copyright. Apart from any use as permitted under the Copyright Act 1968, no part
may be reproduced by any process without prior written permission from The Cancer
Council Australia /Australian Cancer Network. Requests and enquiries concerning
reproduction and rights should be addressed to the Copyright Officer, The Cancer Council
Australia, GPO Box 4708, Sydney NSW 2001, Australia. Website: www.cancer.org.au Email:
<a
href="mailto:info@cancer.org.au">info@cancer.org.au</a></span></p>
<p class=MsoNormal
style='text-autospace:none'><span
style='font-size:11.0pt;
font-family:TimesNewRomanPSMT'> </span></p>
<p class=MsoNormal
style='text-autospace:none'><b><span
style='font-size:11.0pt; font-family:Verdana'>NHMRC
approval</span></b></p> <p
class=MsoNormal
style='text-autospace:none'><b><span
style='font-size:11.0pt;
font-family:Verdana'> </span></b></p>
<p class=MsoNormal
style='text-autospace:none'><span
style='font-size:11.0pt; font-family:TimesNewRomanPSMT'>These
guidelines were approved by the National Health and Medical Research Council at its
159<sup>th</sup> Session on 8 December 2005, under section
14A of the National Health and Medical Research Council Act 1992. Approval for the
guidelines by the NHMRC is granted for a period not exceeding five years, at which date
the approval expires. The NHMRC expects that all guidelines will be reviewed no less
than once every five years. Readers should check with the Australian Cancer Network for
any reviews or updates of these guidelines.</span></p>
<p class=MsoNormal
style='text-autospace:none'><span
style='font-size:11.0pt;
font-family:TimesNewRomanPSMT'> </span></p>
<p class=MsoNormal
style='text-autospace:none'><b><span
style='font-size:11.0pt;
font-family:Verdana'>Disclaimer</span></b></p>
<p class=MsoNormal
style='text-autospace:none'><span
style='font-size:11.0pt; font-family:TimesNewRomanPSMT'>This
document is a general guide to appropriate practice, to be followed only subject to the
clinician judgement in each individual case. The guidelines are designed to provide
information to assist in decision making and are based on the best information available
at the date of compilation (August 2004).</span></p>
<p class=MsoNormal
style='text-autospace:none'><span
style='font-size:11.0pt;
font-family:TimesNewRomanPSMT'> </span></p>
<p class=MsoNormal
style='text-autospace:none'><b><span
style='font-size:11.0pt; font-family:Verdana'>Conflict of
interest</span></b></p> <p
class=MsoNormal style='text-autospace:none'><span
style='font-size:11.0pt;
font-family:TimesNewRomanPSMT'> </span></p>
<p class=MsoNormal
style='text-autospace:none'><span
style='font-size:11.0pt; font-family:TimesNewRomanPSMT'>The
development of these clinical practice guidelines has been by a non-remunerated working
party of the Australian Cancer Network, with further support from The Cancer Council
Australia and the Clinical Oncological Society of
Australia.</span></p> <p class=MsoNormal
style='text-autospace:none'><span
style='font-size:11.0pt; font-family:TimesNewRomanPSMT'>Some
members of the working party have received sponsorship to attend scientific meetings;
been supported in the conducting of clinical trials; or been involved in an advisory
capacity by pharmaceutical and biochemical
companies.</span></p> <p class=MsoNormal
style='text-autospace:none'><b><span
style='font-size:11.0pt;
font-family:Verdana'> </span></b></p>
<p class=MsoNormal
style='text-autospace:none'><b><span
style='font-size:11.0pt; font-family:Verdana'>Periodic
updates</span></b></p> <p
class=MsoNormal style='text-autospace:none'><span
style='font-size:11.0pt; font-family:TimesNewRomanPSMT'>New
information arising in areas considered to be of importance will be posted periodically
on the ACN website (www.cancer.org.au/guidelines). This information will not yet have
been approved by the NHMRC but will be included as appropriate in future editions of the
document.</span></p> <p class=MsoNormal
style='text-autospace:none'><span
style='font-size:11.0pt;
font-family:TimesNewRomanPSMT'> </span></p>
<p class=MsoNormal
style='text-autospace:none'><span
style='font-size:11.0pt; font-family:TimesNewRomanPSMT'>These
guidelines can be downloaded from the Australian Cancer Network website
at</span></p> <p class=MsoNormal
style='text-autospace:none'><span
style='font-size:11.0pt;
font-family:TimesNewRomanPSMT'>www.cancer.org.au/guidelines or from the
National Health and Medical Research Council website: <a
href="http://www.nhmrc.gov.au/">www.nhmrc.gov.au</a></span></p>
<p class=MsoNormal
style='text-autospace:none'><span
style='font-size:11.0pt;
font-family:TimesNewRomanPSMT'> </span></p>
<p class=MsoNormal
style='text-autospace:none'><span
style='font-size:11.0pt; font-family:TimesNewRomanPSMT'>Copies
of this Guideline document can be ordered through the Australian Cancer Network
on</span></p> <p class=MsoNormal
style='text-autospace:none'><span
style='font-size:11.0pt; font-family:TimesNewRomanPSMT'>(02)
9036 3120 or email: <a
href="mailto:acn@cancer.org.au">acn@cancer.org.au</a></span></p>
<p class=MsoNormal
style='text-autospace:none'><span
style='font-size:11.0pt;
font-family:TimesNewRomanPSMT'> </span></p>
<p class=MsoNormal
style='text-autospace:none'><b><span
style='font-size:11.0pt; font-family:Verdana'>Suggested
citation:</span></b></p> <p
class=MsoNormal
style='text-autospace:none'><b><span
style='font-size:11.0pt;
font-family:Verdana'> </span></b></p>
<p class=MsoNormal
style='text-autospace:none'><span
style='font-size:11.0pt;
font-family:Verdana'>A</span><span
style='font-size:11.0pt;font-family:TimesNewRomanPSMT'>ustralian
Cancer Network Diagnosis and Management of Lymphoma Guidelines Working Party. Guidelines
for the Diagnosis and Management of Lymphoma. The Cancer Council Australia and
Australian Cancer Network, Sydney 2005.</span></p> <p
class=MsoNormal><span
lang=EN-AU> </span></p>
</div> </body> </html>
A diagnosis of Lymphoma has been established
<html>
<head></head><body>
<div style="text-align:left;"><font face="Arial">You can select the lyphoma type and stage by clicking on the arrow in initial staging</font> </div>
</body></html>
The patient does in fact not have lymphoma
The disease has progressed
The patient has been treated and is in remission
The patient has died
Evaluate the patient for evidence of Lymphoma
Initial patient evaluation
Does this patient have lymphoma
<html>
<head></head><body>
<div><font face="Arial">Once the patient has had a diagnosis of lymphoma made proceed on with the wizard by clicking the arrow and confirming lymphoma</font></div>
</body></html>
Before Treatment the lymphoma must be staged
<html>
<head></head><body>
<div><font face="Arial">Select the type of lymphoma and the stage here. Data is also collected about clinical findings relevant to treatment</font></div>
</body></html>
Plan treatment according to Diagnosis
Treatment planning
<html>
<head></head><body>
<div><font face="Arial">Please click the arrow to select active treatment</font></div>
</body></html>
Record Chemotherapy treatment here
Chemotherapy order
<html>
<head></head><body>
<div><font face="Arial">To start the wizard click the arrow and register the patient</font></div>
</body></html>
<html>
<head></head><body>
<div><font face="Arial">Every time blood tests are ordered a notification is sent to the bllod cancer registry</font></div>
</body></html>
/*
1) Adult patients with histologically documented “follicular small cleaved” or “follicular mixed small
cleaved and large cell lymphoma”. Pathology will be reviewed centrally (PMCI). Patients who on
review of pathology do not meet this criterion will be ineligible for analysis and may require therapy different from this protocol.
*/
/*
2) Disease limited to stages I and II after adequate staging (see Appendix II)
*/
let question:string = 'Is this Stage I or II'
let answer:Boolean = model.run('Stage_I_or_II')
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'Stage I or II',50)
else
factory.GLIFDecisionResult(question,answer,'Not Stage I or II',50)
endif
else
factory.GLIFDecisionResult(question,answer,'Stage unknown',50)
endif
/*
3) Anticipated life expectancy > 5 years
*/
/*
4) Given written informed consent
*/
/*
5) Been assessed by a radiation oncologist and a medical oncologist/ haematologist
*/
/*
6) WCC > 3.0 x 109/L, platelet count > 100 x 109/L, serum creatinine < 0.15 mmol/L
*/
let question:string = 'WCC > 3.0 x 109/L, platelet count > 100 x 109/L, serum creatinine < 0.15 mmol/L'
let WCC_threshold = Factory.PhysicalQuantity(3.0,'10^9/L')
let platelets_threshold = Factory.PhysicalQuantity(100,'10^9/L')
let creatinine_threshold = Factory.PhysicalQuantity(0.15,'mmol/L')
let WCC: PhysicalQuantity = model.run('WCC')
let platelets: PhysicalQuantity = model.run('Platelets')
let creatinine: PhysicalQuantity = model.run('Creatinine')
let answer: Boolean =
if WCC.isdefined() and platelets.isDefined() and creatinine.isDefined() then
(WCC > WCC_threshold)
and (platelets > platelets_threshold)
and (creatinine < creatinine_threshold)
else
unknown
endif
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'WCC, Platelets and Creatine levels acceptable',50)
else
factory.GLIFDecisionResult(question,answer,'WCC, Platelets and Creatine levels unacceptable',50)
endif
else
factory.GLIFDecisionResult(question,answer,'Observation data missing for WCC, Platelets or Creatinine',50)
endif
/*
7) Ability to commence radiotherapy within 6 weeks of randomisation
*/
/*
1) Received previous systemic cytotoxic chemotherapy
*/
/*
2) Received previous radiotherapy, (except superficial radiation therapy for non-melanoma skin cancers)
*/
/*
3) A medical contraindication to radiotherapy or chemotherapy
*/
/*
4) Any previous or concurrent malignancy other than curatively treated
non-melanoma skin cancer, level 1 malignant melanoma, or in situ cervical
cancer, unless disease and treatment-free for 5 years.
*/
/*
5) Such extensive involvement of the thorax that treatment with radiation therapy alone would
be hazardous because of excessive lung irradiation, even if a shrinking field technique were employed
*/
/*
6) Suspected or confirmed pregnancy. Must not be lactating.
*/
/*
1. Age: Older than 17 years.
*/
// define our assertion or question
let question:string = 'Age older than 17 years.'
// now evaluate an answer.
let answer:boolean = Model.run('Age_older',17)
// and return our response
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'Age is acceptable.',50)
else
factory.GLIFDecisionResult(question,answer,'Too young.',50)
endif
else
factory.GLIFDecisionResult(question,answer,'Age unknown',50)
endif
/*
ECOG performance status < 3 inclusive.
*/
// define our assertion or question
let question:string = 'Is ECOG performance status < 3?'
// now evaluate an answer.
let answer: Boolean = Model.run('ECOG_0_to_2')
// and return our response
// note - due to GELLO language constraints, we are not allowed to assign a
// variable value more than once, so alternative reasons have to be specified
// with sepearate return results.
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'ECOG is < 3',50)
else
factory.GLIFDecisionResult(question,answer,'ECOG is not < 3',50)
endif
else
factory.GLIFDecisionResult(question,answer,'No Results',50)
endif
/*
Laboratory Values.
Hb > 100 gm/L,
WBC > 4.0 x 109/L,
platelets >100x109/L,
GGT, ALT and AST less than twice the upper limit of normal,
creatinine clearance > 60 mL/min.,
*/
// define our assertion or question
let Hb_threshold = Factory.PhysicalQuantity(100,'gm/L')
let WBC_threshold = Factory.PhysicalQuantity(4.0,'10^9/L')
let Platelets_threshold = Factory.PhysicalQuantity(100,'10^9/L')
let creatinine_clearance_threshold = Factory.PhysicalQuantity(60,'mL/min')
let question:string = 'Laboratory Values (Hb, WBC, platelets, GGT, ALT, AST creatinine clearance)'
// now evaluate an answer.
let Hb: PhysicalQuantity = model.run('Hb')
let WBC: PhysicalQuantity = model.run('WCC')
let Platelets: PhysicalQuantity = model.run('Platelets')
let GGT: Observation = model.run('GGT_obs')
let ALT: Observation = model.run('ALT_obs')
let AST: Observation = model.run('AST_obs')
let creatinine_clearance: PhysicalQuantity = model.run('Creatinine_Clearance')
let answer:boolean =
if Hb.isDefined() and
WBC.isDefined() and
Platelets.isDefined() and
GGT.isDefined() and
ALT.isDefined() and
AST.isDefined() and
creatinine_clearance.isDefined() then
(Hb > Hb_threshold)
and (WBC > WBC_threshold)
and (Platelets > Platelets_Threshold)
and (GGT.Value < 2 * GGT.reference_range.upper_limit)
and (ALT.Value < 2 * ALT.reference_range.upper_limit)
and (AST.Value < 2 * AST.reference_range.upper_limit)
and (creatinine_clearance > creatinine_clearance_threshold)
else
unknown
endif
// and return our response
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'Laboratory Value ok.',50)
else
factory.GLIFDecisionResult(question,answer,'Laboratory Values unacceptable',50)
endif
else
if Hb.isundefined() then
factory.GLIFDecisionResult(question,answer,'Missing observation data: (Hb)',50)
else
if WBC.isundefined() then
factory.GLIFDecisionResult(question,answer,'Missing observation data: (WBC)',50)
else
if platelets.isundefined() then
factory.GLIFDecisionResult(question,answer,'Missing observation data: (platelets)',50)
else
if GGT.isundefined() then
factory.GLIFDecisionResult(question,answer,'Missing observation data: (GGT)',50)
else
if ALT.isundefined() then
factory.GLIFDecisionResult(question,answer,'Missing observation data: (ALT)',50)
else
if AST.isundefined() then
factory.GLIFDecisionResult(question,answer,'Missing observation data: (AST)',50)
else
if creatinine_clearance.isundefined() then
factory.GLIFDecisionResult(question,answer,'Missing observation data: (creatinine clearance)',50)
else
factory.GLIFDecisionResult(question,answer,'Missing observation data: (unknown error)',50)
endif
endif
endif
endif
endif
endif
endif
endif
// Origin: C:\SVNStuff\ITOL\Gello Code\LY03\A15.gello
/* Inclusion Criteria:
190818004 | waldenstrom's macroglobulinaemia
277551008 | splenic lymphoma with villous lymphocytes
307623001 | malignant lymphoma - lymphoplasmacytic
Hb <10 g/dl
*/
let AQuestion = "waldenstrom''s macroglobulinaemia, splenic lymphoma with villous lymphocytes or malignant lymphoma - lymphoplasmacytic, Hb <10 g/dl"
let diagnosis_code = factory.codedvalue('at0009','MO_LymphomaType')
let diseases:set(codedvalue) =
set{
factory.codedvalue('190818004','SNOMED-CT'), // waldenstrom's macroglobulinaemia
factory.codedvalue('277551008','SNOMED-CT'), // splenic lymphoma with villous lymphocytes
factory.codedvalue('307623001','SNOMED-CT') // malignant lymphoma - lymphoplasmacytic
}
let Hb_code = factory.codedvalue('718-7','LN')
let hb_threshold = factory.physicalquantity(10,'g/dL')
let has_diagnosis:boolean = observation.code->includes(diagnosis_code)
let Hb_obs = observation->select(code = Hb_code)->sortby(absolutetime)->last()
if HB_obs.isundefined() then
conclude factory.GLIFDecisionResult(AQuestion,unknown,"no Hb observations",50)
else
let Hb_ok:boolean = Hb_obs.value < Hb_threshold
endif
if has_diagnosis then
let diagnosis_obs = observation->select(x|x.code = diagnosis_code and diseases->includes(x.value))
if not diagnosis_obs->isempty() then
if Hb_ok then
conclude factory.GLIFDecisionResult(AQuestion,true,"correct type of lymphoma",50)
else
conclude factory.GLIFDecisionResult(AQuestion,false,"correct type of lymphoma but Hb too high",50)
endif
else
conclude factory.GLIFDecisionResult(AQuestion,false,"not correct type of lymphoma",50)
endif
else
conclude factory.GLIFDecisionResult(AQuestion,unknown,"no diagnosis made",50)
endif
// Origin: C:\SVNStuff\ITOL\Gello Code\LY03\A19.gello
/* Inclusion Criteria:
neutrophils <1.5x10^9/l
*/
let AQuestion = "neutrophils < 1.5x10^9/l"
let neutrophils_code = factory.codedvalue('751-8','LN')
let neutrophils_threshold = factory.physicalquantity(1.5,'10^9/L')
let neutrophils_obs = observation->select(code = neutrophils_code)->sortby(absolutetime)->last()
if neutrophils_obs.isdefined() then
let neutrophils_ok:boolean = neutrophils_obs.value < neutrophils_threshold
if neutrophils_ok then
conclude factory.GLIFDecisionResult(AQuestion,true,"neutrophils ok",50)
else
conclude factory.GLIFDecisionResult(AQuestion,false,"neutrophils too high: " + neutrophils_obs.get_display_string(true),50)
endif
else
conclude factory.GLIFDecisionResult(AQuestion,unknown,"no observation data",50)
endif
// Origin: C:\SVNStuff\ITOL\Gello Code\LY03\A20.gello
/* Inclusion Criteria:
platelets < 150x10^9/l
*/
let AQuestion = "platelets < 150x10^9/l"
let platelets_code = factory.codedvalue('777-3','LN')
let platelets_threshold = factory.physicalquantity(150,'10^9/L')
let platelets_obs = observation->select(code = platelets_code)->sortby(absolutetime)->last()
if platelets_obs.isdefined() then
let platelets_low:boolean = platelets_obs.value < platelets_threshold
if platelets_low then
conclude factory.GLIFDecisionResult(AQuestion,true,"platelets ok.",50)
else
conclude factory.GLIFDecisionResult(AQuestion,false,"platelets too high: " + platelets_obs.get_display_string(true),50)
endif
else
conclude factory.GLIFDecisionResult(AQuestion,unknown,"no observation data",50)
endif
// Origin: C:\SVNStuff\ITOL\Gello Code\LY03\A21.gello
/* Inclusion Criteria:
"clinical evidence of hyperviscosity in terms of neurological or ocular disturbance"
*/
let AQuestion = "clinical evidence of hyperviscosity in terms of neurological or ocular disturbance"
conclude factory.GLIFDecisionResult(AQuestion,unknown,"not specified",50)
// Origin: C:\SVNStuff\ITOL\Gello Code\LY03\A22.gello
// Inclusion Criteria: Age must be > 18 years.
let now = factory.absolutetime("0").now()
let years18 = factory.duration(18,'y')
let dob = patient.date_of_birth
if dob.add(years18) < now then
conclude
factory.GLIFDecisionResult("Age must be > 18 years.",true,"old enough",50)
else
conclude
factory.GLIFDecisionResult("Age must be > 18 years.",false,"too young",50)
endif
// Origin: C:\SVNStuff\ITOL\Gello Code\LY03\A23.gello
/* Inclusion Criteria:
" should not proceed to randomisation on the basis of detection of clonal cells alone. Eligibility will be based on morphological and immunophenotypic criteria (see Appendix 1 of protocol ). Bone marrow should be assessed by (at least) two-colour flow cytometry and the expression of the following antigens determined: surface Ig, CD19, CD20, CD5, CD10 and CD23"
*/
let AQuestion = " should not proceed to randomisation on the basis of detection of clonal cells alone. Eligibility will be based on morphological and immunophenotypic criteria (see Appendix 1 of protocol ). Bone marrow should be assessed by (at least) two-colour flow cytometry and the expression of the following antigens determined: surface Ig, CD19, CD20, CD5, CD10 and CD23"
conclude factory.GLIFDecisionResult(AQuestion,unknown,"not specified",50)
// Origin: C:\SVNStuff\ITOL\Gello Code\LY03\A24.gello
/* Inclusion Criteria:
Performance status grade 0, 1, 2; and "life expectancy of greater than 6 months"
*/
let AQuestion = "Performance status grade 0, 1, 2; and life expectancy of greater than 6 months"
conclude factory.GLIFDecisionResult(AQuestion,unknown,"not specified",50)
// Origin: C:\SVNStuff\ITOL\Gello Code\LY03\A25.gello
/* Inclusion Criteria:
"No concurrent malignancy"
*/
let AQuestion = "No concurrent malignancy"
conclude factory.GLIFDecisionResult(AQuestion,unknown,"not specified",50)
// Origin: C:\SVNStuff\ITOL\Gello Code\LY03\A26.gello
/* Inclusion Criteria:
Adequate renal and hepatic function (serum creatinine <200 mmol/l and AST/ALT <2X upper limit of normal)
*/
let AQuestion = "Adequate renal and hepatic function (serum creatinine <200 mmol/l and AST/ALT <2X upper limit of normal)"
let creatinine_code = factory.codedvalue('14682-9','LN')
let ast_code = factory.codedvalue('1920-8','LN')
let alt_code = factory.codedvalue('1742-6','LN')
let creatinine_obs = observation->select(code = creatinine_code)->sortby(absolutetime)->last()
let ast_obs = observation->select(code = ast_code)->sortby(absolutetime)->last()
let alt_obs = observation->select(code = creatinine_code)->sortby(absolutetime)->last()
let creatinine_threshold = factory.physicalquantity(200,'umol/L')
let renal_ok:boolean =
if creatinine_obs.isdefined() then
creatinine_obs.value < creatinine_threshold
else
unknown
endif
let ast_ok:boolean =
if ast_obs.isdefined() then
ast_obs.value < ast_obs.reference_range.upper_limit * 2
else
unknown
endif
let alt_ok:boolean =
if alt_obs.isdefined() then
alt_obs.value < alt_obs.reference_range.upper_limit * 2
else
unknown
endif
let hepatic_ok:boolean =
if ast_obs.isdefined() and alt_obs.isdefined() then
ast_ok and alt_ok
else
ast_ok or alt_ok
endif
if creatinine_obs.isdefined() and (ast_obs.isdefined() or alt_obs.isdefined()) then
if renal_ok and hepatic_ok then
factory.GLIFDecisionResult(AQuestion,true,"creatinine acceptable",50)
else
factory.GLIFDecisionResult(AQuestion,false,"creatinine too high",50)
endif
else
factory.GLIFDecisionResult(AQuestion,unknown,"no creatinine data",50)
endif
// Origin: C:\SVNStuff\ITOL\Gello Code\LY03\A27.gello
/* Inclusion Criteria:
Negative Direct Coomb’s Test.
*/
let AQuestion = "Negative Direct Coomb's Test."
conclude factory.GLIFDecisionResult(AQuestion,unknown,"not specified",50)
// Origin: C:\SVNStuff\ITOL\Gello Code\LY03\A28.gello
/* Inclusion Criteria:
Having previously signed a written informed consent form.
*/
let AQuestion = "Having previously signed a written informed consent form."
conclude factory.GLIFDecisionResult(AQuestion,unknown,"not specified",50)
// Origin: C:\SVNStuff\ITOL\Gello Code\LY03\B15.gello
/* Exclusion Criteria:
"Severe or life-threatening cardiac, pulmonary, neurological, psychiatric or metabolic disease"
*/
let AQuestion = "Severe or life-threatening cardiac, pulmonary, neurological, psychiatric or metabolic disease"
conclude factory.GLIFDecisionResult(AQuestion,unknown,"not specified",50)
// Origin: C:\SVNStuff\ITOL\Gello Code\LY03\B16.gello
/* Exclusion Criteria:
"Pregnant or lactating women"
*/
let AQuestion = "Pregnant or lactating women"
conclude factory.GLIFDecisionResult(AQuestion,unknown,"not specified",50)
// Origin: C:\SVNStuff\ITOL\Gello Code\LY03\B17.gello
/* Exclusion Criteria:
"Patients with AIDS or AIDS related complex"
*/
let AQuestion = "Patients with AIDS or AIDS related complex"
conclude factory.GLIFDecisionResult(AQuestion,unknown,"not specified",50)
// Origin: C:\SVNStuff\ITOL\Gello Code\LY03\B18.gello
/* Exclusion Criteria:
"Patients with evidence of active Hepatitis C infection"
*/
let AQuestion = "Patients with evidence of active Hepatitis C infection"
conclude factory.GLIFDecisionResult(AQuestion,unknown,"not specified",50)
// Origin: C:\SVNStuff\ITOL\Gello Code\LY03\B19.gello
/* Exclusion Criteria:
Past medical history includes
62479008 | AIDS
or
62246005 | AIDS-like syndrome
or
50711007 | hepatitis virus C
*/
let AQuestion = "Past medical history includes 62479008 | AIDS or 62246005 | AIDS-like syndrome or 50711007 | hepatitis virus C"
let diagnosis_code = factory.codedvalue('at0009','MO_LymphomaType')
let diseases:set(codedvalue) =
set{
factory.codedvalue('62479008','SNOMED-CT'), // AIDS
factory.codedvalue('62246005','SNOMED-CT'), // AIDS-like syndrome
factory.codedvalue('50711007','SNOMED-CT') // hepatitis virus C
}
let has_diagnosis:boolean = observation.code->includes(diagnosis_code)
if has_diagnosis then
let diagnosis_obs = observation->select(x|x.code = diagnosis_code and diseases->includes(x.value))
if not diagnosis_obs->isempty() then
conclude factory.GLIFDecisionResult(AQuestion,true,"has had disease",50)
else
conclude factory.GLIFDecisionResult(AQuestion,false,"not not had disease",50)
endif
else
conclude factory.GLIFDecisionResult(AQuestion,unknown,"no diagnosis made",50)
endif
// LY07/A12
// Inclusion Criteria: Age must be > 18 years.
let now = factory.absolutetime("0").now()
let years18 = factory.duration(18,'y')
let dob = patient.date_of_birth
if dob.add(years18) < now then
conclude
factory.GLIFDecisionResult("Age must be > 18 years.",true,"old enough",50)
else
conclude
factory.GLIFDecisionResult("Age must be > 18 years.",false,"too young",50)
endif
// LY07/A13
/* Inclusion Criteria:
Performance status grade 0, 1, 2"
*/
let AQuestion = "Performance status grade 0, 1, 2"
conclude factory.GLIFDecisionResult(AQuestion,unknown,"not specified",50)
// LY07/A14
/* Inclusion Criteria:
Histologically proven primary testicular diffuse large B-cell non-Hodgkin's lymphoma, untreated
"child of 64572001 | disease |: 116676008 | associated morphology | = 128929007 | non-Hodgkin lymphoma (category) |, 363698007 | finding site = 40689003 | testes structure"
*/
let AQuestion = "Histologically proven primary testicular diffuse large B-cell non-Hodgkin's lymphoma, untreated"
let diagnosis_code = factory.codedvalue('at0009','MO_LymphomaType')
let disease:SD = Factory.Snomedutterance('64572001:116676008=128929007, 363698007=40689003')
let has_diagnosis:boolean = observation.code->includes(diagnosis_code)
if has_diagnosis then
let diagnosis_obs = observation->select(x|x.code = diagnosis_code and disease =x.value)
if not diagnosis_obs->isempty() then
conclude factory.GLIFDecisionResult(AQuestion,true,"correct type of lymphoma",50)
else
conclude factory.GLIFDecisionResult(AQuestion,false,"not correct type of lymphoma",50)
endif
else
conclude factory.GLIFDecisionResult(AQuestion,unknown,"no diagnosis made",50)
endif
// LY07/A15
/* Inclusion Criteria:
"Ann Arbor stage IE or IIE"
*/
let AQuestion = "Ann Arbor stage IE or IIE"
conclude factory.GLIFDecisionResult(AQuestion,unknown,"not specified",50)
// LY07/A16
/* Inclusion Criteria:
"Bidimensionally measurable or evaluable disease. Patients who have had all disease removed by surgery are eligible"
*/
let AQuestion = "Bidimensionally measurable or evaluable disease. Patients who have had all disease removed by surgery are eligible"
conclude factory.GLIFDecisionResult(AQuestion,unknown,"not specified",50)
// LY07/A17
/* Inclusion Criteria:
"Adequate bone marrow reserve (ANC > 1.000/L, Plt > 100.000/L)"
*/
let AQuestion = "Adequate bone marrow reserve (ANC > 1.000/L, Plt > 100.000/L)"
let anc_code = factory.codedvalue('751-8','LN')
let plt_code = factory.codedvalue('777-3','LN')
let anc_obs = observation->select(code = anc_code)->sortby(absolutetime)->last()
let plt_obs = observation->select(code = plt_code)->sortby(absolutetime)->last()
let anc_threshold = factory.physicalquantity(1.0,'10^9/L')
let plt_threshold = factory.physicalquantity(100.0,'10^9/L')
let anc_ok:boolean =
if anc_obs.isdefined() then
anc_obs.value > anc_threshold
else
unknown
endif
let plt_ok:boolean =
if plt_obs.isdefined() then
plt_obs.value > plt_threshold
else
unknown
endif
if (anc_obs.isdefined() and plt_obs.isdefined()) then
if anc_ok and plt_ok then
factory.GLIFDecisionResult(AQuestion,true,"adequate",50)
else
factory.GLIFDecisionResult(AQuestion,false,"inadequate",50)
endif
else
factory.GLIFDecisionResult(AQuestion,unknown,"no ANC or PLT data",50)
endif
// LY07/A19
/* Inclusion Criteria:
"Cardiac ejection fraction > 50% by MUGA scan or echocardiography"
*/
let AQuestion = "Cardiac ejection fraction > 50% by MUGA scan or echocardiography"
conclude factory.GLIFDecisionResult(AQuestion,unknown,"not specified",50)
// LY07/A20
/* Inclusion Criteria:
"No psychiatric illness that precludes understanding concepts of the trial or signing informed consent"
*/
let AQuestion = "No psychiatric illness that precludes understanding concepts of the trial or signing informed consent"
conclude factory.GLIFDecisionResult(AQuestion,unknown,"not specified",50)
// LY07/A21
/* Inclusion Criteria:
"No other major life-threatening illnesses that may preclude chemotherapy"
*/
let AQuestion = "No other major life-threatening illnesses that may preclude chemotherapy"
conclude factory.GLIFDecisionResult(AQuestion,unknown,"not specified",50)
// LY07/A22
/* Inclusion Criteria:
"have given written informed consent prior to any program-specific screening procedure, with the understanding that the consent may be withdrawn by the patient at any time without prejudice"
*/
let AQuestion = "have given written informed consent prior to any program-specific screening procedure, with the understanding that the consent may be withdrawn by the patient at any time without prejudice"
conclude factory.GLIFDecisionResult(AQuestion,unknown,"not specified",50)
// LY07/B12
/* Inclusion Criteria:
"impairment of renal function (creatinine > 2 mg/dl) or liver function (bilirubin > 2 mg/dl) unless due to lymphoma involvement"
*/
let AQuestion = "impairment of renal function (creatinine > 2 mg/dl) or liver function (bilirubin > 2 mg/dl) unless due to lymphoma involvement"
let creatinine_code = factory.codedvalue('14682-9','LN')
let bilirubin_code = factory.codedvalue('14631-6','LN')
let creatinine_obs = observation->select(code = creatinine_code)->sortby(absolutetime)->last()
let bilirubin_obs = observation->select(code = bilirubin_code)->sortby(absolutetime)->last()
let creatinine_threshold = factory.physicalquantity(2 * 88.4,'umol/L')
let bilirubin_threshold = factory.physicalquantity(2 * 17.1,'umol/L')
let creatinine_high:boolean =
if creatinine_obs.isdefined() then
creatinine_obs.value > creatinine_threshold
else
unknown
endif
let bilirubin_high:boolean =
if bilirubin_obs.isdefined() then
bilirubin_obs.value > bilirubin_threshold
else
unknown
endif
if creatinine_obs.isdefined() and bilirubin_obs.isdefined() then
if creatinine_high or bilirubin_high then
factory.GLIFDecisionResult(AQuestion,true,"impaired renal or liver function",50)
else
factory.GLIFDecisionResult(AQuestion,false,"renal and liver function ok",50)
endif
else
factory.GLIFDecisionResult(AQuestion,unknown,"no creatinine or bilirubin data",50)
endif
// LY07/B15
/* Inclusion Criteria:
"HIV positive patients"
*/
let AQuestion = "HIV positive patients"
conclude factory.GLIFDecisionResult(AQuestion,unknown,"not specified",50)
// LY07/B16
/* Inclusion Criteria:
"evolutive malignancy within 5 years with the exception of localized non-melanomatous skin cancer"
*/
let AQuestion = "evolutive malignancy within 5 years with the exception of localized non-melanomatous skin cancer"
conclude factory.GLIFDecisionResult(AQuestion,unknown,"not specified",50)
// Origin: C:\Code\medicalobjects\projects\LymphomaWizard\gello\Prima\A15.gello
// Inclusion Criteria: Bulky disease at study entry according to the GELF criteria: nodal or extranodal mass > 7cm in its greater diameter
factory.GLIFDecisionResult("Bulky disease at study entry according to the GELF criteria: nodal or extranodal mass > 7cm in its greater diameter",
unknown,
"not specified",50)
// Origin: C:\Code\medicalobjects\projects\LymphomaWizard\gello\Prima\A16.gello
// Inclusion cirteria: B symptoms
factory.GLIFDecisionResult("B symptoms",unknown,"not specified",50)
// Origin: C:\Code\medicalobjects\projects\LymphomaWizard\gello\Prima\A17.gello
// Inclusion criterion: Elevated serum LDH or ß2-microglobulin
let Aquestion = "Elevated serum LDH or ß2-microglobulin"
let LDH_codes:Set(CodedValue) =
Set{
factory.codedvalue('2532-0','LN'),
factory.codedvalue('11274001','SNOMED-CT')
}
let Beta_2_microglobulin_codes:Set(CodedValue) =
Set{
factory.codedvalue('1952-1','LN'),
factory.codedvalue('166587008','SNOMED-CT')
}
let obs = Observation->sortby(AbsoluteTime)
let LDH_obs = obs->select(o|LDH_codes->includes(o.code))->last()
let Beta_2_obs = obs->select(o|Beta_2_microglobulin_codes->includes(o.code))->last()
if LDH_obs.isundefined() then
continue // syntactic junk to distinguish if statment from conditional
if Beta_2_obs.isundefined() then
conclude factory.GLIFDecisionResult(Aquestion,unknown,"no LDH or Beta2-microglobulin observations",50)
else
let Beta_2_value = Beta_2_obs.value
let Beta_2_threshold = Beta_2_obs.reference_range.upper_limit
endif
else
let LDH_value = LDH_obs.value
let LDH_threshold = LDH_obs.reference_range.upper_limit
endif
if (LDH_Value > LDH_threshold) or (Beta_2_value > Beta_2_threshold) then
conclude factory.GLIFDecisionResult(Aquestion,true,"LDH or Beta2-microglobulin is elevated",50)
else
conclude factory.GLIFDecisionResult(Aquestion,false,"neither LDH nor Beta2-microglobulin is elevated",50)
endif
// Origin: C:\Code\medicalobjects\projects\LymphomaWizard\gello\Prima\A18.gello
// Inclusion Criteria: - involvement of at least 3 nodal sites (each with a diameter greater than 3 cm)
factory.GLIFDecisionResult("involvement of at least 3 nodal sites (each with a diameter greater than 3 cm)",
unknown,"not specified",50)
// Origin: C:\Code\medicalobjects\projects\LymphomaWizard\gello\Prima\A20.gello
// Inclusion Criteria: symptomatic splenic enlargement
factory.GLIFDecisionResult("symptomatic splenic enlargement",unknown,"not specified",50)
// Origin: C:\Code\medicalobjects\projects\LymphomaWizard\gello\Prima\A21.gello
// Inclusion Criteria: compressive syndrome
factory.GLIFDecisionResult("compressive syndrome",unknown,"not specified",50)
// Origin: C:\Code\medicalobjects\projects\LymphomaWizard\gello\Prima\A22.gello
// Inclusion Criteria: pleural/peritoneal effusion
factory.GLIFDecisionResult("pleural/peritoneal effusionB symptoms",unknown,"not specified",50)
// Origin: C:\Code\medicalobjects\projects\LymphomaWizard\gello\Prima\A23.gello
// Inclusion Criteria: Age must be > 18 years.
let now = factory.absolutetime("0").now()
let years18 = factory.duration(18,'y')
let dob = patient.date_of_birth
if dob.add(years18) < now then
factory.GLIFDecisionResult("Age must be > 18 years.",true,"old enough",50)
else
factory.GLIFDecisionResult("Age must be > 18 years.",false,"too young",50)
endif
// Origin: C:\Code\medicalobjects\projects\LymphomaWizard\gello\Prima\A25-28.gello
//let s: String = ObservationManager.LoadObservationsFromFile(".\TestData.oru ")
let Line1: String = "Inclusion Criteria: Adequate hematological function within 28 days prior to registration (unless those abnormalities are related to lymphoma extension), this includes:"
let Line2: String = "&nl;Hemoglobin >= 8.0 g/dl (5.0 mmol/L)"
let Line3: String = "&nl;Absolute neutrophil count (ANC) >= 1.5 109/L"
let Line4: String = "&nl;Platelet count >= 100 109/L"
let AQuestion: String = Line1.concat(Line2).concat(Line3).concat(Line4)
let AWeight : Integer = 50
let Hemoglobin_codes:set(CodedValue) =
Set {
Factory.CodedValue('718-7','LN'),
Factory.CodedValue('35170002','SNOMED-CT')
}
let ANC_codes:set(CodedValue) =
Set {
Factory.CodedValue('751-8','LN'),
Factory.CodedValue('30630007', 'SNOMED-CT')
}
let Platelet_codes:set(CodedValue) =
Set {
Factory.CodedValue('777-3','LN'),
Factory.CodedValue('104107006', 'SNOMED-CT')
}
let hemoglobin_threshold = factory.physicalquantity(80,'g/L')
let anc_threshold = factory.physicalquantity(1.5,'10^9/L')
let platelet_threshold = factory.physicalquantity(100,'10^9/L')
let days30 = factory.duration(30,'d')
//let reg_date = patient.registration_date.subtract(days30)
//let reg_date = factory.absolutetime('0').now().subtract(days30)
let reg_date = factory.absolutetime('20020401')
let recent_obs = Observation->select(absolutetime >= reg_date)->sortby(absolutetime)
let hemoglobin_value = recent_obs->select(o|hemoglobin_codes->includes(o.code)).value->last()
let anc_value = recent_obs->select(o|anc_codes->includes(o.code)).value->last()
let platelet_value = recent_obs->select(o|platelet_codes->includes(o.code)).value->last()
if hemoglobin_value.isundefined() or anc_value.isundefined() or platelet_value.isundefined() then
conclude
factory.GLIFDecisionResult(AQuestion,unknown,
"No Hemoglobin, Absolute Neutrophil Count or Platelet count observations",AWeight)
else
endif
if (hemoglobin_value >= hemoglobin_threshold)
and (anc_value >= anc_threshold)
and (platelet_value >= platelet_threshold) then
conclude factory.GLIFDecisionResult(AQuestion,true,"Adequate hematological function",AWeight)
else
conclude factory.GLIFDecisionResult(AQuestion,false,"Inadequate hematological function",AWeight)
endif
// Origin: C:\Code\medicalobjects\projects\LymphomaWizard\gello\Prima\A29.gello
// Inclusion Criteria: - Women are not breast feeding, are using effective contraception, are not pregnant and agree not to become pregnant during participation in the trial and during the 12 months thereafter. Men agree not to father a child during participation in the trial and during the 12 months thereafter
factory.GLIFDecisionResult(
"Women are not breast feeding, are using effective contraception, are not pregnant and agree not to become pregnant during participation in the trial and during the 12 months thereafter. Men agree not to father a child during participation in the trial and during the 12 months thereafter",
unknown,
"not specified",50)
// Origin: C:\Code\medicalobjects\projects\LymphomaWizard\gello\Prima\A30.gello
// Inclusion Criteria: Having previously signed a written informed consent form.
factory.GLIFDecisionResult(
"Having previously signed a written informed consent form.",
unknown,
"not specified",50)
// Origin: C:\Code\medicalobjects\projects\LymphomaWizard\gello\Prima\B31.gello
// Exclusion criteria: Transformation to high-grade lymphoma (secondary to “low-grade” follicular lymphoma).
factory.GLIFDecisionResult(
"Transformation to high-grade lymphoma (secondary to "low-grade" follicular lymphoma)",
unknown,
"not specified",50)
// Origin: C:\Code\medicalobjects\projects\LymphomaWizard\gello\Prima\B32.gello
// Exclusion criteria: Grade 3b follicular lymphoma.
factory.GLIFDecisionResult("Grade 3b follicular lymphoma.",
unknown,
"not specified",50)
// Origin: C:\Code\medicalobjects\projects\LymphomaWizard\gello\Prima\B33.gello
// Exclusion criteria: Presence or history of CNS disease (either CNS lymphoma or lymphomatous meningitis).
factory.GLIFDecisionResult(
"Presence or history of CNS disease (either CNS lymphoma or lymphomatous meningitis).",
unknown,
"not specified",50)
// Origin: C:\Code\medicalobjects\projects\LymphomaWizard\gello\Prima\B34.gello
/*
Exclusion criteria:
Patients regularly taking corticosteroids during the last 4 weeks,
unless administered at a dose equivalent to < 20 mg/day prednisone.
*/
let AQuestion = "Patients regularly taking corticosteroids during the last 4 weeks, unless administered at a dose equivalent to < 20 mg/day prednisone."
let days = 28
let days28 = factory.duration(days,'d')
let days_pq = factory.physicalquantity(days,'day')
let recent_date = factory.absolutetime('0').now().subtract(days28)
let recent_med = model.medications->select(effectivetime.high >= recent_date)->sortby(effectivetime.high)
let cort_codes:set(codedvalue) =
set{
factory.codedvalue('xxxxxx','LN'),
factory.codedvalue('xxxxxx','SNOMED-CT')
}
let cort_threshold = factory.physicalquantity(20,'mg/day')
let recent_cort = recent_med->select(d|cort_codes->includes(d.code)).dosequantityhigh
if recent_cort->size() > 0 then
// calculate rate per day - hopefully dose quantities are compatible and measurable should be in mg, or comparable units.
let total_cort:physicalquantity = recent_cort->sum()
let cort_day = total_cort / days_pq
if cort_day < cort_threshold then
conclude factory.GLIFDecisionResult(AQuestion,unknown,
"patient has taken corticosteroids in the past 4 weeks but is < 20 mg/day",
20) // add low weight to this, i.e. higher chance of rejection
else
conclude factory.GLIFDecisionResult(AQuestion,true,
"patient has taken corticosteroids in the past 4 weeks and is >= 20 mg/day",
50)
endif
else
conclude factory.GLIFDecisionResult(AQuestion,false,
"patient has not taken corticosteroids in the past 4 weeks",
50)
endif
// Origin: C:\Code\medicalobjects\projects\LymphomaWizard\gello\Prima\B35.gello
// Exclusion criteria: Patients with prior or concomitant malignancies except non-melanoma skin cancer or adequately treated in situ cervical cancer.
factory.GLIFDecisionResult(
"Patients with prior or concomitant malignancies except non-melanoma skin cancer or adequately treated in situ cervical cancer.",
unknown,
"not specified",50)
// Origin: C:\Code\medicalobjects\projects\LymphomaWizard\gello\Prima\B36.gello
// Exclusion criteria: Major surgery (excluding lymph node biopsy) within 28 days prior to registration.
factory.GLIFDecisionResult(
"Major surgery (excluding lymph node biopsy) within 28 days prior to registration.",
unknown,
"not specified",50)
// Origin: C:\Code\medicalobjects\projects\LymphomaWizard\gello\Prima\B37.gello
// Exclusion criteria: - Poor renal function: Serum creatinine > 2.0 mg/dl (197 µmol/L),
let AQuestion = "Poor renal function: Serum creatinine > 2.0 mg/dl (197 µmol/L)"
let creatinine_codes:set(codedvalue) =
set{
factory.codedvalue('14682-9','LN'),
factory.codedvalue('70901006','LN')
}
let creatinine_threshold = factory.physicalquantity(197,'umol/L')
let days30 = factory.duration(30,'d')
//let reg_date = patient.registration_date.subtract(days30)
let reg_date = factory.absolutetime('0').now().subtract(days30)
let recent_obs = Observation->select(absolutetime >= reg_date)->sortby(absolutetime)
let creatinine_values = recent_obs->select(o|creatinine_codes->includes(o.code)).value
if creatinine_values->size() < 3 then
conclude factory.GLIFDecisionResult(
AQuestion,
unknown,
"insufficient observation creatinine data.",50)
else
let creatinine_mean = creatinine_values->average()
if creatinine_mean > creatinine_threshold then
conclude factory.GLIFDecisionResult(
AQuestion,
true,
"Poor renal function: Serum creatinine too high.",50)
else
conclude factory.GLIFDecisionResult(
AQuestion,
false,
"Renal function ok: Serum creatinine good.",50)
endif
endif
// Origin: C:\Code\medicalobjects\projects\LymphomaWizard\gello\Prima\B38.gello
/* Exclusion criteria: Poor hepatic function:
total bilirubin > 2.0 mg/dl (34 µmol/L),
AST (SGOT) > 3 x the upper limit of normal unless these abnormalities are related to lymphoma.
*/
//let s: String = ObservationManager.LoadObservationsFromFile(".\TestData.oru ")
let AQuestion = "Poor hepatic function:&nl;total bilirubin > 2.0 mg/dl (34 µmol/L),&nl;AST (SGOT) > 3 x the upper limit of normal unless these abnormalities are related to lymphoma."
let bilirubin_codes:set(codedvalue) =
set{
factory.codedvalue('14631-6','LN'),
factory.codedvalue('27171005','SNOMED-CT')
}
let ast_codes:set(codedvalue) =
set{
factory.codedvalue('1920-8','LN'),
factory.codedvalue('250641004','SNOMED-CT')
}
let bilirubin_threshold = factory.physicalquantity(34,'umol/L')
//let days30 = factory.duration(30,'d')
//let reg_date = patient.registration_date.subtract(days30)
//let reg_date = factory.absolutetime('0').now().subtract(days30)
let reg_date = factory.absolutetime('20020401')
let recent_obs = Observation->select(absolutetime >= reg_date)->sortby(absolutetime)
let bilirubin_value = recent_obs->select(o|bilirubin_codes->includes(o.code)).value->last()
let ast_obs = recent_obs->select(o|ast_codes->includes(o.code))->last()
if bilirubin_value.isundefined() or ast_obs.isundefined() then
conclude factory.GLIFDecisionResult(
AQuestion,
unknown,
"insufficient observation data in past 30 days [total bilirubin, AST (SGOT) ]",50)
else
endif
let ast_value = ast_obs.value
let ast_threshold = ast_obs.reference_range.upper_limit * 3
if bilirubin_value > bilirubin_threshold or ast_value > ast_threshold then
conclude factory.GLIFDecisionResult(
AQuestion,
true,
"Poor hepatic function (bilirubin or AST(SGOT) too high).",50)
else
conclude factory.GLIFDecisionResult(
AQuestion,
false,
"Hepatic function ok.",50)
endif
// Origin: C:\Code\medicalobjects\projects\LymphomaWizard\gello\Prima\B39.gello
// Exclusion criteria: Known HIV infection or active HBV or HCV infection.
factory.GLIFDecisionResult(
"Known HIV infection or active HBV or HCV infection.",
unknown,
"not specified",50)
// Origin: C:\Code\medicalobjects\projects\LymphomaWizard\gello\Prima\B40.gello
// Exclusion criteria: Serious underlying medical conditions, which could impair the ability of the patient to participate in the trial (e.g. ongoing infection, uncontrolled diabetes mellitus, gastric ulcers, active autoimmune disease). Judgment is up to the investigator.
factory.GLIFDecisionResult(
"Serious underlying medical conditions, which could impair the ability of the patient to participate in the trial (e.g. ongoing infection, uncontrolled diabetes mellitus, gastric ulcers, active autoimmune disease). Judgment is up to the investigator.",
unknown,
"not specified",50)
// Origin: C:\Code\medicalobjects\projects\LymphomaWizard\gello\Prima\B41.gello
// Exclusion criteria: Life expectancy < 6 months
factory.GLIFDecisionResult(
"Life expectancy < 6 months",
unknown,
"not specified",50)
// Origin: C:\Code\medicalobjects\projects\LymphomaWizard\gello\Prima\B42.gello
// Exclusion criteria: Known sensitivity or allergy to murine products
factory.GLIFDecisionResult(
"Known sensitivity or allergy to murine products",
unknown,
"not specified",50)
// Origin: C:\Code\medicalobjects\projects\LymphomaWizard\gello\Prima\B43.gello
// Exclusion criteria: Treatment within a clinical trial within 30 days prior to trial entry
factory.GLIFDecisionResult(
"Treatment within a clinical trial within 30 days prior to trial entry",
unknown,
"not specified",50)
// Origin: C:\Code\medicalobjects\projects\LymphomaWizard\gello\Prima\B44.gello
// Exclusion criteria: Adult patient under tutelage.
factory.GLIFDecisionResult(
"Adult patient under tutelage.",
unknown,
"not specified",50)
/*
Age 15 to 70 years inclusive.
*/
// define our assertion or question
let question:string = 'Age 15 to 70 years inclusive.'
// now evaluate an answer.
let age = model.run('Age')
let answer:boolean =
if age.isdefined() then
age >= 15 and age <= 70
else
unknown
endif
// and return our response
// note - due to GELLO language constraints, we are not allowed to assign a
// variable value more than once, so alternative reasons have to be specified
// with sepearate return results.
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'Age acceptable',50)
else
factory.GLIFDecisionResult(question,answer,'Too young or too old.',50)
endif
else
factory.GLIFDecisionResult(question,answer,'No age given.',50)
endif
/*
ECOG performance status 0 to 3 inclusive.
*/
// define our assertion or question
let question:string = 'Is ECOG performance status 0 to 3 inclusive?'
// now evaluate an answer.
let answer: Boolean = Model.run('ECOG_0_to_3')
// and return our response
// note - due to GELLO language constraints, we are not allowed to assign a
// variable value more than once, so alternative reasons have to be specified
// with sepearate return results.
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'ECOG is 0 to 3',50)
else
factory.GLIFDecisionResult(question,answer,'ECOG is not 0 to 3',50)
endif
else
factory.GLIFDecisionResult(question,answer,'No Results',50)
endif
/*
A serum creatinine <=.15 mmol/L.
*/
let question:string = 'serum creatinine <= 0.15 mmol/L'
let creatinine_threshold = Factory.PhysicalQuantity(0.15,'mmol/L')
let creatinine: PhysicalQuantity = model.run('Creatinine')
let answer: Boolean =
if creatinine.isDefined() then
(creatinine <= creatinine_threshold)
else
unknown
endif
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'Serum Creatinine levels acceptable',50)
else
factory.GLIFDecisionResult(question,answer,'Serum Creatinine too high',50)
endif
else
factory.GLIFDecisionResult(question,answer,'Observation data missing Serum Creatinine',50)
endif
/*
Adequate hepatic function (bilirubin <= 2.5 x ULN),
*/
let question:string = 'Adequate hepatic function'
let bilirubin: Observation = model.run('Bilirubin_obs')
let answer: Boolean =
if bilirubin.isDefined() then
(bilirubin.value <= 2.5 * bilirubin.reference_range.upper_limit)
else
unknown
endif
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'Bilirubin levels acceptable',50)
else
factory.GLIFDecisionResult(question,answer,'Bilirubin too high',50)
endif
else
factory.GLIFDecisionResult(question,answer,'Observation data missing: Bilirubin',50)
endif
/*
Adequate haemopoietic indices (haemoglobin >= 90, absolute neutrophil count >=1.0, platelets >= 100), unless due to lymphomatous infiltration.
*/
let question:string = 'Adequate haemopoietic indices'
let Hb_threshold = Factory.PhysicalQuantity(90,'g/L')
let neutrophils_threshold = Factory.PhysicalQuantity(1.0,'10^9/L')
let platelets_threshold = Factory.PhysicalQuantity(100,'10^9/L')
let Hb: PhysicalQuantity = model.run('Hb')
let neutrophils: PhysicalQuantity = model.run('Neutrophils')
let platelets: PhysicalQuantity = model.run('Platelets')
let answer: Boolean =
if Hb.isdefined() and neutrophils.isDefined() and platelets.isDefined() then
(Hb >= Hb_threshold)
and (neutrophils > neutrophils_threshold)
and (platelets > platelets_threshold)
else
unknown
endif
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'Haemoglobin, Neutrophils and Platelets acceptable',50)
else
factory.GLIFDecisionResult(question,answer,'Haemoglobin, Neutrophils and Platelets unacceptable',50)
endif
else
factory.GLIFDecisionResult(question,answer,'Observation data missing for Haemoglobin, Neutrophils or Platelets',50)
endif
/*
Age 18 to 65 years inclusive.
*/
// define our assertion or question
let question:string = 'Age 18 to 65 years inclusive.'
// now evaluate an answer.
let age = model.run('Age')
let answer:boolean =
if age.isdefined() then
age >= 18 and age <= 65
else
unknown
endif
// and return our response
// note - due to GELLO language constraints, we are not allowed to assign a
// variable value more than once, so alternative reasons have to be specified
// with sepearate return results.
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'Age acceptable',50)
else
factory.GLIFDecisionResult(question,answer,'Too young or too old.',50)
endif
else
factory.GLIFDecisionResult(question,answer,'No age given.',50)
endif
/*
ECOG performance status >= 2
*/
// define our assertion or question
let question:string = 'Is ECOG performance status <= 2?'
// now evaluate an answer.
let answer: Boolean = Model.run('ECOG_0_to_2')
// and return our response
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'ECOG is 0 to 2',50)
else
factory.GLIFDecisionResult(question,answer,'ECOG is not 0 to 2',50)
endif
else
factory.GLIFDecisionResult(question,answer,'No Results',50)
endif
/*
Poor renal function
(creatinine level>150µmol/l,
poor hepatic function
(total bilirubin level>30mmol/l, transaminases>2.5 maximum normal level)
unless these abnormalities are related to the lymphoma.
*/
let question:string = 'Poor renal or hepatic function'
let creatinine_threshold = Factory.PhysicalQuantity(150,'umol/L')
let bilirubin_threshold = Factory.PhysicalQuantity(30,'mmol/L')
let creatinine: PhysicalQuantity = model.run('Creatinine')
let bilirubin: Physicalquantity = model.run('Bilirubin')
// transaminases = AST, ALT
let ALT: Observation = model.run('ALT_obs')
let AST: Observation = model.run('AST_obs')
let answer: Boolean =
if creatinine.isDefined()
and bilirubin.isDefined()
and ALT.isDefined()
and AST.isDefined() then
(creatinine > creatinine_threshold)
or (bilirubin > bilirubin_threshold)
or (ALT.value > 2.5 * ALT.reference_range.upper_limit)
or (AST.value > 2.5 * AST.reference_range.upper_limit)
else
unknown
endif
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'Poor renal or hepatic function',50)
else
factory.GLIFDecisionResult(question,answer,'Acceptable renal or hepatic function',50)
endif
else
factory.GLIFDecisionResult(question,answer,'Observation data missing: (Creatinine, Bilirubin, ALT or AST)',50)
endif
/*
Poor bone marrow reserve as defined by neutrophils<1.5 or platelets<100, unless related to bone marrow infiltration.
*/
let question:string = 'Poor bone marrow reserve?'
let neutrophils_threshold = Factory.PhysicalQuantity(1.5,'10^9/L')
let platelets_threshold = Factory.PhysicalQuantity(100,'10^9/L')
let neutrophils: PhysicalQuantity = model.run('Neutrophils')
let platelets: PhysicalQuantity = model.run('Platelets')
let answer: Boolean =
if neutrophils.isDefined() and platelets.isDefined() then
(neutrophils < neutrophils_threshold)
or (platelets < platelets_threshold)
else
unknown
endif
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'Neutrophils or Platelets are low',50)
else
factory.GLIFDecisionResult(question,answer,'Neutrophils and Platelets are acceptable',50)
endif
else
factory.GLIFDecisionResult(question,answer,'Observation data missing for Neutrophils or Platelets',50)
endif
/*
Stage III or Stage IV
*/
// define our assertion or question
let question:string = 'Either Stage III or Stage IV'
// now evaluate an answer.
//let answer:boolean = patient.age >= 18
let answer:boolean = Model.run('Stage_III_or_IV')
// and return our response
// note - due to GELLO language constraints, we are not allowed to assign a
// variable value more than once, so alternative reasons have to be specified
// with sepearate return results.
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'Is Stage III or IV',50)
else
factory.GLIFDecisionResult(question,answer,'Not Stage III or IV',50)
endif
else
factory.GLIFDecisionResult(question,answer,'Unknown Stage',50)
endif
/*
5. patients with an International Prognostic Score (IPS) >=3
IPS is defined as the number of the following adverse factors :
FACTOR
------
Age >= 45 years
Sex = male
Stage IV
WBC >=15*109/l
Lymphocytes count < 0.6*109/l or < 8% WBC
Albumin < 4 g/dl
Hemoglobin < 10.5 g/dl (< 105 g/l or < 6.5 mmol/l)
*/
let question:string = 'patients with an International Prognostic Score (IPS) >=3'
let WBC_threshold = factory.physicalquantity(15,'10^9/L')
let Lymphocytes_threshold = factory.physicalquantity(0.6,'10^9/L')
let Albumin_threshold = factory.physicalquantity(4,'g/dL')
let Hemoglobin_threshold = factory.physicalquantity(10.5,'g/dL')
let age: Integer = model.run('Age')
let Gender: String = model.patient.gender
let Is_Stage_IV: Boolean = model.run('Stage_IV')
let WBC: PhysicalQuantity = model.run('WCC')
let Lymphocytes: PhysicalQuantity = model.run('Lymphocytes')
let Albumin: PhysicalQuantity = model.run('Albumin')
let Hemoglobin: PhysicalQuantity = model.run('Hb')
let factors:set(boolean) =
Set{
if age.isdefined() then
age >= 45
else
unknown
endif,
Gender = 'M',
Is_Stage_IV,
if WBC.isdefined() then
WBC >= WBC_threshold
else
unknown
endif,
if lymphocytes.isdefined() then
Lymphocytes >= Lymphocytes_threshold
else
unknown
endif,
if Albumin.isdefined() then
Albumin < Albumin_threshold
else
unknown
endif,
if hemoglobin.isdefined() then
Hemoglobin < Hemoglobin_threshold
else
unknown
endif
}
let ips = factors->select(i|i = true)->size()
let missing_data = factors->select(i|i = unknown)->size() > 0
// now evaluate an answer.
let answer:boolean =
if not missing_data then
ips >= 3
else
unknown
endif
// and return our response
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'IPS >= 3',50)
else
factory.GLIFDecisionResult(question,answer,'IPS not >= 3',50)
endif
else
factory.GLIFDecisionResult(question,answer,'IPS indeterminate (missing data).',50)
endif
/*
Age 16 to 60 years inclusive.
*/
// define our assertion or question
let question:string = 'Age 16 to 60 years inclusive.'
// now evaluate an answer.
let age = model.run('Age')
let answer:boolean =
if age.isdefined() then
age >= 16 and age <= 60
else
unknown
endif
// and return our response
// note - due to GELLO language constraints, we are not allowed to assign a
// variable value more than once, so alternative reasons have to be specified
// with sepearate return results.
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'Age acceptable',50)
else
factory.GLIFDecisionResult(question,answer,'Too young or too old.',50)
endif
else
factory.GLIFDecisionResult(question,answer,'No age given.',50)
endif
/*
ECOG performance status >= 2
*/
// define our assertion or question
let question:string = 'Is ECOG performance status <= 2?'
// now evaluate an answer.
let answer: Boolean = Model.run('ECOG_0_to_2')
// and return our response
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'ECOG is 0 to 2',50)
else
factory.GLIFDecisionResult(question,answer,'ECOG is not 0 to 2',50)
endif
else
factory.GLIFDecisionResult(question,answer,'No Results',50)
endif
/*
16. adequate liver (bilirubin <= 2.5 x normal)
and renal (creatinine <= 150 µmol/L or <= 2.0 mg/dL) function,
unless abnormalities are due to HDAdequate hepatic function (bilirubin <= 2.5 x ULN),
*/
let question:string = 'Adequate hepatic and renal function?'
let creatinine_threshold = Factory.PhysicalQuantity(150,'umol/L')
let bilirubin: Observation = model.run('Bilirubin_obs')
let creatinine: PhysicalQuantity = model.run('Creatinine')
let answer: Boolean =
if bilirubin.isDefined() and creatinine.isdefined() then
(bilirubin.value <= 2.5 * bilirubin.reference_range.upper_limit)
and (creatinine <= creatinine_threshold)
else
unknown
endif
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'Adequate hepatic and renal function',50)
else
factory.GLIFDecisionResult(question,answer,'Inadequate hepatic and renal function',50)
endif
else
factory.GLIFDecisionResult(question,answer,'Observation data missing: (Bilirubin or Creatinine)',50)
endif
/*
17. leukocytes >2.0*109/l and platelets >100*109/l
*/
let question:string = 'Leukocytes and platelets acceptable?'
let leukocytes_threshold = Factory.PhysicalQuantity(2.0,'10^9/L')
let platelets_threshold = Factory.PhysicalQuantity(100,'10^9/L')
let leukocytes: PhysicalQuantity = model.run('Leukocytes')
let platelets: PhysicalQuantity = model.run('Platelets')
let answer: Boolean =
if leukocytes.isDefined() and platelets.isDefined() then
(leukocytes > leukocytes_threshold)
and (platelets > platelets_threshold)
else
unknown
endif
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'Leukocytes and Platelets are acceptable',50)
else
factory.GLIFDecisionResult(question,answer,'Leukocytes or Platelets are too',50)
endif
else
factory.GLIFDecisionResult(question,answer,'Observation data missing (Leukocytes or Platelets)',50)
endif
<html>
<head>
<style><!--
.Normal{text-align:left;font-size:12.00pt;font-family:'Times New Roman';margin-left:0.00in;margin-right:0.00in;}
.Default Paragraph Font{}
--></style></head><body>
<div><b><font face="Arial" size=4 color="black">PRIMA – Primary Rituximab and Maintenance Trial </font></b></div>
<div> </div>
<div><font face="Arial Greek" size=3 color="black">A multicentre phase II open-label randomised study in patients with advanced follicular lymphoma evaluating the benefit of maintenance therapy with rituximab after induction of response with chemotherapy plus rituximab in comparison with no maintenance therapy</font></div>
<div> </div>
<div><b><font face="Arial Greek" size=3 color="black">INCLUSION CRITERIA: </font></b></div>
<div> </div>
<div><font face="Arial Greek" size=3 color="black">Histologically confirmed follicular lymphoma grade 1, 2 or 3a. </font></div>
<div> </div>
<div><font face="Arial Greek" size=3 color="black">Patients previously untreated. </font></div>
<div> </div>
<div><font face="Arial Greek" size=3 color="black">Patients with at least one of the following symptoms requiring initiation of treatment: </font></div>
<div><font face="Arial Greek" size=3 color="black">	Bulky disease at study entry according to the GELF criteria: nodal or extranodal mass > 7cm in its greater diameter </font></div>
<div><font face="Arial Greek" size=3 color="black">	B symptoms </font></div>
<div><font face="Arial Greek" size=3 color="black">	Elevated serum LDH or ß2-microglobulin </font></div>
<div> </div>
<div><font face="Arial Greek" size=3 color="black">Involvement of at least 3 nodal sites (each with a diameter greater than 3 cm) </font></div>
<div><font face="Arial Greek" size=3 color="black">	symptomatic splenic enlargement </font></div>
<div><font face="Arial Greek" size=3 color="black">	compressive syndrome </font></div>
<div><font face="Arial Greek" size=3 color="black">	pleural/peritoneal effusion </font></div>
<div> </div>
<div> </div>
<div><font face="Arial Greek" size=3 color="black">Age must be > 18 years. </font></div>
<div> </div>
<div><font face="Arial Greek" size=3 color="black">Performance status < 2 on the ECOG scale</font></div>
<div> </div>
<div><font face="Arial Greek" size=3 color="black">Adequate hematological function within 28 days prior to registration (unless those abnormalities are related to lymphoma extension), this includes: </font></div>
<div><font face="Arial Greek" size=3 color="black">	Hemoglobin = 8.0 g/dl (5.0 mmol/L) </font></div>
<div><font face="Arial Greek" size=3 color="black">	Absolute neutrophil count (ANC) = 1.5 109/L </font></div>
<div><font face="Arial Greek" size=3 color="black">	Platelet count = 100 109/L </font></div>
<div> </div>
<div><font face="Arial Greek" size=3 color="black">Women are not breast feeding, are using effective contraception, are not pregnant and agree not to become pregnant during participation in the trial and during the 12 months thereafter. Men agree not to father a child during participation in the trial and during the 12 months thereafter. </font></div>
<div> </div>
<div><font face="Arial Greek" size=3 color="black">Having previously signed a written informed consent form.</font></div>
<div> </div>
<div><b><font face="Arial Greek" size=3 color="black">EXCLUSION CRITERIA</font></b></div>
<div> </div>
<div><font face="Arial Greek" size=3 color="black">Transformation to high-grade lymphoma (secondary to “low-grade” follicular lymphoma). </font></div>
<div> </div>
<div><font face="Arial Greek" size=3 color="black">Grade 3b follicular lymphoma. </font></div>
<div> </div>
<div><font face="Arial Greek" size=3 color="black">Presence or history of CNS disease (either CNS lymphoma or lymphomatous meningitis). </font></div>
<div> </div>
<div><font face="Arial Greek" size=3 color="black">Patients regularly taking corticosteroids during the last 4 weeks, unless administered at a dose equivalent to < 20 mg/day prednisone. </font></div>
<div> </div>
<div><font face="Arial Greek" size=3 color="black">Patients with prior or concomitant malignancies except non-melanoma skin cancer or adequately treated in situ cervical cancer. </font></div>
<div> </div>
<div><font face="Arial Greek" size=3 color="black">Major surgery (excluding lymph node biopsy) within 28 days prior to registration. </font></div>
<div> </div>
<div><font face="Arial Greek" size=3 color="black">Poor renal function: Serum creatinine > 2.0 mg/dl (197 µmol/L), </font></div>
<div> </div>
<div><font face="Arial Greek" size=3 color="black">Poor hepatic function: total bilirubin > 2.0 mg/dl (34 µmol/L), AST (SGOT) > 3 x the upper limit of normal unless these abnormalities are related to lymphoma. </font></div>
<div> </div>
<div><font face="Arial Greek" size=3 color="black">Known HIV infection or active HBV or HCV infection. </font></div>
<div> </div>
<div><font face="Arial Greek" size=3 color="black">Serious underlying medical conditions, which could impair the ability of the patient to participate in the trial (e.g. ongoing infection, uncontrolled diabetes mellitus, gastric ulcers, active autoimmune disease). Judgment is up to the investigator. </font></div>
<div> </div>
<div><font face="Arial Greek" size=3 color="black">Life expectancy < 6 months </font></div>
<div> </div>
<div><font face="Arial Greek" size=3 color="black">Known sensitivity or allergy to murine products </font></div>
<div> </div>
<div><font face="Arial Greek" size=3 color="black">Treatment within a clinical trial within 30 days prior to trial entry </font></div>
<div> </div>
<div><font face="Arial Greek" size=3 color="black">Adult patient under tutelage.</font></div>
<div> </div>
<div><b><font face="Arial Greek" size=3 color="black">Trial centres currently registered (Sept 06) </font></b></div>
<div> </div>
<div><font face="Arial Greek" size=3 color="black">Albury Base/Murray Valley Private, Alfred, Ashford Cancer Centre, Auckland, Ballarat, Bendigo, Box Hill, Canberra, Christchurch, Concord, Frankston,Fremantle, Geelong, Gosford, Hobart, Mater Newcastle, Middlemore, North Shore, Peter MacCallum, Prince of Wales (NSW), Princess Alexandra, Queen Elizabeth, Royal Adelaide, Royal North Shore, Royal Perth, Sir Charles Gairdner, St George, St Vincent's Melbourne, St Vincent's Sydney, Townsville, Wesley, Westmead, </font></div>
<div> </div>
</body></html>
<html>
<head></head><body>
<div><b><font face="Arial" size=4>NHLLOW-5 TROG 99.03</font></b></div>
<div> </div>
<div><font face="Arial">Trans Tasman Radiation Oncology Group</font></div>
<div> </div>
<div><font face="Arial">A randomised multcentre trial of involved field radiotherapy versus involved field radiotherapy plus chemotherapy for Stage I-II Low Grade Follicular Lymphoma</font></div>
<div> </div>
<div><b><font face="Arial">Inclusion Criteria</font></b></div>
<div> </div>
<div><font face="Arial">1) Adult patients with histologically documented “follicular small cleaved” or “follicular mixed small cleaved and large cell lymphoma”. Pathology will be reviewed centrally (PMCI). Patients who on review of pathology do not meet this criterion will be ineligible for analysis and may require therapy different from this protocol.</font></div>
<div><font face="Arial">2) Disease limited to stages I and II after adequate staging (see Appendix II)</font></div>
<div><font face="Arial">3) Anticipated life expectancy > 5 years</font></div>
<div><font face="Arial">4) Given written informed consent</font></div>
<div><font face="Arial">5) Been assessed by a radiation oncologist and a medical oncologist/ haematologist</font></div>
<div><font face="Arial">6) WCC > 3.0 x 109/L, platelet count > 100 x 109/L, serum creatinine < 0.15 mmol/L</font></div>
<div><font face="Arial">7) Ability to commence radiotherapy within 6 weeks of randomisation</font></div>
<div> </div>
<div><b><font face="Arial">Exclusion Criteria</font></b></div>
<div> </div>
<div><font face="Arial">1) Received previous systemic cytotoxic chemotherapy</font></div>
<div><font face="Arial">2) Received previous radiotherapy, (except superficial radiation therapy for non-melanoma skin cancers)</font></div>
<div><font face="Arial">3) A medical contraindication to radiotherapy or chemotherapy</font></div>
<div><font face="Arial">4) Any previous or concurrent malignancy other than curatively treated non-melanoma skin cancer, level 1 malignant melanoma, or in situ cervical cancer, unless disease and treatment-free for 5 years.</font></div>
<div><font face="Arial">5) Such extensive involvement of the thorax that treatment with radiation therapy alone would be hazardous because of excessive lung irradiation, even if a shrinking field technique were employed</font></div>
<div><font face="Arial">6) Suspected or confirmed pregnancy. Must not be lactating.</font></div>
<div> </div>
<div><b><font face="Arial">Minimum Investigations to Determine Eligibility</font></b></div>
<div> </div>
<div><i><font face="Arial">All assessments must be undertaken within 4 weeks of randomisati</font></i><font face="Arial">on.</font></div>
<div> </div>
<div><font face="Arial">1) Full history and examination</font></div>
<div><font face="Arial">2) Complete blood counts including differential white cell counts and ESR</font></div>
<div><font face="Arial">3) Serum ALT/AST, albumin, bilirubin, ALP, LDH, urea, creatinine, Na, K, Ca</font></div>
<div><font face="Arial">4) CT scan from neck to pelvis and where appropriate, CT or MRI of paranasal sinuses, Waldeyer’s region or other involved anatomic location.</font></div>
<div><font face="Arial">5) Unilateral or (preferably) bilateral iliac bone marrow biopsy </font></div>
<div> </div>
<div><b><font face="Arial">Trial centres currently registered NHLLOW-5 (Sept 06) </font></b></div>
<div> </div>
<div><font face="Arial">Albury Base/Murray Valley Private, Auckland, Austin/Repat, Canberra, East Coast Cancer Centre, Geelong, Launceston, Mater Brisbane, Mater Newcastle, Peter MacCallum, Prince of Wales (NSW), Princess Alexandra, Queen Elizabeth, Royal Adelaide, Royal Brisbane, Sir Charles Gairdner, St George, Waikato, Wellington, Westmead</font></div>
<div> </div>
<div> </div>
</body></html>
<html>
<head></head><body>
<div><b><font face="Arial" size=4>ALLG LY02 TROG 99.04</font></b></div>
<div> </div>
<div><font face="Arial">A prospective, non-randomised study of chemotherapy </font></div>
<div><font face="Arial">And radiotherapy for osteolymphoma (ol). </font></div>
<div> </div>
<div><b><font face="Arial">Inclusion Criteria </font></b></div>
<div> </div>
<div><font face="Arial">Pathology: Histologically proven OL, classified according to the WHO classification (App’x 19.2). Patients with small non-cleaved (Burkitt’s and non-Burkitt’s), lymphoblastic lymphoma or Hodgkin’s disease will not be eligible, however immunoblastic lymphomas behave similarly to diffuse large cell lymphomas and are eligible. Wherever possible, sections should be submitted as described in the pathology section (8.0). </font></div>
<div> </div>
<div><font face="Arial">Site: Any bony site will be considered. Eligible cases will be divided into two groups in an attempt to define cases suitable for future trials. All patients must have evidence of bone involvement. These groups are defined as A (Standard or “Classical” OL), and B (Locally Extensive or multifocal OL). Note that both categories can include patients with pathological fractures at presentation. The categories are summarised in this table, then defined in detail: </font></div>
<div><font face="Arial">Osteolymphoma classification summary table: </font></div>
<div> </div>
<div><font face="Arial">Group A: Solitary tumour with no extraosseous component, or with an extraosseous component which satisfies any one or more of the following criteria: </font></div>
<div><font face="Arial">	1. Less in largest diameter than the intraosseous component, or </font></div>
<div><font face="Arial">	2. Containing bone elements such as periosteal layering or bone sequestra, or </font></div>
<div><font face="Arial">	3. Anatomically distant from conventional lymph node groups. </font></div>
<div> </div>
<div><font face="Arial">Group B: Solitary tumour which has either: </font></div>
<div><font face="Arial">	1. An extraosseous component beyond that listed above, or </font></div>
<div><font face="Arial">	2. Occurred in a conventional node group but involving adjacent bone(s). </font></div>
<div><font face="Arial">	3. Or, Multifocal sites of disease within a single bone, or in adjacent bones. </font></div>
<div> </div>
<div> </div>
<div><font face="Arial">A. Classical OL. This includes patients with tumours contained within bone, and those with a limited extraosseous soft tissue component. The definition of limited is that the largest diameter of the extraosseous component is no greater than the largest diameter of the intraosseous component. Tumours which have a larger soft tissue component can be included if there are features suggesting expansion of the bone from within. This includes cases with the onionskin periosteal layering effect, and those with evidence of bone elements (sequestra) within the soft tissue mass. Tumours with extensive soft tissue components without evidence of expansion from within can only fall into category A if they are in sites where there would not be expected to be a major anatomical group of lymph nodes (cervical, supraclavicular, axillary, mediastinal, paraaortic, iliac, or inguinal. </font></div>
<div> </div>
<div><font face="Arial">B. Locally extensive or multifocal OL. This includes patients with solitary OL tumours with a soft tissue component that fails to satisfy the requirements of A, above. It may include patients in whom the centre of the tumour is clearly outside the affected bone. This category also includes patients with multifocal disease in a single bone, or in adjacent bones such that the area of known disease can be contained within a single radiotherapy volume. </font></div>
<div><font face="Arial">Stage: Patients in the above categories will fall into Ann Arbor stages IE, except that patients with multifocal disease exclusively within a single bone or adjacent bones (normally considered stage IV) are included in classification B above. Completion of conventional staging procedures for NHL is required before registration and is described in section 7.0 . Patients with B symptoms are included in the study. </font></div>
<div> </div>
<div><font face="Arial">Age: Older than 17 years. </font></div>
<div> </div>
<div><font face="Arial">ECOG performance status < 3 (App’x 19.1). </font></div>
<div> </div>
<div><font face="Arial">Minimum expected survival or accessibility for follow-up: 6 months </font></div>
<div> </div>
<div><font face="Arial">Laboratory Values. Hb > 100 gm/L, WBC > 4.0 x 109/L, platelets >100x109/L, GGT, ALT and AST less than twice the upper limit of normal, creatinine clearance > 60 mL/min., no significant cardiac history, and either a normal cardiac ejection fraction or echocardiogram. </font></div>
<div> </div>
<div><font face="Arial">Patients capable of childbearing are using adequate contraception. </font></div>
<div> </div>
<div><font face="Arial">Written, informed consent (App’x 19.4). </font></div>
<div> </div>
<div><b><font face="Arial">Exclusion Criteria </font></b></div>
<div> </div>
<div><font face="Arial">Previous radiotherapy or chemotherapy </font></div>
<div> </div>
<div><font face="Arial">Previous malignancy other than non-melanomatous skin cancers or carcinoma-in-situ of the cervix. </font></div>
<div> </div>
<div><font face="Arial">Medically unfit to undergo any component of the treatment (including pregnancy or lactation), or any medical condition likely to limit survival to less than six months. </font></div>
<div> </div>
<div><b><font face="Arial">Trial centres currently registered LY02 (Sept 06) </font></b></div>
<div> </div>
<div><font face="Arial">Auckland, Geelong, Hobart, John Flynn, Launceston, Liverpool, Mater Newcastle, Palmerston North, Peter MacCallum, Princess Alexandra, Queensland Radium Institute, Royal Adelaide, Royal Brisbane, Royal Prince Alfred, Sir Charles Gairdner, Townsville, Waikato, Wesley, Westmead, Wollongong, </font></div>
<div> </div>
<div> </div>
</body></html>
<html>
<head></head><body>
<div><b><font face="Arial" size=4>LY03 /WM1 </font></b></div>
<div> </div>
<div><font face="Arial">A randomised trial of chlorambucil versus fludarabine as initial therapy of Waldenström’s macroglobulinaemia and splenic lymphoma with villous lymphocytes.</font></div>
<div> </div>
<div><b><font face="Arial">Inclusion criteria.</font></b></div>
<div> </div>
<div><font face="Arial">All patients with previously untreated WM, SLVL and non-IgM LPL who require therapeutic intervention as judged by their primary physicians. As a guide to the indications for treatment, haematological suppression to Hb <10 g/dl, or neutrophils <1.5x109/l or platelets <150x109/l suggests that patients will benefit from therapy as would clinical evidence of hyperviscosity in terms of neurological or ocular disturbance. Patients without either haematological or clinical abnormalities should not proceed to randomisation on the basis of detection of clonal cells alone. Eligibility will be based on morphological and immunophenotypic criteria (see Appendix 1 of protocol ). Bone marrow should be assessed by (at least) two-colour flow cytometry and the expression of the following antigens determined: surface Ig, CD19, CD20, CD5, CD10 and CD23.</font></div>
<div> </div>
<div><font face="Arial">	Age 18 years or above.</font></div>
<div><font face="Arial"> 	Performance status grade 0, 1, 2, and life expectancy of greater than 6 months.</font></div>
<div><font face="Arial"> 	No concurrent malignancy.</font></div>
<div><font face="Arial">	Adequate renal and hepatic function (serum creatinine <200 mmol/l and AST/ALT <2X upper limit of normal).</font></div>
<div><font face="Arial">	Negative Direct Coomb’s Test.</font></div>
<div><font face="Arial">	Informed consent.</font></div>
<div> </div>
<div><b><font face="Arial">Exclusion criteria.</font></b></div>
<div> </div>
<div><font face="Arial">Severe or life-threatening cardiac, pulmonary, neurological, psychiatric or metabolic disease.</font></div>
<div> </div>
<div><font face="Arial">Pregnant or lactating women (women of child bearing potential and all men are strongly advised to use appropriate contraceptive precautions during and for at least 6 months after treatment in the study).</font></div>
<div> </div>
<div><font face="Arial">Patients with AIDS or AIDS related complex.</font></div>
<div> </div>
<div><font face="Arial">Patients with evidence of active Hepatitis C infection.</font></div>
<div> </div>
<div><b><font face="Arial">Trial centres currently registered LY03 (Sept 06) </font></b></div>
<div> </div>
<div><font face="Arial">Canberra, Geelong, Mater Newcastle, Peter MacCallum, Princess Alexandra, Queen Elizabeth, Townsville, Wollongong, </font></div>
<div> </div>
</body></html>
<html>
<head></head><body>
<div><b><font face="Arial" size=4>LY07 </font></b></div>
<div> </div>
<div><font face="Arial">A PHASE II STUDY OF CHOP, WITH INTRATHECAL METHOTREXATE FOLLOWED BY RADIOTHERAPY IN PATIENTS WITH PRIMARY TESTICULAR NON-HODGKIN’S LYMPHOMA</font></div>
<div> </div>
<div><b><font face="Arial">INCLUSION CRITERIA</font></b></div>
<div> </div>
<div><font face="Arial">age = 18 years.</font></div>
<div> </div>
<div><font face="Arial">ECOG performance status 0-2</font></div>
<div> </div>
<div><font face="Arial">Histologically proven primary testicular diffuse large B-cell non-Hodgkin’s lymphoma, untreated</font></div>
<div> </div>
<div><font face="Arial">Ann Arbor stage IE or IIE. Bilateral testicular involvement at presentation will not be considered stage IV. In these patients the final Ann Arbor stage will be determined by the extent of nodal involvement.</font></div>
<div> </div>
<div><font face="Arial">Bidimensionally measurable or evaluable disease. Patients who have had all disease removed by surgery are eligible.</font></div>
<div> </div>
<div><font face="Arial">Adequate bone marrow reserve (ANC > 1.000/L, Plt > 100.000/L)</font></div>
<div> </div>
<div><font face="Arial">Cardiac ejection fraction ³ 50% by MUGA scan or echocardiography</font></div>
<div> </div>
<div><font face="Arial">No psychiatric illness that precludes understanding concepts of the trial or signing informed consent</font></div>
<div> </div>
<div><font face="Arial">No other major life-threatening illnesses that may preclude chemotherapy</font></div>
<div> </div>
<div><font face="Arial">Have given written informed consent prior to any program-specific screening procedure, with the understanding that the consent may be withdrawn by the patient at any time without prejudice</font></div>
<div> </div>
<div><b><font face="Arial">EXCLUSION CRITERIA</font></b></div>
<div> </div>
<div><font face="Arial">Impairment of renal function (creatinine > 2 mg/dl) or liver function (bilirubin > 2 mg/dl) unless due to lymphoma involvement</font></div>
<div> </div>
<div><font face="Arial">HIV positive patients</font></div>
<div> </div>
<div><font face="Arial">Evolutive malignancy within 5 years with the exception of localized non-melanomatous skin cancer</font></div>
<div> </div>
<div> </div>
<div><b><font face="Arial">Trial centres currently registered LY07 (Sept 06)</font></b></div>
<div> </div>
<div><font face="Arial">Peter MacCallum </font></div>
<div><font face="Arial"> </font></div>
<div> </div>
</body></html>
<html>
<head></head><body>
<div><b><font face="Arial" size=4>AUSTRALASIAN LEUKAEMIA AND LYMPHOMA GROUP ALLG NHL11 PROTOCOL</font></b></div>
<div> </div>
<div><font face="Arial">A phase-II study of a modified “Hyper-CVAD” frontline therapy for patients with poor prognosis diffuse large B-cell and peripheral T-cell Non-Hodgkin’s lymphoma</font></div>
<div> </div>
<div><b><font face="Arial">Inclusion Criteria</font></b></div>
<div> </div>
<div><font face="Arial">Patients with previously untreated mature (post-thymic) T-cell or NK-cell NHL and an IPI score of ??2. Histologic classification will be according to the WHO classification, and includes the following categories; peripheral T-cell lymphomas, unspecified (all cytologic categories), angioimmunoblastic T-cell lymphoma, extranodal NK/T cell lymphoma, nasal type, enteropathy-type T-cell lymphoma, hepatosplenic T-cell lymphoma, subcutaneous panniculitis-like T-cell lymphoma or systemic anaplastic large cell (CD30+) lymphoma (Tand null-cell types).</font></div>
<div> </div>
<div><font face="Arial">The following T-lineage disorders are not eligible: precursor T-lymphoblastic lymphoma, TPLL, T-cell large granular lymphocytic leukemia, aggressive NK-cell leukaemia, blastic NKcell lymphoma, mycosis fungoides (and its variants), and HTLV-1-related adult T-cell leukemia / lymphoma.</font></div>
<div><font face="Arial">Anaplastic large cell (CD30+) lymphoma limited to the skin (primary cutaneous CD30+ ALCL) has consistently been reported to have a favourable prognosis with standard treatment approaches regardless of International Prognostic Factors Index score,27 and so would not be considered eligible for this study.</font></div>
<div><font face="Arial">OR Patients with previously untreated diffuse large B-cell NHL (including the variants mediastinal (thymic) B-cell NHL and intravascular large B-cell NHL) and an IPI score of >?2.</font></div>
<div> </div>
<div><font face="Arial">Age 15 to 70 years inclusive.</font></div>
<div> </div>
<div><font face="Arial">ECOG performance status 0 to 3 inclusive.</font></div>
<div> </div>
<div><font face="Arial">A serum creatinine ??0.15 mmol/L. Adequate hepatic function (bilirubin ??2.5 x ULN), and haemopoietic indices (haemoglobin >?90, absolute neutrophil count >?1.0, platelets > 100), unless due to lymphomatous infiltration.</font></div>
<div> </div>
<div><font face="Arial">Confirmed seronegativity for antibodies to HIV .</font></div>
<div> </div>
<div><font face="Arial">Normal left ventricular ejection fraction, according to institutional criteria.</font></div>
<div> </div>
<div><font face="Arial">Written informed consent must be obtained from each patient prior to registration and start of treatment.</font></div>
<div> </div>
<div><b><font face="Arial">Exclusion Criteria</font></b></div>
<div> </div>
<div><font face="Arial">Prior diagnosis of “low-grade” NHL, although patients with discordant bone marrow histology (i.e. small cell lymphomatous infiltrate of marrow) are eligible.</font></div>
<div> </div>
<div><font face="Arial">Prior treatment for NHL.</font></div>
<div> </div>
<div><font face="Arial">Past history of serious cardiac, pulmonary, hepatic or renal disease,</font></div>
<div> </div>
<div><font face="Arial">A past history of cancer (other than non-melanoma skin cancer or carcinoma of the cervix in situ).</font></div>
<div> </div>
<div><font face="Arial">Contraindication to the use of the study drugs, including known sensitivity to E. Coli derived preparations. This includes agreement to use a medically acceptable and effective means of contraception throughout the treatment period for both male and female patients of childbearing potential.</font></div>
<div><font face="Arial">Pregnant women or breast-feeding mothers.</font></div>
<div> </div>
<div><font face="Arial">History of solid-organ transplantation.</font></div>
<div> </div>
<div> </div>
<div><b><font face="Arial">Trial centres currently registered NHL 11 (Sept 06)</font></b></div>
<div> </div>
<div><font face="Arial">Albury Base/Murray Valley Private, Auckland, Ballarat, Canberra, Geelong, Launceston, Mater Newcastle, Peter MacCallum, Pretoria, Princess Alexandra, Queen Elizabeth, Royal Adelaide, Royal North Shore, Royal Perth, Royal Prince Alfred, Toowoomba, Townsville, Westmead, Wollongong, </font></div>
<div> </div>
</body></html>
<html>
<head></head><body>
<div><b><font face="Arial" size=4>ALLG NHL 13 / GELA CORAL: 50-03B</font></b></div>
<div> </div>
<div><font face="Arial">RANDOMIZED STUDY OF ICE PLUS RITUXIMAB (R-ICE) VERSUS DHAP PLUS RITUXIMAB (RDHAP) IN PREVIOUSLY TREATED PATIENTS WITH CD 20 POSITIVE DIFFUSE LARGE B-CELL LYMPHOMA, ELIGIBLE FOR TRANSPLANTATION FOLLOWED BY RANDOMIZED MAINTENANCE TREATMENT WITH RITUXIMAB</font></div>
<div> </div>
<div><b><font face="Arial">Inclusion criteria</font></b></div>
<div> </div>
<div><font face="Arial">Patient with histologically proven, CD 20+ diffuse large B cell lymphoma in 1st relapse after CR, less than PR or partial response to first line treatment</font></div>
<div> </div>
<div><font face="Arial">Aged from 18 to 65 years, inclusive</font></div>
<div> </div>
<div><font face="Arial">Eligible for transplant</font></div>
<div> </div>
<div><font face="Arial">Previously treated with chemotherapy regimen containing anthracyclines with or without rituximab</font></div>
<div> </div>
<div><font face="Arial">ECOG performance status = 2</font></div>
<div> </div>
<div><font face="Arial">With a minimum life expectancy of 3 months</font></div>
<div> </div>
<div><font face="Arial">Signed informed consent form prior to randomization</font></div>
<div> </div>
<div><b><font face="Arial">Exclusion criteria </font></b></div>
<div> </div>
<div><font face="Arial">Burkitt , mantle cell, T-cell lymphoma.</font></div>
<div> </div>
<div><font face="Arial">CD 20-negative NHL</font></div>
<div> </div>
<div><font face="Arial">Documents HIV or HBV disease (in the absence of vaccination).</font></div>
<div> </div>
<div><font face="Arial">Central nervous system or meningeal involvement by lymphoma.</font></div>
<div> </div>
<div><font face="Arial">Not previously treated with anthracycline-containing regimens.</font></div>
<div> </div>
<div><font face="Arial">Prior transplantation</font></div>
<div> </div>
<div><font face="Arial">Contraindication to any drug contained in the chemotherapy regimens.</font></div>
<div> </div>
<div><font face="Arial">Any serious active disease or co-morbid medical condition (according to the investigator’s decision and information provided in the IDB).</font></div>
<div> </div>
<div><font face="Arial">Poor renal function (creatinine level>150µmol/l, poor hepatic function (total bilirubin level>30mmol/l, transaminases>2.5 maximum normal level) unless</font></div>
<div><font face="Arial">these abnormalities are related to the lymphoma.</font></div>
<div> </div>
<div><font face="Arial">Poor bone marrow reserve as defined by neutrophils<1.5 or platelets<100, unless related to bone marrow infiltration.</font></div>
<div> </div>
<div><font face="Arial">Any history of cancer during the last 5 years, with the exception of non-melanoma skin tumors or stage 0 (in situ) cervical carcinoma.</font></div>
<div> </div>
<div><font face="Arial">Pregnant woman</font></div>
<div> </div>
<div><font face="Arial">Treatment with any investigational drug within 30 days before planned first cycle of chemotherapy and during the study.</font></div>
<div> </div>
<div><font face="Arial">Adult patient unable to give informed consent because of intellectual impairment</font></div>
<div> </div>
<div><b><font face="Arial">Trial centres currently registered NHL 13 (Sept 06)</font></b></div>
<div> </div>
<div><font face="Arial">Albury Base/Murray Valley Private, Auckland, Austin/Repat, Cabrini, Canberra, Christchurch, Concord, Dunedin, Flinders Medical Centre, Geelong, Hobart, Palmerston North, Peter MacCallum, Princess Alexandra, Royal Adelaide, Royal Brisbane, Royal Melbourne, Royal North Shore, Royal Perth, Royal Prince Alfred, Sir Charles Gairdner, St Vincent's Sydney, Townsville, Wellington, </font></div>
<div> </div>
</body></html>
<html>
<head></head><body>
<div><b><font face="Arial" size=4>ALLG HD4 / Intergroup Study (EORTC protocol 20012)</font></b></div>
<div> </div>
<div><font face="Arial">BEACOPP (4 cycles escalated + 4 cycles baseline) versus</font></div>
<div><font face="Arial">ABVD (8 cycles) in stage III & IV Hodgkin’s lymphoma</font></div>
<div> </div>
<div><b><font face="Arial">Inclusion criteria:</font></b></div>
<div> </div>
<div><font face="Arial">Histologically documented Hodgkin’s lymphoma/disease, except for the subtype lymphocyte predominant, nodular type (nodular paragranuloma)</font></div>
<div> </div>
<div><font face="Arial">Clinical stage III or IV</font></div>
<div> </div>
<div><font face="Arial">Presence of at least one bi-dimensionally measurable target lesion, as defined in protocol (chapter 7.2) </font></div>
<div> </div>
<div><font face="Arial">Patients with extranodal disease only will be eligible if they have at least one bi-dimensionally measurable extranodal lesion. Patients with no nodal or visceral measurable disease CANNOT be included.</font></div>
<div> </div>
<div><font face="Arial">Patients with an International Prognostic Score (IPS) =3 IPS is defined as the number of the following adverse factors :</font></div>
<div><font face="Arial">	FACTOR</font></div>
<div><font face="Arial">	Age = 45 years</font></div>
<div><font face="Arial">	Sex = male</font></div>
<div><font face="Arial">	Stage IV</font></div>
<div><font face="Arial">	WBC =15*109/l</font></div>
<div><font face="Arial">	Lymphocytes count < 0.6*109/l or < 8% WBC</font></div>
<div><font face="Arial">	Albumin < 4 g/dl</font></div>
<div><font face="Arial">	Hemoglobin < 10.5 g/dl (< 105 g/l or < 6.5 mmol/l)</font></div>
<div> </div>
<div><font face="Arial">Age 16-60 years</font></div>
<div> </div>
<div><font face="Arial">No prior therapy for Hodgkin's disease</font></div>
<div> </div>
<div><font face="Arial">WHO performance status grades 0, 1, or 2</font></div>
<div> </div>
<div><font face="Arial">No potentially childbearing patients without effective contraception</font></div>
<div> </div>
<div><font face="Arial">Patients should not be pregnant or lactating.</font></div>
<div> </div>
<div><font face="Arial">No concomitant or previous malignancies other than basal cell skin tumors or in situ uterine cervix carcinoma.</font></div>
<div> </div>
<div><font face="Arial">No severe cardio-pulmonary, neurological or metabolic disease, interfering with normal life expectancy or normal application of protocol treatment (patients with LEVF<50 and RF<30% are not eligible)</font></div>
<div> </div>
<div><font face="Arial">No severe active infection</font></div>
<div> </div>
<div><font face="Arial">No psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule</font></div>
<div> </div>
<div><font face="Arial">No known HIV or HTLV1 positivity</font></div>
<div> </div>
<div><font face="Arial">Adequate liver (bilirubin = 2.5 x normal) and renal (creatinine = 150 µmol/L or = 2.0 mg/dL) function, unless abnormalities are due to HD</font></div>
<div> </div>
<div><font face="Arial">Leukocytes >2.0*109/l and platelets >100*109/l</font></div>
<div> </div>
<div><font face="Arial">No history of uncontrolled HBV infection defined as presence of HBS antigen or absence of HBS antigen but presence of anti-HBc antibody without anti-HBS antibody</font></div>
<div> </div>
<div><font face="Arial">Written informed consent according to ICH/GCP and/or applicable national laws. Parent’s consent for patients under 18 years of age according to applicable national laws.</font></div>
<div> </div>
<div><b><font face="Arial">Trial centres currently registered (Sept 06) </font></b></div>
<div> </div>
<div><font face="Arial">Albury Base/Murray Valley Private, Auckland, Canberra, Hobart, Princess Alexandra, Royal Adelaide, Royal Perth, St Vincent's Melbourne, Westmead </font></div>
<div> </div>
</body></html>
Treatment planning
Determine trial suitability
Treatment planning
Meets trial criteria
Review aggressive lymphoma staging
Diffuse large B-cell lymphoma management A
Mantle cell lymphoma management
Mediastinal (thymic) large B-cell lymphoma
Peripheral T-cell lymphoma management
/*
Sample Gello for GLIF decision.
A GLIF decision condition returns a structured result of GELLO type GLIFDecisionResult.
The result has several parts..
1. Question.
This is the question being asked or assertion being made.
It should be stated in such a way as to return a true or false answer.
For example
"Is age is 18 years or older?"
True: patient is 18 or more
False: patient is younger than 18
2. Answer.
This is what the GELLO program will determine in response to the question
or condition being determined, or assertion being made.
A "true" answer means that the condition passed. (yes to question)
A "false" answer means that the condition failed. (no to question)
A "unknown" answer typically means there was insufficient data to
give a definite yes or no to the question.
3. Reason.
This is an informative message stating the reason for the decision being made.
It is not used in used in determining the overall result of the condition, however
it will be used to present an informative message to the GLIF when reviewing a decision
that was evaluated.
4. Weight.
When a decision cannot be determined (e.g. unknown) a weight may be returned
between 0 and 100. it represents how close to yes or no the answer is,
with 0 meaning "no" and 100 meaning "yes". 50 is equivalent to "don't know"
*/
// define our assertion or question
let question:string = 'Is this Diffuse large B-cell lymphoma'
Let IDL : Set(CodedValue) = Set{
Factory.Codedvalue('at0025^Diffuse large B-cell^MO_LymphomaType')
}
// now evaluate an answer.
//See if we have diagnosis data
let path: String = '1.1.1'
let OBS : Observation = Model.find_observation('Lymphoma_Wizard_Core', path)
let answer:Boolean =
if OBS.isUndefined() then
unknown
else
if IDL-> includes(OBS.value) then
true
else
false
endif
endif
// note - due to GELLO language constraints, we are not allowed to assign a
// variable value more than once, so alternative reasons have to be specified
// with sepearate return results.
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'Diffuse large B-cell lymphoma',50)
else
factory.GLIFDecisionResult(question,answer,'Not Correct type',50)
endif
else
factory.GLIFDecisionResult(question,answer,'Diagnosis uncertain',50)
endif
/*
Sample Gello for GLIF decision.
A GLIF decision condition returns a structured result of GELLO type GLIFDecisionResult.
The result has several parts..
1. Question.
This is the question being asked or assertion being made.
It should be stated in such a way as to return a true or false answer.
For example
"Is age is 18 years or older?"
True: patient is 18 or more
False: patient is younger than 18
2. Answer.
This is what the GELLO program will determine in response to the question
or condition being determined, or assertion being made.
A "true" answer means that the condition passed. (yes to question)
A "false" answer means that the condition failed. (no to question)
A "unknown" answer typically means there was insufficient data to
give a definite yes or no to the question.
3. Reason.
This is an informative message stating the reason for the decision being made.
It is not used in used in determining the overall result of the condition, however
it will be used to present an informative message to the GLIF when reviewing a decision
that was evaluated.
4. Weight.
When a decision cannot be determined (e.g. unknown) a weight may be returned
between 0 and 100. it represents how close to yes or no the answer is,
with 0 meaning "no" and 100 meaning "yes". 50 is equivalent to "don't know"
*/
// define our assertion or question
let question:string = 'Is this Mantle cell Lymphoma'
Let IDL : Set(CodedValue) = Set{
Factory.Codedvalue('at0024^mantle cell lymphomar^MO_LymphomaType')
}
// now evaluate an answer.
//See if we have diagnosis data
let path: String = '1.1.1'
let OBS : Observation = Model.find_observation('Lymphoma_Wizard_Core', path)
let answer:Boolean =
if OBS.isUndefined() then
unknown
else
if IDL-> includes(OBS.value) then
true
else
false
endif
endif
// note - due to GELLO language constraints, we are not allowed to assign a
// variable value more than once, so alternative reasons have to be specified
// with sepearate return results.
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'Mantle cell Lymphoma',50)
else
factory.GLIFDecisionResult(question,answer,'Not Correct type',50)
endif
else
factory.GLIFDecisionResult(question,answer,'Diagnosis uncertain',50)
endif
/*
Sample Gello for GLIF decision.
A GLIF decision condition returns a structured result of GELLO type GLIFDecisionResult.
The result has several parts..
1. Question.
This is the question being asked or assertion being made.
It should be stated in such a way as to return a true or false answer.
For example
"Is age is 18 years or older?"
True: patient is 18 or more
False: patient is younger than 18
2. Answer.
This is what the GELLO program will determine in response to the question
or condition being determined, or assertion being made.
A "true" answer means that the condition passed. (yes to question)
A "false" answer means that the condition failed. (no to question)
A "unknown" answer typically means there was insufficient data to
give a definite yes or no to the question.
3. Reason.
This is an informative message stating the reason for the decision being made.
It is not used in used in determining the overall result of the condition, however
it will be used to present an informative message to the GLIF when reviewing a decision
that was evaluated.
4. Weight.
When a decision cannot be determined (e.g. unknown) a weight may be returned
between 0 and 100. it represents how close to yes or no the answer is,
with 0 meaning "no" and 100 meaning "yes". 50 is equivalent to "don't know"
*/
// define our assertion or question
let question:string = 'Is this small lymphocyctic Lymphoma'
Let IDL : Set(CodedValue) = Set{
Factory.Codedvalue('at0026^Mediastinal (thymic) large B-cell lymphoma^MO_LymphomaType')
}
// now evaluate an answer.
//See if we have diagnosis data
let path: String = '1.1.1'
let OBS : Observation = Model.find_observation('Lymphoma_Wizard_Core', path)
let answer:Boolean =
if OBS.isUndefined() then
unknown
else
if IDL-> includes(OBS.value) then
true
else
false
endif
endif
// note - due to GELLO language constraints, we are not allowed to assign a
// variable value more than once, so alternative reasons have to be specified
// with sepearate return results.
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'Mediastinal (thymic)large B-cell lymphoma',50)
else
factory.GLIFDecisionResult(question,answer,'Not Correct type',50)
endif
else
factory.GLIFDecisionResult(question,answer,'Diagnosis uncertain',50)
endif
/*
Sample Gello for GLIF decision.
A GLIF decision condition returns a structured result of GELLO type GLIFDecisionResult.
The result has several parts..
1. Question.
This is the question being asked or assertion being made.
It should be stated in such a way as to return a true or false answer.
For example
"Is age is 18 years or older?"
True: patient is 18 or more
False: patient is younger than 18
2. Answer.
This is what the GELLO program will determine in response to the question
or condition being determined, or assertion being made.
A "true" answer means that the condition passed. (yes to question)
A "false" answer means that the condition failed. (no to question)
A "unknown" answer typically means there was insufficient data to
give a definite yes or no to the question.
3. Reason.
This is an informative message stating the reason for the decision being made.
It is not used in used in determining the overall result of the condition, however
it will be used to present an informative message to the GLIF when reviewing a decision
that was evaluated.
4. Weight.
When a decision cannot be determined (e.g. unknown) a weight may be returned
between 0 and 100. it represents how close to yes or no the answer is,
with 0 meaning "no" and 100 meaning "yes". 50 is equivalent to "don't know"
*/
// define our assertion or question
let question:string = 'Is this Peripheral T-cell lymphoma'
Let IDL : Set(CodedValue) = Set{
Factory.Codedvalue('at0044^Peripheral T-cell lymphoma^MO_LymphomaType')
}
// now evaluate an answer.
//See if we have diagnosis data
let path: String = '1.1.1'
let OBS : Observation = Model.find_observation('Lymphoma_Wizard_Core', path)
let answer:Boolean =
if OBS.isUndefined() then
unknown
else
if IDL-> includes(OBS.value) then
true
else
false
endif
endif
// note - due to GELLO language constraints, we are not allowed to assign a
// variable value more than once, so alternative reasons have to be specified
// with sepearate return results.
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'Peripheral T-cell lymphoma',50)
else
factory.GLIFDecisionResult(question,answer,'Not Correct type',50)
endif
else
factory.GLIFDecisionResult(question,answer,'Diagnosis uncertain',50)
endif
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="9.2.1_files/filelist.xml">
<link rel=Edit-Time-Data href="9.2.1_files/editdata.mso">
<link rel=OLE-Object-Data href="9.2.1_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-01-23T21:56:08Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
text-align:center;}
.xl26
{mso-style-parent:style0;
font-weight:700;
font-family:Arial, sans-serif;
mso-font-charset:0;}
.xl27
{mso-style-parent:style0;
font-weight:700;
font-family:Arial, sans-serif;
mso-font-charset:0;
background:#CCFFFF;
mso-pattern:auto none;}
.xl28
{mso-style-parent:style0;
font-weight:700;
font-family:Arial, sans-serif;
mso-font-charset:0;
text-align:center;
background:#CCFFFF;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Print>
<x:ValidPrinterInfo/>
<x:HorizontalResolution>600</x:HorizontalResolution>
<x:VerticalResolution>600</x:VerticalResolution>
</x:Print>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>6</x:ActiveRow>
<x:ActiveCol>1</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=534 style='border-collapse:
collapse;table-layout:fixed;width:401pt'>
<col width=436 style='mso-width-source:userset;mso-width-alt:15945;width:327pt'>
<col class=xl25 width=98 style='mso-width-source:userset;mso-width-alt:3584;
width:74pt'>
<col width=191 style='mso-width-source:userset;mso-width-alt:6985;width:143pt'>
<col width=192 style='mso-width-source:userset;mso-width-alt:7021;width:144pt'>
<tr class=xl26 height=17 style='height:12.75pt'>
<td height=17 class=xl27 width=436 style='height:12.75pt;width:327pt'>Text</td>
<td class=xl28 width=98 style='width:74pt'>Evidence level</td>
</tr>
<tr height=58 style='mso-height-source:userset;height:43.5pt'>
<td height=58 class=xl24 width=436 style='height:43.5pt;width:327pt'>Predicted
indicators for lymph node biopsy are age greater than 40 years,<br>
supraclavicular location, node diameter over 2.25 cm, firmard
texture,<br>
and lack of tenderness.</td>
<td class=xl25 x:num>3</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=436 style='width:327pt'></td>
<td width=98 style='width:74pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
3
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="9.2.2_files/filelist.xml">
<link rel=Edit-Time-Data href="9.2.2_files/editdata.mso">
<link rel=OLE-Object-Data href="9.2.2_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-01T00:56:15Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
text-align:center;}
.xl26
{mso-style-parent:style0;
background:#CCFFCC;
mso-pattern:auto none;}
.xl27
{mso-style-parent:style0;
text-align:center;
background:#CCFFCC;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>5</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=534 style='border-collapse:
collapse;table-layout:fixed;width:401pt'>
<col width=425 style='mso-width-source:userset;mso-width-alt:15542;width:319pt'>
<col class=xl25 width=109 style='mso-width-source:userset;mso-width-alt:3986;
width:82pt'>
<col width=143 style='mso-width-source:userset;mso-width-alt:5229;width:107pt'>
<col width=80 style='mso-width-source:userset;mso-width-alt:2925;width:60pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl26 width=425 style='height:12.75pt;width:319pt'>Text</td>
<td class=xl27 width=109 style='width:82pt'>Evidence level</td>
</tr>
<tr height=68 style='mso-height-source:userset;height:51.0pt'>
<td height=68 class=xl24 width=425 style='height:51.0pt;width:319pt'>Fine-needle
aspiration (FNA) is generally the biopsy investigation of choice in the
initial triage in peripheral lymphadenopathy. It should be accompanied by
flow cytometry (FCM) studies.</td>
<td class=xl25 x:num>4</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=425 style='width:319pt'></td>
<td width=109 style='width:82pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="9.2.4_files/filelist.xml">
<link rel=Edit-Time-Data href="9.2.4_files/editdata.mso">
<link rel=OLE-Object-Data href="9.2.4_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-01T00:57:41Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
background:#CCFFCC;
mso-pattern:auto none;}
.xl26
{mso-style-parent:style0;
text-align:center;
background:#CCFFCC;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>6</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=504 style='border-collapse:
collapse;table-layout:fixed;width:379pt'>
<col width=406 style='mso-width-source:userset;mso-width-alt:14848;width:305pt'>
<col class=xl24 width=98 style='mso-width-source:userset;mso-width-alt:3584;
width:74pt'>
<col width=124 style='mso-width-source:userset;mso-width-alt:4534;width:93pt'>
<col width=96 style='mso-width-source:userset;mso-width-alt:3510;width:72pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=406 style='height:12.75pt;width:305pt'>Text</td>
<td class=xl26 width=98 style='width:74pt'>Evidence level</td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'>Full blood count and chest x-ray should
be performed before biopsy.</td>
<td class=xl24 x:num>4</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=406 style='width:305pt'></td>
<td width=98 style='width:74pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="9.2.3_files/filelist.xml">
<link rel=Edit-Time-Data href="9.2.3_files/editdata.mso">
<link rel=OLE-Object-Data href="9.2.3_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-01T00:57:09Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
text-align:center;}
.xl26
{mso-style-parent:style0;
background:#CCFFCC;
mso-pattern:auto none;}
.xl27
{mso-style-parent:style0;
text-align:center;
background:#CCFFCC;
mso-pattern:auto none;}
.xl28
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl29
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>9</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=588 style='border-collapse:
collapse;table-layout:fixed;width:441pt'>
<col width=477 style='mso-width-source:userset;mso-width-alt:17444;width:358pt'>
<col class=xl25 width=111 style='mso-width-source:userset;mso-width-alt:4059;
width:83pt'>
<col width=126 style='mso-width-source:userset;mso-width-alt:4608;width:95pt'>
<col width=110 style='mso-width-source:userset;mso-width-alt:4022;width:83pt'>
<col width=273 style='mso-width-source:userset;mso-width-alt:9984;width:205pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl26 width=477 style='height:12.75pt;width:358pt'>Text</td>
<td class=xl27 width=111 style='width:83pt'>Evidence level</td>
</tr>
<tr height=10 style='mso-height-source:userset;height:7.5pt'>
<td height=10 style='height:7.5pt'></td>
<td class=xl25></td>
</tr>
<tr height=65 style='mso-height-source:userset;height:48.75pt'>
<td height=65 class=xl28 width=477 style='height:48.75pt;width:358pt'>Excisional
lymph node biopsy is essential for the primary diagnosis, subtyping and
clinical management of lymphoma presenting as peripheral lymphadenopathy.</td>
<td class=xl29 x:num>4</td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl24 style='height:12.75pt'></td>
<td class=xl25></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=477 style='width:358pt'></td>
<td width=111 style='width:83pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
Some parts of the form are currently hidden, click on the grey rectangles on the left of the window that opens from here (green arrow)
4
Top Level Guideline
/*
Sample Gello for GLIF decision.
A GLIF decision condition returns a structured result of GELLO type GLIFDecisionResult.
The result has several parts..
1. Question.
This is the question being asked or assertion being made.
It should be stated in such a way as to return a true or false answer.
For example
"Is age is 18 years or older?"
True: patient is 18 or more
False: patient is younger than 18
2. Answer.
This is what the GELLO program will determine in response to the question
or condition being determined, or assertion being made.
A "true" answer means that the condition passed. (yes to question)
A "false" answer means that the condition failed. (no to question)
A "unknown" answer typically means there was insufficient data to
give a definite yes or no to the question.
3. Reason.
This is an informative message stating the reason for the decision being made.
It is not used in used in determining the overall result of the condition, however
it will be used to present an informative message to the GLIF when reviewing a decision
that was evaluated.
4. Weight.
When a decision cannot be determined (e.g. unknown) a weight may be returned
between 0 and 100. it represents how close to yes or no the answer is,
with 0 meaning "no" and 100 meaning "yes". 50 is equivalent to "don't know"
*/
// define our assertion or question
let question:string = 'Is this Hodgkins Lymphoma'
// now evaluate an answer.
//See if we have diagnosis data
let path: String = '1.1.1'
let OBS : Observation = Model.find_observation('Lymphoma_Wizard_Core', path)
//setup all the current diagnoses
//Hodgkins
let Group01: Set(CodedValue) =
Set{
//Hodgkin lymphoma
Factory.CodedValue('at0049^Hodgkin lymphoma^MO_LymphomaType'),
//Nodular lymphocytic-predominant Hodgkin lymphoma
Factory.CodedValue('at0050^Nodular lymphocytic-predominant Hodgkin lymphoma^MO_LymphomaType'),
//Classical Hodgkin lymphoma
Factory.CodedValue('at0051^Classical Hodgkin lymphoma^MO_LymphomaType'),
//Nodular sclerosis Hodgkin lymphoma
Factory.CodedValue('at0052', 'MO_LymphomaType'),
//Lymphocyte-rich Hodgkin lymphoma
Factory.CodedValue('at0053', 'MO_LymphomaType'),
//Mixed cellularity Hodgkin lymphoma
Factory.CodedValue('at0054', 'MO_LymphomaType'),
//Lymphocyte-depleted Hodgkin lymphoma
Factory.CodedValue('at0055', 'MO_LymphomaType')
}
let answer:Boolean =
if OBS.isUndefined() then
unknown
else
if Group01->includes(OBS.value) then
true
else
false
endif
endif
// note - due to GELLO language constraints, we are not allowed to assign a
// variable value more than once, so alternative reasons have to be specified
// with sepearate return results.
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'Patient has Hodgkins disease',50)
else
factory.GLIFDecisionResult(question,answer,'Patient does not have Hodgkins',50)
endif
else
factory.GLIFDecisionResult(question,answer,'Diagnosis unclear',50)
endif
Follow this for NHL
NHL management
Follow this for HL management
Hodgkin Lymphoma management A
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="11.8_files/filelist.xml">
<link rel=Edit-Time-Data href="11.8_files/editdata.mso">
<link rel=OLE-Object-Data href="11.8_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-01T01:06:34Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:#CCFFCC;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>0</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=579 style='border-collapse:
collapse;table-layout:fixed;width:434pt'>
<col width=579 style='mso-width-source:userset;mso-width-alt:21174;width:434pt'>
<col width=126 style='mso-width-source:userset;mso-width-alt:4608;width:95pt'>
<col width=110 style='mso-width-source:userset;mso-width-alt:4022;width:83pt'>
<col width=273 style='mso-width-source:userset;mso-width-alt:9984;width:205pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=579 style='height:12.75pt;width:434pt'> </td>
</tr>
<tr height=153 style='height:114.75pt'>
<td height=153 class=xl24 width=579 style='height:114.75pt;width:434pt'>When
a confident diagnosis of HL is made after an adequate biopsy, a comprehensive
assessment of the patient is essential, including a detailed history and
examination. Careful recording of the size and distribution of all visible
and/or palpable lesions is essential. symptoms, namely weight loss
greater than 10% in the past six months, fevers over 38 degrees or drenching
night-sweats, should be specifically asked about. Other disease-associated
symptoms, such as alcohol-induced pain and pruritis, should be recorded.
Co-morbid conditions, such as heart disease, which could influence the
tolerance of treatment, should also be recorded. Full dental evaluation is
recommended if radiotherapy is planned to the oral cavity or salivary glands.</td>
</tr>
<tr height=238 style='height:178.5pt;mso-xlrowspan:14'>
<td height=238 style='height:178.5pt'></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl24 style='height:12.75pt'></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=579 style='width:434pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="11.11.3_files/filelist.xml">
<link rel=Edit-Time-Data href="11.11.3_files/editdata.mso">
<link rel=OLE-Object-Data href="11.11.3_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-01T01:08:50Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl27
{mso-style-parent:style0;
background:#CCFFCC;
mso-pattern:auto none;}
.xl28
{mso-style-parent:style0;
text-align:center;
background:#CCFFCC;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>9</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=693 style='border-collapse:
collapse;table-layout:fixed;width:520pt'>
<col width=292 style='mso-width-source:userset;mso-width-alt:10678;width:219pt'>
<col class=xl24 width=95 style='mso-width-source:userset;mso-width-alt:3474;
width:71pt'>
<col width=306 style='mso-width-source:userset;mso-width-alt:11190;width:230pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl27 width=292 style='height:12.75pt;width:219pt'>Text</td>
<td class=xl28 width=95 style='width:71pt'>Evidence level</td>
<td class=xl27 width=306 style='width:230pt'>References</td>
</tr>
<tr height=9 style='mso-height-source:userset;height:6.75pt'>
<td height=9 style='height:6.75pt'></td>
<td class=xl24></td>
<td></td>
</tr>
<tr height=161 style='mso-height-source:userset;height:120.75pt'>
<td height=161 class=xl25 width=292 style='height:120.75pt;width:219pt'>Bone
marrow biopsy is recommended in at least those cases with stage >IIA.</td>
<td class=xl26 x:num>4</td>
<td class=xl25 width=306 style='width:230pt'>Munker R, Hasenclever D,
Brosteanu O, Hiller E, Diehl V. Bone marrow involvement in Hodgkin's disease:
an analysis of 135 consecutive cases. German Hodgkin's Lymphoma Study Group.
J Clin Oncol 1995; 13: 403-9.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=292 style='width:219pt'></td>
<td width=95 style='width:71pt'></td>
<td width=306 style='width:230pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="11.9_files/filelist.xml">
<link rel=Edit-Time-Data href="11.9_files/editdata.mso">
<link rel=OLE-Object-Data href="11.9_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-01T01:07:26Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:#CCFFCC;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>3</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=479 style='border-collapse:
collapse;table-layout:fixed;width:359pt'>
<col width=479 style='mso-width-source:userset;mso-width-alt:17517;width:359pt'>
<col width=126 style='mso-width-source:userset;mso-width-alt:4608;width:95pt'>
<col width=110 style='mso-width-source:userset;mso-width-alt:4022;width:83pt'>
<col width=273 style='mso-width-source:userset;mso-width-alt:9984;width:205pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=479 style='height:12.75pt;width:359pt'> </td>
</tr>
<tr height=123 style='mso-height-source:userset;height:92.25pt'>
<td height=123 class=xl24 width=479 style='height:92.25pt;width:359pt'>Routine
haematological and biochemical indices should include full blood counts, LDH,
liver function tests, ESR, albumin and creatinine, which either document
organ function or provide prognostic information. Thyroid function tests
should be performed if the thyroid region is to be irradiated. A test for HIV
should be considered, although it is very rare for HIV infection to present
as lymphoma.</td>
</tr>
<tr height=238 style='height:178.5pt;mso-xlrowspan:14'>
<td height=238 style='height:178.5pt'></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl24 style='height:12.75pt'></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=479 style='width:359pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="11.11.4_files/filelist.xml">
<link rel=Edit-Time-Data href="11.11.4_files/editdata.mso">
<link rel=OLE-Object-Data href="11.11.4_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-01T01:10:26Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl27
{mso-style-parent:style0;
background:#CCFFCC;
mso-pattern:auto none;}
.xl28
{mso-style-parent:style0;
text-align:center;
background:#CCFFCC;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>4</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=869 style='border-collapse:
collapse;table-layout:fixed;width:652pt'>
<col width=353 style='mso-width-source:userset;mso-width-alt:12909;width:265pt'>
<col class=xl24 width=85 style='mso-width-source:userset;mso-width-alt:3108;
width:64pt'>
<col width=431 style='mso-width-source:userset;mso-width-alt:15762;width:323pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl27 width=353 style='height:12.75pt;width:265pt'>Text</td>
<td class=xl28 width=85 style='width:64pt'>Evidence level</td>
<td class=xl27 width=431 style='width:323pt'>References</td>
</tr>
<tr height=10 style='mso-height-source:userset;height:7.5pt'>
<td height=10 style='height:7.5pt'></td>
<td class=xl24></td>
<td></td>
</tr>
<tr height=336 style='mso-height-source:userset;height:252.0pt'>
<td height=336 class=xl25 width=353 style='height:252.0pt;width:265pt'>FDG-PET
scanning or, if unavailable, gallium scanning, are recommended for staging in
all cases. Positron emission tomography (PET) is superior to gallium.</td>
<td class=xl26 x:num>4</td>
<td class=xl25 width=431 style='width:323pt'>1. Weihrauch MR, Re D, Bischoff
S et al. Whole-body positron emission tomography using 18Ffluorodeoxyglucose
for initial staging of patients with Hodgkin's disease. Ann Hematol 2002; 81:
20-5.<br>
2. Zinzani PL, Magagnoli M, Chierichetti F et al. The role of positron
emission tomography (PET) in the management of lymphoma patients. Ann Oncol
1999; 10: 1181-4.<br>
3. Jerusalem G, Beguin Y, Fassotte MF et al. Whole-body positron emission
tomography using 18F-fluorodeoxyglucose compared to standard procedures for
staging patients with Hodgkin's disease. Haematologica 2001; 86:
266-73.<br>
4. Wirth A, Seymour JF, Hicks RJ et al. Fluorine-18 fluorodeoxyglucose
positron emission tomography, gallium-67 scintigraphy, and conventional
staging for Hodgkin's disease and non- Hodgkin's lymphoma. Am J Med 2002;
112: 262-8.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=353 style='width:265pt'></td>
<td width=85 style='width:64pt'></td>
<td width=431 style='width:323pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="11.11.1_files/filelist.xml">
<link rel=Edit-Time-Data href="11.11.1_files/editdata.mso">
<link rel=OLE-Object-Data href="11.11.1_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-01T01:11:51Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl27
{mso-style-parent:style0;
background:#CCFFCC;
mso-pattern:auto none;}
.xl28
{mso-style-parent:style0;
text-align:center;
background:#CCFFCC;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>18</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=858 style='border-collapse:
collapse;table-layout:fixed;width:644pt'>
<col width=359 style='mso-width-source:userset;mso-width-alt:13129;width:269pt'>
<col class=xl24 width=93 style='mso-width-source:userset;mso-width-alt:3401;
width:70pt'>
<col width=406 style='mso-width-source:userset;mso-width-alt:14848;width:305pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl27 width=359 style='height:12.75pt;width:269pt'>Text</td>
<td class=xl28 width=93 style='width:70pt'>Evidence level</td>
<td class=xl27 width=406 style='width:305pt'>References</td>
</tr>
<tr height=9 style='mso-height-source:userset;height:6.75pt'>
<td height=9 style='height:6.75pt'></td>
<td class=xl24></td>
<td></td>
</tr>
<tr height=205 style='mso-height-source:userset;height:153.75pt'>
<td height=205 class=xl25 width=359 style='height:153.75pt;width:269pt'>All
patients should undergo CT scans of at least the neck, chest, abdomen and
pelvis.</td>
<td class=xl26 x:num>4</td>
<td class=xl25 width=406 style='width:305pt'>1. Castellino RA, Blank N, Hoppe
RT, Cho C. Hodgkin disease: contributions of chest CT in the initial staging
evaluation. Radiology 1986; 160: 603-5.<br>
2. Hopper KD, Diehl LF, Lesar M, Barnes M, Granger E, Baumann J. Hodgkin
disease: clinical utility of CT in initial staging and treatment. Radiology
1988; 169: 17-22.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=359 style='width:269pt'></td>
<td width=93 style='width:70pt'></td>
<td width=406 style='width:305pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="11.7_files/filelist.xml">
<link rel=Edit-Time-Data href="11.7_files/editdata.mso">
<link rel=OLE-Object-Data href="11.7_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-01T01:15:13Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:#CCFFCC;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>7</x:ActiveRow>
<x:RangeSelection>$A$8:$A$9</x:RangeSelection>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=585 style='border-collapse:
collapse;table-layout:fixed;width:439pt'>
<col width=585 style='mso-width-source:userset;mso-width-alt:21394;width:439pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=585 style='height:12.75pt;width:439pt'> </td>
</tr>
<tr height=80 style='mso-height-source:userset;height:60.0pt'>
<td height=80 class=xl24 width=585 style='height:60.0pt;width:439pt'>The Ann
Arbor system of staging was developed to characterise the extent of disease
in patients with HL, but is also applied to other lymphomas (not used in
entities like CNS lymphoma or mycosis fungoids). It is more useful in HL than
non-Hodgkin lymphoma (NHL) because of the common tendency of HL to spread in
an orderly way to adjacent lymph node groups.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=585 style='width:439pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
This will take you to an Ann Arbor staging tool
/*
Stage III or Stage IV
*/
// define our assertion or question
let question:string = 'Either Stage III or Stage IV'
// now evaluate an answer.
//let answer:boolean = patient.age >= 18
let answer:boolean = Model.run('Stage_III_or_IV')
// and return our response
// note - due to GELLO language constraints, we are not allowed to assign a
// variable value more than once, so alternative reasons have to be specified
// with sepearate return results.
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'Is Stage III or IV',50)
else
factory.GLIFDecisionResult(question,answer,'Not Stage III or IV',50)
endif
else
factory.GLIFDecisionResult(question,answer,'Unknown Stage',50)
endif
Hodgkin Lymphoma management C
Hodgkin Lymphoma management B
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="11.16.1.2_files/filelist.xml">
<link rel=Edit-Time-Data href="11.16.1.2_files/editdata.mso">
<link rel=OLE-Object-Data href="11.16.1.2_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-20T09:20:07Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8122</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
background:#FFFF99;
mso-pattern:auto none;}
.xl26
{mso-style-parent:style0;
text-align:center;
background:#FFFF99;
mso-pattern:auto none;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>13</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=880 style='border-collapse:
collapse;table-layout:fixed;width:660pt'>
<col width=364 style='mso-width-source:userset;mso-width-alt:13312;width:273pt'>
<col class=xl24 width=109 style='mso-width-source:userset;mso-width-alt:3986;
width:82pt'>
<col width=407 style='mso-width-source:userset;mso-width-alt:14884;width:305pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=364 style='height:12.75pt;width:273pt'>Text</td>
<td class=xl26 width=109 style='width:82pt'>Evidence level</td>
<td class=xl25 width=407 style='width:305pt'>References</td>
</tr>
<tr height=8 style='mso-height-source:userset;height:6.0pt'>
<td height=8 style='height:6.0pt'></td>
<td class=xl24></td>
<td></td>
</tr>
<tr height=74 style='mso-height-source:userset;height:55.5pt'>
<td height=74 class=xl27 width=364 style='height:55.5pt;width:273pt'>All
subgroups of early Hodgkin lymphoma should be treated with a regimen that
covers the spleen, supra-diaphragmatic and paraaortic lymph nodes, such as
chemotherapy and involved-field radiotherapy, or subtotal nodal irradiation.</td>
<td class=xl28 x:num>1</td>
<td class=xl27 width=407 style='width:305pt'>Tubiana M, Henry-Amar M, Hayat M
et al. The EORTC treatment of early stages of Hodgkin's disease: the role of
radiotherapy. Int J Radiat Oncol Biol Phys 1984; 10: 197-210.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=364 style='width:273pt'></td>
<td width=109 style='width:82pt'></td>
<td width=407 style='width:305pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="11.16.1.1_files/filelist.xml">
<link rel=Edit-Time-Data href="11.16.1.1_files/editdata.mso">
<link rel=OLE-Object-Data href="11.16.1.1_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-01-31T09:33:16Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
background:#CCFFFF;
mso-pattern:auto none;}
.xl26
{mso-style-parent:style0;
text-align:center;
background:#CCFFFF;
mso-pattern:auto none;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>17</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=927 style='border-collapse:
collapse;table-layout:fixed;width:696pt'>
<col width=376 style='mso-width-source:userset;mso-width-alt:13750;width:282pt'>
<col class=xl24 width=109 style='mso-width-source:userset;mso-width-alt:3986;
width:82pt'>
<col width=442 style='mso-width-source:userset;mso-width-alt:16164;width:332pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=376 style='height:12.75pt;width:282pt'>Text</td>
<td class=xl26 width=109 style='width:82pt'>Evidence level</td>
<td class=xl25 width=442 style='width:332pt'>References</td>
</tr>
<tr height=90 style='mso-height-source:userset;height:67.5pt'>
<td height=90 class=xl27 width=376 style='height:67.5pt;width:282pt'>Early-stage
Hodgkin lymphoma should be subdivided by favourable and unfavourable
characteristics and treatment tailored accordingly.</td>
<td class=xl28 x:num>2</td>
<td class=xl27 width=442 style='width:332pt'>Chisesi T, Federico M, Levis A
et al. ABVD versus stanford V versus MEC in unfavourable Hodgkin's lymphoma:
results of a randomised trial. Ann Oncol 2002; 13 Suppl 1: 102-6.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=376 style='width:282pt'></td>
<td width=109 style='width:82pt'></td>
<td width=442 style='width:332pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
// Origin: C:\Code\medicalobjects\projects\LymphomaWizard\gello\Prima\A23.gello
// Inclusion Criteria: Age must be <= 40 years.
let question = "Age must be <= 40 years."
let decision:boolean = model.run('Age_at_most',40)
//let age = patient.age_at(factory.absolutetime('0').now())
if decision then
factory.GLIFDecisionResult(question,true,"young enough",50)
else
factory.GLIFDecisionResult(question,false,"too old",50)
endif
// ESR < 70
// define our assertion or question
let question:string = 'ESR < 70?'
// now evaluate an answer.
let answer:boolean = model.run('ESR_less_than',70)
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'ESR is less than 70',50)
else
factory.GLIFDecisionResult(question,answer,'ESR is not less than 70',50)
endif
else
factory.GLIFDecisionResult(question,answer,'no ESR observation data',50)
endif
/*
Sample Gello for GLIF decision.
A GLIF decision condition returns a structured result of GELLO type GLIFDecisionResult.
The result has several parts..
1. Question.
This is the question being asked or assertion being made.
It should be stated in such a way as to return a true or false answer.
For example
"Is age is 18 years or older?"
True: patient is 18 or more
False: patient is younger than 18
2. Answer.
This is what the GELLO program will determine in response to the question
or condition being determined, or assertion being made.
A "true" answer means that the condition passed. (yes to question)
A "false" answer means that the condition failed. (no to question)
A "unknown" answer typically means there was insufficient data to
give a definite yes or no to the question.
3. Reason.
This is an informative message stating the reason for the decision being made.
It is not used in used in determining the overall result of the condition, however
it will be used to present an informative message to the GLIF when reviewing a decision
that was evaluated.
4. Weight.
When a decision cannot be determined (e.g. unknown) a weight may be returned
between 0 and 100. it represents how close to yes or no the answer is,
with 0 meaning "no" and 100 meaning "yes". 50 is equivalent to "don't know"
*/
// define our assertion or question
let question:string = 'Number of Involved Nodes <= 3'
// now evaluate an answer.
let NumberSites: Real = Model.run('Number_nodal_sites')
let answer:boolean =
if NumberSites < 1 then
unknown
else
if NumberSites <= 3 then
true
else
false
endif
endif
// and return our response
// note - due to GELLO language constraints, we are not allowed to assign a
// variable value more than once, so alternative reasons have to be specified
// with sepearate return results.
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'Is <= 3 lymph nodes',50)
else
factory.GLIFDecisionResult(question,answer,'> 3 lymph nodes',50)
endif
else
factory.GLIFDecisionResult(question,answer,'Number of nodes unknown',50)
endif
/*
Sample Gello for GLIF decision.
A GLIF decision condition returns a structured result of GELLO type GLIFDecisionResult.
The result has several parts..
1. Question.
This is the question being asked or assertion being made.
It should be stated in such a way as to return a true or false answer.
For example
"Is age is 18 years or older?"
True: patient is 18 or more
False: patient is younger than 18
2. Answer.
This is what the GELLO program will determine in response to the question
or condition being determined, or assertion being made.
A "true" answer means that the condition passed. (yes to question)
A "false" answer means that the condition failed. (no to question)
A "unknown" answer typically means there was insufficient data to
give a definite yes or no to the question.
3. Reason.
This is an informative message stating the reason for the decision being made.
It is not used in used in determining the overall result of the condition, however
it will be used to present an informative message to the GLIF when reviewing a decision
that was evaluated.
4. Weight.
When a decision cannot be determined (e.g. unknown) a weight may be returned
between 0 and 100. it represents how close to yes or no the answer is,
with 0 meaning "no" and 100 meaning "yes". 50 is equivalent to "don't know"
*/
// define our assertion or question
let question:string = 'Stage IA, IB or IIB'
// now evaluate an answer.
//let answer:boolean = patient.age >= 18
let answer:boolean = Model.run('Stage_IA_IB_IIB')
// and return our response
// note - due to GELLO language constraints, we are not allowed to assign a
// variable value more than once, so alternative reasons have to be specified
// with sepearate return results.
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'Was Stage Ia, Ib or IIb',50)
else
factory.GLIFDecisionResult(question,answer,'Incorrect stage',50)
endif
else
factory.GLIFDecisionResult(question,answer,'Unknown Stage',50)
endif
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="11.16.1.3_files/filelist.xml">
<link rel=Edit-Time-Data href="11.16.1.3_files/editdata.mso">
<link rel=OLE-Object-Data href="11.16.1.3_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-01-31T09:40:35Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl27
{mso-style-parent:style0;
background:#CCFFFF;
mso-pattern:auto none;}
.xl28
{mso-style-parent:style0;
text-align:center;
background:#CCFFFF;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>7</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=939 style='border-collapse:
collapse;table-layout:fixed;width:704pt'>
<col width=415 style='mso-width-source:userset;mso-width-alt:15177;width:311pt'>
<col class=xl24 width=88 style='mso-width-source:userset;mso-width-alt:3218;
width:66pt'>
<col width=436 style='mso-width-source:userset;mso-width-alt:15945;width:327pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl27 width=415 style='height:12.75pt;width:311pt'>Text</td>
<td class=xl28 width=88 style='width:66pt'>Evidence level</td>
<td class=xl27 width=436 style='width:327pt'>References</td>
</tr>
<tr height=9 style='mso-height-source:userset;height:6.75pt'>
<td height=9 style='height:6.75pt'></td>
<td class=xl24></td>
<td></td>
</tr>
<tr height=206 style='mso-height-source:userset;height:154.5pt'>
<td height=206 class=xl25 width=415 style='height:154.5pt;width:311pt'>Early
stage Hodgkin lymphoma with favourable characteristics should be treated by a
combination of involved-field radiotherapy and systemic chemotherapy. The
current recommendation is that chemotherapy should consist of four cycles of
ABVD. Involved-field radiation therapy should be delivered to all of the
sites that were involved by Hodgkin lymphoma at diagnosis.</td>
<td class=xl26 x:num>2</td>
<td class=xl25 width=436 style='width:327pt'>Tubiana M, Henry-Amar M, Hayat M
et al. The EORTC treatment of early stages of Hodgkin's disease: the role of
radiotherapy. Int J Radiat Oncol Biol Phys 1984; 10: 197-210.<br>
Engert A, Schiller P, Josting A et al. Involved-field radiotherapy is equally
effective and less toxic compared with extended-field radiotherapy after four
cycles of chemotherapy in patients with early-stage unfavorable Hodgkin's
lymphoma: results of the HD8 trial of the German Hodgkin's Lymphoma Study
Group. J Clin Oncol 2003; 21: 3601-8.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=415 style='width:311pt'></td>
<td width=88 style='width:66pt'></td>
<td width=436 style='width:327pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
2
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="11.16.1.4_files/filelist.xml">
<link rel=Edit-Time-Data href="11.16.1.4_files/editdata.mso">
<link rel=OLE-Object-Data href="11.16.1.4_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-01-31T09:39:22Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl27
{mso-style-parent:style0;
background:#CCFFFF;
mso-pattern:auto none;}
.xl28
{mso-style-parent:style0;
text-align:center;
background:#CCFFFF;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>12</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=915 style='border-collapse:
collapse;table-layout:fixed;width:687pt'>
<col width=411 style='mso-width-source:userset;mso-width-alt:15030;width:308pt'>
<col class=xl24 width=86 style='mso-width-source:userset;mso-width-alt:3145;
width:65pt'>
<col width=418 style='mso-width-source:userset;mso-width-alt:15286;width:314pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl27 width=411 style='height:12.75pt;width:308pt'>Text</td>
<td class=xl28 width=86 style='width:65pt'>Evidence level</td>
<td class=xl27 width=418 style='width:314pt'>References</td>
</tr>
<tr height=7 style='mso-height-source:userset;height:5.25pt'>
<td height=7 style='height:5.25pt'></td>
<td class=xl24></td>
<td></td>
</tr>
<tr height=201 style='mso-height-source:userset;height:150.75pt'>
<td height=201 class=xl25 width=411 style='height:150.75pt;width:308pt'>Early
stage Hodkin lymphoma with unfavourable characteristics should be treated by
a combination of involved-field radiotherapy and systemic chemotherapy.
Chemotherapy should consist of six cycles of ABVD. Involved-field radiation
therapy should be delivered to all of the sites that were involved by Hodgkin
lymphoma at diagnosis.</td>
<td class=xl26 x:num>2</td>
<td class=xl25 width=418 style='width:314pt'>1. Noordijk EM, Carde P, Mandard
AM et al. Preliminary results of the EORTC-GPMC controlled clinical trial H7
in early-stage Hodgkin's disease. EORTC Lymphoma Cooperative Group. Groupe
Pierre-et-Marie-Curie. Ann Oncol 1994; 5 Suppl 2: 107-12.<br>
2. Cosset JM, Ferme C, Noordijk EM, Dubray BM, Thirion P, Henry-Amar M.
Combined Modality Treatment for Poor Prognosis Stages I and II Hodgkin's
Disease. Semin Radiat Oncol<br>
1996; 6: 185-95.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=411 style='width:308pt'></td>
<td width=86 style='width:65pt'></td>
<td width=418 style='width:314pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
2
Treatment planning
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="11.16.2.1_files/filelist.xml">
<link rel=Edit-Time-Data href="11.16.2.1_files/editdata.mso">
<link rel=OLE-Object-Data href="11.16.2.1_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-01-31T09:54:22Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
background:#CCFFFF;
mso-pattern:auto none;}
.xl26
{mso-style-parent:style0;
text-align:center;
background:#CCFFFF;
mso-pattern:auto none;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>11</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=804 style='border-collapse:
collapse;table-layout:fixed;width:604pt'>
<col width=338 style='mso-width-source:userset;mso-width-alt:12361;width:254pt'>
<col class=xl24 width=109 style='mso-width-source:userset;mso-width-alt:3986;
width:82pt'>
<col width=357 style='mso-width-source:userset;mso-width-alt:13056;width:268pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=338 style='height:12.75pt;width:254pt'>Text</td>
<td class=xl26 width=109 style='width:82pt'>Evidence level</td>
<td class=xl25 width=357 style='width:268pt'>References</td>
</tr>
<tr height=10 style='mso-height-source:userset;height:7.5pt'>
<td height=10 style='height:7.5pt'></td>
<td class=xl24></td>
<td></td>
</tr>
<tr height=166 style='mso-height-source:userset;height:124.5pt'>
<td height=166 class=xl27 width=338 style='height:124.5pt;width:254pt'>Chemotherapy
should be used for all patients with advanced Hodgkin lymphoma</td>
<td class=xl28 x:num>3</td>
<td class=xl27 width=357 style='width:268pt'>1. DeVita VT, Jr., Simon RM,
Hubbard SM et al. Curability of advanced Hodgkin's disease with chemotherapy.
Long-term follow-up of MOPP-treated patients at the National Cancer
Institute. Ann Intern Med 1980; 92: 587-95.<br>
2. Stein RS, Golomb HM, Diggs CH et al. Anatomic substages of stage III-A
Hodgkin's disease. A collaborative study. Ann Intern Med 1980; 92: 159-65.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=338 style='width:254pt'></td>
<td width=109 style='width:82pt'></td>
<td width=357 style='width:268pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
3
<html>
<head></head><body>
<div><font face="Arial">Serum albumin < 40 g/dL</font></div>
<div><font face="Arial">Haemoglobin < 10.5 g/dL</font></div>
<div><font face="Arial">Male sex</font></div>
<div><font face="Arial">Age >= 45 years</font></div>
<div><font face="Arial">Ann Arbor Stage IV disease</font></div>
<div><font face="Arial">WCC < 15</font></div>
<div><font face="Arial">Lymphocytes > 0.6 or > 8% of WCC</font></div>
</body></html>
// Gets Internaitonal Prognostic score (Hasenclever) and decides
// Age must be <= 65 years.
let question = "Age must be <= 65 years."
let now = factory.absolutetime("0").now()
let age = patient.age_at(now)
if age < 65 then
factory.GLIFDecisionResult(question,true,"young enough (< 65)",50)
else
factory.GLIFDecisionResult(question,false,"too old ( >= 65)",50)
endif
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="11.16.2.2_files/filelist.xml">
<link rel=Edit-Time-Data href="11.16.2.2_files/editdata.mso">
<link rel=OLE-Object-Data href="11.16.2.2_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-01-31T09:56:01Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl26
{mso-style-parent:style0;
mso-number-format:"\@";
text-align:center;
vertical-align:top;}
.xl27
{mso-style-parent:style0;
background:#CCFFFF;
mso-pattern:auto none;}
.xl28
{mso-style-parent:style0;
text-align:center;
background:#CCFFFF;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>5</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=765 style='border-collapse:
collapse;table-layout:fixed;width:574pt'>
<col width=357 style='mso-width-source:userset;mso-width-alt:13056;width:268pt'>
<col class=xl24 width=99 style='mso-width-source:userset;mso-width-alt:3620;
width:74pt'>
<col width=309 style='mso-width-source:userset;mso-width-alt:11300;width:232pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl27 width=357 style='height:12.75pt;width:268pt'>Text</td>
<td class=xl28 width=99 style='width:74pt'>Evidence level</td>
<td class=xl27 width=309 style='width:232pt'>References</td>
</tr>
<tr height=13 style='mso-height-source:userset;height:9.75pt'>
<td height=13 style='height:9.75pt'></td>
<td class=xl24></td>
<td></td>
</tr>
<tr height=223 style='mso-height-source:userset;height:167.25pt'>
<td height=223 class=xl25 width=357 style='height:167.25pt;width:268pt'>ABVD
chemotherapy is recommended as a standard chemotherapy regimen for advanced
Hodgkin lymphoma patients with an international prognostic score < 4. ABVD
is superior to alternating MOPP/ABVD or MOPP/ABV hybrid because of lower
toxicity. Chemotherapy should be continued for a minimum of six cycles. A
minimum of two further cycles of chemotherapy should be given after a
complete response has been attained.</td>
<td class=xl26>2 - 4</td>
<td class=xl25 width=309 style='width:232pt'>1. Canellos GP. Is ABVD the
standard regimen for Hodgkin's disease based on randomized CALGB comparison
of MOPP, ABVD and MOPP alternating with ABVD? Leukemia 1996; 10 Suppl 2:
s68.<br>
2. Diehl V, Franklin J, Hasenclever D et al. BEACOPP: a new regimen for
advanced Hodgkin's disease. German Hodgkin's Lymphoma Study Group. Ann Oncol
1998; 9 Suppl 5: 67-71.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=357 style='width:268pt'></td>
<td width=99 style='width:74pt'></td>
<td width=309 style='width:232pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
2
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="11.16.2.3_files/filelist.xml">
<link rel=Edit-Time-Data href="11.16.2.3_files/editdata.mso">
<link rel=OLE-Object-Data href="11.16.2.3_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-01-31T09:57:06Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl26
{mso-style-parent:style0;
background:#CCFFFF;
mso-pattern:auto none;}
.xl27
{mso-style-parent:style0;
text-align:center;
background:#CCFFFF;
mso-pattern:auto none;
white-space:normal;}
.xl28
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl29
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>12</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=802 style='border-collapse:
collapse;table-layout:fixed;width:602pt'>
<col width=361 style='mso-width-source:userset;mso-width-alt:13202;width:271pt'>
<col class=xl24 width=57 style='mso-width-source:userset;mso-width-alt:2084;
width:43pt'>
<col width=384 style='mso-width-source:userset;mso-width-alt:14043;width:288pt'>
<tr height=37 style='mso-height-source:userset;height:27.75pt'>
<td height=37 class=xl26 width=361 style='height:27.75pt;width:271pt'>Text</td>
<td class=xl27 width=57 style='width:43pt'>Evidence level</td>
<td class=xl26 width=384 style='width:288pt'>References</td>
</tr>
<tr height=10 style='mso-height-source:userset;height:7.5pt'>
<td height=10 style='height:7.5pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=106 style='mso-height-source:userset;height:79.5pt'>
<td height=106 class=xl28 width=361 style='height:79.5pt;width:271pt'>BEACOPP
(standard dose) should be considered in patients younger than 65 with
advanced Hodgkin lymphoma and a prognostic score >=4.</td>
<td class=xl29 x:num>2</td>
<td class=xl28 width=384 style='width:288pt'>Diehl V, Franklin J,
Pfreundschuh M et al. Standard and increased-dose BEACOPP chemotherapy
compared with COPP-ABVD for advanced Hodgkin's disease. N Engl J Med 2003;
348: 2386-95.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=361 style='width:271pt'></td>
<td width=57 style='width:43pt'></td>
<td width=384 style='width:288pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
2
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="11.16.2.4_files/filelist.xml">
<link rel=Edit-Time-Data href="11.16.2.4_files/editdata.mso">
<link rel=OLE-Object-Data href="11.16.2.4_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-01-31T09:57:58Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl26
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl27
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl28
{mso-style-parent:style0;
background:#CCFFFF;
mso-pattern:auto none;}
.xl29
{mso-style-parent:style0;
text-align:center;
background:#CCFFFF;
mso-pattern:auto none;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>14</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=825 style='border-collapse:
collapse;table-layout:fixed;width:619pt'>
<col width=395 style='mso-width-source:userset;mso-width-alt:14445;width:296pt'>
<col class=xl24 width=57 style='mso-width-source:userset;mso-width-alt:2084;
width:43pt'>
<col width=373 style='mso-width-source:userset;mso-width-alt:13641;width:280pt'>
<tr height=37 style='mso-height-source:userset;height:27.75pt'>
<td height=37 class=xl28 width=395 style='height:27.75pt;width:296pt'>Text</td>
<td class=xl29 width=57 style='width:43pt'>Evidence level</td>
<td class=xl28 width=373 style='width:280pt'>References</td>
</tr>
<tr height=15 style='mso-height-source:userset;height:11.25pt'>
<td height=15 style='height:11.25pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=100 style='mso-height-source:userset;height:75.0pt'>
<td height=100 class=xl26 width=395 style='height:75.0pt;width:296pt'>There
is no group of patients that can be prospectively identified with a prognosis
so poor that high-dose chemotherapy and haematopoietic stem cell
transplantation can only be recommended for relapsed patients as primary
treatment.</td>
<td class=xl27 x:num>4</td>
<td class=xl26 width=373 style='width:280pt'>Carella AM. Stem Cell
Transplantation for Hodgkin's Disease: A Review of the Literature. Clin
Lymphoma 2002; 2: 212-21.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=395 style='width:296pt'></td>
<td width=57 style='width:43pt'></td>
<td width=373 style='width:280pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
//get mediastinal mass ratio from acrehtyped data or ask
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="11.16.2.7_files/filelist.xml">
<link rel=Edit-Time-Data href="11.16.2.7_files/editdata.mso">
<link rel=OLE-Object-Data href="11.16.2.7_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-01T01:25:04Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl26
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl27
{mso-style-parent:style0;
mso-number-format:"\@";
text-align:center;
vertical-align:top;}
.xl28
{mso-style-parent:style0;
background:#FFFF99;
mso-pattern:auto none;}
.xl29
{mso-style-parent:style0;
text-align:center;
background:#FFFF99;
mso-pattern:auto none;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>0</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>32519</x:Id>
<x:DivID>11.16.2.7_32519</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\11.16.2.7.htm"/>
<x:Title>Consider role of radiotherapy for bulky disease (2)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=836 style='border-collapse:
collapse;table-layout:fixed;width:627pt'>
<col width=388 style='mso-width-source:userset;mso-width-alt:14189;width:291pt'>
<col class=xl24 width=57 style='mso-width-source:userset;mso-width-alt:2084;
width:43pt'>
<col width=391 style='mso-width-source:userset;mso-width-alt:14299;width:293pt'>
<tr height=37 style='mso-height-source:userset;height:27.75pt'>
<td height=37 class=xl28 width=388 style='height:27.75pt;width:291pt'>Text</td>
<td class=xl29 width=57 style='width:43pt'>Evidence level</td>
<td class=xl28 width=391 style='width:293pt'>References</td>
</tr>
<tr height=12 style='mso-height-source:userset;height:9.0pt'>
<td height=12 style='height:9.0pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=203 style='mso-height-source:userset;height:152.25pt'>
<td height=203 class=xl26 width=388 style='height:152.25pt;width:291pt'>Consolidative
involved-field radiotherapy is recommended after chemotherapy for patients
with bulky mediastinal masses. Chemotherapy should be given for a mimimum of
six cycles.</td>
<td class=xl27>2 - 4</td>
<td class=xl26 width=391 style='width:293pt'>1. Fabian CJ, Mansfield CM,
Dahlberg S et al. Low-dose involved field radiation after chemotherapy in
advanced Hodgkin disease. A Southwest Oncology Group randomized study. Ann
Intern Med 1994; 120: 903-12.<br>
2. Raemaekers J, Burgers M, Henry-Amar M et al. Patients with stage III/IV
Hodgkin's disease in partial remission after MOPP/ABV chemotherapy have
excellent prognosis after additional involved-field radiotherapy: interim
results from the ongoing EORTC-LCG and GPMC phase III trial. The EORTC Lymphoma
Cooperative Group and Groupe Pierre-et-Marie-Curie. Ann Oncol 1997; 8 Suppl
1: 111-4.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=388 style='width:291pt'></td>
<td width=57 style='width:43pt'></td>
<td width=391 style='width:293pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="11.16.2.6_files/filelist.xml">
<link rel=Edit-Time-Data href="11.16.2.6_files/editdata.mso">
<link rel=OLE-Object-Data href="11.16.2.6_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-01T01:25:27Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl26
{mso-style-parent:style0;
background:#FFFF99;
mso-pattern:auto none;}
.xl27
{mso-style-parent:style0;
text-align:center;
background:#FFFF99;
mso-pattern:auto none;
white-space:normal;}
.xl28
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl29
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>10</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>4083</x:Id>
<x:DivID>11.16.2.6_4083</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\11.16.2.6.htm"/>
<x:Title>Consider role of radiotherapy for bulky disease (1)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=894 style='border-collapse:
collapse;table-layout:fixed;width:671pt'>
<col width=414 style='mso-width-source:userset;mso-width-alt:15140;width:311pt'>
<col class=xl24 width=57 style='mso-width-source:userset;mso-width-alt:2084;
width:43pt'>
<col width=423 style='mso-width-source:userset;mso-width-alt:15469;width:317pt'>
<tr height=37 style='mso-height-source:userset;height:27.75pt'>
<td height=37 class=xl26 width=414 style='height:27.75pt;width:311pt'>Text</td>
<td class=xl27 width=57 style='width:43pt'>Evidence level</td>
<td class=xl26 width=423 style='width:317pt'>References</td>
</tr>
<tr height=12 style='mso-height-source:userset;height:9.0pt'>
<td height=12 style='height:9.0pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=250 style='mso-height-source:userset;height:187.5pt'>
<td height=250 class=xl28 width=414 style='height:187.5pt;width:311pt'>In
bulky sites and in sites that fail to achieve complete remission after
chemotherapy, radiotherapy can improve freedom from progression in advanced
Hodgkin lymphoma.</td>
<td class=xl29 x:num>2</td>
<td class=xl28 width=423 style='width:317pt'>1. Fabian CJ, Mansfield CM,
Dahlberg S et al. Low-dose involved field radiation after chemotherapy in
advanced Hodgkin disease. A Southwest Oncology Group randomized study. Ann
Intern Med 1994; 120: 903-12.<br>
2. Raemaekers J, Burgers M, Henry-Amar M et al. Patients with stage III/IV
Hodgkin's disease in partial remission after MOPP/ABV chemotherapy have
excellent prognosis after additional involved-field radiotherapy: interim
results from the ongoing EORTC-LCG and GPMC phase III trial. The EORTC Lymphoma
Cooperative Group and Groupe Pierre-et-Marie-Curie. Ann Oncol 1997; 8 Suppl
1: 111-4.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=414 style='width:311pt'></td>
<td width=57 style='width:43pt'></td>
<td width=423 style='width:317pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
Note there are two guidelines in this link
2
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="11.16.2.5_files/filelist.xml">
<link rel=Edit-Time-Data href="11.16.2.5_files/editdata.mso">
<link rel=OLE-Object-Data href="11.16.2.5_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-01-31T09:58:49Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl26
{mso-style-parent:style0;
background:#CCFFFF;
mso-pattern:auto none;}
.xl27
{mso-style-parent:style0;
text-align:center;
background:#CCFFFF;
mso-pattern:auto none;
white-space:normal;}
.xl28
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl29
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>9</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=764 style='border-collapse:
collapse;table-layout:fixed;width:574pt'>
<col width=366 style='mso-width-source:userset;mso-width-alt:13385;width:275pt'>
<col class=xl24 width=57 style='mso-width-source:userset;mso-width-alt:2084;
width:43pt'>
<col width=341 style='mso-width-source:userset;mso-width-alt:12470;width:256pt'>
<tr height=37 style='mso-height-source:userset;height:27.75pt'>
<td height=37 class=xl26 width=366 style='height:27.75pt;width:275pt'>Text</td>
<td class=xl27 width=57 style='width:43pt'>Evidence level</td>
<td class=xl26 width=341 style='width:256pt'>References</td>
</tr>
<tr height=11 style='mso-height-source:userset;height:8.25pt'>
<td height=11 style='height:8.25pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=74 style='mso-height-source:userset;height:55.5pt'>
<td height=74 class=xl28 width=366 style='height:55.5pt;width:275pt'>Radiotherapy
is not recommended after modern chemotherapy as routine treatment to
non-bulky sites in advanced Hodgkin lymphoma that have attained complete
response.</td>
<td class=xl29 x:num>2</td>
<td class=xl28 width=341 style='width:256pt'>Aleman BM, Raemaekers JM,
Tirelli U et al. Involved-field radiotherapy for advanced Hodgkin's lymphoma.
N Engl J Med 2003; 348: 2396-406.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=366 style='width:275pt'></td>
<td width=57 style='width:43pt'></td>
<td width=341 style='width:256pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
2
Treatment planning
/*
Sample Gello for GLIF decision.
A GLIF decision condition returns a structured result of GELLO type GLIFDecisionResult.
The result has several parts..
1. Question.
This is the question being asked or assertion being made.
It should be stated in such a way as to return a true or false answer.
For example
"Is age is 18 years or older?"
True: patient is 18 or more
False: patient is younger than 18
2. Answer.
This is what the GELLO program will determine in response to the question
or condition being determined, or assertion being made.
A "true" answer means that the condition passed. (yes to question)
A "false" answer means that the condition failed. (no to question)
A "unknown" answer typically means there was insufficient data to
give a definite yes or no to the question.
3. Reason.
This is an informative message stating the reason for the decision being made.
It is not used in used in determining the overall result of the condition, however
it will be used to present an informative message to the GLIF when reviewing a decision
that was evaluated.
4. Weight.
When a decision cannot be determined (e.g. unknown) a weight may be returned
between 0 and 100. it represents how close to yes or no the answer is,
with 0 meaning "no" and 100 meaning "yes". 50 is equivalent to "don't know"
*/
// define our assertion or question
let question:string = 'Stage I or II'
// now evaluate an answer.
//let answer:boolean = patient.age >= 18
let answer:boolean = Model.run('Stage_I_or_II')
// and return our response
// note - due to GELLO language constraints, we are not allowed to assign a
// variable value more than once, so alternative reasons have to be specified
// with sepearate return results.
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'Is Stage I or II',50)
else
factory.GLIFDecisionResult(question,answer,'Not stage I or II',50)
endif
else
factory.GLIFDecisionResult(question,answer,'No Result',50)
endif
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="13.6.1.5_files/filelist.xml">
<link rel=Edit-Time-Data href="13.6.1.5_files/editdata.mso">
<link rel=OLE-Object-Data href="13.6.1.5_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-01-31T10:40:40Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl27
{mso-style-parent:style0;
background:#FFCC99;
mso-pattern:auto none;}
.xl28
{mso-style-parent:style0;
text-align:center;
background:#FFCC99;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>2</x:ActiveRow>
<x:ActiveCol>5</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=805 style='border-collapse:
collapse;table-layout:fixed;width:605pt'>
<col width=334 style='mso-width-source:userset;mso-width-alt:12214;width:251pt'>
<col class=xl24 width=93 style='mso-width-source:userset;mso-width-alt:3401;
width:70pt'>
<col width=378 style='mso-width-source:userset;mso-width-alt:13824;width:284pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl27 width=334 style='height:12.75pt;width:251pt'>Text</td>
<td class=xl28 width=93 style='width:70pt'>Evidence level</td>
<td class=xl27 width=378 style='width:284pt'>References</td>
</tr>
<tr height=9 style='mso-height-source:userset;height:6.75pt'>
<td height=9 style='height:6.75pt'></td>
<td class=xl24></td>
<td></td>
</tr>
<tr height=439 style='mso-height-source:userset;height:329.25pt'>
<td height=439 class=xl25 width=334 style='height:329.25pt;width:251pt'>CHOP
chemotherapy is equivalent in outcome to other chemotherapy regimens with
decreased toxicity. Dose escalation of CHOP or CHOP-like regimens does not
improve overall survival.</td>
<td class=xl26 x:num>2</td>
<td class=xl25 width=378 style='width:284pt'>1. DeVita VT, Jr., Canellos GP,
Chabner B, Schein P, Hubbard SP, Young RC. Advanced diffuse histiocytic
lymphoma, a potentially curable disease. Lancet 1975; 1: 2480. <br>
2. Fisher RI, Gaynor ER, Dahlberg S, et al. Comparison of a standard
regimen (CHOP) with three intensive chemotherapy regimens for advanced
non-Hodgkin lymphoma. N Engl J Med 1993; 328: 1002.<br>
3. Messori A, Vaiani M, Trippoli S, Rigacci L, Jerkeman M, Longo G.
Survival in patients with intermediate or high grade non-Hodgkin lymphoma:
meta-analysis of randomized studies comparing third generation regimens with
CHOP. Br J Cancer 2001; 84: 303.<br>
4. Pavlovsky S, Santarelli MT, Erazo A, et al. Results of a randomized
study of previouslyuntreated intermediate and high grade lymphoma using CHOP
versus CNOP. Ann Oncol 1992; 3: 205.<br>
5. Nair R, Ramakrishnan G, Nair NN, et al. A randomized comparison of the
efficacy and toxicity of epirubicin and doxorubicin in the treatment of
patients with non-Hodgkin lymphoma. Cancer 1998; 82: 2282.<br>
6. Zinzani PL, Martelli M, Storti S, et al. Phase III comparative trial
using CHOP vs CIOP in the treatment of advanced intermediate-grade
non-Hodgkin lymphoma. Leuk Lymphoma 1995; 19: 3295.<br>
7. Wolf M, Matthews J, Stone JM, et al. Dose-intensification does not
improve outcome in aggressive non-Hodgkin lymphoma (NHL), report of a
randomized trial by the Australasian Leukaemia and Lymphoma Group. Blood
2000; 832a.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=334 style='width:251pt'></td>
<td width=93 style='width:70pt'></td>
<td width=378 style='width:284pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
2
// Age must be > 60 years.
let question = "Age must be > 60 years."
let now = factory.absolutetime("0").now()
let age = patient.age_at(now)
if age > 60 then
factory.GLIFDecisionResult(question,true,"old enough (> 60)",50)
else
factory.GLIFDecisionResult(question,false,"too young ( <= 60)",50)
endif
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="13.6.1.6_files/filelist.xml">
<link rel=Edit-Time-Data href="13.6.1.6_files/editdata.mso">
<link rel=OLE-Object-Data href="13.6.1.6_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-01-31T10:41:05Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
background:#FFCC99;
mso-pattern:auto none;}
.xl26
{mso-style-parent:style0;
text-align:center;
background:#FFCC99;
mso-pattern:auto none;
white-space:normal;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl29
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>8</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>2575</x:Id>
<x:DivID>13.6.1.6_2575</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\13.6.1.6.htm"/>
<x:Title>Recommended treatment for advanced-stage DLBCL (2)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=819 style='border-collapse:
collapse;table-layout:fixed;width:615pt'>
<col width=397 style='mso-width-source:userset;mso-width-alt:14518;width:298pt'>
<col class=xl24 width=64 style='width:48pt'>
<col width=358 style='mso-width-source:userset;mso-width-alt:13092;width:269pt'>
<tr height=34 style='mso-height-source:userset;height:25.5pt'>
<td height=34 class=xl25 width=397 style='height:25.5pt;width:298pt'>Text</td>
<td class=xl26 width=64 style='width:48pt'>Evidence level</td>
<td class=xl25 width=358 style='width:269pt'>References</td>
</tr>
<tr height=10 style='mso-height-source:userset;height:7.5pt'>
<td height=10 style='height:7.5pt'></td>
<td class=xl29></td>
<td></td>
</tr>
<tr height=469 style='mso-height-source:userset;height:351.75pt'>
<td height=469 class=xl27 width=397 style='height:351.75pt;width:298pt'>The
addition of rituximab to CHOP is superior to CHOP in patients older than 60
years.</td>
<td class=xl28 x:num>2</td>
<td class=xl27 width=358 style='width:269pt'>1. Maloney DG, Smith B,
Appelbaum FR. The antitumor effect of monoclonal anti-CD20 antibody therapy
includes direct anti-proliferative activity and induction of apoptosis in
CD20 positive non-Hodgkin lymphoma cell lines. Blood 1996; 637a.<br>
2. Coiffier B, Haioun C, Ketterer N, et al. Rituximab (anti-CD20 monoclonal
antibody) for the treatment of patients with relapsing or refractory
aggressive lymphoma: a multicenter phase II study. Blood 1998; 92:
19272.<br>
3. Vose JM, Link BK, Grossbard ML, et al. Phase II study of rituximab in
combination with chop chemotherapy in patients with previously untreated,
aggressive non-Hodgkin lymphoma. J Clin Oncol 2001; 19: 3897.<br>
4. Coiffier B, Lepage E, Briere J, et al. CHOP chemotherapy plus rituximab
compared with CHOP alone in elderly patients with diffuse large-B-cell
lymphoma. N Engl J Med 2002; 346: 2352.<br>
5. Coiffier, B. 2003. ASH.<br>
6. Mounier N, Briere J, Gisselbrecht C, et al. Rituximab plus CHOP (R-CHOP)
overcomes bcl-2 associated resistance to chemotherapy in elderly patients
with diffuse large B-cell lymphoma (DLBCL). Blood 2003; 101: 42794.<br>
7. Habermann TM, Weller EA, Morrison PA, et al. Phase III trial of
rituximab-CHOP (RCHOP) vs CHOP with a second randomization to maintenance
rituximab (MR) or observation in patients 60 years of age and older with
diffuse large B-cell lymphoma (DLBCL). Blood 2003.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=397 style='width:298pt'></td>
<td width=64 style='width:48pt'></td>
<td width=358 style='width:269pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
2
/*
Elevated LDH
*/
// define our assertion or question
let question:string = 'Is LDH High'
// now evaluate an answer.
let answer: Boolean = Model.run('LDH_above_normal')
// and return our response
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'LDH Is elevated',50)
else
factory.GLIFDecisionResult(question,answer,'LDH not elevated',50)
endif
else
factory.GLIFDecisionResult(question,answer,'No Results',50)
endif
/*
Sample Gello for GLIF decision.
A GLIF decision condition returns a structured result of GELLO type GLIFDecisionResult.
The result has several parts..
1. Question.
This is the question being asked or assertion being made.
It should be stated in such a way as to return a true or false answer.
For example
"Is age is 18 years or older?"
True: patient is 18 or more
False: patient is younger than 18
2. Answer.
This is what the GELLO program will determine in response to the question
or condition being determined, or assertion being made.
A "true" answer means that the condition passed. (yes to question)
A "false" answer means that the condition failed. (no to question)
A "unknown" answer typically means there was insufficient data to
give a definite yes or no to the question.
3. Reason.
This is an informative message stating the reason for the decision being made.
It is not used in used in determining the overall result of the condition, however
it will be used to present an informative message to the GLIF when reviewing a decision
that was evaluated.
4. Weight.
When a decision cannot be determined (e.g. unknown) a weight may be returned
between 0 and 100. it represents how close to yes or no the answer is,
with 0 meaning "no" and 100 meaning "yes". 50 is equivalent to "don't know"
*/
// define our assertion or question
let question:string = 'Is LDH Normal'
// now evaluate an answer.
let answer: Boolean = Model.run('LDH_normal')
// and return our response
// note - due to GELLO language constraints, we are not allowed to assign a
// variable value more than once, so alternative reasons have to be specified
// with sepearate return results.
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'LDH Is normal',50)
else
factory.GLIFDecisionResult(question,answer,'LDH elevated',50)
endif
else
factory.GLIFDecisionResult(question,answer,'No Results',50)
endif
/*
Sample Gello for GLIF decision.
A GLIF decision condition returns a structured result of GELLO type GLIFDecisionResult.
The result has several parts..
1. Question.
This is the question being asked or assertion being made.
It should be stated in such a way as to return a true or false answer.
For example
"Is age is 18 years or older?"
True: patient is 18 or more
False: patient is younger than 18
2. Answer.
This is what the GELLO program will determine in response to the question
or condition being determined, or assertion being made.
A "true" answer means that the condition passed. (yes to question)
A "false" answer means that the condition failed. (no to question)
A "unknown" answer typically means there was insufficient data to
give a definite yes or no to the question.
3. Reason.
This is an informative message stating the reason for the decision being made.
It is not used in used in determining the overall result of the condition, however
it will be used to present an informative message to the GLIF when reviewing a decision
that was evaluated.
4. Weight.
When a decision cannot be determined (e.g. unknown) a weight may be returned
between 0 and 100. it represents how close to yes or no the answer is,
with 0 meaning "no" and 100 meaning "yes". 50 is equivalent to "don't know"
*/
// define our assertion or question
let question:string = 'Is ECOG Performance 2 or greater'
// now evaluate an answer.
let answer: Boolean = Model.run('ECOG2_or_greater')
// and return our response
// note - due to GELLO language constraints, we are not allowed to assign a
// variable value more than once, so alternative reasons have to be specified
// with sepearate return results.
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'ECOG is > =2',50)
else
factory.GLIFDecisionResult(question,answer,'ECOG 0 or 1',50)
endif
else
factory.GLIFDecisionResult(question,answer,'No Results',50)
endif
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="13.6.1.2_files/filelist.xml">
<link rel=Edit-Time-Data href="13.6.1.2_files/editdata.mso">
<link rel=OLE-Object-Data href="13.6.1.2_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-01-31T10:38:40Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl27
{mso-style-parent:style0;
background:#FFCC99;
mso-pattern:auto none;}
.xl28
{mso-style-parent:style0;
text-align:center;
background:#FFCC99;
mso-pattern:auto none;
white-space:normal;}
.xl29
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>6</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>71</x:Id>
<x:DivID>13.6.1.2_71</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\13.6.1.2.htm"/>
<x:Title>Recommended treatment for localised aggressive lymphoma (2)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=845 style='border-collapse:
collapse;table-layout:fixed;width:634pt'>
<col width=384 style='mso-width-source:userset;mso-width-alt:14043;width:288pt'>
<col class=xl24 width=64 style='width:48pt'>
<col width=397 style='mso-width-source:userset;mso-width-alt:14518;width:298pt'>
<tr height=34 style='mso-height-source:userset;height:25.5pt'>
<td height=34 class=xl27 width=384 style='height:25.5pt;width:288pt'>Text</td>
<td class=xl28 width=64 style='width:48pt'>Evidence level</td>
<td class=xl27 width=397 style='width:298pt'>References</td>
</tr>
<tr height=14 style='mso-height-source:userset;height:10.5pt'>
<td height=14 style='height:10.5pt'></td>
<td class=xl29></td>
<td></td>
</tr>
<tr height=172 style='mso-height-source:userset;height:129.0pt'>
<td height=172 class=xl25 width=384 style='height:129.0pt;width:288pt'>Patients
with bulky stage I, stage II, high LDH, ECOG >2 and/or three or more
disease sites should be treated with 6 cycles of CHOP followed by
involved-field radiation to 300 Gy.</td>
<td class=xl26 x:num>2</td>
<td class=xl25 width=397 style='width:298pt'>1. Glick J, Kim K, Earle J,
Oonnell M. An ECOG randomized phase III trial of CHOP vs CHOP +
radiotherapy (XRT) for intermediate grade early stage non-Hodgkin lymphoma
(NHL). Proc Am Soc Clin Oncol 1995; 391.<br>
2. Horning SJ, Glick J, Kim K. CHOP v CHOP + radiotherapy (RT) for
limited-stage diffuse aggressive lymphoma. Blood 2001; 724a.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=384 style='width:288pt'></td>
<td width=64 style='width:48pt'></td>
<td width=397 style='width:298pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
2
/*
Sample Gello for GLIF decision.
A GLIF decision condition returns a structured result of GELLO type GLIFDecisionResult.
The result has several parts..
1. Question.
This is the question being asked or assertion being made.
It should be stated in such a way as to return a true or false answer.
For example
"Is age is 18 years or older?"
True: patient is 18 or more
False: patient is younger than 18
2. Answer.
This is what the GELLO program will determine in response to the question
or condition being determined, or assertion being made.
A "true" answer means that the condition passed. (yes to question)
A "false" answer means that the condition failed. (no to question)
A "unknown" answer typically means there was insufficient data to
give a definite yes or no to the question.
3. Reason.
This is an informative message stating the reason for the decision being made.
It is not used in used in determining the overall result of the condition, however
it will be used to present an informative message to the GLIF when reviewing a decision
that was evaluated.
4. Weight.
When a decision cannot be determined (e.g. unknown) a weight may be returned
between 0 and 100. it represents how close to yes or no the answer is,
with 0 meaning "no" and 100 meaning "yes". 50 is equivalent to "don't know"
*/
// define our assertion or question
let question:string = 'Stage I disease'
// now evaluate an answer.
let answer:boolean = Model.run('Stage_I')
// and return our response
// note - due to GELLO language constraints, we are not allowed to assign a
// variable value more than once, so alternative reasons have to be specified
// with sepearate return results.
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'Is Stage I',50)
else
factory.GLIFDecisionResult(question,answer,'Not Stage I',50)
endif
else
factory.GLIFDecisionResult(question,answer,'Stage uncertain',50)
endif
/*
Sample Gello for GLIF decision.
A GLIF decision condition returns a structured result of GELLO type GLIFDecisionResult.
The result has several parts..
1. Question.
This is the question being asked or assertion being made.
It should be stated in such a way as to return a true or false answer.
For example
"Is age is 18 years or older?"
True: patient is 18 or more
False: patient is younger than 18
2. Answer.
This is what the GELLO program will determine in response to the question
or condition being determined, or assertion being made.
A "true" answer means that the condition passed. (yes to question)
A "false" answer means that the condition failed. (no to question)
A "unknown" answer typically means there was insufficient data to
give a definite yes or no to the question.
3. Reason.
This is an informative message stating the reason for the decision being made.
It is not used in used in determining the overall result of the condition, however
it will be used to present an informative message to the GLIF when reviewing a decision
that was evaluated.
4. Weight.
When a decision cannot be determined (e.g. unknown) a weight may be returned
between 0 and 100. it represents how close to yes or no the answer is,
with 0 meaning "no" and 100 meaning "yes". 50 is equivalent to "don't know"
*/
// define our assertion or question
let question:string = 'Is LDH Normal'
// now evaluate an answer.
let answer: Boolean = Model.run('LDH_normal')
// and return our response
// note - due to GELLO language constraints, we are not allowed to assign a
// variable value more than once, so alternative reasons have to be specified
// with sepearate return results.
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'LDH Is normal',50)
else
factory.GLIFDecisionResult(question,answer,'LDH elevated',50)
endif
else
factory.GLIFDecisionResult(question,answer,'No Results',50)
endif
/*
Sample Gello for GLIF decision.
A GLIF decision condition returns a structured result of GELLO type GLIFDecisionResult.
The result has several parts..
1. Question.
This is the question being asked or assertion being made.
It should be stated in such a way as to return a true or false answer.
For example
"Is age is 18 years or older?"
True: patient is 18 or more
False: patient is younger than 18
2. Answer.
This is what the GELLO program will determine in response to the question
or condition being determined, or assertion being made.
A "true" answer means that the condition passed. (yes to question)
A "false" answer means that the condition failed. (no to question)
A "unknown" answer typically means there was insufficient data to
give a definite yes or no to the question.
3. Reason.
This is an informative message stating the reason for the decision being made.
It is not used in used in determining the overall result of the condition, however
it will be used to present an informative message to the GLIF when reviewing a decision
that was evaluated.
4. Weight.
When a decision cannot be determined (e.g. unknown) a weight may be returned
between 0 and 100. it represents how close to yes or no the answer is,
with 0 meaning "no" and 100 meaning "yes". 50 is equivalent to "don't know"
*/
// define our assertion or question
let question:string = 'ECOG 0 or 1'
// now evaluate an answer.
//let answer:boolean = patient.age >= 18
let answer:boolean = Model.run('ECOG_0_or_1')
// and return our response
// note - due to GELLO language constraints, we are not allowed to assign a
// variable value more than once, so alternative reasons have to be specified
// with sepearate return results.
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'Enter you reason for acceptance here...',50)
else
factory.GLIFDecisionResult(question,answer,'Enter your reason for failure here...',50)
endif
else
factory.GLIFDecisionResult(question,answer,'Enter your reason for failure here...',50)
endif
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="13.6.1.1_files/filelist.xml">
<link rel=Edit-Time-Data href="13.6.1.1_files/editdata.mso">
<link rel=OLE-Object-Data href="13.6.1.1_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-01T01:30:25Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl27
{mso-style-parent:style0;
background:#FFCC99;
mso-pattern:auto none;}
.xl28
{mso-style-parent:style0;
text-align:center;
background:#FFCC99;
mso-pattern:auto none;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>4</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>25675</x:Id>
<x:DivID>13.6.1.1_25675</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\13.6.1.1.htm"/>
<x:Title>Recommended treatment for localised aggressive lymphoma (1)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=878 style='border-collapse:
collapse;table-layout:fixed;width:659pt'>
<col width=383 style='mso-width-source:userset;mso-width-alt:14006;width:287pt'>
<col class=xl24 width=65 style='mso-width-source:userset;mso-width-alt:2377;
width:49pt'>
<col width=430 style='mso-width-source:userset;mso-width-alt:15725;width:323pt'>
<tr height=34 style='mso-height-source:userset;height:25.5pt'>
<td height=34 class=xl27 width=383 style='height:25.5pt;width:287pt'>Text</td>
<td class=xl28 width=65 style='width:49pt'>Evidence level</td>
<td class=xl27 width=430 style='width:323pt'>References</td>
</tr>
<tr height=10 style='mso-height-source:userset;height:7.5pt'>
<td height=10 style='height:7.5pt'></td>
<td class=xl24></td>
<td></td>
</tr>
<tr height=354 style='mso-height-source:userset;height:265.5pt'>
<td height=354 class=xl25 width=383 style='height:265.5pt;width:287pt'>Patients
with non-bulky stage I, with normal LDH and ECOG PS <1, should be treated
with three cycles of CHOP and involved-field radiation therapy to a dose of
300 Gy.</td>
<td class=xl26>2, 3</td>
<td class=xl25 width=430 style='width:323pt'>1. Chen MG, Prosnitz LR,
Gonzalez-Serva A, Fischer DB. Results of radiotherapy in control of stage I
and II non-Hodgkin lymphoma. Cancer 1979; 43: 12454.<br>
2. Fuks Z, Kaplan HS. Recurrence rates following radiation therapy of
nodular and diffuse malignant lymphomas. Radiology 1973; 108: 6754.<br>
3. Kaminski MS, Coleman CN, Colby TV, Cox RS, Rosenberg SA. Factors
predicting survival in adults with stage I and II large-cell lymphoma treated
with primary radiation therapy. Ann Intern Med 1986; 104: 7476.<br>
4. Tondini C, Zanini M, Lombardi F, et al. Combined modality treatment with
primary CHOP chemotherapy followed by locoregional irradiation in stage I or
II histologically aggressive non-Hodgkin lymphomas. J Clin Oncol 1993; 11:
720.<br>
5. Shenkier TN, Voss N, Fairey R, et al. Brief chemotherapy and
involved-region irradiation for limited-stage diffuse large-cell lymphoma: an
18-year experience from the British Columbia Cancer Agency. J Clin Oncol
2002; 20: 19704.<br>
6. Miller MT, LeBlanc M, Spier CM. CHOP alone compared to CHOP plus
radiotherapy for early stage aggressive non-Hodgkin lymphomas: update of
the Southwest Oncology Group (SWOG) randomized trial. Blood 2001; 724a.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=383 style='width:287pt'></td>
<td width=65 style='width:49pt'></td>
<td width=430 style='width:323pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
3
Diffuse large B-cell lymphoma management B
Diffuse large B-cell lymphoma management B
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="13.6.1.3_files/filelist.xml">
<link rel=Edit-Time-Data href="13.6.1.3_files/editdata.mso">
<link rel=OLE-Object-Data href="13.6.1.3_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-01-31T10:38:56Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl27
{mso-style-parent:style0;
background:#FFCC99;
mso-pattern:auto none;}
.xl28
{mso-style-parent:style0;
text-align:center;
background:#FFCC99;
mso-pattern:auto none;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>9</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>6368</x:Id>
<x:DivID>13.6.1.3_6368</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\13.6.1.3.htm"/>
<x:Title>Recommended treatment for localised aggressive lymphoma (3)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=819 style='border-collapse:
collapse;table-layout:fixed;width:614pt'>
<col width=405 style='mso-width-source:userset;mso-width-alt:14811;width:304pt'>
<col class=xl24 width=59 style='mso-width-source:userset;mso-width-alt:2157;
width:44pt'>
<col width=355 style='mso-width-source:userset;mso-width-alt:12982;width:266pt'>
<tr height=34 style='mso-height-source:userset;height:25.5pt'>
<td height=34 class=xl27 width=405 style='height:25.5pt;width:304pt'>Text</td>
<td class=xl28 width=59 style='width:44pt'>Evidence level</td>
<td class=xl27 width=355 style='width:266pt'>References</td>
</tr>
<tr height=7 style='mso-height-source:userset;height:5.25pt'>
<td height=7 style='height:5.25pt'></td>
<td class=xl24></td>
<td></td>
</tr>
<tr height=93 style='mso-height-source:userset;height:69.75pt'>
<td height=93 class=xl25 width=405 style='height:69.75pt;width:304pt'>Radiotherapy
may be unnecessary in elderly patients with localised aggressive lymphoma.</td>
<td class=xl26 x:num>2</td>
<td class=xl25 width=355 style='width:266pt'>Fillet G, Bonnet C. Radiotherapy
is unnecessary in elderly patients with localized aggressive non-Hodgkin
lymphoma: results of the GELA LNH 93-4 study. Blood 2002; 92a.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=405 style='width:304pt'></td>
<td width=59 style='width:44pt'></td>
<td width=355 style='width:266pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="13.6.1.7_files/filelist.xml">
<link rel=Edit-Time-Data href="13.6.1.7_files/editdata.mso">
<link rel=OLE-Object-Data href="13.6.1.7_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-01-31T10:41:32Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl26
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl27
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl28
{mso-style-parent:style0;
background:#FFCC99;
mso-pattern:auto none;}
.xl29
{mso-style-parent:style0;
text-align:center;
background:#FFCC99;
mso-pattern:auto none;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>8</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>8983</x:Id>
<x:DivID>13.6.1.7_8983</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\13.6.1.7.htm"/>
<x:Title>CHOP Chemotherapy and Etoposide</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=872 style='border-collapse:
collapse;table-layout:fixed;width:655pt'>
<col width=398 style='mso-width-source:userset;mso-width-alt:14555;width:299pt'>
<col class=xl24 width=58 style='mso-width-source:userset;mso-width-alt:2121;
width:44pt'>
<col width=416 style='mso-width-source:userset;mso-width-alt:15213;width:312pt'>
<tr height=39 style='mso-height-source:userset;height:29.25pt'>
<td height=39 class=xl28 width=398 style='height:29.25pt;width:299pt'>Text</td>
<td class=xl29 width=58 style='width:44pt'>Evidence level</td>
<td class=xl28 width=416 style='width:312pt'>References</td>
</tr>
<tr height=10 style='mso-height-source:userset;height:7.5pt'>
<td height=10 style='height:7.5pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=116 style='mso-height-source:userset;height:87.0pt'>
<td height=116 class=xl26 width=398 style='height:87.0pt;width:299pt'>Etoposide
added to CHOP therapy in low-risk patients younger than 60 years is superior
in time to treatment failure than CHOP.</td>
<td class=xl27 x:num>2</td>
<td class=xl26 width=416 style='width:312pt'>Pfreundschuh M, Truemper L,
Kloess M, et al. 2-weekly or 3-weekly CHOP Chemotherapy with or without
etoposide for the Treatment of Young Patients with Good Prognosis (Normal
LDH) Aggressive Lymphomas: Results of the NHL-B1 trial of the DSHNHL [German
High Grade Non-Hodgkin Lymphoma Group]. Blood 2004;..</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=398 style='width:299pt'></td>
<td width=58 style='width:44pt'></td>
<td width=416 style='width:312pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="13.6.1.8_files/filelist.xml">
<link rel=Edit-Time-Data href="13.6.1.8_files/editdata.mso">
<link rel=OLE-Object-Data href="13.6.1.8_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-01T01:33:18Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:#FFCC99;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>5</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>16053</x:Id>
<x:DivID>13.6.1.8_16053</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\13.6.1.8.htm"/>
<x:Title>Special populations</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=746 style='border-collapse:
collapse;table-layout:fixed;width:560pt'>
<col width=746 style='mso-width-source:userset;mso-width-alt:27282;width:560pt'>
<col width=256 style='mso-width-source:userset;mso-width-alt:9362;width:192pt'>
<col width=190 style='mso-width-source:userset;mso-width-alt:6948;width:143pt'>
<col width=192 style='mso-width-source:userset;mso-width-alt:7021;width:144pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=746 style='height:12.75pt;width:560pt'> </td>
</tr>
<tr height=111 style='mso-height-source:userset;height:83.25pt'>
<td height=111 class=xl24 width=746 style='height:83.25pt;width:560pt'>Prophylactic
G-CSF should be considered in elderly patients and also in patients thought
to be at high-risk, which is defined as:<br>
- pre-existing neutropenia due to disease<br>
- extensive previous chemotherapy or significant previous radiation therapy<br>
- history of recurrent febrile neutropenia while receiving chemotherapy of
similar or lower-dose intensity<br>
- at risk for serious infection (e.g. poor performance status, decreased
immune function, open wounds, or active tissue infection) <br>
Careful consideration should be given in the use of anthracyclines in this
group of patients with potential cardiac dysfunction.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=746 style='width:560pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
2
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="13.6.1.4_files/filelist.xml">
<link rel=Edit-Time-Data href="13.6.1.4_files/editdata.mso">
<link rel=OLE-Object-Data href="13.6.1.4_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-01-31T10:39:27Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl26
{mso-style-parent:style0;
background:#FFCC99;
mso-pattern:auto none;}
.xl27
{mso-style-parent:style0;
text-align:center;
background:#FFCC99;
mso-pattern:auto none;
white-space:normal;}
.xl28
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl29
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>8</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>11189</x:Id>
<x:DivID>13.6.1.4_11189</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\13.6.1.4.htm"/>
<x:Title>Recommended treatment for localised aggressive lymphoma (4)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=781 style='border-collapse:
collapse;table-layout:fixed;width:586pt'>
<col width=376 style='mso-width-source:userset;mso-width-alt:13750;width:282pt'>
<col class=xl24 width=60 style='mso-width-source:userset;mso-width-alt:2194;
width:45pt'>
<col width=345 style='mso-width-source:userset;mso-width-alt:12617;width:259pt'>
<tr height=37 style='mso-height-source:userset;height:27.75pt'>
<td height=37 class=xl26 width=376 style='height:27.75pt;width:282pt'>Text</td>
<td class=xl27 width=60 style='width:45pt'>Evidence level</td>
<td class=xl26 width=345 style='width:259pt'>References</td>
</tr>
<tr height=11 style='mso-height-source:userset;height:8.25pt'>
<td height=11 style='height:8.25pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=127 style='mso-height-source:userset;height:95.25pt'>
<td height=127 class=xl28 width=376 style='height:95.25pt;width:282pt'>Patients
with low-risk localised aggressive lymphoma may be treated with more
intensive sequential chemotherapy, omitting radiation therapy.</td>
<td class=xl29 x:num>2</td>
<td class=xl28 width=345 style='width:259pt'>Reyes F, Lepage E, et al.
Superiority of chemotherapy alone with the ACVBP regimen over treatment with
three cycles of CHOP plus radiotherapy in low-risk localized aggressive
lymphoma: the LNH93-1 GELA study. Blood 2002; 93a.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=376 style='width:282pt'></td>
<td width=60 style='width:45pt'></td>
<td width=345 style='width:259pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="13.6.1.8_files/filelist.xml">
<link rel=Edit-Time-Data href="13.6.1.8_files/editdata.mso">
<link rel=OLE-Object-Data href="13.6.1.8_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-01T01:33:18Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:#FFCC99;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>5</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>16053</x:Id>
<x:DivID>13.6.1.8_16053</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\13.6.1.8.htm"/>
<x:Title>Special populations</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=746 style='border-collapse:
collapse;table-layout:fixed;width:560pt'>
<col width=746 style='mso-width-source:userset;mso-width-alt:27282;width:560pt'>
<col width=256 style='mso-width-source:userset;mso-width-alt:9362;width:192pt'>
<col width=190 style='mso-width-source:userset;mso-width-alt:6948;width:143pt'>
<col width=192 style='mso-width-source:userset;mso-width-alt:7021;width:144pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=746 style='height:12.75pt;width:560pt'> </td>
</tr>
<tr height=111 style='mso-height-source:userset;height:83.25pt'>
<td height=111 class=xl24 width=746 style='height:83.25pt;width:560pt'>Prophylactic
G-CSF should be considered in elderly patients and also in patients thought
to be at high-risk, which is defined as:<br>
- pre-existing neutropenia due to disease<br>
- extensive previous chemotherapy or significant previous radiation therapy<br>
- history of recurrent febrile neutropenia while receiving chemotherapy of
similar or lower-dose intensity<br>
- at risk for serious infection (e.g. poor performance status, decreased
immune function, open wounds, or active tissue infection) <br>
Careful consideration should be given in the use of anthracyclines in this
group of patients with potential cardiac dysfunction.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=746 style='width:560pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="13.6.1.9_files/filelist.xml">
<link rel=Edit-Time-Data href="13.6.1.9_files/editdata.mso">
<link rel=OLE-Object-Data href="13.6.1.9_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-01-31T10:42:28Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl27
{mso-style-parent:style0;
background:#FFCC99;
mso-pattern:auto none;}
.xl28
{mso-style-parent:style0;
text-align:center;
background:#FFCC99;
mso-pattern:auto none;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>2</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>25915</x:Id>
<x:DivID>13.6.1.9_25915</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\13.6.1.9.htm"/>
<x:Title>Front-line high-dose therapy with stem cell support</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=752 style='border-collapse:
collapse;table-layout:fixed;width:564pt'>
<col width=335 style='mso-width-source:userset;mso-width-alt:12251;width:251pt'>
<col class=xl24 width=72 style='mso-width-source:userset;mso-width-alt:2633;
width:54pt'>
<col width=345 style='mso-width-source:userset;mso-width-alt:12617;width:259pt'>
<tr height=40 style='mso-height-source:userset;height:30.0pt'>
<td height=40 class=xl27 width=335 style='height:30.0pt;width:251pt'>Text</td>
<td class=xl28 width=72 style='width:54pt'>Evidence level</td>
<td class=xl27 width=345 style='width:259pt'>References</td>
</tr>
<tr height=12 style='mso-height-source:userset;height:9.0pt'>
<td height=12 style='height:9.0pt'></td>
<td class=xl24></td>
<td></td>
</tr>
<tr height=461 style='mso-height-source:userset;height:345.75pt'>
<td height=461 class=xl25 width=335 style='height:345.75pt;width:251pt'>Up-front
high-dose therapy with autologous stem cell transplantation cannot be
recommended outside of a clinical trial.</td>
<td class=xl26 x:num>2</td>
<td class=xl25 width=345 style='width:259pt'>1. Philip T, Guglielmi C,
Hagenbeek A, et al. Autologous bone marrow transplantation as compared with
salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin
lymphoma. N Engl J Med 1995; 333: 1540.<br>
2. Haioun C, Lepage E, Gisselbrecht C, et al. Comparison of autologous bone
marrow transplantation with sequential chemotherapy for intermediate-grade
and high-grade non-Hodgkin lymphoma in first complete remission: a study of
464 patients. Groupe dtude des Lymphomes de ldulte. J Clin Oncol 1994;
12: 25431.<br>
3. Haioun C, Lepage E, Gisselbrecht C, et al. Survival benefit of high-dose
therapy in poor-risk aggressive non-Hodgkin lymphoma: final analysis of the
prospective LNH87-2 protocol a Groupe dtude des Lymphomes de ldulte
study. J Clin Oncol 2000; 18: 30250.<br>
4. Gisselbrecht C, Lepage E, Molina T, et al. Shortened first-line
high-dose chemotherapy for patients with poor-prognosis aggressive lymphoma.
J Clin Oncol 2002; 20: 2472.<br>
5. Strehl J, Mey U, Glasmacher A, et al. High-dose chemotherapy followed by
autologous stem cell transplantation as first-line therapy in aggressive
non-Hodgkin lymphoma: a metaanalysis. Haematologica 2003; 88:
13045.<br>
6. Fisher RI. Autologous stem-cell transplantation as a component of
initial treatment for poor risk patients with aggressive non-Hodgkin
lymphoma: resolved issues versus remaining<span style='mso-spacerun:yes'> </span>opportunity. J Clin Oncol 2002; 20: 4411.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=335 style='width:251pt'></td>
<td width=72 style='width:54pt'></td>
<td width=345 style='width:259pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="13.6.1.10_files/filelist.xml">
<link rel=Edit-Time-Data href="13.6.1.10_files/editdata.mso">
<link rel=OLE-Object-Data href="13.6.1.10_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-01-31T10:42:48Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
.font0
{color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;}
.font5
{color:windowtext;
font-size:10.0pt;
font-weight:700;
font-style:normal;
text-decoration:none;
font-family:Arial, sans-serif;
mso-font-charset:0;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:#FFCC99;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>6</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>30462</x:Id>
<x:DivID>13.6.1.10_30462</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\13.6.1.10.htm"/>
<x:Title>Central nervous system prophylaxis</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=586 style='border-collapse:
collapse;table-layout:fixed;width:440pt'>
<col width=586 style='mso-width-source:userset;mso-width-alt:21430;width:440pt'>
<col width=256 style='mso-width-source:userset;mso-width-alt:9362;width:192pt'>
<col width=190 style='mso-width-source:userset;mso-width-alt:6948;width:143pt'>
<col width=192 style='mso-width-source:userset;mso-width-alt:7021;width:144pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=586 style='height:12.75pt;width:440pt'> </td>
</tr>
<tr height=209 style='mso-height-source:userset;height:156.75pt'>
<td height=209 class=xl24 width=586 style='height:156.75pt;width:440pt'>Central
nervous system (CNS) relapse of lymphoma is usually fatal despite therapy,
and effective prophylaxis is desirable. It occurs in between 5% and 30% of
patients with aggressive<span style='mso-spacerun:yes'></span>lymphoma. The
incidence is insufficient to justify universal CNS prophylaxis. Many attempts
have been made to identify factors associated with a high rate of CNS
relapse. There is general agreement that patients with <font class="font5">testicular
and paranasal sinuses involvement</font><font class="font0"> should receive
prophylaxis. For other groups, there are two large retrospective studies for
guidance. Involvement of more than one extranodal site and a raised LDH was
the only independent predictor of CNS recurrence. Patients with both risk
factors had a 17.4% incidence of CNS recurrence at one year compared to a
2.8% incidence if one or neither of these factors was present. A study by the
HOVON group reported the risk of CNS recurrence to be related to the IPI
score. Low-risk patients had a 0% incidence; high-risk had a 27% risk of CNS
recurrence. The optimal prophylactic therapy is unclear. In most cases,
intrathecal chemotherapy with methotrexate or cytarabine is used. However, a
26% rate of CNS relapse in high-risk patients given prophylactic treatment
with intrathecal chemotherapy has been reported.</font></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=586 style='width:440pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
Treatment planning
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.3.2_files/filelist.xml">
<link rel=Edit-Time-Data href="12.3.2_files/editdata.mso">
<link rel=OLE-Object-Data href="12.3.2_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-01T00:29:17Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
white-space:normal;}
.xl26
{mso-style-parent:style0;
background:#CCFFFF;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Print>
<x:ValidPrinterInfo/>
<x:PaperSizeIndex>9</x:PaperSizeIndex>
<x:HorizontalResolution>-3</x:HorizontalResolution>
<x:VerticalResolution>0</x:VerticalResolution>
</x:Print>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>10</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=786 style='border-collapse:
collapse;table-layout:fixed;width:590pt'>
<col width=638 style='mso-width-source:userset;mso-width-alt:23332;width:479pt'>
<col class=xl24 width=148 style='mso-width-source:userset;mso-width-alt:5412;
width:111pt'>
<col width=124 style='mso-width-source:userset;mso-width-alt:4534;width:93pt'>
<col width=96 style='mso-width-source:userset;mso-width-alt:3510;width:72pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl26 width=638 style='height:12.75pt;width:479pt'> </td>
<td class=xl24 width=148 style='width:111pt'></td>
</tr>
<tr height=119 style='height:89.25pt'>
<td height=119 class=xl25 width=638 style='height:89.25pt;width:479pt'>In
addition to investigations directed by the history and clinical examination,
staging requirements include:<br>
- full blood examination and manual differential with flow cytometry if
there is a lymphocytosis or morphologically abnormal lymphocytes present,
Coomb test<br>
- bone marrow aspirate and biopsy, with a minimum total length of 2.0 cm
and at least four levels examined<br>
- full biochemical profile including uric acid, LDH, β2-microglobulin,
and serum protein electrophoresis<br>
- disease specific molecular marker eg bcl - 2</td>
<td class=xl24></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=638 style='width:479pt'></td>
<td width=148 style='width:111pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.3.1_files/filelist.xml">
<link rel=Edit-Time-Data href="12.3.1_files/editdata.mso">
<link rel=OLE-Object-Data href="12.3.1_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-01T00:30:49Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
white-space:normal;}
.xl26
{mso-style-parent:style0;
background:#CCFFFF;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>3</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=728 style='border-collapse:
collapse;table-layout:fixed;width:546pt'>
<col width=580 style='mso-width-source:userset;mso-width-alt:21211;width:435pt'>
<col class=xl24 width=148 style='mso-width-source:userset;mso-width-alt:5412;
width:111pt'>
<col width=124 style='mso-width-source:userset;mso-width-alt:4534;width:93pt'>
<col width=96 style='mso-width-source:userset;mso-width-alt:3510;width:72pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl26 width=580 style='height:12.75pt;width:435pt'> </td>
<td class=xl24 width=148 style='width:111pt'></td>
</tr>
<tr height=51 style='height:38.25pt'>
<td height=51 class=xl25 width=580 style='height:38.25pt;width:435pt'>In
addition to investigations directed by the history and clinical examination,
staging requirements<br>
include CT scanning of the chest/abdomen/pelvis.</td>
<td class=xl24></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=580 style='width:435pt'></td>
<td width=148 style='width:111pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.4.8_files/filelist.xml">
<link rel=Edit-Time-Data href="12.4.8_files/editdata.mso">
<link rel=OLE-Object-Data href="12.4.8_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-01-31T22:25:44Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
white-space:normal;}
.xl26
{mso-style-parent:style0;
background:#FFFF99;
mso-pattern:auto none;
white-space:normal;}
.xl27
{mso-style-parent:style0;
text-align:center;
background:#FFFF99;
mso-pattern:auto none;
white-space:normal;}
.xl28
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl29
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl30
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Print>
<x:ValidPrinterInfo/>
<x:PaperSizeIndex>9</x:PaperSizeIndex>
<x:HorizontalResolution>-3</x:HorizontalResolution>
<x:VerticalResolution>0</x:VerticalResolution>
</x:Print>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>0</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>24262</x:Id>
<x:DivID>12.4.8_24262</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.4.8.htm"/>
<x:Title>Low grade lymphoma FLIPI - measure and record</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=829 style='border-collapse:
collapse;table-layout:fixed;width:622pt'>
<col width=368 style='mso-width-source:userset;mso-width-alt:13458;width:276pt'>
<col class=xl24 width=60 style='mso-width-source:userset;mso-width-alt:2194;
width:45pt'>
<col width=401 style='mso-width-source:userset;mso-width-alt:14665;width:301pt'>
<tr class=xl25 height=34 style='height:25.5pt'>
<td height=34 class=xl26 width=368 style='height:25.5pt;width:276pt'>Text</td>
<td class=xl27 width=60 style='width:45pt'>Evidence level</td>
<td class=xl26 width=401 style='width:301pt'>References</td>
</tr>
<tr class=xl25 height=10 style='mso-height-source:userset;height:7.5pt'>
<td height=10 class=xl25 style='height:7.5pt'></td>
<td class=xl30></td>
<td class=xl25></td>
</tr>
<tr height=103 style='mso-height-source:userset;height:77.25pt'>
<td height=103 class=xl28 width=368 style='height:77.25pt;width:276pt'>At the
time of diagnosis, the factors constituting the follicular lymphoma
international prognostic index (FLIPI) should be measured and recorded in all
patients.</td>
<td class=xl29 x:num>4</td>
<td class=xl28 width=401 style='width:301pt'>Solal-Celigny P, Bernard J, Roy
P. Follicular lymphoma international prognostic project. Ann.Oncol.
13(Suppl.), 18. 2002</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=368 style='width:276pt'></td>
<td width=60 style='width:45pt'></td>
<td width=401 style='width:301pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
// stage from core data is any of the following: I, IA, IB, II, IIA, IIB,
//III, IIIA, IIIAE, IIIAES, IIIB, IIIBE, IIIBES
let question: String = 'Check Stage is I, II or III'
let path: String = '4.2'
let O3 : Observation = Model.find_observation('Lymphoma_Wizard_Core', path)
//let IsPresent: Codedvalue =Factory.CodedValue('31874001', 'SNOMED-CT')
Let IsPresent: Boolean = true
let answer: Boolean =
if O3.isUndefined() then
Unknown
else
if O3.value_type = 'ST' then
if IsPresent.equals (O3.Value) then
true
else
false
endif
else
false
endif
endif
if answer = true then
factory.GLIFDecisionResult(question, answer, 'Stage is I, II, or III',50)
else
if answer = false then
factory.GLIFDecisionResult(question, answer, ' Stage is not I, II, or III',50)
else
factory.GLIFDecisionResult(question, answer, ' Stage is I, II, or III is unknown',50)
endif
endif
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.4.1_files/filelist.xml">
<link rel=Edit-Time-Data href="12.4.1_files/editdata.mso">
<link rel=OLE-Object-Data href="12.4.1_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-01T00:31:44Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl29
{mso-style-parent:style0;
background:#FFFF99;
mso-pattern:auto none;
white-space:normal;}
.xl30
{mso-style-parent:style0;
text-align:center;
background:#FFFF99;
mso-pattern:auto none;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Print>
<x:ValidPrinterInfo/>
<x:PaperSizeIndex>9</x:PaperSizeIndex>
<x:HorizontalResolution>-3</x:HorizontalResolution>
<x:VerticalResolution>0</x:VerticalResolution>
</x:Print>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>5</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>27309</x:Id>
<x:DivID>12.4.1_27309</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.4.1.htm"/>
<x:Title>FL staging (1)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=956 style='border-collapse:
collapse;table-layout:fixed;width:717pt'>
<col width=475 style='mso-width-source:userset;mso-width-alt:17371;width:356pt'>
<col class=xl24 width=79 style='mso-width-source:userset;mso-width-alt:2889;
width:59pt'>
<col width=402 style='mso-width-source:userset;mso-width-alt:14701;width:302pt'>
<tr class=xl25 height=34 style='height:25.5pt'>
<td height=34 class=xl29 width=475 style='height:25.5pt;width:356pt'>Text</td>
<td class=xl30 width=79 style='width:59pt'>Evidence level</td>
<td class=xl29 width=402 style='width:302pt'>References</td>
</tr>
<tr class=xl25 height=9 style='mso-height-source:userset;height:6.75pt'>
<td height=9 class=xl25 style='height:6.75pt'></td>
<td class=xl26></td>
<td class=xl25></td>
</tr>
<tr height=337 style='mso-height-source:userset;height:252.75pt'>
<td height=337 class=xl27 width=475 style='height:252.75pt;width:356pt'>Before
embarking on potentially curative radiation therapy for patients with
clinical stage III "low-grade" lymphoma, staging should include
functional imaging with PET or thallium scanning.</td>
<td class=xl28 x:num>3</td>
<td class=xl27 width=402 style='width:302pt'>1. Blum RH, Seymour JF, Wirth A,
MacManus M, Hicks RJ. Frequent impact of fluorodeoxyglucose positron emission
tomography on the staging and management of patients with indolent
non-Hodgkin lymphoma. Clin Lymphoma 2003; 4: 43<br>
2. Roach PJ, Cooper RA, Arthur CK, Ravich RB. Comparison of thallium-201
and gallium-67 scintigraphy in the evaluation of non-Hodgkin lymphoma. Aust
N Z J Med 1998; 28: 33.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=475 style='width:356pt'></td>
<td width=79 style='width:59pt'></td>
<td width=402 style='width:302pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.4.2_files/filelist.xml">
<link rel=Edit-Time-Data href="12.4.2_files/editdata.mso">
<link rel=OLE-Object-Data href="12.4.2_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-01T00:32:17Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl29
{mso-style-parent:style0;
background:#FFFF99;
mso-pattern:auto none;
white-space:normal;}
.xl30
{mso-style-parent:style0;
text-align:center;
background:#FFFF99;
mso-pattern:auto none;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Print>
<x:ValidPrinterInfo/>
<x:PaperSizeIndex>9</x:PaperSizeIndex>
<x:HorizontalResolution>-3</x:HorizontalResolution>
<x:VerticalResolution>0</x:VerticalResolution>
</x:Print>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>6</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>671</x:Id>
<x:DivID>12.4.2_671</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.4.2.htm"/>
<x:Title>FL staging (2)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=992 style='border-collapse:
collapse;table-layout:fixed;width:744pt'>
<col width=405 style='mso-width-source:userset;mso-width-alt:14811;width:304pt'>
<col class=xl24 width=60 style='mso-width-source:userset;mso-width-alt:2194;
width:45pt'>
<col width=527 style='mso-width-source:userset;mso-width-alt:19273;width:395pt'>
<tr class=xl25 height=34 style='height:25.5pt'>
<td height=34 class=xl29 width=405 style='height:25.5pt;width:304pt'>Text</td>
<td class=xl30 width=60 style='width:45pt'>Evidence level</td>
<td class=xl29 width=527 style='width:395pt'>References</td>
</tr>
<tr class=xl25 height=9 style='mso-height-source:userset;height:6.75pt'>
<td height=9 class=xl25 style='height:6.75pt'></td>
<td class=xl26></td>
<td class=xl25></td>
</tr>
<tr height=272 style='mso-height-source:userset;height:204.0pt'>
<td height=272 class=xl27 width=405 style='height:204.0pt;width:304pt'>Before
embarking on potentially curative radiation therapy for patients with
clinical stage III "low-grade" lymphoma, staging should include
careful examination of multiple levels of a bone marrow biopsy specimen
≥ 2.0 cm in length.</td>
<td class=xl28 x:num>3</td>
<td class=xl27 width=527 style='width:395pt'>1. Cheson BD, Horning SJ,
Coiffier B, et al. Report of an international workshop to standardize
response criteria for non-Hodgkin lymphomas. NCI Sponsored International
Working Group. J Clin Oncol 1999; 17: 1244<br>
2. Campbell JK, Matthews JP, Seymour JF, Wolf MM, Juneja SK. Optimum
trephine length in the assessment of bone marrow involvement in patients with
diffuse large cell lymphoma. Ann Oncol 2003; 14: 273.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=405 style='width:304pt'></td>
<td width=60 style='width:45pt'></td>
<td width=527 style='width:395pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
//stage is any of the following: III, IIIA, IIIAE, IIIAES, IIIB, IIIBE, IIIBES
// stage is any of the following: I, IA, IB, II, IIA, IIB
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.4.3_files/filelist.xml">
<link rel=Edit-Time-Data href="12.4.3_files/editdata.mso">
<link rel=OLE-Object-Data href="12.4.3_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-01T00:44:09Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
white-space:normal;}
.xl26
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl27
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl28
{mso-style-parent:style0;
background:#FFFF99;
mso-pattern:auto none;
white-space:normal;}
.xl29
{mso-style-parent:style0;
text-align:center;
background:#FFFF99;
mso-pattern:auto none;
white-space:normal;}
.xl30
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Print>
<x:ValidPrinterInfo/>
<x:PaperSizeIndex>9</x:PaperSizeIndex>
<x:HorizontalResolution>-3</x:HorizontalResolution>
<x:VerticalResolution>0</x:VerticalResolution>
</x:Print>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>9</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>5298</x:Id>
<x:DivID>12.4.3_5298</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.4.3.htm"/>
<x:Title>Radiotherapy for low grade Follicular Lymphoma (1)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=802 style='border-collapse:
collapse;table-layout:fixed;width:602pt'>
<col width=373 style='mso-width-source:userset;mso-width-alt:13641;width:280pt'>
<col class=xl24 width=60 style='mso-width-source:userset;mso-width-alt:2194;
width:45pt'>
<col width=369 style='mso-width-source:userset;mso-width-alt:13494;width:277pt'>
<tr class=xl25 height=34 style='height:25.5pt'>
<td height=34 class=xl28 width=373 style='height:25.5pt;width:280pt'>Text</td>
<td class=xl29 width=60 style='width:45pt'>Evidence level</td>
<td class=xl28 width=369 style='width:277pt'>References</td>
</tr>
<tr class=xl25 height=12 style='mso-height-source:userset;height:9.0pt'>
<td height=12 class=xl25 style='height:9.0pt'></td>
<td class=xl30></td>
<td class=xl25></td>
</tr>
<tr height=100 style='mso-height-source:userset;height:75.0pt'>
<td height=100 class=xl26 width=373 style='height:75.0pt;width:280pt'>Treatment
for adult patients with clinical stage I or II "low-grade"
follicular lymphoma should include involved-field radiation therapy of 306
Gy.</td>
<td class=xl27 x:num>3</td>
<td class=xl26 width=369 style='width:277pt'>MacManus MP, Seymour JF.
Management of localized low-grade follicular lymphomas. Australas Radiol
2001; 45: 3264.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=373 style='width:280pt'></td>
<td width=60 style='width:45pt'></td>
<td width=369 style='width:277pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.4.4_files/filelist.xml">
<link rel=Edit-Time-Data href="12.4.4_files/editdata.mso">
<link rel=OLE-Object-Data href="12.4.4_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-01T00:44:33Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
white-space:normal;}
.xl26
{mso-style-parent:style0;
background:#FFFF99;
mso-pattern:auto none;
white-space:normal;}
.xl27
{mso-style-parent:style0;
text-align:center;
background:#FFFF99;
mso-pattern:auto none;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl29
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl30
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Print>
<x:ValidPrinterInfo/>
<x:PaperSizeIndex>9</x:PaperSizeIndex>
<x:HorizontalResolution>-3</x:HorizontalResolution>
<x:VerticalResolution>0</x:VerticalResolution>
</x:Print>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>10</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>15881</x:Id>
<x:DivID>12.4.4_15881</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.4.4.htm"/>
<x:Title>Radiotherapy for low grade Follicular Lymphoma (2)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=879 style='border-collapse:
collapse;table-layout:fixed;width:660pt'>
<col width=433 style='mso-width-source:userset;mso-width-alt:15835;width:325pt'>
<col class=xl24 width=60 style='mso-width-source:userset;mso-width-alt:2194;
width:45pt'>
<col width=386 style='mso-width-source:userset;mso-width-alt:14116;width:290pt'>
<tr class=xl25 height=34 style='height:25.5pt'>
<td height=34 class=xl26 width=433 style='height:25.5pt;width:325pt'>Text</td>
<td class=xl27 width=60 style='width:45pt'>Evidence level</td>
<td class=xl26 width=386 style='width:290pt'>References</td>
</tr>
<tr class=xl25 height=10 style='mso-height-source:userset;height:7.5pt'>
<td height=10 class=xl25 style='height:7.5pt'></td>
<td class=xl28></td>
<td class=xl25></td>
</tr>
<tr height=150 style='mso-height-source:userset;height:112.5pt'>
<td height=150 class=xl29 width=433 style='height:112.5pt;width:325pt'>Patients
with stage I "low-grade" follicular lymphoma who are rendered
apparently disease free after the diagnostic biopsy and have a life
expectancy of less than five years may be observed without further therapy.</td>
<td class=xl30 x:num>4</td>
<td class=xl29 width=386 style='width:290pt'>Soubeyran P, Eghbali H, Trojani
M, Bonichon F, Richaud P, Hoerni B. Is there any place for a wait-and-see
policy in stage I0 follicular lymphoma? A study of 43 consecutive patients in
a single center. Ann Oncol 1996; 7: 713.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=433 style='width:325pt'></td>
<td width=60 style='width:45pt'></td>
<td width=386 style='width:290pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.4.5_files/filelist.xml">
<link rel=Edit-Time-Data href="12.4.5_files/editdata.mso">
<link rel=OLE-Object-Data href="12.4.5_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-01T00:38:42Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl27
{mso-style-parent:style0;
background:#FFFF99;
mso-pattern:auto none;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
background:#FFFF99;
mso-pattern:auto none;
white-space:normal;}
.xl29
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl30
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Print>
<x:ValidPrinterInfo/>
<x:PaperSizeIndex>9</x:PaperSizeIndex>
<x:HorizontalResolution>-3</x:HorizontalResolution>
<x:VerticalResolution>0</x:VerticalResolution>
</x:Print>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>8</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>22980</x:Id>
<x:DivID>12.4.5_22980</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.4.5.htm"/>
<x:Title>Radiotherapy for low grade Follicular Lymphoma (3)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=854 style='border-collapse:
collapse;table-layout:fixed;width:641pt'>
<col width=426 style='mso-width-source:userset;mso-width-alt:15579;width:320pt'>
<col class=xl24 width=60 style='mso-width-source:userset;mso-width-alt:2194;
width:45pt'>
<col width=368 style='mso-width-source:userset;mso-width-alt:13458;width:276pt'>
<tr class=xl25 height=34 style='height:25.5pt'>
<td height=34 class=xl27 width=426 style='height:25.5pt;width:320pt'>Text</td>
<td class=xl28 width=60 style='width:45pt'>Evidence level</td>
<td class=xl27 width=368 style='width:276pt'>References</td>
</tr>
<tr class=xl25 height=11 style='mso-height-source:userset;height:8.25pt'>
<td height=11 class=xl25 style='height:8.25pt'></td>
<td class=xl26></td>
<td class=xl25></td>
</tr>
<tr height=139 style='mso-height-source:userset;height:104.25pt'>
<td height=139 class=xl29 width=426 style='height:104.25pt;width:320pt'>Combined
modality treatment with both IF XRT and combination chemotherapy based on
alkylating agents is a reasonable option for adult patients with clinical
stage I or II "low-grade" follicular lymphoma.</td>
<td class=xl30 x:num>3</td>
<td class=xl29 width=368 style='width:276pt'>Seymour JF, Pro B, Fuller LM, et
al. Long-term follow-up of a prospective study of combined modality therapy
for stage II indolent non-Hodgkin lymphoma. J Clin Oncol 2003; 21:
21152.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=426 style='width:320pt'></td>
<td width=60 style='width:45pt'></td>
<td width=368 style='width:276pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.4.6_files/filelist.xml">
<link rel=Edit-Time-Data href="12.4.6_files/editdata.mso">
<link rel=OLE-Object-Data href="12.4.6_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-01-31T22:28:11Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl29
{mso-style-parent:style0;
background:#CCFFFF;
mso-pattern:auto none;
white-space:normal;}
.xl30
{mso-style-parent:style0;
text-align:center;
background:#CCFFFF;
mso-pattern:auto none;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Print>
<x:ValidPrinterInfo/>
<x:PaperSizeIndex>9</x:PaperSizeIndex>
<x:HorizontalResolution>-3</x:HorizontalResolution>
<x:VerticalResolution>0</x:VerticalResolution>
</x:Print>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>7</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=1037 style='border-collapse:
collapse;table-layout:fixed;width:778pt'>
<col width=490 style='mso-width-source:userset;mso-width-alt:17920;width:368pt'>
<col class=xl24 width=60 style='mso-width-source:userset;mso-width-alt:2194;
width:45pt'>
<col width=487 style='mso-width-source:userset;mso-width-alt:17810;width:365pt'>
<tr class=xl25 height=34 style='height:25.5pt'>
<td height=34 class=xl29 width=490 style='height:25.5pt;width:368pt'>Text</td>
<td class=xl30 width=60 style='width:45pt'>Evidence level</td>
<td class=xl29 width=487 style='width:365pt'>References</td>
</tr>
<tr class=xl25 height=11 style='mso-height-source:userset;height:8.25pt'>
<td height=11 class=xl25 style='height:8.25pt'></td>
<td class=xl26></td>
<td class=xl25></td>
</tr>
<tr height=446 style='mso-height-source:userset;height:334.5pt'>
<td height=446 class=xl27 width=490 style='height:334.5pt;width:368pt'>There
have been phase III studies exploring the benefit of adding chemotherapy to
local IF XRT in patients with stage II disease. With the exception of the
BNLI study of the addition of low-dose oral chlorambucil, these trials have
been of marginal value because of limited power to detect differences in
outcomes.</td>
<td class=xl28></td>
<td class=xl27 width=487 style='width:365pt'>1. Kelsey SM, Newland AC, Hudson
GV, Jelliffe AM. A British National Lymphoma Investigation randomised trial
of single agent chlorambucil plus radiotherapy versus radiotherapy alone in
low grade, localised non-Hodgkins lymphoma. Med Oncol 1994; 11:195.<br>
2. Carde P, Burgers JM, van Glabbeke M, et al. Combined
radiotherapy-chemotherapy for early stages non-Hodgkin lymphoma: the
1975980 EORTC controlled lymphoma trial. Radiother Oncol 1984; 2:
3012.<br>
3. Monfardini S, Banfi A, Bonadonna G, et al. Improved five year survival
after combined radiotherapy-chemotherapy for stage II non-Hodgkin
lymphoma. Int J Radiat Oncol Biol Phys 1980; 6: 1254.<br>
4. Nissen NI, Ersboll J, Hansen HS, et al. A randomized study of
radiotherapy versus radiotherapy plus chemotherapy in stage II
non-Hodgkin lymphomas. Cancer 1983; 52:1.<br>
5. Canellos GP, DeVita VT, Young RC, Chabner BA, Schein PS, Johnson RE.
Therapy of advanced lymphocytic lymphoma a preliminary report of a randomized
trial between combination chemotherapy (CVP) and intensive radiotherapy. Br J
Cancer 1975; 31 SUPPL 2:4740.<br>
6. Yahalom J, Varsos G, Fuks Z, Myers J, Clarkson BD, Straus DJ. Adjuvant
cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy after
radiation therapy in stage I low-grade and intermediate-grade non-Hodgkin
lymphoma. Results of a prospective randomized study. Cancer 1993; 71:
23420.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=490 style='width:368pt'></td>
<td width=60 style='width:45pt'></td>
<td width=487 style='width:365pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.4.7_files/filelist.xml">
<link rel=Edit-Time-Data href="12.4.7_files/editdata.mso">
<link rel=OLE-Object-Data href="12.4.7_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-01T00:45:26Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
white-space:normal;}
.xl26
{mso-style-parent:style0;
background:#FFFF99;
mso-pattern:auto none;
white-space:normal;}
.xl27
{mso-style-parent:style0;
text-align:center;
background:#FFFF99;
mso-pattern:auto none;
white-space:normal;}
.xl28
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl29
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl30
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Print>
<x:ValidPrinterInfo/>
<x:PaperSizeIndex>9</x:PaperSizeIndex>
<x:HorizontalResolution>-3</x:HorizontalResolution>
<x:VerticalResolution>0</x:VerticalResolution>
</x:Print>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>3</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>15936</x:Id>
<x:DivID>12.4.7_15936</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.4.7.htm"/>
<x:Title>Low grade lymphoma - lymphatic irradiation - haematopoietic progenitor</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=851 style='border-collapse:
collapse;table-layout:fixed;width:638pt'>
<col width=408 style='mso-width-source:userset;mso-width-alt:14921;width:306pt'>
<col class=xl24 width=60 style='mso-width-source:userset;mso-width-alt:2194;
width:45pt'>
<col width=383 style='mso-width-source:userset;mso-width-alt:14006;width:287pt'>
<tr class=xl25 height=34 style='height:25.5pt'>
<td height=34 class=xl26 width=408 style='height:25.5pt;width:306pt'>Text</td>
<td class=xl27 width=60 style='width:45pt'>Evidence level</td>
<td class=xl26 width=383 style='width:287pt'>References</td>
</tr>
<tr class=xl25 height=10 style='mso-height-source:userset;height:7.5pt'>
<td height=10 class=xl25 style='height:7.5pt'></td>
<td class=xl30></td>
<td class=xl25></td>
</tr>
<tr height=97 style='mso-height-source:userset;height:72.75pt'>
<td height=97 class=xl28 width=408 style='height:72.75pt;width:306pt'>Wide-field
"comprehensive lymphatic irradiation" should be considered for
patients with clinical stage III disease after careful and complete staging.</td>
<td class=xl29 x:num>3</td>
<td class=xl28 width=383 style='width:287pt'>Murtha AD, Rupnow BA, Hansosn J,
Knox SJ, Hoppe R. Long-term follow-up of patients with stage III follicular
lymphoma treated with primary radiotherapy at Stanford University. Int J
Radiat Oncol Biol Phys 2001; 49: 35.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=408 style='width:306pt'></td>
<td width=60 style='width:45pt'></td>
<td width=383 style='width:287pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
Absence of all of the following:
• pruritis of B-symptoms
• rapid generalised disease progression
• ‘life-endangering’ organ involvement
• marrow compromise (Haemoglobin =100 g/L, WBC <3.0, or platelets <100)
• bone lesions
• renal infiltration, and
• macroscopic liver involvement.
All of the following:
• maximum diameter of any site of disease <7 cm
• fewer than three nodal sites with a diameter >3 cm
• absence of systemic symptoms
• no ‘substantial’ splenic involvement (spleen <16 cm in length based on CT measurement)
• no significant serous effusions clinically evident or on chest X-ray
• absence of risk of local compressive symptoms (epidural, ureteral, etc.), and
• no circulating lymphoma cells or peripheral blood cytopenias (haemoglobin >10 g/dl, neutrophils >1.5 and platelets >100).
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.4.9_files/filelist.xml">
<link rel=Edit-Time-Data href="12.4.9_files/editdata.mso">
<link rel=OLE-Object-Data href="12.4.9_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-01T00:46:09Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl29
{mso-style-parent:style0;
background:#FFFF99;
mso-pattern:auto none;
white-space:normal;}
.xl30
{mso-style-parent:style0;
text-align:center;
background:#FFFF99;
mso-pattern:auto none;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Print>
<x:ValidPrinterInfo/>
<x:PaperSizeIndex>9</x:PaperSizeIndex>
<x:HorizontalResolution>-3</x:HorizontalResolution>
<x:VerticalResolution>0</x:VerticalResolution>
</x:Print>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>9</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>1076</x:Id>
<x:DivID>12.4.9_1076</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.4.9.htm"/>
<x:Title>Low grade lymphoma - 'watch and wait' criteria (1)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=742 style='border-collapse:
collapse;table-layout:fixed;width:556pt'>
<col width=343 style='mso-width-source:userset;mso-width-alt:12544;width:257pt'>
<col class=xl24 width=60 style='mso-width-source:userset;mso-width-alt:2194;
width:45pt'>
<col width=339 style='mso-width-source:userset;mso-width-alt:12397;width:254pt'>
<tr class=xl25 height=34 style='height:25.5pt'>
<td height=34 class=xl29 width=343 style='height:25.5pt;width:257pt'>Text</td>
<td class=xl30 width=60 style='width:45pt'>Evidence level</td>
<td class=xl29 width=339 style='width:254pt'>References</td>
</tr>
<tr class=xl25 height=12 style='mso-height-source:userset;height:9.0pt'>
<td height=12 class=xl25 style='height:9.0pt'></td>
<td class=xl26></td>
<td class=xl25></td>
</tr>
<tr height=114 style='mso-height-source:userset;height:85.5pt'>
<td height=114 class=xl27 width=343 style='height:85.5pt;width:257pt'>Where a
"watch and wait" approach is applied in the initial management of a
patient with advanced-stage follicular lymphoma, regular monitoring and
active surveillance for disease progression is mandatory.</td>
<td class=xl28 x:num>4</td>
<td class=xl27 width=339 style='width:254pt'>Ardeshna KM, Smith P, Norton A,
et al. Long-term effect of a watch and wait policy versus immediate systemic
treatment for asymptomatic advanced-stage non-Hodgkin lymphoma: a randomised
controlled trial. Lancet 2003; 362: 5162.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=343 style='width:257pt'></td>
<td width=60 style='width:45pt'></td>
<td width=339 style='width:254pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.4.10_files/filelist.xml">
<link rel=Edit-Time-Data href="12.4.10_files/editdata.mso">
<link rel=OLE-Object-Data href="12.4.10_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-01T00:46:52Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl27
{mso-style-parent:style0;
background:#CCFFFF;
mso-pattern:auto none;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
background:#CCFFFF;
mso-pattern:auto none;
white-space:normal;}
.xl29
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl30
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Print>
<x:ValidPrinterInfo/>
<x:PaperSizeIndex>9</x:PaperSizeIndex>
<x:HorizontalResolution>-3</x:HorizontalResolution>
<x:VerticalResolution>0</x:VerticalResolution>
</x:Print>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>8</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=1017 style='border-collapse:
collapse;table-layout:fixed;width:763pt'>
<col width=457 style='mso-width-source:userset;mso-width-alt:16713;width:343pt'>
<col class=xl24 width=60 style='mso-width-source:userset;mso-width-alt:2194;
width:45pt'>
<col width=500 style='mso-width-source:userset;mso-width-alt:18285;width:375pt'>
<tr class=xl25 height=34 style='height:25.5pt'>
<td height=34 class=xl27 width=457 style='height:25.5pt;width:343pt'>Text</td>
<td class=xl28 width=60 style='width:45pt'>Evidence level</td>
<td class=xl27 width=500 style='width:375pt'>References</td>
</tr>
<tr class=xl25 height=11 style='mso-height-source:userset;height:8.25pt'>
<td height=11 class=xl25 style='height:8.25pt'></td>
<td class=xl26></td>
<td class=xl25></td>
</tr>
<tr height=134 style='mso-height-source:userset;height:100.5pt'>
<td height=134 class=xl29 width=457 style='height:100.5pt;width:343pt'>Patients
who are initially managed by a "watch and wait" policy and who
either develop symptomatic disease, or have disease that progresses beyond
the criteria for "low tumour burden", should commence therapy.</td>
<td class=xl30 x:num>4</td>
<td class=xl29 width=500 style='width:375pt'>Ardeshna KM, Smith P, Norton A,
et al. Long-term effect of a watch and wait policy versus immediate systemic
treatment for asymptomatic advanced-stage non-Hodgkin lymphoma: a randomised
controlled trial. Lancet 2003; 362: 5162.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=457 style='width:343pt'></td>
<td width=60 style='width:45pt'></td>
<td width=500 style='width:375pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.4.11_files/filelist.xml">
<link rel=Edit-Time-Data href="12.4.11_files/editdata.mso">
<link rel=OLE-Object-Data href="12.4.11_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-01T00:47:37Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl29
{mso-style-parent:style0;
background:#FFFF99;
mso-pattern:auto none;
white-space:normal;}
.xl30
{mso-style-parent:style0;
text-align:center;
background:#FFFF99;
mso-pattern:auto none;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Print>
<x:ValidPrinterInfo/>
<x:PaperSizeIndex>9</x:PaperSizeIndex>
<x:HorizontalResolution>-3</x:HorizontalResolution>
<x:VerticalResolution>0</x:VerticalResolution>
</x:Print>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>11</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>30364</x:Id>
<x:DivID>12.4.11_30364</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.4.11.htm"/>
<x:Title>Low grade lymphoma - 'watch and wait' criteria (3)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=1041 style='border-collapse:
collapse;table-layout:fixed;width:781pt'>
<col width=455 style='mso-width-source:userset;mso-width-alt:16640;width:341pt'>
<col class=xl24 width=60 style='mso-width-source:userset;mso-width-alt:2194;
width:45pt'>
<col width=526 style='mso-width-source:userset;mso-width-alt:19236;width:395pt'>
<tr class=xl25 height=34 style='height:25.5pt'>
<td height=34 class=xl29 width=455 style='height:25.5pt;width:341pt'>Text</td>
<td class=xl30 width=60 style='width:45pt'>Evidence level</td>
<td class=xl29 width=526 style='width:395pt'>References</td>
</tr>
<tr class=xl25 height=9 style='mso-height-source:userset;height:6.75pt'>
<td height=9 class=xl25 style='height:6.75pt'></td>
<td class=xl26></td>
<td class=xl25></td>
</tr>
<tr height=278 style='mso-height-source:userset;height:208.5pt'>
<td height=278 class=xl27 width=455 style='height:208.5pt;width:341pt'>Asymptomatic
patients who do not fulfil the criteria for "low tumour burden"
follicular lymphoma, using either of the validated criteria, should commence
treatment at the time of diagnosis.</td>
<td class=xl28 x:num>4</td>
<td class=xl27 width=526 style='width:395pt'>1. Ardeshna KM, Smith P, Norton
A, et al. Long-term effect of a watch and wait policy versus immediate
systemic treatment for asymptomatic advanced-stage non-Hodgkin lymphoma: a
randomised controlled trial. Lancet 2003; 362: 5162.<br>
2. Brice P, Bastion Y, Lepage E, et al. Comparison in low-tumor-burden
follicular lymphomas between an initial no-treatment policy, prednimustine,
or interferon alfa: a randomized study from the Groupe dtude des Lymphomes
Folliculaires. Groupe dtude des Lymphomes deldulte. J Clin Oncol 1997;
15: 1110.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=455 style='width:341pt'></td>
<td width=60 style='width:45pt'></td>
<td width=526 style='width:395pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.4.12_files/filelist.xml">
<link rel=Edit-Time-Data href="12.4.12_files/editdata.mso">
<link rel=OLE-Object-Data href="12.4.12_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-01-31T22:23:18Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl29
{mso-style-parent:style0;
background:#FFFF99;
mso-pattern:auto none;
white-space:normal;}
.xl30
{mso-style-parent:style0;
text-align:center;
background:#FFFF99;
mso-pattern:auto none;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Print>
<x:ValidPrinterInfo/>
<x:PaperSizeIndex>9</x:PaperSizeIndex>
<x:HorizontalResolution>-3</x:HorizontalResolution>
<x:VerticalResolution>0</x:VerticalResolution>
</x:Print>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>8</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>11489</x:Id>
<x:DivID>12.4.12_11489</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.4.12.htm"/>
<x:Title>Low grade lymphoma - therapy for advanced stage follicular lymphoma</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=866 style='border-collapse:
collapse;table-layout:fixed;width:650pt'>
<col width=402 style='mso-width-source:userset;mso-width-alt:14701;width:302pt'>
<col class=xl24 width=60 style='mso-width-source:userset;mso-width-alt:2194;
width:45pt'>
<col width=404 style='mso-width-source:userset;mso-width-alt:14774;width:303pt'>
<tr class=xl25 height=34 style='height:25.5pt'>
<td height=34 class=xl29 width=402 style='height:25.5pt;width:302pt'>Text</td>
<td class=xl30 width=60 style='width:45pt'>Evidence level</td>
<td class=xl29 width=404 style='width:303pt'>References</td>
</tr>
<tr class=xl25 height=8 style='mso-height-source:userset;height:6.0pt'>
<td height=8 class=xl25 style='height:6.0pt'></td>
<td class=xl26></td>
<td class=xl25></td>
</tr>
<tr height=289 style='mso-height-source:userset;height:216.75pt'>
<td height=289 class=xl27 width=402 style='height:216.75pt;width:302pt'>Single-agent
alkylating agents with or without corticosteroids (using published schedules)
are a suitable treatment for patients with advanced-stage follicular
lymphoma.</td>
<td class=xl28 x:num>2</td>
<td class=xl27 width=404 style='width:303pt'>1. Ezdinli EZ, Anderson JR,
Melvin F, Glick JH, Davis TE, Oonnell MJ. Moderate versus aggressive
chemotherapy of nodular lymphocytic poorly differentiated lymphoma. J Clin
Oncol 1985; 3: 7695.<br>
2. Lister TA, Cullen MH, Beard ME, et al. Comparison of combined and
single-agent chemotherapy in non-Hodgkin lymphoma of favourable
histological type. Br Med J 1978; 1: 533.<br>
3. Kimby E, Bjorkholm M, Gahrton G, et al. Chlorambucil/prednisone vs. CHOP
in symptomatic low-grade non-Hodgkin lymphomas: a randomized trial from the
Lymphoma Group of Central Sweden. Ann Oncol 1994; 5 Suppl 2: 671.<br>
4. Peterson BA, Petroni GR, Frizzera G, et al. Prolonged single-agent
versus combination chemotherapy in indolent follicular lymphomas: a study of
the cancer and leukemia group B.<br>
J Clin Oncol 2003; 21: 55.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=402 style='width:302pt'></td>
<td width=60 style='width:45pt'></td>
<td width=404 style='width:303pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.4.13_files/filelist.xml">
<link rel=Edit-Time-Data href="12.4.13_files/editdata.mso">
<link rel=OLE-Object-Data href="12.4.13_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-01-31T22:22:55Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl29
{mso-style-parent:style0;
background:#FFFF99;
mso-pattern:auto none;
white-space:normal;}
.xl30
{mso-style-parent:style0;
text-align:center;
background:#FFFF99;
mso-pattern:auto none;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Print>
<x:ValidPrinterInfo/>
<x:PaperSizeIndex>9</x:PaperSizeIndex>
<x:HorizontalResolution>-3</x:HorizontalResolution>
<x:VerticalResolution>0</x:VerticalResolution>
</x:Print>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>8</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>24639</x:Id>
<x:DivID>12.4.13_24639</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.4.13.htm"/>
<x:Title>Low grade lymphoma - therapy for advanced stage follicular lymphoma (2)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=886 style='border-collapse:
collapse;table-layout:fixed;width:665pt'>
<col width=416 style='mso-width-source:userset;mso-width-alt:15213;width:312pt'>
<col class=xl24 width=60 style='mso-width-source:userset;mso-width-alt:2194;
width:45pt'>
<col width=410 style='mso-width-source:userset;mso-width-alt:14994;width:308pt'>
<tr class=xl25 height=34 style='height:25.5pt'>
<td height=34 class=xl29 width=416 style='height:25.5pt;width:312pt'>Text</td>
<td class=xl30 width=60 style='width:45pt'>Evidence level</td>
<td class=xl29 width=410 style='width:308pt'>References</td>
</tr>
<tr class=xl25 height=12 style='mso-height-source:userset;height:9.0pt'>
<td height=12 class=xl25 style='height:9.0pt'></td>
<td class=xl26></td>
<td class=xl25></td>
</tr>
<tr height=269 style='mso-height-source:userset;height:201.75pt'>
<td height=269 class=xl27 width=416 style='height:201.75pt;width:312pt'>Combination
chemotherapy regimens (e.g. CVP or CHOP) may be used where a shorter
treatment duration or more rapid disease response is desired, although these
regimens are not consistently associated with any long-term improvement in
quality or duration of disease response, or overall survival.</td>
<td class=xl28 x:num>2</td>
<td class=xl27 width=410 style='width:308pt'>1. Lister TA, Cullen MH, Beard
ME, et al. Comparison of combined and single-agent chemotherapy in
non-Hodgkin lymphoma of favourable histological type. Br Med J 1978; 1:
533.<br>
2. Kimby E, Bjorkholm M, Gahrton G, et al. Chlorambucil/prednisone vs. CHOP
in symptomatic low-grade non-Hodgkin lymphomas: a randomized trial from the
Lymphoma Group of Central Sweden. Ann Oncol 1994; 5 Suppl 2: 671.<br>
3. Peterson BA, Petroni GR, Frizzera G, et al. Prolonged single-agent
versus combination chemotherapy in indolent follicular lymphomas: a study of
the cancer and leukemia group B.<br>
J Clin Oncol 2003; 21: 55.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=416 style='width:312pt'></td>
<td width=60 style='width:45pt'></td>
<td width=410 style='width:308pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.4.14_files/filelist.xml">
<link rel=Edit-Time-Data href="12.4.14_files/editdata.mso">
<link rel=OLE-Object-Data href="12.4.14_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-01-31T22:22:42Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl29
{mso-style-parent:style0;
background:#FFFF99;
mso-pattern:auto none;
white-space:normal;}
.xl30
{mso-style-parent:style0;
text-align:center;
background:#FFFF99;
mso-pattern:auto none;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Print>
<x:ValidPrinterInfo/>
<x:PaperSizeIndex>9</x:PaperSizeIndex>
<x:HorizontalResolution>-3</x:HorizontalResolution>
<x:VerticalResolution>0</x:VerticalResolution>
</x:Print>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>9</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>8050</x:Id>
<x:DivID>12.4.14_8050</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.4.14.htm"/>
<x:Title>Low-grade lymphoma advanced disease response and radiotherapy (clinical trial)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=846 style='border-collapse:
collapse;table-layout:fixed;width:635pt'>
<col width=404 style='mso-width-source:userset;mso-width-alt:14774;width:303pt'>
<col class=xl24 width=60 style='mso-width-source:userset;mso-width-alt:2194;
width:45pt'>
<col width=382 style='mso-width-source:userset;mso-width-alt:13970;width:287pt'>
<tr class=xl25 height=34 style='height:25.5pt'>
<td height=34 class=xl29 width=404 style='height:25.5pt;width:303pt'>Text</td>
<td class=xl30 width=60 style='width:45pt'>Evidence level</td>
<td class=xl29 width=382 style='width:287pt'>References</td>
</tr>
<tr class=xl25 height=10 style='mso-height-source:userset;height:7.5pt'>
<td height=10 class=xl25 style='height:7.5pt'></td>
<td class=xl26></td>
<td class=xl25></td>
</tr>
<tr height=93 style='mso-height-source:userset;height:69.75pt'>
<td height=93 class=xl27 width=404 style='height:69.75pt;width:303pt'>Where a
patient with advanced-stage follicular lymphoma has achieved a compete
response to initial therapy, irradiation to nodal sites of disease (initially
bulky or otherwise) is not recommended outside of the context of a clinical
trial.</td>
<td class=xl28 x:num>2</td>
<td class=xl27 width=382 style='width:287pt'>Portlock CS, Rosenberg SA,
Glatstein E, Kaplan HS. Treatment of advanced non-Hodgkin lymphomas with
favorable histologies: preliminary results of a prospective trial. Blood
1976; 47: 7476.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=404 style='width:303pt'></td>
<td width=60 style='width:45pt'></td>
<td width=382 style='width:287pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
Follicular lymphoma management B
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.4.15_files/filelist.xml">
<link rel=Edit-Time-Data href="12.4.15_files/editdata.mso">
<link rel=OLE-Object-Data href="12.4.15_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-01-31T22:22:28Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl29
{mso-style-parent:style0;
background:#FFFF99;
mso-pattern:auto none;
white-space:normal;}
.xl30
{mso-style-parent:style0;
text-align:center;
background:#FFFF99;
mso-pattern:auto none;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Print>
<x:ValidPrinterInfo/>
<x:PaperSizeIndex>9</x:PaperSizeIndex>
<x:HorizontalResolution>-3</x:HorizontalResolution>
<x:VerticalResolution>0</x:VerticalResolution>
</x:Print>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>2</x:ActiveRow>
<x:ActiveCol>6</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>26346</x:Id>
<x:DivID>12.4.15_26346</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.4.15.htm"/>
<x:Title>Low-grade lymphoma ggressivetreatment</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=842 style='border-collapse:
collapse;table-layout:fixed;width:632pt'>
<col width=380 style='mso-width-source:userset;mso-width-alt:13897;width:285pt'>
<col class=xl24 width=60 style='mso-width-source:userset;mso-width-alt:2194;
width:45pt'>
<col width=402 style='mso-width-source:userset;mso-width-alt:14701;width:302pt'>
<tr class=xl25 height=34 style='height:25.5pt'>
<td height=34 class=xl29 width=380 style='height:25.5pt;width:285pt'>Text</td>
<td class=xl30 width=60 style='width:45pt'>Evidence level</td>
<td class=xl29 width=402 style='width:302pt'>References</td>
</tr>
<tr class=xl25 height=17 style='height:12.75pt'>
<td height=17 class=xl25 style='height:12.75pt'></td>
<td class=xl26></td>
<td class=xl25></td>
</tr>
<tr height=424 style='mso-height-source:userset;height:318.0pt'>
<td height=424 class=xl27 width=380 style='height:318.0pt;width:285pt'>Pending
the availability of further data from phase III studies, where motivated and
informed patients have been made fully aware of the promising but
inconclusive data regarding potential overall survival benefits of initial
aggressive treatment approaches and wish to pursue such a strategy, initial
therapy attempting to achieve maximal cytoreduction (potentially guided by
molecular assessment of minimal residual disease) is a reasonable approach in
carefully selected cases.</td>
<td class=xl28 x:num>2</td>
<td class=xl27 width=402 style='width:302pt'>1. Tsimberidou AM, McLaughlin P,
Younes A, et al. Fludarabine, mitoxantrone, dexamethasone (FND) compared with
an alternating triple therapy (ATT) regimen in patients with stage IV<br>
indolent lymphoma. Blood 2002; 100: 4351.<br>
2. McLaughlin P, Rodriguez MA, Hagemeister FB, Romaguera J, Sarris AH,
Younes A, Dang NH, Goy A, Samaniego F, Hess M. Stage IV indolent lymphoma: a
randomized study of<br>
concurrent vs. sequential use of FND chemotherapy (fludarabine,
mitoxantrone, dexamethasone) and rituximab (R) monoclonal antibody therapy,
with interferon maintenance. Proceedings of the American Society of Clinical
Oncology 22, 564. 2003.<br>
3. Czuczman MS. Immunochemotherapy in indolent non-Hodgkin lymphoma.
Semin Oncol<br>
4. Czuczman MS, Fallon A, Mohr A, et al. Rituximab in combination with CHOP
or fludarabine in low-grade lymphoma. Semin Oncol 2002; 29: 360.<br>
5. Hiddemann W, Dreyling MH, Forstpointner R, Kneba M, Woermann B,
Lengfelder E, Schmits R, Resier M, Metzner B, Schmitz N, Truemper L,
Eimermacher M, Parwaresch R.<br>
Combined immuno-chemotherapy (R-CHOP) significantly improves time to
treatment failure in first line therapy of follicular lymphoma results of a
prospective randomized trial of the German Low Grade Lymphoma Study Group
(GLSG). Blood 11(Suppl.), 104a. 2003.<br>
</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=380 style='width:285pt'></td>
<td width=60 style='width:45pt'></td>
<td width=402 style='width:302pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.4.16_files/filelist.xml">
<link rel=Edit-Time-Data href="12.4.16_files/editdata.mso">
<link rel=OLE-Object-Data href="12.4.16_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-01-31T22:22:13Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl29
{mso-style-parent:style0;
background:#FFFF99;
mso-pattern:auto none;
white-space:normal;}
.xl30
{mso-style-parent:style0;
text-align:center;
background:#FFFF99;
mso-pattern:auto none;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Print>
<x:ValidPrinterInfo/>
<x:PaperSizeIndex>9</x:PaperSizeIndex>
<x:HorizontalResolution>-3</x:HorizontalResolution>
<x:VerticalResolution>0</x:VerticalResolution>
</x:Print>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>2</x:ActiveRow>
<x:ActiveCol>4</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>16434</x:Id>
<x:DivID>12.4.16_16434</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.4.16.htm"/>
<x:Title>Low-grade lymphoma criteria for therapy with interferon</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=846 style='border-collapse:
collapse;table-layout:fixed;width:634pt'>
<col width=403 style='mso-width-source:userset;mso-width-alt:14738;width:302pt'>
<col class=xl24 width=59 style='mso-width-source:userset;mso-width-alt:2157;
width:44pt'>
<col width=384 style='mso-width-source:userset;mso-width-alt:14043;width:288pt'>
<tr class=xl25 height=34 style='height:25.5pt'>
<td height=34 class=xl29 width=403 style='height:25.5pt;width:302pt'>Text</td>
<td class=xl30 width=59 style='width:44pt'>Evidence level</td>
<td class=xl29 width=384 style='width:288pt'>References</td>
</tr>
<tr class=xl25 height=10 style='mso-height-source:userset;height:7.5pt'>
<td height=10 class=xl25 style='height:7.5pt'></td>
<td class=xl26></td>
<td class=xl25></td>
</tr>
<tr height=382 style='mso-height-source:userset;height:286.5pt'>
<td height=382 class=xl27 width=403 style='height:286.5pt;width:302pt'>The
use of interferon-α maintenance after anthracycline-based initial
therapy (e.g. CHOP) may be considered on an individual patient basis.</td>
<td class=xl28 x:num>2</td>
<td class=xl27 width=384 style='width:288pt'>1. Solal-Celigny P, Lepage E,
Brousse N, et al. Doxorubicin-containing regimen with or without interferon
alfa-2b for advanced follicular lymphomas: final analysis of survival and
toxicity in the Groupe dtude des Lymphomes Folliculaires 86 Trial. J Clin
Oncol 1998; 16: 2332.<br>
2. Smalley RV, Andersen JW, Hawkins MJ, et al. Interferon alfa combined
with cytotoxic chemotherapy for patients with non-Hodgkin lymphoma. N Engl
J Med 1992; 327: 13361.<br>
3. Rohatiner AZS, Gregory W, Peterson B, Smaller R, Solal-Celigny P,
Hagenbeek A, Bijnens L, Unterhalt M, Chisesi T, Aviles A, Lister TA. A
meta-analysis (MA) of randomised trials<br>
evaluating the role of interferon (IFN) as treatment for follicular
lymphoma (FL). Proceedings of the American Society of Clinical Oncology 17,
4a. 1998</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=403 style='width:302pt'></td>
<td width=59 style='width:44pt'></td>
<td width=384 style='width:288pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.4.17_files/filelist.xml">
<link rel=Edit-Time-Data href="12.4.17_files/editdata.mso">
<link rel=OLE-Object-Data href="12.4.17_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-01-31T22:21:57Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl29
{mso-style-parent:style0;
background:#FFFF99;
mso-pattern:auto none;
white-space:normal;}
.xl30
{mso-style-parent:style0;
text-align:center;
background:#FFFF99;
mso-pattern:auto none;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Print>
<x:ValidPrinterInfo/>
<x:PaperSizeIndex>9</x:PaperSizeIndex>
<x:HorizontalResolution>-3</x:HorizontalResolution>
<x:VerticalResolution>0</x:VerticalResolution>
</x:Print>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>13</x:ActiveRow>
<x:ActiveCol>5</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>26033</x:Id>
<x:DivID>12.4.17_26033</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.4.17.htm"/>
<x:Title>Low-grade lymphoma radioimmunotherapy criteria</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=785 style='border-collapse:
collapse;table-layout:fixed;width:589pt'>
<col width=382 style='mso-width-source:userset;mso-width-alt:13970;width:287pt'>
<col class=xl24 width=59 style='mso-width-source:userset;mso-width-alt:2157;
width:44pt'>
<col width=344 style='mso-width-source:userset;mso-width-alt:12580;width:258pt'>
<tr class=xl25 height=34 style='height:25.5pt'>
<td height=34 class=xl29 width=382 style='height:25.5pt;width:287pt'>Text</td>
<td class=xl30 width=59 style='width:44pt'>Evidence level</td>
<td class=xl29 width=344 style='width:258pt'>References</td>
</tr>
<tr class=xl25 height=10 style='mso-height-source:userset;height:7.5pt'>
<td height=10 class=xl25 style='height:7.5pt'></td>
<td class=xl26></td>
<td class=xl25></td>
</tr>
<tr height=218 style='mso-height-source:userset;height:163.5pt'>
<td height=218 class=xl27 width=382 style='height:163.5pt;width:287pt'>For
patients who fulfil specific criteria (specifically <25% bone marrow
infiltration), the use of radioimmunotherapy is associated with a higher rate
of disease control and should be considered in preference to single-agent
rituximab.</td>
<td class=xl28 x:num>2</td>
<td class=xl27 width=344 style='width:258pt'>Witzig TE, Gordon LI, Cabanillas
F, et al. Randomized controlled trial of yttrium-90-labeled ibritumomab
tiuxetan radioimmunotherapy versus rituximab immunotherapy for patients with
relapsed or refractory low-grade, follicular, or transformed B-cell non-Hodgkin
lymphoma. J Clin Oncol 2002; 20: 24533.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=382 style='width:287pt'></td>
<td width=59 style='width:44pt'></td>
<td width=344 style='width:258pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.4.18_files/filelist.xml">
<link rel=Edit-Time-Data href="12.4.18_files/editdata.mso">
<link rel=OLE-Object-Data href="12.4.18_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-01-31T22:21:41Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl29
{mso-style-parent:style0;
background:#FFFF99;
mso-pattern:auto none;
white-space:normal;}
.xl30
{mso-style-parent:style0;
text-align:center;
background:#FFFF99;
mso-pattern:auto none;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Print>
<x:ValidPrinterInfo/>
<x:PaperSizeIndex>9</x:PaperSizeIndex>
<x:HorizontalResolution>-3</x:HorizontalResolution>
<x:VerticalResolution>0</x:VerticalResolution>
</x:Print>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>10</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>17494</x:Id>
<x:DivID>12.4.18_17494</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.4.18.htm"/>
<x:Title>Low-grade lymphoma auto HCST indication (1)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=823 style='border-collapse:
collapse;table-layout:fixed;width:617pt'>
<col width=403 style='mso-width-source:userset;mso-width-alt:14738;width:302pt'>
<col class=xl24 width=60 style='mso-width-source:userset;mso-width-alt:2194;
width:45pt'>
<col width=360 style='mso-width-source:userset;mso-width-alt:13165;width:270pt'>
<tr class=xl25 height=34 style='height:25.5pt'>
<td height=34 class=xl29 width=403 style='height:25.5pt;width:302pt'>Text</td>
<td class=xl30 width=60 style='width:45pt'>Evidence level</td>
<td class=xl29 width=360 style='width:270pt'>References</td>
</tr>
<tr class=xl25 height=10 style='mso-height-source:userset;height:7.5pt'>
<td height=10 class=xl25 style='height:7.5pt'></td>
<td class=xl26></td>
<td class=xl25></td>
</tr>
<tr height=105 style='mso-height-source:userset;height:78.75pt'>
<td height=105 class=xl27 width=403 style='height:78.75pt;width:302pt'>Auto-HSCT
may be indicated in patients who have failed at least one conventional
chemotherapeutic regimen.</td>
<td class=xl28 x:num>2</td>
<td class=xl27 width=360 style='width:270pt'>Schouten HC, Qian W, Kvaloy S,
et al. High-dose therapy improves progression-free survival and survival in
relapsed follicular non-Hodgkin lymphoma: results from the randomized
European CUP trial. J Clin Oncol 2003; 21: 39187.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=403 style='width:302pt'></td>
<td width=60 style='width:45pt'></td>
<td width=360 style='width:270pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.4.19_files/filelist.xml">
<link rel=Edit-Time-Data href="12.4.19_files/editdata.mso">
<link rel=OLE-Object-Data href="12.4.19_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-01-31T22:21:25Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl29
{mso-style-parent:style0;
background:#FFFF99;
mso-pattern:auto none;
white-space:normal;}
.xl30
{mso-style-parent:style0;
text-align:center;
background:#FFFF99;
mso-pattern:auto none;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Print>
<x:ValidPrinterInfo/>
<x:PaperSizeIndex>9</x:PaperSizeIndex>
<x:HorizontalResolution>-3</x:HorizontalResolution>
<x:VerticalResolution>0</x:VerticalResolution>
</x:Print>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>5</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>7778</x:Id>
<x:DivID>12.4.19_7778</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.4.19.htm"/>
<x:Title>Low grade lymphoma - auto HCST - indication (2)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=813 style='border-collapse:
collapse;table-layout:fixed;width:610pt'>
<col width=402 style='mso-width-source:userset;mso-width-alt:14701;width:302pt'>
<col class=xl24 width=60 style='mso-width-source:userset;mso-width-alt:2194;
width:45pt'>
<col width=351 style='mso-width-source:userset;mso-width-alt:12836;width:263pt'>
<tr class=xl25 height=34 style='height:25.5pt'>
<td height=34 class=xl29 width=402 style='height:25.5pt;width:302pt'>Text</td>
<td class=xl30 width=60 style='width:45pt'>Evidence level</td>
<td class=xl29 width=351 style='width:263pt'>References</td>
</tr>
<tr class=xl25 height=8 style='mso-height-source:userset;height:6.0pt'>
<td height=8 class=xl25 style='height:6.0pt'></td>
<td class=xl26></td>
<td class=xl25></td>
</tr>
<tr height=207 style='mso-height-source:userset;height:155.25pt'>
<td height=207 class=xl27 width=402 style='height:155.25pt;width:302pt'>The
use of auto-HSCT as part of up-front treatment remains controversial.</td>
<td class=xl28 x:num="3.4">3,4</td>
<td class=xl27 width=351 style='width:263pt'>1. Sebban C, Belanger C, Brousse
N, et al. Comparison of CHVP+Interferon with CHOP followed by autologous stem
cell transplantation with TBI conditioning regimen in untreated patients with
high tumour burden follicular lymphoma: results of the randomised GELF94
trial (GELA study group). Blood 2003; 102.<br>
2. Deconinck E, Foussard C, Bertrand P, et al. Value of autologous stem
cell transplantation in first line therapy of follicular lymphoma with high
tumour burden: final results of the GEOLAMS 064 Trial. Blood 2003; 102.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=402 style='width:302pt'></td>
<td width=60 style='width:45pt'></td>
<td width=351 style='width:263pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.4.20_files/filelist.xml">
<link rel=Edit-Time-Data href="12.4.20_files/editdata.mso">
<link rel=OLE-Object-Data href="12.4.20_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-01-31T22:21:07Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl29
{mso-style-parent:style0;
background:#99CCFF;
mso-pattern:auto none;
white-space:normal;}
.xl30
{mso-style-parent:style0;
text-align:center;
background:#99CCFF;
mso-pattern:auto none;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Print>
<x:ValidPrinterInfo/>
<x:PaperSizeIndex>9</x:PaperSizeIndex>
<x:HorizontalResolution>-3</x:HorizontalResolution>
<x:VerticalResolution>0</x:VerticalResolution>
</x:Print>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>5</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>22589</x:Id>
<x:DivID>12.4.20_22589</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.4.20.htm"/>
<x:Title>Low-grade lymphoma auto-HCST and NST considerations (1)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=825 style='border-collapse:
collapse;table-layout:fixed;width:619pt'>
<col width=402 style='mso-width-source:userset;mso-width-alt:14701;width:302pt'>
<col class=xl24 width=60 style='mso-width-source:userset;mso-width-alt:2194;
width:45pt'>
<col width=363 style='mso-width-source:userset;mso-width-alt:13275;width:272pt'>
<tr class=xl25 height=34 style='height:25.5pt'>
<td height=34 class=xl29 width=402 style='height:25.5pt;width:302pt'>Text</td>
<td class=xl30 width=60 style='width:45pt'>Evidence level</td>
<td class=xl29 width=363 style='width:272pt'>References</td>
</tr>
<tr class=xl25 height=9 style='mso-height-source:userset;height:6.75pt'>
<td height=9 class=xl25 style='height:6.75pt'></td>
<td class=xl26></td>
<td class=xl25></td>
</tr>
<tr height=187 style='height:140.25pt'>
<td height=187 class=xl27 width=402 style='height:140.25pt;width:302pt'>Conventional
sibling allogeneic HSCT should be limited to young patients with poor
prognosis follicular lymphoma who have limited comorbidities.</td>
<td class=xl28 x:num>4</td>
<td class=xl27 width=363 style='width:272pt'>1. Annual report of the
International Bone Marrow Transplant Registry. 2003. International Bone
Marrow Transplant Registry (IBMTR).<br>
2. Verdonck LF, Dekker AW, Lokhorst HM, Petersen EJ, Nieuwenhuis HK.
Allogeneic versus autologous bone marrow transplantation for refractory and
recurrent low-grade non-<br>
Hodgkin lymphoma. Blood 1997; 90: 4201.<br>
3. van Besien K, Sobocinski KA, Rowlings PA, et al. Allogeneic bone marrow
transplantation for low-grade lymphoma. Blood 1998; 92: 1832.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=402 style='width:302pt'></td>
<td width=60 style='width:45pt'></td>
<td width=363 style='width:272pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.4.21_files/filelist.xml">
<link rel=Edit-Time-Data href="12.4.21_files/editdata.mso">
<link rel=OLE-Object-Data href="12.4.21_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-01-31T22:20:34Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl29
{mso-style-parent:style0;
background:#99CCFF;
mso-pattern:auto none;
white-space:normal;}
.xl30
{mso-style-parent:style0;
text-align:center;
background:#99CCFF;
mso-pattern:auto none;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Print>
<x:ValidPrinterInfo/>
<x:PaperSizeIndex>9</x:PaperSizeIndex>
<x:HorizontalResolution>-3</x:HorizontalResolution>
<x:VerticalResolution>0</x:VerticalResolution>
</x:Print>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>5</x:ActiveRow>
<x:ActiveCol>6</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>9682</x:Id>
<x:DivID>12.4.21_9682</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.4.21.htm"/>
<x:Title>Low-grade lymphoma auto-HCST and NST considerations (2)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=800 style='border-collapse:
collapse;table-layout:fixed;width:601pt'>
<col width=378 style='mso-width-source:userset;mso-width-alt:13824;width:284pt'>
<col class=xl24 width=60 style='mso-width-source:userset;mso-width-alt:2194;
width:45pt'>
<col width=362 style='mso-width-source:userset;mso-width-alt:13238;width:272pt'>
<tr class=xl25 height=34 style='height:25.5pt'>
<td height=34 class=xl29 width=378 style='height:25.5pt;width:284pt'>Text</td>
<td class=xl30 width=60 style='width:45pt'>Evidence level</td>
<td class=xl29 width=362 style='width:272pt'>References</td>
</tr>
<tr class=xl25 height=11 style='mso-height-source:userset;height:8.25pt'>
<td height=11 class=xl25 style='height:8.25pt'></td>
<td class=xl26></td>
<td class=xl25></td>
</tr>
<tr height=396 style='mso-height-source:userset;height:297.0pt'>
<td height=396 class=xl27 width=378 style='height:297.0pt;width:284pt'>NST
can be considered in patients with poor prognosis follicular lymphoma, but
should optimally be performed in the context of approved clinical trials.</td>
<td class=xl28 x:num="3.4">3,4</td>
<td class=xl27 width=362 style='width:272pt'>1. Slavin S, Nagler A, Naparstek
E, et al. Nonmyeloablative stem cell transplantation and cell therapy as an
alternative to conventional bone marrow transplantation with lethal
cytoreduction for the treatment of malignant and nonmalignant hematologic diseases.
Blood 1998; 91: 7563.<br>
2. Khouri IF, Keating M, Korbling M, et al. Transplant-lite: induction of
graft-versusmalignancy using fludarabine-based nonablative chemotherapy and
allogeneic blood progenitor-cell transplantation as treatment for lymphoid
malignancies. J Clin Oncol 1998; 16: 28174.<br>
3. Khouri IF, Saliba RM, Giralt SA, et al. Nonablative allogeneic
hematopoietic transplantation as adoptive immunotherapy for indolent
lymphoma: low incidence of toxicity, acute graft versus-host disease, and
treatment-related mortality. Blood 2001; 98: 3595.<br>
4. Robinson SP, Goldstone AH, Mackinnon S, et al. Chemoresistant or
aggressive lymphoma predicts for a poor outcome following reduced-intensity
allogeneic progenitor cell transplantation: an analysis from the Lymphoma
Working Party of the European Group for Blood and Bone Marrow
Transplantation. Blood 2002; 100: 4310.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=378 style='width:284pt'></td>
<td width=60 style='width:45pt'></td>
<td width=362 style='width:272pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
Treatment planning
Gastric MALT
Non-gastric MALT
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="17.3.5.1_files/filelist.xml">
<link rel=Edit-Time-Data href="17.3.5.1_files/editdata.mso">
<link rel=OLE-Object-Data href="17.3.5.1_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-02T00:04:54Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:left;}
.xl27
{mso-style-parent:style0;
background:silver;
mso-pattern:auto none;}
.xl28
{mso-style-parent:style0;
background:silver;
mso-pattern:auto none;
white-space:normal;}
.xl29
{mso-style-parent:style0;
text-align:center;
background:silver;
mso-pattern:auto none;
white-space:normal;}
.xl30
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl31
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl32
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl33
{mso-style-parent:style0;
text-align:left;
vertical-align:top;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Print>
<x:ValidPrinterInfo/>
<x:PaperSizeIndex>9</x:PaperSizeIndex>
<x:HorizontalResolution>-3</x:HorizontalResolution>
<x:VerticalResolution>0</x:VerticalResolution>
</x:Print>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>15</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>31924</x:Id>
<x:DivID>17.3.5.1_31924</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\17.3.5.1.htm"/>
<x:Title>Gastric MALT lymphoma staging and evaluation</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=804 style='border-collapse:
collapse;table-layout:fixed;width:603pt'>
<col width=388 style='mso-width-source:userset;mso-width-alt:14189;width:291pt'>
<col class=xl24 width=60 style='mso-width-source:userset;mso-width-alt:2194;
width:45pt'>
<col width=356 style='mso-width-source:userset;mso-width-alt:13019;width:267pt'>
<tr class=xl25 height=34 style='height:25.5pt'>
<td height=34 class=xl28 width=388 style='height:25.5pt;width:291pt'>Text</td>
<td class=xl29 width=60 style='width:45pt'>Evidence level</td>
<td class=xl28 width=356 style='width:267pt'>References</td>
</tr>
<tr class=xl25 height=12 style='mso-height-source:userset;height:9.0pt'>
<td height=12 class=xl25 style='height:9.0pt'></td>
<td class=xl30></td>
<td class=xl25></td>
</tr>
<tr height=420 style='mso-height-source:userset;height:315.0pt'>
<td height=420 class=xl31 width=388 style='height:315.0pt;width:291pt'>Patients
should be staged as for lymphomas in general. Endoscopic ultrasound should be
included in the staging process if experienced operators are available.
Markers for the t(11;18) (q21; q21) translocation should be obtained on
tumour biopsy samples.</td>
<td class=xl32 x:num>3</td>
<td class=xl33 width=356 style='width:267pt'>1. Yahalom J, Isaacson PG, Zucca
E. Extranodal marginal zone B-cell lymphoma of mucosa associated lymphoid
tissue. In: Mauch PM, Armitage J (eds.): Lippincott, 2004.<br>
2. Caletti G, Fusaroli P, Togliani T. EUS in MALT lymphoma. Gastrointest
Endosc 2002; 56: S2126.<br>
3. Fusaroli P, Buscarini E, Peyre S, et al. Interobserver agreement in
staging gastric malt lymphoma by EUS. Gastrointest Endosc 2002; 55:
662.<br>
4. Puspok A, Raderer M, Chott A, Dragosics B, Gangl A, Schofl R. Endoscopic
ultrasound in the follow up and response assessment of patients with primary
gastric lymphoma. Gut 2002; 51: 691.<br>
5. Fischbach W, Goebeler-Kolve ME, Greiner A. Diagnostic accuracy of EUS in
the local staging of primary gastric lymphoma: results of a prospective,
multicenter study comparing EUS with histopathologic stage. Gastrointest
Endosc 2002; 56: 69600.<br>
6. Liu H, Ruskon-Fourmestraux A, Lavergne-Slove A, et al. Resistance of
t(11;18) positive gastric mucosa-associated lymphoid tissue lymphoma to
Helicobacter pylori eradication therapy. Lancet 2001; 357: 390. <br>
7. Starostik P, Patzner J, Greiner A, et al. Gastric marginal zone B-cell
lymphomas of MALT type develop along 2 distinct pathogenetic pathways. Blood
2002; 99: 3.</td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl24></td>
<td class=xl26></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl24></td>
<td class=xl26></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl24></td>
<td class=xl26></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl24></td>
<td class=xl26></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl24></td>
<td class=xl26></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl24></td>
<td class=xl26></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl24></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl24></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl24></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl24></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl24></td>
<td class=xl27> </td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=388 style='width:291pt'></td>
<td width=60 style='width:45pt'></td>
<td width=356 style='width:267pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="17.1_files/filelist.xml">
<link rel=Edit-Time-Data href="17.1_files/editdata.mso">
<link rel=OLE-Object-Data href="17.1_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2007-02-02T02:50:52Z</o:Created>
<o:LastSaved>2007-02-02T03:29:17Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
vertical-align:top;
border-top:.5pt solid windowtext;
border-right:none;
border-bottom:.5pt solid windowtext;
border-left:none;
white-space:normal;}
.xl26
{mso-style-parent:style0;
border-top:none;
border-right:none;
border-bottom:.5pt solid windowtext;
border-left:none;}
.xl27
{mso-style-parent:style0;
vertical-align:middle;
border-top:none;
border-right:none;
border-bottom:.5pt solid windowtext;
border-left:none;
background:#CC99FF;
mso-pattern:auto none;
white-space:normal;}
.xl28
{mso-style-parent:style0;
font-family:"Times New Roman", serif;
mso-font-charset:0;
text-align:left;
vertical-align:top;
border-top:.5pt solid windowtext;
border-right:none;
border-bottom:.5pt solid windowtext;
border-left:none;}
.xl29
{mso-style-parent:style0;
font-family:"Times New Roman", serif;
mso-font-charset:0;
text-align:left;
vertical-align:top;}
.xl30
{mso-style-parent:style0;
vertical-align:top;
border-top:none;
border-right:none;
border-bottom:.5pt solid windowtext;
border-left:none;}
.xl31
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl32
{mso-style-parent:style0;
vertical-align:top;
border-top:.5pt solid windowtext;
border-right:none;
border-bottom:none;
border-left:none;
white-space:normal;}
.xl33
{mso-style-parent:style0;
vertical-align:top;
border-top:none;
border-right:none;
border-bottom:.5pt solid windowtext;
border-left:none;
white-space:normal;}
.xl34
{mso-style-parent:style0;
font-size:9.0pt;
font-family:Arial, sans-serif;
mso-font-charset:0;
vertical-align:top;
border-top:.5pt solid windowtext;
border-right:none;
border-bottom:none;
border-left:none;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Print>
<x:ValidPrinterInfo/>
<x:HorizontalResolution>600</x:HorizontalResolution>
<x:VerticalResolution>600</x:VerticalResolution>
</x:Print>
<x:Selected/>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
<x:ActiveRow>9</x:ActiveRow>
<x:ActiveCol>4</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
<x:ExcelWorksheet>
<x:Name>Sheet2</x:Name>
<x:WorksheetOptions>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
<x:ExcelWorksheet>
<x:Name>Sheet3</x:Name>
<x:WorksheetOptions>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>8070</x:WindowHeight>
<x:WindowWidth>15180</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>90</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=786 style='border-collapse:
collapse;table-layout:fixed;width:590pt'>
<col width=64 style='width:48pt'>
<col width=260 style='mso-width-source:userset;mso-width-alt:9508;width:195pt'>
<col width=110 style='mso-width-source:userset;mso-width-alt:4022;width:83pt'>
<col width=80 style='mso-width-source:userset;mso-width-alt:2925;width:60pt'>
<col width=208 style='mso-width-source:userset;mso-width-alt:7606;width:156pt'>
<col width=64 style='width:48pt'>
<tr height=8 style='mso-height-source:userset;height:6.0pt'>
<td height=8 width=64 style='height:6.0pt;width:48pt'></td>
<td width=260 style='width:195pt'></td>
<td width=110 style='width:83pt'></td>
<td width=80 style='width:60pt'></td>
<td width=208 style='width:156pt'></td>
<td width=64 style='width:48pt'></td>
</tr>
<tr height=79 style='mso-height-source:userset;height:59.25pt'>
<td height=79 class=xl27 width=64 style='height:59.25pt;width:48pt'>TNM stage</td>
<td class=xl27 width=260 style='width:195pt'>Lugano staging system for
gastro-intestinal lymphomas</td>
<td class=xl27 width=110 style='width:83pt'>TNM staging system adapted for
gastric lymphoma</td>
<td class=xl27 width=80 style='width:60pt'>Ann Arbor stage</td>
<td class=xl27 width=208 style='width:156pt'>Tumour extension</td>
<td class=xl24></td>
</tr>
<tr height=88 style='mso-height-source:userset;height:66.0pt'>
<td height=88 class=xl28 style='height:66.0pt;border-top:none'>I</td>
<td class=xl25 width=260 style='border-top:none;width:195pt'>Confined to
gastrointestinal tract (single primary or multiple, non-contiguous)</td>
<td class=xl25 width=110 style='border-top:none;width:83pt'>T1 N0 M0<br>
<br>
T2 N0 M0<br>
<br>
T3 N0 M0</td>
<td class=xl25 width=80 style='border-top:none;width:60pt'>IE<br>
<br>
IE<br>
<br>
IE</td>
<td class=xl31 width=208 style='width:156pt'>Mucosa, submucosa<br>
<br>
Muscularis propria<br>
<br>
Serosa</td>
<td></td>
</tr>
<tr height=92 style='mso-height-source:userset;height:69.0pt'>
<td height=92 class=xl28 style='height:69.0pt;border-top:none'>II</td>
<td class=xl25 width=260 style='border-top:none;width:195pt'>Extending into
abdomen<br>
<br>
II1 = local nodal involvement<br>
<br>
II2 = distant nodal involvement</td>
<td class=xl25 width=110 style='border-top:none;width:83pt'><br>
<br>
T1 N1 M0<br>
<br>
T1 N2 M0</td>
<td class=xl25 width=80 style='border-top:none;width:60pt'><br>
<br>
IIE<br>
<br>
IIE</td>
<td class=xl25 width=208 style='width:156pt'><br>
<br>
Perigastric lymph nodes<br>
<br>
More distant regional lymph nodes</td>
<td></td>
</tr>
<tr height=46 style='mso-height-source:userset;height:34.5pt'>
<td height=46 class=xl28 style='height:34.5pt;border-top:none'>IIE</td>
<td class=xl25 width=260 style='border-top:none;width:195pt'>Penetration of
serosa to involve adjacent organs or tissues</td>
<td class=xl25 width=110 style='border-top:none;width:83pt'>T4 N0 M0</td>
<td class=xl25 width=80 style='border-top:none;width:60pt'>IE</td>
<td class=xl25 width=208 style='border-top:none;width:156pt'>Invasion of
adjacent structures</td>
<td></td>
</tr>
<tr height=47 style='mso-height-source:userset;height:35.25pt'>
<td height=47 class=xl29 style='height:35.25pt'>IV</td>
<td class=xl25 width=260 style='border-top:none;width:195pt'>Disseminated
extranodal involvement or concomitant metastases</td>
<td class=xl25 width=110 style='border-top:none;width:83pt'>T1 N3 M0</td>
<td class=xl25 width=80 style='border-top:none;width:60pt'>IIIE</td>
<td rowspan=2 class=xl32 width=208 style='border-bottom:.5pt solid black;
border-top:none;width:156pt'>Lymph nodes on both sides of the
diaphragm/distant (e.g. bone marrow or additional extranodal sites)</td>
<td></td>
</tr>
<tr height=39 style='mso-height-source:userset;height:29.25pt'>
<td height=39 class=xl26 style='height:29.25pt'> </td>
<td class=xl30>Supradiaphragmatic nodal involvement</td>
<td class=xl30>T1 N0 M1</td>
<td class=xl30>IVE</td>
<td></td>
</tr>
<tr height=41 style='mso-height-source:userset;height:30.75pt'>
<td height=41 style='height:30.75pt'></td>
<td colspan=4 class=xl34 width=658 style='width:494pt'>Source: Yahalom J,
Isaacson PG, Zucca E. Extranodal marginal zone B-cell lymphoma of
mucosa-associated lymphoid tissue. In: Mauch PM, Armitage J (eds.):
Lippincott, 2004.</td>
<td></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=64 style='width:48pt'></td>
<td width=260 style='width:195pt'></td>
<td width=110 style='width:83pt'></td>
<td width=80 style='width:60pt'></td>
<td width=208 style='width:156pt'></td>
<td width=64 style='width:48pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="17.3.8.1_files/filelist.xml">
<link rel=Edit-Time-Data href="17.3.8.1_files/editdata.mso">
<link rel=OLE-Object-Data href="17.3.8.1_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-02T00:05:19Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:silver;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>5</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>8954</x:Id>
<x:DivID>17.3.8.1_8954</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\17.3.8.1.htm"/>
<x:Title>Cytogenetic markers</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=453 style='border-collapse:
collapse;table-layout:fixed;width:340pt'>
<col width=453 style='mso-width-source:userset;mso-width-alt:16566;width:340pt'>
<col width=126 style='mso-width-source:userset;mso-width-alt:4608;width:95pt'>
<col width=110 style='mso-width-source:userset;mso-width-alt:4022;width:83pt'>
<col width=273 style='mso-width-source:userset;mso-width-alt:9984;width:205pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=453 style='height:12.75pt;width:340pt'> </td>
</tr>
<tr height=26 style='mso-height-source:userset;height:19.5pt'>
<td height=26 class=xl24 width=453 style='height:19.5pt;width:340pt'>The
t(11;18) translocation marker will predict resistance to antibiotic therapy.</td>
</tr>
<tr height=238 style='height:178.5pt;mso-xlrowspan:14'>
<td height=238 style='height:178.5pt'></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl24 style='height:12.75pt'></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=453 style='width:340pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="17.3.9.2_files/filelist.xml">
<link rel=Edit-Time-Data href="17.3.9.2_files/editdata.mso">
<link rel=OLE-Object-Data href="17.3.9.2_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-02T00:05:54Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:silver;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>6</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>18418</x:Id>
<x:DivID>17.3.9.2_18418</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\17.3.9.2.htm"/>
<x:Title>Advanced-stage disease and the t(11;18) translocation</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=480 style='border-collapse:
collapse;table-layout:fixed;width:360pt'>
<col width=480 style='mso-width-source:userset;mso-width-alt:17554;width:360pt'>
<col width=126 style='mso-width-source:userset;mso-width-alt:4608;width:95pt'>
<col width=110 style='mso-width-source:userset;mso-width-alt:4022;width:83pt'>
<col width=273 style='mso-width-source:userset;mso-width-alt:9984;width:205pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=480 style='height:12.75pt;width:360pt'> </td>
</tr>
<tr height=78 style='mso-height-source:userset;height:58.5pt'>
<td height=78 class=xl24 width=480 style='height:58.5pt;width:360pt'>Patients
with more advanced-stage disease and the t(11;18) translocation are unlikely
to respond to H.pylori eradication. It has been recommended that a trial of
eradication therapy is worthwhile, as a minority of such patients will have
lymphoma regression.</td>
</tr>
<tr height=238 style='height:178.5pt;mso-xlrowspan:14'>
<td height=238 style='height:178.5pt'></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl24 style='height:12.75pt'></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=480 style='width:360pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="17.3.9.1_files/filelist.xml">
<link rel=Edit-Time-Data href="17.3.9.1_files/editdata.mso">
<link rel=OLE-Object-Data href="17.3.9.1_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-02T00:07:45Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:silver;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>5</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>14693</x:Id>
<x:DivID>17.3.9.1_14693</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\17.3.9.1.htm"/>
<x:Title>Gastric MALT lymphoma treatment</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=478 style='border-collapse:
collapse;table-layout:fixed;width:359pt'>
<col width=478 style='mso-width-source:userset;mso-width-alt:17481;width:359pt'>
<col width=126 style='mso-width-source:userset;mso-width-alt:4608;width:95pt'>
<col width=110 style='mso-width-source:userset;mso-width-alt:4022;width:83pt'>
<col width=273 style='mso-width-source:userset;mso-width-alt:9984;width:205pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=478 style='height:12.75pt;width:359pt'> </td>
</tr>
<tr height=47 style='mso-height-source:userset;height:35.25pt'>
<td height=47 class=xl24 width=478 style='height:35.25pt;width:359pt'>Antibiotic
therapy for H.pylori is regarded as standard primary treatment. There are
many series documenting histological regression after successful eradication.</td>
</tr>
<tr height=238 style='height:178.5pt;mso-xlrowspan:14'>
<td height=238 style='height:178.5pt'></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl24 style='height:12.75pt'></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=478 style='width:359pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="17.3.10.1_files/filelist.xml">
<link rel=Edit-Time-Data href="17.3.10.1_files/editdata.mso">
<link rel=OLE-Object-Data href="17.3.10.1_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-02T00:08:17Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl29
{mso-style-parent:style0;
background:silver;
mso-pattern:auto none;
white-space:normal;}
.xl30
{mso-style-parent:style0;
text-align:center;
background:silver;
mso-pattern:auto none;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Print>
<x:ValidPrinterInfo/>
<x:PaperSizeIndex>9</x:PaperSizeIndex>
<x:HorizontalResolution>-3</x:HorizontalResolution>
<x:VerticalResolution>0</x:VerticalResolution>
</x:Print>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>2</x:ActiveRow>
<x:ActiveCol>3</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>28165</x:Id>
<x:DivID>17.3.10.1_28165</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\17.3.10.1.htm"/>
<x:Title>Treatment of gastric MALT lymphoma (1)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=806 style='border-collapse:
collapse;table-layout:fixed;width:604pt'>
<col width=319 style='mso-width-source:userset;mso-width-alt:11666;width:239pt'>
<col class=xl24 width=60 style='mso-width-source:userset;mso-width-alt:2194;
width:45pt'>
<col width=427 style='mso-width-source:userset;mso-width-alt:15616;width:320pt'>
<tr class=xl25 height=34 style='height:25.5pt'>
<td height=34 class=xl29 width=319 style='height:25.5pt;width:239pt'>Text</td>
<td class=xl30 width=60 style='width:45pt'>Evidence level</td>
<td class=xl29 width=427 style='width:320pt'>References</td>
</tr>
<tr class=xl25 height=12 style='mso-height-source:userset;height:9.0pt'>
<td height=12 class=xl25 style='height:9.0pt'></td>
<td class=xl26></td>
<td class=xl25></td>
</tr>
<tr height=355 style='mso-height-source:userset;height:266.25pt'>
<td height=355 class=xl27 width=319 style='height:266.25pt;width:239pt'>Standard
triple therapy should be used in all patients (H-pylori positive and
negative).</td>
<td class=xl28 x:num>3</td>
<td class=xl27 width=427 style='width:320pt'>1. Liu H, Ruskon-Fourmestraux A,
Lavergne-Slove A, et al. Resistance of t(11;18) positive gastric
mucosa-associated lymphoid tissue lymphoma to Helicobacter pylori
eradication<br>
therapy. Lancet 2001; 357: 390.<br>
2. Liu H, Ye H, Ruskone-Fourmestraux A, et al. T(11;18) is a marker for all
stage gastric MALT lymphomas that will not respond to H. pylori eradication.
Gastroenterology 2002; 122: 12864.<br>
3. Ye H, Liu H, Raderer M, et al. High incidence of t(11;18)(q21;q21) in
Helicobacter pylorinegative gastric MALT lymphoma. Blood 2003; 101:
25470.<br>
4. Starostik P, Patzner J, Greiner A, et al. Gastric marginal zone B-cell
lymphomas of MALT type develop along 2 distinct pathogenetic pathways. Blood
2002; 99: 3. <br>
5. Yahalom J, Isaacson PG, Zucca E. Extranodal marginal zone B-cell
lymphoma of mucosaassociated lymphoid tissue. In: Mauch PM, Armitage J
(eds.): Lippincott, 2004. <br>
6. Kahl BS. Update: gastric MALT lymphoma. Curr Opin Oncol 2003; 15:
3472.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=319 style='width:239pt'></td>
<td width=60 style='width:45pt'></td>
<td width=427 style='width:320pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="17.3.7_files/filelist.xml">
<link rel=Edit-Time-Data href="17.3.7_files/editdata.mso">
<link rel=OLE-Object-Data href="17.3.7_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-02T00:09:52Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:silver;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>5</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>6479</x:Id>
<x:DivID>17.3.7_6479</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\17.3.7.htm"/>
<x:Title>Persistent evidence of disease after antibiotics</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=536 style='border-collapse:
collapse;table-layout:fixed;width:402pt'>
<col width=536 style='mso-width-source:userset;mso-width-alt:19602;width:402pt'>
<col width=126 style='mso-width-source:userset;mso-width-alt:4608;width:95pt'>
<col width=110 style='mso-width-source:userset;mso-width-alt:4022;width:83pt'>
<col width=273 style='mso-width-source:userset;mso-width-alt:9984;width:205pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=536 style='height:12.75pt;width:402pt'> </td>
</tr>
<tr height=83 style='mso-height-source:userset;height:62.25pt'>
<td height=83 class=xl24 width=536 style='height:62.25pt;width:402pt'>Despite
complete remissions of low-grade gastric MALT lymphomas after cure of
H.pylori infection, many patients display evidence of monoclonal B cells
during follow up. Thiede group in Germany suggest that patients with
monoclonal PCR should be observed closely, whereas long-term PCR negativity
may indicate cure of the disease.</td>
</tr>
<tr height=238 style='height:178.5pt;mso-xlrowspan:14'>
<td height=238 style='height:178.5pt'></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl24 style='height:12.75pt'></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=536 style='width:402pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="17.3.10.2_files/filelist.xml">
<link rel=Edit-Time-Data href="17.3.10.2_files/editdata.mso">
<link rel=OLE-Object-Data href="17.3.10.2_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-02T00:09:35Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl29
{mso-style-parent:style0;
background:silver;
mso-pattern:auto none;
white-space:normal;}
.xl30
{mso-style-parent:style0;
text-align:center;
background:silver;
mso-pattern:auto none;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Print>
<x:ValidPrinterInfo/>
<x:PaperSizeIndex>9</x:PaperSizeIndex>
<x:HorizontalResolution>-3</x:HorizontalResolution>
<x:VerticalResolution>0</x:VerticalResolution>
</x:Print>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>8</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>31355</x:Id>
<x:DivID>17.3.10.2_31355</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\17.3.10.2.htm"/>
<x:Title>Treatment of gastric MALT lymphoma (2)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=777 style='border-collapse:
collapse;table-layout:fixed;width:583pt'>
<col width=359 style='mso-width-source:userset;mso-width-alt:13129;width:269pt'>
<col class=xl24 width=60 style='mso-width-source:userset;mso-width-alt:2194;
width:45pt'>
<col width=358 style='mso-width-source:userset;mso-width-alt:13092;width:269pt'>
<tr class=xl25 height=34 style='height:25.5pt'>
<td height=34 class=xl29 width=359 style='height:25.5pt;width:269pt'>Text</td>
<td class=xl30 width=60 style='width:45pt'>Evidence level</td>
<td class=xl29 width=358 style='width:269pt'>References</td>
</tr>
<tr class=xl25 height=11 style='mso-height-source:userset;height:8.25pt'>
<td height=11 class=xl25 style='height:8.25pt'></td>
<td class=xl26></td>
<td class=xl25></td>
</tr>
<tr height=186 style='mso-height-source:userset;height:139.5pt'>
<td height=186 class=xl27 width=359 style='height:139.5pt;width:269pt'>Patients
require endoscopic follow up with biopsy initially, at two months after
eradication, and then yearly.</td>
<td class=xl28 x:num>3</td>
<td class=xl27 width=358 style='width:269pt'>Starostik P, Patzner J, Greiner
A, et al. Gastric marginal zone B-cell lymphomas of MALT type develop along 2
distinct pathogenetic pathways. Blood 2002; 99: 3.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=359 style='width:269pt'></td>
<td width=60 style='width:45pt'></td>
<td width=358 style='width:269pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="17.3.8.2_files/filelist.xml">
<link rel=Edit-Time-Data href="17.3.8.2_files/editdata.mso">
<link rel=OLE-Object-Data href="17.3.8.2_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-02T00:08:40Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:silver;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>4</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>11856</x:Id>
<x:DivID>17.3.8.2_11856</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\17.3.8.2.htm"/>
<x:Title>Endoscopic ultrasound</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=450 style='border-collapse:
collapse;table-layout:fixed;width:338pt'>
<col width=450 style='mso-width-source:userset;mso-width-alt:16457;width:338pt'>
<col width=126 style='mso-width-source:userset;mso-width-alt:4608;width:95pt'>
<col width=110 style='mso-width-source:userset;mso-width-alt:4022;width:83pt'>
<col width=273 style='mso-width-source:userset;mso-width-alt:9984;width:205pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=450 style='height:12.75pt;width:338pt'> </td>
</tr>
<tr height=117 style='mso-height-source:userset;height:87.75pt'>
<td height=117 class=xl24 width=450 style='height:87.75pt;width:338pt'>EUS
has predicted outcome of treatment of MALT lymphoma following simple
eradication therapy of H-pylori. Thus patients with disease limited to the
mucosa and/or submucosa at EUS will show complete remission rates up to 100%,
whereas very few patients with a more extensive infiltration will show
complete remission. The TNM classification appears to be more appropriate for
staging lesions by EUS.</td>
</tr>
<tr height=238 style='height:178.5pt;mso-xlrowspan:14'>
<td height=238 style='height:178.5pt'></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl24 style='height:12.75pt'></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=450 style='width:338pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="17.3.10.4_files/filelist.xml">
<link rel=Edit-Time-Data href="17.3.10.4_files/editdata.mso">
<link rel=OLE-Object-Data href="17.3.10.4_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-02T00:09:28Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl29
{mso-style-parent:style0;
background:silver;
mso-pattern:auto none;
white-space:normal;}
.xl30
{mso-style-parent:style0;
text-align:center;
background:silver;
mso-pattern:auto none;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Print>
<x:ValidPrinterInfo/>
<x:PaperSizeIndex>9</x:PaperSizeIndex>
<x:HorizontalResolution>-3</x:HorizontalResolution>
<x:VerticalResolution>0</x:VerticalResolution>
</x:Print>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>7</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>4983</x:Id>
<x:DivID>17.3.10.4_4983</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\17.3.10.4.htm"/>
<x:Title>Treatment of gastric MALT lymphoma (4)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=775 style='border-collapse:
collapse;table-layout:fixed;width:582pt'>
<col width=362 style='mso-width-source:userset;mso-width-alt:13238;width:272pt'>
<col class=xl24 width=60 style='mso-width-source:userset;mso-width-alt:2194;
width:45pt'>
<col width=353 style='mso-width-source:userset;mso-width-alt:12909;width:265pt'>
<tr class=xl25 height=34 style='height:25.5pt'>
<td height=34 class=xl29 width=362 style='height:25.5pt;width:272pt'>Text</td>
<td class=xl30 width=60 style='width:45pt'>Evidence level</td>
<td class=xl29 width=353 style='width:265pt'>References</td>
</tr>
<tr class=xl25 height=9 style='mso-height-source:userset;height:6.75pt'>
<td height=9 class=xl25 style='height:6.75pt'></td>
<td class=xl26></td>
<td class=xl25></td>
</tr>
<tr height=304 style='mso-height-source:userset;height:228.0pt'>
<td height=304 class=xl27 width=362 style='height:228.0pt;width:272pt'>In
general, patients with gastric MALT lymphoma do not require surgery, because
results of radiotherapy and/or chemotherapy are superior.</td>
<td class=xl28 x:num>3</td>
<td class=xl27 width=353 style='width:265pt'>1. Koch P, del Valle F, Berdel
WE, et al. Primary gastrointestinal non-Hodgkin lymphoma: I. Anatomic and
histologic distribution, clinical features, and survival data of 371 patients
registered in the German Multicenter Study GIT NHL 01/92. J Clin Oncol 2001;
19: 38613.<br>
2. Yoon SS, Coit DG, Portlock CS, Karpeh MS. The diminishing role of
surgery in the treatment of gastric lymphoma. Ann Surg 2004; 240: 287.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=362 style='width:272pt'></td>
<td width=60 style='width:45pt'></td>
<td width=353 style='width:265pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="17.3.10.3_files/filelist.xml">
<link rel=Edit-Time-Data href="17.3.10.3_files/editdata.mso">
<link rel=OLE-Object-Data href="17.3.10.3_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-02T00:09:04Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl29
{mso-style-parent:style0;
background:silver;
mso-pattern:auto none;
white-space:normal;}
.xl30
{mso-style-parent:style0;
text-align:center;
background:silver;
mso-pattern:auto none;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Print>
<x:ValidPrinterInfo/>
<x:PaperSizeIndex>9</x:PaperSizeIndex>
<x:HorizontalResolution>-3</x:HorizontalResolution>
<x:VerticalResolution>0</x:VerticalResolution>
</x:Print>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>7</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>1847</x:Id>
<x:DivID>17.3.10.3_1847</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\17.3.10.3.htm"/>
<x:Title>Treatment of gastric MALT lymphoma (3)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=737 style='border-collapse:
collapse;table-layout:fixed;width:553pt'>
<col width=333 style='mso-width-source:userset;mso-width-alt:12178;width:250pt'>
<col class=xl24 width=60 style='mso-width-source:userset;mso-width-alt:2194;
width:45pt'>
<col width=344 style='mso-width-source:userset;mso-width-alt:12580;width:258pt'>
<tr class=xl25 height=34 style='height:25.5pt'>
<td height=34 class=xl29 width=333 style='height:25.5pt;width:250pt'>Text</td>
<td class=xl30 width=60 style='width:45pt'>Evidence level</td>
<td class=xl29 width=344 style='width:258pt'>References</td>
</tr>
<tr class=xl25 height=12 style='mso-height-source:userset;height:9.0pt'>
<td height=12 class=xl25 style='height:9.0pt'></td>
<td class=xl26></td>
<td class=xl25></td>
</tr>
<tr height=309 style='mso-height-source:userset;height:231.75pt'>
<td height=309 class=xl27 width=333 style='height:231.75pt;width:250pt'>Patients
failing to respond to eradication therapy may require radiation therapy.</td>
<td class=xl28 x:num>3</td>
<td class=xl27 width=344 style='width:258pt'>1. Schechter NR, Portlock CS,
Yahalom J. Treatment of mucosa-associated lymphoid tissue lymphoma of the
stomach with radiation alone. J Clin Oncol 1998; 16: 19161.<br>
2. Tsang RW, Gospodarowicz MK, Pintilie M, et al. Stage I and II MALT
lymphoma: results of treatment with radiotherapy. Int J Radiat Oncol Biol
Phys 2001; 50: 12584.<br>
3. Tsang RW, Gospodarowicz MK, Pintilie M, et al. Localized
mucosa-associated lymphoid tissue lymphoma treated with radiation therapy has
excellent clinical outcome. J Clin Oncol 2003; 21: 41574.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=333 style='width:250pt'></td>
<td width=60 style='width:45pt'></td>
<td width=344 style='width:258pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
Treatment planning
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="14.3.2.2_files/filelist.xml">
<link rel=Edit-Time-Data href="14.3.2.2_files/editdata.mso">
<link rel=OLE-Object-Data href="14.3.2.2_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-02T02:12:50Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl26
{mso-style-parent:style0;
background:#CC99FF;
mso-pattern:auto none;}
.xl27
{mso-style-parent:style0;
text-align:center;
background:#CC99FF;
mso-pattern:auto none;
white-space:normal;}
.xl28
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl29
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>6</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>16292</x:Id>
<x:DivID>14.3.2.2_16292</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\14.3.2.2.htm"/>
<x:Title>High-grade lymphoma specialist pathologist, bone marrow and cerebrospinal fluid assessment (2)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=843 style='border-collapse:
collapse;table-layout:fixed;width:633pt'>
<col width=396 style='mso-width-source:userset;mso-width-alt:14482;width:297pt'>
<col class=xl24 width=66 style='mso-width-source:userset;mso-width-alt:2413;
width:50pt'>
<col width=381 style='mso-width-source:userset;mso-width-alt:13933;width:286pt'>
<tr height=32 style='mso-height-source:userset;height:24.0pt'>
<td height=32 class=xl26 width=396 style='height:24.0pt;width:297pt'>Text</td>
<td class=xl27 width=66 style='width:50pt'>Evidence level</td>
<td class=xl26 width=381 style='width:286pt'>References</td>
</tr>
<tr height=12 style='mso-height-source:userset;height:9.0pt'>
<td height=12 style='height:9.0pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=129 style='mso-height-source:userset;height:96.75pt'>
<td height=129 class=xl28 width=396 style='height:96.75pt;width:297pt'>Patients
with newly diagnosed high-grade lymphoma should have mandatory assessment of
bone marrow and cerebrospinal fluid.</td>
<td class=xl29 x:num>4</td>
<td class=xl28 width=381 style='width:286pt'>Patte C, Philip T, Rodary C, et
al. High survival rate in advanced-stage B-cell lymphomas and leukemias
without CNS involvement with a short intensive polychemotherapy: results from
the French Pediatric Oncology Society of a randomized trial of 216 children.
J Clin Oncol 1991; 9: 1232.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=396 style='width:297pt'></td>
<td width=66 style='width:50pt'></td>
<td width=381 style='width:286pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="14.3.2.3_files/filelist.xml">
<link rel=Edit-Time-Data href="14.3.2.3_files/editdata.mso">
<link rel=OLE-Object-Data href="14.3.2.3_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-02T02:13:15Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl26
{mso-style-parent:style0;
background:#CC99FF;
mso-pattern:auto none;}
.xl27
{mso-style-parent:style0;
text-align:center;
background:#CC99FF;
mso-pattern:auto none;
white-space:normal;}
.xl28
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl29
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>9</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>28875</x:Id>
<x:DivID>14.3.2.3_28875</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\14.3.2.3.htm"/>
<x:Title>High-grade lymphoma multidisciplinary care</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=782 style='border-collapse:
collapse;table-layout:fixed;width:586pt'>
<col width=352 style='mso-width-source:userset;mso-width-alt:12873;width:264pt'>
<col class=xl24 width=67 style='mso-width-source:userset;mso-width-alt:2450;
width:50pt'>
<col width=363 style='mso-width-source:userset;mso-width-alt:13275;width:272pt'>
<tr height=39 style='mso-height-source:userset;height:29.25pt'>
<td height=39 class=xl26 width=352 style='height:29.25pt;width:264pt'>Text</td>
<td class=xl27 width=67 style='width:50pt'>Evidence level</td>
<td class=xl26 width=363 style='width:272pt'>References</td>
</tr>
<tr height=12 style='mso-height-source:userset;height:9.0pt'>
<td height=12 style='height:9.0pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=87 style='mso-height-source:userset;height:65.25pt'>
<td height=87 class=xl28 width=352 style='height:65.25pt;width:264pt'>Patients
with newly diagnosed high-grade lymphoma should ideally be managed in
specialist units experienced in treating these disorders.</td>
<td class=xl29 x:num>4</td>
<td class=xl28 width=363 style='width:272pt'>1. Mauch PM, Armitage JA, et al.
Non-Hodgkin Lymphoma. Lippincott, 2003.<br>
2. <www.doh.gov.uk/cancer>. 2004.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=352 style='width:264pt'></td>
<td width=67 style='width:50pt'></td>
<td width=363 style='width:272pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="14.1_files/filelist.xml">
<link rel=Edit-Time-Data href="14.1_files/editdata.mso">
<link rel=OLE-Object-Data href="14.1_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-02T02:11:34Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:#CC99FF;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>7</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>26573</x:Id>
<x:DivID>14.1_26573</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\14.1.htm"/>
<x:Title>High grade lymphoma</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=470 style='border-collapse:
collapse;table-layout:fixed;width:353pt'>
<col width=470 style='mso-width-source:userset;mso-width-alt:17188;width:353pt'>
<col width=256 style='mso-width-source:userset;mso-width-alt:9362;width:192pt'>
<col width=190 style='mso-width-source:userset;mso-width-alt:6948;width:143pt'>
<col width=273 style='mso-width-source:userset;mso-width-alt:9984;width:205pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=470 style='height:12.75pt;width:353pt'> </td>
</tr>
<tr height=264 style='mso-height-source:userset;height:198.0pt'>
<td height=264 class=xl24 width=470 style='height:198.0pt;width:353pt'>The
high-grade lymphomas (HGL) are a small group of histologically diverse
tumours with a number of biological and clinical features in common.<span
style='mso-spacerun:yes'></span>These are rare lymphomas, affecting
predominantly younger people, and characterised by very high growth rates.
Patients frequently present with rapidly growing tumours that interfere with
or obstruct vital organ function. For<span style='mso-spacerun:yes'> </span>example, the mediastinum is a common site of presentation of LL,
leading to superior vena cava obstruction, tracheal compression, or
pericardial effusion, frequently presenting as an acute medical emergency.
Similarly, ureteric obstruction may result from a rapidly enlarging
retroperitoneal mass due to BL. Efforts at diagnosis are often compromised or
truncated because of the rapid development of medical complications from the
underlying disease. The high-grade lymphomas have a high propensity to
disseminate into bone marrow, central nervous system (CNS) and other
sanctuary sites, a feature that shapes the treatment strategy for these
patients. The rarity of these lymphomas, the frequency of complications
related to early disease and treatment, and the complexity of protocols for
curative therapy, argue in favour of these patients being treated by
experienced specialist teams.</td>
</tr>
<tr height=238 style='height:178.5pt;mso-xlrowspan:14'>
<td height=238 style='height:178.5pt'></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl24 style='height:12.75pt'></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=470 style='width:353pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="14.3.2.1_files/filelist.xml">
<link rel=Edit-Time-Data href="14.3.2.1_files/editdata.mso">
<link rel=OLE-Object-Data href="14.3.2.1_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-02T02:12:26Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
background:#CC99FF;
mso-pattern:auto none;}
.xl26
{mso-style-parent:style0;
text-align:center;
background:#CC99FF;
mso-pattern:auto none;
white-space:normal;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>6</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>10007</x:Id>
<x:DivID>14.3.2.1_10007</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\14.3.2.1.htm"/>
<x:Title>High-grade lymphoma specialist pathologist, bone marrow and cerebrospinal fluid assessment (1)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=811 style='border-collapse:
collapse;table-layout:fixed;width:609pt'>
<col width=397 style='mso-width-source:userset;mso-width-alt:14518;width:298pt'>
<col class=xl24 width=66 style='mso-width-source:userset;mso-width-alt:2413;
width:50pt'>
<col width=348 style='mso-width-source:userset;mso-width-alt:12726;width:261pt'>
<tr height=37 style='mso-height-source:userset;height:27.75pt'>
<td height=37 class=xl25 width=397 style='height:27.75pt;width:298pt'>Text</td>
<td class=xl26 width=66 style='width:50pt'>Evidence level</td>
<td class=xl25 width=348 style='width:261pt'>References</td>
</tr>
<tr height=11 style='mso-height-source:userset;height:8.25pt'>
<td height=11 style='height:8.25pt'></td>
<td class=xl24></td>
<td></td>
</tr>
<tr height=127 style='mso-height-source:userset;height:95.25pt'>
<td height=127 class=xl27 width=397 style='height:95.25pt;width:298pt'>Biopsies
of tissues suspected to be Burkitt or other high-grade lymphoma should be
referred for review by a pathologist skilled in lymphoma diagnosis.</td>
<td class=xl28 x:num>4</td>
<td class=xl27 width=348 style='width:261pt'>Soslow RA, Baergen RN, Warnke
RA. B-lineage lymphoblastic lymphoma is a clinicopathologic entity distinct
from other histologically similar aggressive lymphomas with blastic
morphology. Cancer 1999; 85: 26484.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=397 style='width:298pt'></td>
<td width=66 style='width:50pt'></td>
<td width=348 style='width:261pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="14.3.1_files/filelist.xml">
<link rel=Edit-Time-Data href="14.3.1_files/editdata.mso">
<link rel=OLE-Object-Data href="14.3.1_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-02T02:11:56Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:#CC99FF;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>3</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>2871</x:Id>
<x:DivID>14.3.1_2871</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\14.3.1.htm"/>
<x:Title>Pathological diagnosis</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=445 style='border-collapse:
collapse;table-layout:fixed;width:334pt'>
<col width=445 style='mso-width-source:userset;mso-width-alt:16274;width:334pt'>
<col width=256 style='mso-width-source:userset;mso-width-alt:9362;width:192pt'>
<col width=190 style='mso-width-source:userset;mso-width-alt:6948;width:143pt'>
<col width=273 style='mso-width-source:userset;mso-width-alt:9984;width:205pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=445 style='height:12.75pt;width:334pt'> </td>
</tr>
<tr height=110 style='mso-height-source:userset;height:82.5pt'>
<td height=110 class=xl24 width=445 style='height:82.5pt;width:334pt'>The
pathological diagnosis can be made on biopsy of nodal or extra-nodal tissue,
or on bone marrow aspirate and trephine biopsy in leukemic patients. For the
purpose of these guidelines, the finding of 100% Ki-67 positivity on
immunostaining is required for the diagnosis of BL or BLL. All such cases
should be referred to a specialist lymphoma histopathologist for diagnostic
confirmation.</td>
</tr>
<tr height=238 style='height:178.5pt;mso-xlrowspan:14'>
<td height=238 style='height:178.5pt'></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl24 style='height:12.75pt'></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=445 style='width:334pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="14.4_files/filelist.xml">
<link rel=Edit-Time-Data href="14.4_files/editdata.mso">
<link rel=OLE-Object-Data href="14.4_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-02T02:16:08Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl27
{mso-style-parent:style0;
background:#CC99FF;
mso-pattern:auto none;}
.xl28
{mso-style-parent:style0;
text-align:center;
background:#CC99FF;
mso-pattern:auto none;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>2</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>8080</x:Id>
<x:DivID>14.4_8080</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\14.4.htm"/>
<x:Title>Intensive treatment of Burkitt lymphoma</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=860 style='border-collapse:
collapse;table-layout:fixed;width:646pt'>
<col width=388 style='mso-width-source:userset;mso-width-alt:14189;width:291pt'>
<col class=xl24 width=70 style='mso-width-source:userset;mso-width-alt:2560;
width:53pt'>
<col width=402 style='mso-width-source:userset;mso-width-alt:14701;width:302pt'>
<tr height=35 style='mso-height-source:userset;height:26.25pt'>
<td height=35 class=xl27 width=388 style='height:26.25pt;width:291pt'>Text</td>
<td class=xl28 width=70 style='width:53pt'>Evidence level</td>
<td class=xl27 width=402 style='width:302pt'>References</td>
</tr>
<tr height=10 style='mso-height-source:userset;height:7.5pt'>
<td height=10 style='height:7.5pt'></td>
<td class=xl24></td>
<td></td>
</tr>
<tr height=421 style='mso-height-source:userset;height:315.75pt'>
<td height=421 class=xl25 width=388 style='height:315.75pt;width:291pt'>Adults
with Burkitt lymphoma should be treated, where possible, with intensive
combination chemotherapy of relatively limited duration, according to one of
the recently published treatment regimens.</td>
<td class=xl26 x:num>3</td>
<td class=xl25 width=402 style='width:302pt'>1. Patte C, Philip T, Rodary C,
et al. High survival rate in advanced-stage B-cell lymphomas and leukemias
without CNS involvement with a short intensive polychemotherapy: results from
the French Pediatric Oncology Society of a randomized trial of 216 children.
J Clin Oncol 1991; 9: 1232.<br>
2. Magrath I, Adde M, Shad A, et al. Adults and children with small
non-cleaved-cell lymphoma have a similar excellent outcome when treated with
the same chemotherapy regimen. J Clin Oncol 1996; 14: 9254.<br>
3. Mead GM, Sydes MR, Walewski J, et al. An international evaluation of
CODOX-M and CODOX-M alternating with IVAC in adult Burkitt lymphoma:
results of United Kingdom Lymphoma Group LY06 study. Ann Oncol 2002; 13:
12644.<br>
4. Schwenn MR, Blattner SR, Lynch E, Weinstein HJ. HiC-COM: a 2-month
intensive chemotherapy regimen for children with stage III and IV Burkitt
lymphoma and B-cell acute lymphoblastic leukemia. J Clin Oncol 1991; 9:
133.<br>
5. Thomas DA, Cortes J, Orien S, et al. Hyper-CVAD program in
Burkitt-type adult acute lymphoblastic leukemia. J Clin Oncol 1999; 17:
24610.<br>
6. Reiter A, Schrappe M, Parwaresch R, et al. Non-Hodgkin lymphomas of
childhood and adolescence: results of a treatment stratified for biologic
subtypes and stage a report of the<br>
Berlin-Frankfurt-Munster Group. J Clin Oncol 1995; 13: 3592.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=388 style='width:291pt'></td>
<td width=70 style='width:53pt'></td>
<td width=402 style='width:302pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="14.3.2_files/filelist.xml">
<link rel=Edit-Time-Data href="14.3.2_files/editdata.mso">
<link rel=OLE-Object-Data href="14.3.2_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-02T02:14:59Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:#CC99FF;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>23738</x:Id>
<x:DivID>14.3.2_23738</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\14.3.2.htm"/>
<x:Title>T-LL staging</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=579 style='border-collapse:
collapse;table-layout:fixed;width:434pt'>
<col width=579 style='mso-width-source:userset;mso-width-alt:21174;width:434pt'>
<col width=256 style='mso-width-source:userset;mso-width-alt:9362;width:192pt'>
<col width=190 style='mso-width-source:userset;mso-width-alt:6948;width:143pt'>
<col width=273 style='mso-width-source:userset;mso-width-alt:9984;width:205pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=579 style='height:12.75pt;width:434pt'> </td>
</tr>
<tr height=102 style='height:76.5pt'>
<td height=102 class=xl24 width=579 style='height:76.5pt;width:434pt'>Aside
from the issue of marrow involvement, it is recommended that where possible,
patients with suspected or confirmed T-LL have full staging procedures
carried out, including complete blood count, biochemical profile including
LDH and uric acid, radiological staging with chest X-ray and CAT scans of
chest, abdomen and pelvis, and CSF examination by lumbar puncture. A formal
tissue biopsy of nodal or extra-nodal tissue should be performed unless
precluded by clinical circumstances.</td>
</tr>
<tr height=238 style='height:178.5pt;mso-xlrowspan:14'>
<td height=238 style='height:178.5pt'></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl24 style='height:12.75pt'></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=579 style='width:434pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="14.5_files/filelist.xml">
<link rel=Edit-Time-Data href="14.5_files/editdata.mso">
<link rel=OLE-Object-Data href="14.5_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-02T02:21:22Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
background:#CC99FF;
mso-pattern:auto none;}
.xl26
{mso-style-parent:style0;
text-align:center;
background:#CC99FF;
mso-pattern:auto none;
white-space:normal;}
.xl27
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl28
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl29
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>5</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>1011</x:Id>
<x:DivID>14.5_1011</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\14.5.htm"/>
<x:Title>Lymphoblastic lymphoma intensive treatment</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=789 style='border-collapse:
collapse;table-layout:fixed;width:592pt'>
<col width=363 style='mso-width-source:userset;mso-width-alt:13275;width:272pt'>
<col class=xl24 width=62 style='mso-width-source:userset;mso-width-alt:2267;
width:47pt'>
<col width=364 style='mso-width-source:userset;mso-width-alt:13312;width:273pt'>
<tr height=35 style='mso-height-source:userset;height:26.25pt'>
<td height=35 class=xl25 width=363 style='height:26.25pt;width:272pt'>Text</td>
<td class=xl26 width=62 style='width:47pt'>Evidence level</td>
<td class=xl25 width=364 style='width:273pt'>References</td>
</tr>
<tr height=11 style='mso-height-source:userset;height:8.25pt'>
<td height=11 style='height:8.25pt'></td>
<td class=xl27></td>
<td></td>
</tr>
<tr height=276 style='mso-height-source:userset;height:207.0pt'>
<td height=276 class=xl28 width=363 style='height:207.0pt;width:272pt'>Adults
with lymphoblastic lymphoma should be treated with a regimen designed for
therapy of acute lymphoblastic leukaemia. This must include CNS prophylaxis.</td>
<td class=xl29 x:num>3</td>
<td class=xl28 width=364 style='width:273pt'>1. Morel P, Lepage E, Brice P,
et al. Prognosis and treatment of lymphoblastic lymphoma in adults: a report
on 80 patients. J Clin Oncol 1992; 10: 10785.<br>
2. Coleman CN, Cohen JR, Burke JS, Rosenberg SA. Lymphoblastic lymphoma in
adults: results of a pilot protocol. Blood 1981; 57: 6794.<br>
3. van Besien K, Ha CS, Murphy S, et al. Risk factors, treatment, and
outcome of central nervous system recurrence in adults with
intermediate-grade and immunoblastic lymphoma. Blood 1998; 91: 11784.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=363 style='width:272pt'></td>
<td width=62 style='width:47pt'></td>
<td width=364 style='width:273pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
High grade lymphoma management B
Treatment planning
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="14.5.1_files/filelist.xml">
<link rel=Edit-Time-Data href="14.5.1_files/editdata.mso">
<link rel=OLE-Object-Data href="14.5.1_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-02T02:16:43Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:#CC99FF;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>7</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>11987</x:Id>
<x:DivID>14.5.1_11987</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\14.5.1.htm"/>
<x:Title>Prophylaxis and treatment of sanctuary sites</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=432 style='border-collapse:
collapse;table-layout:fixed;width:324pt'>
<col width=432 style='mso-width-source:userset;mso-width-alt:15798;width:324pt'>
<col width=256 style='mso-width-source:userset;mso-width-alt:9362;width:192pt'>
<col width=190 style='mso-width-source:userset;mso-width-alt:6948;width:143pt'>
<col width=110 style='mso-width-source:userset;mso-width-alt:4022;width:83pt'>
<col width=273 style='mso-width-source:userset;mso-width-alt:9984;width:205pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=432 style='height:12.75pt;width:324pt'> </td>
</tr>
<tr height=75 style='mso-height-source:userset;height:56.25pt'>
<td height=75 class=xl24 width=432 style='height:56.25pt;width:324pt'>There
is a high rate of relapse in the CNS during or after systemic treatment with
chemotherapy for high-grade NHL (HGNHL). Patients with a high LDH or
involvement of head and neck sites have been reported to be at greater risk.
Prophylactic treatment of the CNS is mandatory.</td>
</tr>
<tr height=238 style='height:178.5pt;mso-xlrowspan:14'>
<td height=238 style='height:178.5pt'></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl24 style='height:12.75pt'></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=432 style='width:324pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="14.5.3.2_files/filelist.xml">
<link rel=Edit-Time-Data href="14.5.3.2_files/editdata.mso">
<link rel=OLE-Object-Data href="14.5.3.2_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-02T02:18:56Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
background:#99CCFF;
mso-pattern:auto none;}
.xl26
{mso-style-parent:style0;
text-align:center;
background:#99CCFF;
mso-pattern:auto none;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>14</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=885 style='border-collapse:
collapse;table-layout:fixed;width:665pt'>
<col width=361 style='mso-width-source:userset;mso-width-alt:13202;width:271pt'>
<col class=xl24 width=98 style='mso-width-source:userset;mso-width-alt:3584;
width:74pt'>
<col width=426 style='mso-width-source:userset;mso-width-alt:15579;width:320pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=361 style='height:12.75pt;width:271pt'>Text</td>
<td class=xl26 width=98 style='width:74pt'>Evidence level</td>
<td class=xl25 width=426 style='width:320pt'>References</td>
</tr>
<tr height=11 style='mso-height-source:userset;height:8.25pt'>
<td height=11 style='height:8.25pt'></td>
<td class=xl24></td>
<td></td>
</tr>
<tr height=75 style='mso-height-source:userset;height:56.25pt'>
<td height=75 class=xl27 width=361 style='height:56.25pt;width:271pt'>Prophylaxis
with fluids and allopurinol should be given before starting therapy.</td>
<td class=xl28 x:num>4</td>
<td class=xl27 width=426 style='width:320pt'>van Besien K, Ha CS, Murphy S,
et al. Risk factors, treatment, and outcome of central nervous system
recurrence in adults with intermediate-grade and immunoblastic lymphoma.
Blood 1998; 91: 11784.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=361 style='width:271pt'></td>
<td width=98 style='width:74pt'></td>
<td width=426 style='width:320pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="14.5.5_files/filelist.xml">
<link rel=Edit-Time-Data href="14.5.5_files/editdata.mso">
<link rel=OLE-Object-Data href="14.5.5_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-02T02:19:48Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
.font0
{color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;}
.font5
{color:windowtext;
font-size:10.0pt;
font-weight:700;
font-style:normal;
text-decoration:none;
font-family:Arial, sans-serif;
mso-font-charset:0;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
background:#99CCFF;
mso-pattern:auto none;}
.xl26
{mso-style-parent:style0;
text-align:center;
background:#99CCFF;
mso-pattern:auto none;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Print>
<x:ValidPrinterInfo/>
<x:HorizontalResolution>600</x:HorizontalResolution>
<x:VerticalResolution>600</x:VerticalResolution>
</x:Print>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>9</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=859 style='border-collapse:
collapse;table-layout:fixed;width:644pt'>
<col width=371 style='mso-width-source:userset;mso-width-alt:13568;width:278pt'>
<col class=xl24 width=104 style='mso-width-source:userset;mso-width-alt:3803;
width:78pt'>
<col width=384 style='mso-width-source:userset;mso-width-alt:14043;width:288pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=371 style='height:12.75pt;width:278pt'>Text</td>
<td class=xl26 width=104 style='width:78pt'>Evidence level</td>
<td class=xl25 width=384 style='width:288pt'>References</td>
</tr>
<tr height=10 style='mso-height-source:userset;height:7.5pt'>
<td height=10 style='height:7.5pt'></td>
<td class=xl24></td>
<td></td>
</tr>
<tr height=143 style='mso-height-source:userset;height:107.25pt'>
<td height=143 class=xl27 width=371 style='height:107.25pt;width:278pt'>Adjuvant
radiotherapy is <font class="font5">not </font><font class="font0">indicated
in treatment of sites of original bulk disease in high-grade lymphoma.</font></td>
<td class=xl28 x:num>2</td>
<td class=xl27 width=384 style='width:288pt'>Link MP, Donaldson SS, Berard
CW, Shuster JJ, Murphy SB. Results of treatment of childhood localized
non-Hodgkin lymphoma with combination chemotherapy with or without
radiotherapy. N Engl J Med 1990; 322: 11694.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=371 style='width:278pt'></td>
<td width=104 style='width:78pt'></td>
<td width=384 style='width:288pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="14.5.6_files/filelist.xml">
<link rel=Edit-Time-Data href="14.5.6_files/editdata.mso">
<link rel=OLE-Object-Data href="14.5.6_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-02T02:20:20Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl26
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl27
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl28
{mso-style-parent:style0;
background:#CC99FF;
mso-pattern:auto none;}
.xl29
{mso-style-parent:style0;
text-align:center;
background:#CC99FF;
mso-pattern:auto none;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>10</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>14831</x:Id>
<x:DivID>14.5.6_14831</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\14.5.6.htm"/>
<x:Title>High-dose chemotherapy and autologous stem cell support</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=810 style='border-collapse:
collapse;table-layout:fixed;width:608pt'>
<col width=387 style='mso-width-source:userset;mso-width-alt:14153;width:290pt'>
<col class=xl24 width=65 style='mso-width-source:userset;mso-width-alt:2377;
width:49pt'>
<col width=358 style='mso-width-source:userset;mso-width-alt:13092;width:269pt'>
<tr height=36 style='mso-height-source:userset;height:27.0pt'>
<td height=36 class=xl28 width=387 style='height:27.0pt;width:290pt'>Text</td>
<td class=xl29 width=65 style='width:49pt'>Evidence level</td>
<td class=xl28 width=358 style='width:269pt'>References</td>
</tr>
<tr height=12 style='mso-height-source:userset;height:9.0pt'>
<td height=12 style='height:9.0pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=206 style='mso-height-source:userset;height:154.5pt'>
<td height=206 class=xl26 width=387 style='height:154.5pt;width:290pt'>High-dose
chemotherapy with autologous stem cell support is effective therapy for
patients with lymphoblastic lymphoma in first remission, but it has not been
proven to produce superior disease free survival. Ideally, it should be used
only in the context of a clinical trial.</td>
<td class=xl27 x:num>3</td>
<td class=xl26 width=358 style='width:269pt'>1. Verdonck LF, Dekker AW, de
Gast GC, Lokhorst HM, Nieuwenhuis HK. Autologous bone marrow transplantation
for adult poor-risk lymphoblastic lymphoma in first remission. J Clin Oncol
1992; 10: 644.<br>
2. Jost LM, Jacky E, Dommann-Scherrer C, et al. Short-term weekly
chemotherapy followed by high-dose therapy with autologous bone marrow
transplantation for lymphoblastic and Burkitt lymphomas in adult patients.
Ann Oncol 1995; 6: 4451.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=387 style='width:290pt'></td>
<td width=65 style='width:49pt'></td>
<td width=358 style='width:269pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="14.5.7_files/filelist.xml">
<link rel=Edit-Time-Data href="14.5.7_files/editdata.mso">
<link rel=OLE-Object-Data href="14.5.7_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-02T02:20:59Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:#CC99FF;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>7</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>25618</x:Id>
<x:DivID>14.5.7_25618</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\14.5.7.htm"/>
<x:Title>Follow up and management of late effects of therapy</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=579 style='border-collapse:
collapse;table-layout:fixed;width:434pt'>
<col width=579 style='mso-width-source:userset;mso-width-alt:21174;width:434pt'>
<col width=256 style='mso-width-source:userset;mso-width-alt:9362;width:192pt'>
<col width=190 style='mso-width-source:userset;mso-width-alt:6948;width:143pt'>
<col width=273 style='mso-width-source:userset;mso-width-alt:9984;width:205pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=579 style='height:12.75pt;width:434pt'> </td>
</tr>
<tr height=193 style='mso-height-source:userset;height:144.75pt'>
<td height=193 class=xl24 width=579 style='height:144.75pt;width:434pt'>Long-term
follow up requires (a) that the patient eventually takes responsibility for
his or her medical care and (b) the identification of a regular/consistent
family medical practitioner supported by a specialist centre. Specific
issues:<br>
- fertility<br>
- puberty delayed rare<br>
- growth if CNS prophylaxis includes radiotherapy, more marked if
includes spine/pituitary<br>
- second malignant neoplasms brain tumours cranial irradiation;
myelodysplasia, AML<br>
- hypothyroidism scatter effect of radiotherapy<br>
- IQ performance and psycho-social adjustment<br>
- cardiac-anthracyclines long-term follow up shows cardiac failure even
with low doses of anthracycline</td>
</tr>
<tr height=238 style='height:178.5pt;mso-xlrowspan:14'>
<td height=238 style='height:178.5pt'></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl24 style='height:12.75pt'></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=579 style='width:434pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
Treatment planning
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.6.2.4_files/filelist.xml">
<link rel=Edit-Time-Data href="12.6.2.4_files/editdata.mso">
<link rel=OLE-Object-Data href="12.6.2.4_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-05T22:47:03Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl27
{mso-style-parent:style0;
background:#99CCFF;
mso-pattern:auto none;}
.xl28
{mso-style-parent:style0;
text-align:center;
background:#99CCFF;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>2</x:ActiveRow>
<x:ActiveCol>6</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>32365</x:Id>
<x:DivID>12.6.2.4_32365</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.6.2.4.htm"/>
<x:Title>Low-grade lymphoma extra-gastric marginal zone lymphoma therapeutic options (2)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=959 style='border-collapse:
collapse;table-layout:fixed;width:720pt'>
<col width=398 style='mso-width-source:userset;mso-width-alt:14555;width:299pt'>
<col class=xl24 width=89 style='mso-width-source:userset;mso-width-alt:3254;
width:67pt'>
<col width=472 style='mso-width-source:userset;mso-width-alt:17261;width:354pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl27 width=398 style='height:12.75pt;width:299pt'>Text</td>
<td class=xl28 width=89 style='width:67pt'>Evidence level</td>
<td class=xl27 width=472 style='width:354pt'>References</td>
</tr>
<tr height=12 style='mso-height-source:userset;height:9.0pt'>
<td height=12 style='height:9.0pt'></td>
<td class=xl24></td>
<td></td>
</tr>
<tr height=402 style='mso-height-source:userset;height:301.5pt'>
<td height=402 class=xl25 width=398 style='height:301.5pt;width:299pt'>Patients
with symptomatic or progressive disseminated marginal zone lymphoma should be
treated with single-agent chemotherapy (alkylating agents/nucleoside
analogues/rituximab have similar levels of activity). There is no apparent
benefit from the use of combination chemotherapy regimens (e.g. CHOP) as
initial therapy. There is no benefit from the addition of anthracylines to
alkylating agents (e.g. chlorambucil).</td>
<td class=xl26 x:num="3.2">3,2</td>
<td class=xl25 width=472 style='width:354pt'>1. Berger F, Felman P,
Thieblemont C, et al. Non-MALT marginal zone B-cell lymphomas: a description
of clinical presentation and outcome in 124 patients. Blood 2000; 95:
1950.<br>
2. Hammel P, Haioun C, Chaumette MT, et al. Efficacy of single-agent chemotherapy
in lowgrade B-cell mucosa-associated lymphoid tissue lymphoma with prominent
gastric expression. J lin Oncol 1995; 13: 2524.<br>
3. Conconi A, Martinelli G, Thieblemont C, et al. Clinical activity of
rituximab in extranodal marginal zone B-cell lymphoma of MALT type. Blood
2003; 102: 2741.<br>
4. Jager G, Neumeister P, Brezinschek R, et al. Treatment of extranodal
marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type with
cladribine: a phase II study. J Clin Oncol 2002; 20: 3872.<br>
5. Foran JM, Rohatiner AZ, Coiffier B, et al. Multicenter phase II study of
fludarabine phosphate for patients with newly diagnosed lymphoplasmacytoid
lymphoma, Waldenstrom macroglobulinemia, and mantle-cell lymphoma. J Clin Oncol
1999; 17: 5463.<br>
6. Zucca E, Conconi A, Pedrinis E, et al. Nongastric marginal zone B-cell
lymphoma of mucosa-associated lymphoid tissue. Blood 2003; 101:
24895.<br>
7. Fisher RI, Dahlberg S, Nathwani BN, Banks PM, Miller TP, Grogan TM. A
clinical analysis of two indolent lymphoma entities: mantle cell lymphoma and
marginal zone lymphoma<br>
(including the mucosa-associated lymphoid tissue and monocytoid B-cell
subcategories): a Southwest Oncology Group study. Blood 1995; 85: 10752.<br>
8. Baldini L, Brugiatelli M, Luminari S, et al. Treatment of indolent
B-Cell nonfollicular lymphomas: final results of the LL01 randomized trial of
the Gruppo Italiano per lo Studio dei Linfomi. J Clin Oncol 2003; 21:
14595.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=398 style='width:299pt'></td>
<td width=89 style='width:67pt'></td>
<td width=472 style='width:354pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.6.2.3_files/filelist.xml">
<link rel=Edit-Time-Data href="12.6.2.3_files/editdata.mso">
<link rel=OLE-Object-Data href="12.6.2.3_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-05T22:46:30Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl26
{mso-style-parent:style0;
background:#99CCFF;
mso-pattern:auto none;}
.xl27
{mso-style-parent:style0;
text-align:center;
background:#99CCFF;
mso-pattern:auto none;
white-space:normal;}
.xl28
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl29
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>12</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>25136</x:Id>
<x:DivID>12.6.2.3_25136</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.6.2.3.htm"/>
<x:Title>Low-grade lymphoma extra-gastric marginal zone lymphoma therapeutic options (1)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=755 style='border-collapse:
collapse;table-layout:fixed;width:567pt'>
<col width=345 style='mso-width-source:userset;mso-width-alt:12617;width:259pt'>
<col class=xl24 width=66 style='mso-width-source:userset;mso-width-alt:2413;
width:50pt'>
<col width=344 style='mso-width-source:userset;mso-width-alt:12580;width:258pt'>
<tr height=34 style='mso-height-source:userset;height:25.5pt'>
<td height=34 class=xl26 width=345 style='height:25.5pt;width:259pt'>Text</td>
<td class=xl27 width=66 style='width:50pt'>Evidence level</td>
<td class=xl26 width=344 style='width:258pt'>References</td>
</tr>
<tr height=11 style='mso-height-source:userset;height:8.25pt'>
<td height=11 style='height:8.25pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=82 style='mso-height-source:userset;height:61.5pt'>
<td height=82 class=xl28 width=345 style='height:61.5pt;width:259pt'>Patients
with asymptomatic disseminated marginal zone lymphoma may be observed without
initial therapy.</td>
<td class=xl29 x:num>3</td>
<td class=xl28 width=344 style='width:258pt'>Berger F, Felman P, Thieblemont
C, et al. Non-MALT marginal zone B-cell lymphomas: a description of clinical
presentation and outcome in 124 patients. Blood 2000; 95: 1950.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=345 style='width:259pt'></td>
<td width=66 style='width:50pt'></td>
<td width=344 style='width:258pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.6.2.1_files/filelist.xml">
<link rel=Edit-Time-Data href="12.6.2.1_files/editdata.mso">
<link rel=OLE-Object-Data href="12.6.2.1_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-05T22:45:38Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
background:#99CCFF;
mso-pattern:auto none;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
background:#99CCFF;
mso-pattern:auto none;
white-space:normal;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>10</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>9175</x:Id>
<x:DivID>12.6.2.1_9175</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.6.2.1.htm"/>
<x:Title>Low-grade lymphoma extra-gastric marginal zone lymphoma pathogen treatment urgency</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=899 style='border-collapse:
collapse;table-layout:fixed;width:674pt'>
<col width=403 style='mso-width-source:userset;mso-width-alt:14738;width:302pt'>
<col class=xl24 width=61 style='mso-width-source:userset;mso-width-alt:2230;
width:46pt'>
<col width=435 style='mso-width-source:userset;mso-width-alt:15908;width:326pt'>
<tr height=34 style='height:25.5pt'>
<td height=34 class=xl25 width=403 style='height:25.5pt;width:302pt'>Text</td>
<td class=xl26 width=61 style='width:46pt'>Evidence level</td>
<td class=xl25 width=435 style='width:326pt'>References</td>
</tr>
<tr height=11 style='mso-height-source:userset;height:8.25pt'>
<td height=11 style='height:8.25pt'></td>
<td class=xl24></td>
<td></td>
</tr>
<tr height=200 style='mso-height-source:userset;height:150.0pt'>
<td height=200 class=xl27 width=403 style='height:150.0pt;width:302pt'>Where
an identified pathogen is associated with extra-gastric marginal zone
lymphoma, and there is no clinical urgency to obtain immediate disease
regression, eradication therapy directed against the identified pathogen is
recommended.</td>
<td class=xl28 x:num>3</td>
<td class=xl27 width=435 style='width:326pt'>1. Noordijk EM, Carde P, Mandard
AM et al. Preliminary results of the EORTC-GPMC controlled clinical trial H7
in early-stage Hodgkin's disease. EORTC Lymphoma Cooperative Group. Groupe
Pierre-et-Marie-Curie. Ann Oncol 1994; 5 Suppl 2: 107-12.<br>
2. Cosset JM, Ferme C, Noordijk EM, Dubray BM, Thirion P, Henry-Amar M.
Combined Modality Treatment for Poor Prognosis Stages I and II Hodgkin's
Disease. Semin Radiat Oncol<br>
1996; 6: 185-95.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=403 style='width:302pt'></td>
<td width=61 style='width:46pt'></td>
<td width=435 style='width:326pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.6.2.5_files/filelist.xml">
<link rel=Edit-Time-Data href="12.6.2.5_files/editdata.mso">
<link rel=OLE-Object-Data href="12.6.2.5_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-05T22:47:21Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:#99CCFF;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>9</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>4602</x:Id>
<x:DivID>12.6.2.5_4602</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.6.2.5.htm"/>
<x:Title>Transformation to aggressive lymphoma</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=572 style='border-collapse:
collapse;table-layout:fixed;width:429pt'>
<col width=572 style='mso-width-source:userset;mso-width-alt:20918;width:429pt'>
<col width=256 style='mso-width-source:userset;mso-width-alt:9362;width:192pt'>
<col width=190 style='mso-width-source:userset;mso-width-alt:6948;width:143pt'>
<col width=192 style='mso-width-source:userset;mso-width-alt:7021;width:144pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=572 style='height:12.75pt;width:429pt'> </td>
</tr>
<tr height=64 style='mso-height-source:userset;height:48.0pt'>
<td height=64 class=xl24 width=572 style='height:48.0pt;width:429pt'>The
lifetime risk of developing histological transformation to a histologically
aggressive NHL is approximately 100%, and is influenced by the presence or
absence of the t(11;18)(q21;q21)<br>
translocation. The relative frequency of this translocation varies
according to the organ involved.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=572 style='width:429pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.6.2.2_files/filelist.xml">
<link rel=Edit-Time-Data href="12.6.2.2_files/editdata.mso">
<link rel=OLE-Object-Data href="12.6.2.2_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-05T22:46:09Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
background:#99CCFF;
mso-pattern:auto none;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
background:#99CCFF;
mso-pattern:auto none;
white-space:normal;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl29
{mso-style-parent:style0;
white-space:normal;}
.xl30
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>8</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>16759</x:Id>
<x:DivID>12.6.2.2_16759</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.6.2.2.htm"/>
<x:Title>Low-grade lymphoma extra-gastric marginal zone lymphoma durable local control</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=1007 style='border-collapse:
collapse;table-layout:fixed;width:755pt'>
<col width=408 style='mso-width-source:userset;mso-width-alt:14921;width:306pt'>
<col class=xl24 width=79 style='mso-width-source:userset;mso-width-alt:2889;
width:59pt'>
<col width=520 style='mso-width-source:userset;mso-width-alt:19017;width:390pt'>
<tr height=34 style='height:25.5pt'>
<td height=34 class=xl25 width=408 style='height:25.5pt;width:306pt'>Text</td>
<td class=xl26 width=79 style='width:59pt'>Evidence level</td>
<td class=xl25 width=520 style='width:390pt'>References</td>
</tr>
<tr height=12 style='mso-height-source:userset;height:9.0pt'>
<td height=12 class=xl29 style='height:9.0pt'></td>
<td class=xl30></td>
<td class=xl29></td>
</tr>
<tr height=241 style='mso-height-source:userset;height:180.75pt'>
<td height=241 class=xl27 width=408 style='height:180.75pt;width:306pt'>Where
there is no associated infective agent identified, successful eradication of
the agent is not associated with disease regression, or there is clinical
urgency to achieve disease regression, localised irradiation using 255 Gy
is highly effective in achieving durable local control for extra-gastric
marginal zone lymphoma (nodal and non-nodal).</td>
<td class=xl28 x:num>3</td>
<td class=xl27 width=520 style='width:390pt'>1. Tsang RW, Gospodarowicz MK,
Pintilie M, et al. Localized mucosa-associated lymphoid tissue lymphoma
treated with radiation therapy has excellent clinical outcome. J Clin Oncol
2003; 21: 41574.<br>
2. Liao Z, Ha CS, McLaughlin P, et al. Mucosa-associated lymphoid tissue
lymphoma with initial supradiaphragmatic presentation: natural history and
patterns of disease progression. Int J Radiat Oncol Biol Phys 2000; 48:
39903.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=408 style='width:306pt'></td>
<td width=79 style='width:59pt'></td>
<td width=520 style='width:390pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
Treatment planning
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="16.3.6.1_files/filelist.xml">
<link rel=Edit-Time-Data href="16.3.6.1_files/editdata.mso">
<link rel=OLE-Object-Data href="16.3.6.1_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-05T23:09:05Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl29
{mso-style-parent:style0;
background:#99CC00;
mso-pattern:auto none;
white-space:normal;}
.xl30
{mso-style-parent:style0;
text-align:center;
background:#99CC00;
mso-pattern:auto none;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Print>
<x:ValidPrinterInfo/>
<x:PaperSizeIndex>9</x:PaperSizeIndex>
<x:HorizontalResolution>-3</x:HorizontalResolution>
<x:VerticalResolution>0</x:VerticalResolution>
</x:Print>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>9</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>9409</x:Id>
<x:DivID>16.3.6.1_9409</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\16.3.6.1.htm"/>
<x:Title>Management for lymphomas associated with HIV (1)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=814 style='border-collapse:
collapse;table-layout:fixed;width:611pt'>
<col width=382 style='mso-width-source:userset;mso-width-alt:13970;width:287pt'>
<col class=xl24 width=60 style='mso-width-source:userset;mso-width-alt:2194;
width:45pt'>
<col width=372 style='mso-width-source:userset;mso-width-alt:13604;width:279pt'>
<tr class=xl25 height=34 style='height:25.5pt'>
<td height=34 class=xl29 width=382 style='height:25.5pt;width:287pt'>Text</td>
<td class=xl30 width=60 style='width:45pt'>Evidence level</td>
<td class=xl29 width=372 style='width:279pt'>References</td>
</tr>
<tr class=xl25 height=8 style='mso-height-source:userset;height:6.0pt'>
<td height=8 class=xl25 style='height:6.0pt'></td>
<td class=xl26></td>
<td class=xl25></td>
</tr>
<tr height=189 style='mso-height-source:userset;height:141.75pt'>
<td height=189 class=xl27 width=382 style='height:141.75pt;width:287pt'>Full-dose
CHOP should be considered the current standard of care for HIV-related
lymphoma, although new data are awaited.</td>
<td class=xl28 x:num>4</td>
<td class=xl27 width=372 style='width:279pt'>1. Kaplan LD, Straus DJ, Testa
MA, et al. Low-dose compared with standard-dose m-BACOD chemotherapy for
non-Hodgkin lymphoma associated with human immunodeficiency virus
infection. National Institute of Allergy and Infectious Diseases AIDS
Clinical Trials Group. N Engl J Med 1997; 336: 1641.<br>
2. Fisher RI, Gaynor ER, Dahlberg S, et al. Comparison of a standard
regimen (CHOP) with three intensive chemotherapy regimens for advanced
non-Hodgkin lymphoma. N Engl J Med 1993; 328: 1002.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=382 style='width:287pt'></td>
<td width=60 style='width:45pt'></td>
<td width=372 style='width:279pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="16.3.6.2_files/filelist.xml">
<link rel=Edit-Time-Data href="16.3.6.2_files/editdata.mso">
<link rel=OLE-Object-Data href="16.3.6.2_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-05T23:09:19Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl29
{mso-style-parent:style0;
background:#99CC00;
mso-pattern:auto none;
white-space:normal;}
.xl30
{mso-style-parent:style0;
text-align:center;
background:#99CC00;
mso-pattern:auto none;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Print>
<x:ValidPrinterInfo/>
<x:PaperSizeIndex>9</x:PaperSizeIndex>
<x:HorizontalResolution>-3</x:HorizontalResolution>
<x:VerticalResolution>0</x:VerticalResolution>
</x:Print>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>9</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>12711</x:Id>
<x:DivID>16.3.6.2_12711</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\16.3.6.2.htm"/>
<x:Title>Management for lymphomas associated with HIV (2)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=815 style='border-collapse:
collapse;table-layout:fixed;width:611pt'>
<col width=399 style='mso-width-source:userset;mso-width-alt:14592;width:299pt'>
<col class=xl24 width=60 style='mso-width-source:userset;mso-width-alt:2194;
width:45pt'>
<col width=356 style='mso-width-source:userset;mso-width-alt:13019;width:267pt'>
<tr class=xl25 height=34 style='height:25.5pt'>
<td height=34 class=xl29 width=399 style='height:25.5pt;width:299pt'>Text</td>
<td class=xl30 width=60 style='width:45pt'>Evidence level</td>
<td class=xl29 width=356 style='width:267pt'>References</td>
</tr>
<tr class=xl25 height=11 style='mso-height-source:userset;height:8.25pt'>
<td height=11 class=xl25 style='height:8.25pt'></td>
<td class=xl26></td>
<td class=xl25></td>
</tr>
<tr height=200 style='mso-height-source:userset;height:150.0pt'>
<td height=200 class=xl27 width=399 style='height:150.0pt;width:299pt'>Highly
active anti-retroviral therapy (HAART) should be commenced or maximised in
patients with HIV-related lymphoma.</td>
<td class=xl28 x:num>3</td>
<td class=xl27 width=356 style='width:267pt'>1. Little RF, Pittaluga S, Grant
N, et al. Highly effective treatment of acquired immunodeficiency
syndrome-related lymphoma with dose-adjusted EPOCH: impact of antiretroviral
therapy suspension and tumor biology. Blood 2003; 101: 4653.<br>
2. Antinori A, Cingolani A, Alba L, et al. Better response to chemotherapy
and prolonged survival in AIDS-related lymphomas responding to highly active
antiretroviral therapy. AIDS 2001; 15: 14831.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=399 style='width:299pt'></td>
<td width=60 style='width:45pt'></td>
<td width=356 style='width:267pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="16.3.6.3_files/filelist.xml">
<link rel=Edit-Time-Data href="16.3.6.3_files/editdata.mso">
<link rel=OLE-Object-Data href="16.3.6.3_files/oledata.mso">
<title>Management for lymphomas associated with HIV (3)</title>
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-05T22:57:54Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl27
{mso-style-parent:style0;
background:#99CC00;
mso-pattern:auto none;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
background:#99CC00;
mso-pattern:auto none;
white-space:normal;}
.xl29
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl30
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Print>
<x:ValidPrinterInfo/>
<x:PaperSizeIndex>9</x:PaperSizeIndex>
<x:HorizontalResolution>-3</x:HorizontalResolution>
<x:VerticalResolution>0</x:VerticalResolution>
</x:Print>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>2</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=736 style='border-collapse:
collapse;table-layout:fixed;width:552pt'>
<col width=357 style='mso-width-source:userset;mso-width-alt:13056;width:268pt'>
<col class=xl24 width=60 style='mso-width-source:userset;mso-width-alt:2194;
width:45pt'>
<col width=319 style='mso-width-source:userset;mso-width-alt:11666;width:239pt'>
<tr class=xl25 height=34 style='height:25.5pt'>
<td height=34 class=xl27 width=357 style='height:25.5pt;width:268pt'>Text</td>
<td class=xl28 width=60 style='width:45pt'>Evidence level</td>
<td class=xl27 width=319 style='width:239pt'>References</td>
</tr>
<tr class=xl25 height=12 style='mso-height-source:userset;height:9.0pt'>
<td height=12 class=xl25 style='height:9.0pt'></td>
<td class=xl26></td>
<td class=xl25></td>
</tr>
<tr height=115 style='mso-height-source:userset;height:86.25pt'>
<td height=115 class=xl29 width=357 style='height:86.25pt;width:268pt'>Hodgkin
lymphoma should be managed as for non-HIV patients, with the addition of
HAART.</td>
<td class=xl30 x:num>3</td>
<td class=xl29 width=319 style='width:239pt'>Spina M, Gabarre J, Rossi G, et
al. Stanford V regimen and concomitant HAART in patients with Hodgkin disease
and HIV infection. Blood 2002; 100: 1984.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=357 style='width:268pt'></td>
<td width=60 style='width:45pt'></td>
<td width=319 style='width:239pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="16.3.6.4_files/filelist.xml">
<link rel=Edit-Time-Data href="16.3.6.4_files/editdata.mso">
<link rel=OLE-Object-Data href="16.3.6.4_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-05T23:09:32Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:#99CC00;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>9</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>21478</x:Id>
<x:DivID>16.3.6.4_21478</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\16.3.6.4.htm"/>
<x:Title>Primary CNS lymphoma - HIV</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=444 style='border-collapse:
collapse;table-layout:fixed;width:333pt'>
<col width=444 style='mso-width-source:userset;mso-width-alt:16237;width:333pt'>
<col width=126 style='mso-width-source:userset;mso-width-alt:4608;width:95pt'>
<col width=110 style='mso-width-source:userset;mso-width-alt:4022;width:83pt'>
<col width=273 style='mso-width-source:userset;mso-width-alt:9984;width:205pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=444 style='height:12.75pt;width:333pt'> </td>
</tr>
<tr height=42 style='mso-height-source:userset;height:31.5pt'>
<td height=42 class=xl24 width=444 style='height:31.5pt;width:333pt'>Primary
CNS lymphoma should be managed as for non-HIV patients with the addition of
highly active anti-retroviral therapy (HAART).</td>
</tr>
<tr height=238 style='height:178.5pt;mso-xlrowspan:14'>
<td height=238 style='height:178.5pt'></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl24 style='height:12.75pt'></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=444 style='width:333pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
Treatment planning
Lymphoproliferative disease associated with a primary immune disorder management
HIV-related lymphoma management
Post - transplant lymphoproliferative disorder management
Methotrexate - associated lymphoproliferative disorder management
/*
Sample Gello for GLIF decision.
A GLIF decision condition returns a structured result of GELLO type GLIFDecisionResult.
The result has several parts..
1. Question.
This is the question being asked or assertion being made.
It should be stated in such a way as to return a true or false answer.
For example
"Is age is 18 years or older?"
True: patient is 18 or more
False: patient is younger than 18
2. Answer.
This is what the GELLO program will determine in response to the question
or condition being determined, or assertion being made.
A "true" answer means that the condition passed. (yes to question)
A "false" answer means that the condition failed. (no to question)
A "unknown" answer typically means there was insufficient data to
give a definite yes or no to the question.
3. Reason.
This is an informative message stating the reason for the decision being made.
It is not used in used in determining the overall result of the condition, however
it will be used to present an informative message to the GLIF when reviewing a decision
that was evaluated.
4. Weight.
When a decision cannot be determined (e.g. unknown) a weight may be returned
between 0 and 100. it represents how close to yes or no the answer is,
with 0 meaning "no" and 100 meaning "yes". 50 is equivalent to "don't know"
*/
// define our assertion or question
let question:string = 'Is this Lymphoproliferative disease assoc with a primary imune disorder'
Let IDL : Set(CodedValue) = Set{
Factory.Codedvalue('at0057^Lymphoproliferative disease assoc with a primary imune disorder^MO_LymphomaType')
}
// now evaluate an answer.
//See if we have diagnosis data
let path: String = '1.1.1'
let OBS : Observation = Model.find_observation('Lymphoma_Wizard_Core', path)
let answer:Boolean =
if OBS.isUndefined() then
unknown
else
if IDL-> includes(OBS.value) then
true
else
false
endif
endif
// note - due to GELLO language constraints, we are not allowed to assign a
// variable value more than once, so alternative reasons have to be specified
// with sepearate return results.
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'Lymphoproliferative disease assoc with a primary imune disorder',50)
else
factory.GLIFDecisionResult(question,answer,'Not Correct type',50)
endif
else
factory.GLIFDecisionResult(question,answer,'Diagnosis uncertain',50)
endif
/*
Sample Gello for GLIF decision.
A GLIF decision condition returns a structured result of GELLO type GLIFDecisionResult.
The result has several parts..
1. Question.
This is the question being asked or assertion being made.
It should be stated in such a way as to return a true or false answer.
For example
"Is age is 18 years or older?"
True: patient is 18 or more
False: patient is younger than 18
2. Answer.
This is what the GELLO program will determine in response to the question
or condition being determined, or assertion being made.
A "true" answer means that the condition passed. (yes to question)
A "false" answer means that the condition failed. (no to question)
A "unknown" answer typically means there was insufficient data to
give a definite yes or no to the question.
3. Reason.
This is an informative message stating the reason for the decision being made.
It is not used in used in determining the overall result of the condition, however
it will be used to present an informative message to the GLIF when reviewing a decision
that was evaluated.
4. Weight.
When a decision cannot be determined (e.g. unknown) a weight may be returned
between 0 and 100. it represents how close to yes or no the answer is,
with 0 meaning "no" and 100 meaning "yes". 50 is equivalent to "don't know"
*/
// define our assertion or question
let question:string = 'Is this HIV-related lymphoma'
Let IDL : Set(CodedValue) = Set{
Factory.Codedvalue('at0058^HIV-related lymphoma^MO_LymphomaType')
}
// now evaluate an answer.
//See if we have diagnosis data
let path: String = '1.1.1'
let OBS : Observation = Model.find_observation('Lymphoma_Wizard_Core', path)
let answer:Boolean =
if OBS.isUndefined() then
unknown
else
if IDL-> includes(OBS.value) then
true
else
false
endif
endif
// note - due to GELLO language constraints, we are not allowed to assign a
// variable value more than once, so alternative reasons have to be specified
// with sepearate return results.
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'HIV-related lymphoma',50)
else
factory.GLIFDecisionResult(question,answer,'Not Correct type',50)
endif
else
factory.GLIFDecisionResult(question,answer,'Diagnosis uncertain',50)
endif
/*
Sample Gello for GLIF decision.
A GLIF decision condition returns a structured result of GELLO type GLIFDecisionResult.
The result has several parts..
1. Question.
This is the question being asked or assertion being made.
It should be stated in such a way as to return a true or false answer.
For example
"Is age is 18 years or older?"
True: patient is 18 or more
False: patient is younger than 18
2. Answer.
This is what the GELLO program will determine in response to the question
or condition being determined, or assertion being made.
A "true" answer means that the condition passed. (yes to question)
A "false" answer means that the condition failed. (no to question)
A "unknown" answer typically means there was insufficient data to
give a definite yes or no to the question.
3. Reason.
This is an informative message stating the reason for the decision being made.
It is not used in used in determining the overall result of the condition, however
it will be used to present an informative message to the GLIF when reviewing a decision
that was evaluated.
4. Weight.
When a decision cannot be determined (e.g. unknown) a weight may be returned
between 0 and 100. it represents how close to yes or no the answer is,
with 0 meaning "no" and 100 meaning "yes". 50 is equivalent to "don't know"
*/
// define our assertion or question
let question:string = 'Is this Post transplant lymphoproliferative disorder'
Let IDL : Set(CodedValue) = Set{
Factory.Codedvalue('at0059^Post transplant lymphoproliferative disorder^MO_LymphomaType')
}
// now evaluate an answer.
//See if we have diagnosis data
let path: String = '1.1.1'
let OBS : Observation = Model.find_observation('Lymphoma_Wizard_Core', path)
let answer:Boolean =
if OBS.isUndefined() then
unknown
else
if IDL-> includes(OBS.value) then
true
else
false
endif
endif
// note - due to GELLO language constraints, we are not allowed to assign a
// variable value more than once, so alternative reasons have to be specified
// with sepearate return results.
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'Post transplant lymphoproliferative disorder',50)
else
factory.GLIFDecisionResult(question,answer,'Not Correct type',50)
endif
else
factory.GLIFDecisionResult(question,answer,'Diagnosis uncertain',50)
endif
/*
Sample Gello for GLIF decision.
A GLIF decision condition returns a structured result of GELLO type GLIFDecisionResult.
The result has several parts..
1. Question.
This is the question being asked or assertion being made.
It should be stated in such a way as to return a true or false answer.
For example
"Is age is 18 years or older?"
True: patient is 18 or more
False: patient is younger than 18
2. Answer.
This is what the GELLO program will determine in response to the question
or condition being determined, or assertion being made.
A "true" answer means that the condition passed. (yes to question)
A "false" answer means that the condition failed. (no to question)
A "unknown" answer typically means there was insufficient data to
give a definite yes or no to the question.
3. Reason.
This is an informative message stating the reason for the decision being made.
It is not used in used in determining the overall result of the condition, however
it will be used to present an informative message to the GLIF when reviewing a decision
that was evaluated.
4. Weight.
When a decision cannot be determined (e.g. unknown) a weight may be returned
between 0 and 100. it represents how close to yes or no the answer is,
with 0 meaning "no" and 100 meaning "yes". 50 is equivalent to "don't know"
*/
// define our assertion or question
let question:string = 'Is this Methotrexate-associated lymphoproliferative disorder'
Let IDL : Set(CodedValue) = Set{
Factory.Codedvalue('at0060^Methotrexate-associated lymphoproliferative disorder^MO_LymphomaType')
}
// now evaluate an answer.
//See if we have diagnosis data
let path: String = '1.1.1'
let OBS : Observation = Model.find_observation('Lymphoma_Wizard_Core', path)
let answer:Boolean =
if OBS.isUndefined() then
unknown
else
if IDL-> includes(OBS.value) then
true
else
false
endif
endif
// note - due to GELLO language constraints, we are not allowed to assign a
// variable value more than once, so alternative reasons have to be specified
// with sepearate return results.
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'Methotrexate-associated lymphoproliferative disorder',50)
else
factory.GLIFDecisionResult(question,answer,'Not Correct type',50)
endif
else
factory.GLIFDecisionResult(question,answer,'Diagnosis uncertain',50)
endif
Initial patient evaluation
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="9.2.0_files/filelist.xml">
<link rel=Edit-Time-Data href="9.2.0_files/editdata.mso">
<link rel=OLE-Object-Data href="9.2.0_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-21T10:21:06Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8122</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:#FF9900;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>7</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=572 style='border-collapse:
collapse;table-layout:fixed;width:429pt'>
<col width=572 style='mso-width-source:userset;mso-width-alt:20918;width:429pt'>
<col width=256 style='mso-width-source:userset;mso-width-alt:9362;width:192pt'>
<col width=190 style='mso-width-source:userset;mso-width-alt:6948;width:143pt'>
<col width=192 style='mso-width-source:userset;mso-width-alt:7021;width:144pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=572 style='height:12.75pt;width:429pt'> </td>
</tr>
<tr height=40 style='mso-height-source:userset;height:30.0pt'>
<td height=40 class=xl24 width=572 style='height:30.0pt;width:429pt'>Full
blood count may provide definitive diagnostic information, as can simple
serological studies for EBV, CMV, toxoplasmosis, HIV and other viruses.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=572 style='width:429pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
Click on the green arrow for things to happen
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="9.2.4_files/filelist.xml">
<link rel=Edit-Time-Data href="9.2.4_files/editdata.mso">
<link rel=OLE-Object-Data href="9.2.4_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T08:41:05Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
background:#CCFFCC;
mso-pattern:auto none;}
.xl26
{mso-style-parent:style0;
text-align:center;
background:#CCFFCC;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>6</x:ActiveRow>
<x:RangeSelection>$A$7:$A$8</x:RangeSelection>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=504 style='border-collapse:
collapse;table-layout:fixed;width:379pt'>
<col width=406 style='mso-width-source:userset;mso-width-alt:14848;width:305pt'>
<col class=xl24 width=98 style='mso-width-source:userset;mso-width-alt:3584;
width:74pt'>
<col width=124 style='mso-width-source:userset;mso-width-alt:4534;width:93pt'>
<col width=96 style='mso-width-source:userset;mso-width-alt:3510;width:72pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=406 style='height:12.75pt;width:305pt'>Text</td>
<td class=xl26 width=98 style='width:74pt'>Evidence level</td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'>Full blood count and chest x-ray should
be performed before biopsy.</td>
<td class=xl24 x:num>4</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=406 style='width:305pt'></td>
<td width=98 style='width:74pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
let question: String = 'Check if Mediastinal Mass on Imaging'
//let arch = Model.Archetypes->sortBy(AbsoluteTime)
//let RF = arch -> select(archetype_id = 'Lymphoma_finding') -> lastN(1)
//let O: Observation = RF[0]
let path: String = '1.3.1'
let O2 : Observation = Model.find_observation('Radiology_Findings', path)
//this is true
let IsPresent: Codedvalue = Factory.CodedValue('31874001', 'SNOMED-CT')
//let ud: Boolean = O2.isUndefined()
let answer: Boolean =
if O2.isUndefined() then
Unknown
else
//we have an Observation
if O2.value_type = 'CE' then
//see if matches value
if IsPresent.equals(O2.Value) then
true
else
false
endif
else
false
endif
endif
if answer then
factory.GLIFDecisionResult(question,answer, 'Mediastinal mass present',50)
else
if answer = false then
factory.GLIFDecisionResult(question, answer, 'Mediastinal mass absent', 50)
else
factory.GLIFDecisionResult(question, answer, 'Mediastinal mass status unknown', 50)
endif
endif
let question: String = 'Abdo or Retroperitineal Lymphadeopathy'
let path1: String = '1.2'
let O2 : Observation = Model.find_observation('Radiology_Findings', path1)
//this is true
let IsPresent: Codedvalue = Factory.CodedValue('31874001', 'SNOMED-CT')
let D1: Boolean =
if O2.isUndefined() then
Unknown
else
//we have an Observation
if O2.value_type = 'CE' then
//see if matches value
if IsPresent.equals(O2.Value) then
true
else
false
endif
else
false
endif
endif
let path2: String = '1.4'
let O3 : Observation = Model.find_observation('Radiology_Findings', path1)
let D2: Boolean =
if O3.isUndefined() then
Unknown
else
//we have an Observation
if O3.value_type = 'CE' then
//see if matches value
if IsPresent.equals(O3.Value) then
true
else
false
endif
else
false
endif
endif
Let answer: Boolean = D1 or D2
if answer then
factory.GLIFDecisionResult(question,answer, 'Abdominal of Retroperitoneal lymphadeopathy present',50)
else
if answer = false then
factory.GLIFDecisionResult(question, answer, 'Abdo/retroperitoneal lymphadeopathy absent', 50)
else
factory.GLIFDecisionResult(question, answer, 'Status unknown', 50)
endif
endif
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="9.3.1_files/filelist.xml">
<link rel=Edit-Time-Data href="9.3.1_files/editdata.mso">
<link rel=OLE-Object-Data href="9.3.1_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2007-02-05T23:31:22Z</o:Created>
<o:LastSaved>2007-02-05T23:32:48Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
background:#FF9900;
mso-pattern:auto none;}
.xl25
{mso-style-parent:style0;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
<x:ActiveRow>11</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
<x:ExcelWorksheet>
<x:Name>Sheet2</x:Name>
<x:WorksheetOptions>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
<x:ExcelWorksheet>
<x:Name>Sheet3</x:Name>
<x:WorksheetOptions>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>8070</x:WindowHeight>
<x:WindowWidth>19020</x:WindowWidth>
<x:WindowTopX>120</x:WindowTopX>
<x:WindowTopY>90</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=586 style='border-collapse:
collapse;table-layout:fixed;width:440pt'>
<col width=586 style='mso-width-source:userset;mso-width-alt:21430;width:440pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl24 width=586 style='height:12.75pt;width:440pt'> </td>
</tr>
<tr height=118 style='mso-height-source:userset;height:88.5pt'>
<td height=118 class=xl25 width=586 style='height:88.5pt;width:440pt'>The
differential diagnosis may include sarcoidosis, tuberculosis, metastatic
carcinoma and thymoma. Mediastinoscopy with biopsy may be an appropriate
approach to biopsy. In some circumstances, bone marrow biopsy prior to the
procedure may be appropriate. The rare instances of lymphoma involving lung
parenchyma (isolated) may require open thoracotomy and lung biopsy.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=586 style='width:440pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="9.3.2_files/filelist.xml">
<link rel=Edit-Time-Data href="9.3.2_files/editdata.mso">
<link rel=OLE-Object-Data href="9.3.2_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2007-02-05T23:32:53Z</o:Created>
<o:LastSaved>2007-02-05T23:34:29Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
background:#FF9900;
mso-pattern:auto none;}
.xl25
{mso-style-parent:style0;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
<x:ActiveRow>7</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
<x:ExcelWorksheet>
<x:Name>Sheet2</x:Name>
<x:WorksheetOptions>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
<x:ExcelWorksheet>
<x:Name>Sheet3</x:Name>
<x:WorksheetOptions>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>8070</x:WindowHeight>
<x:WindowWidth>19020</x:WindowWidth>
<x:WindowTopX>120</x:WindowTopX>
<x:WindowTopY>90</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=456 style='border-collapse:
collapse;table-layout:fixed;width:342pt'>
<col width=456 style='mso-width-source:userset;mso-width-alt:16676;width:342pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl24 width=456 style='height:12.75pt;width:342pt'> </td>
</tr>
<tr height=57 style='mso-height-source:userset;height:42.75pt'>
<td height=57 class=xl25 width=456 style='height:42.75pt;width:342pt'>An
alternative to open biopsy is CT-guided core biopsies or laparoscopic lymph
node biopsy, depending on the location of the lesions to be biopsied.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=456 style='width:342pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="9.4_files/filelist.xml">
<link rel=Edit-Time-Data href="9.4_files/editdata.mso">
<link rel=OLE-Object-Data href="9.4_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2007-02-05T23:34:33Z</o:Created>
<o:LastSaved>2007-02-05T23:36:04Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
background:#FF9900;
mso-pattern:auto none;}
.xl25
{mso-style-parent:style0;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
<x:ActiveRow>1</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
<x:ExcelWorksheet>
<x:Name>Sheet2</x:Name>
<x:WorksheetOptions>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
<x:ExcelWorksheet>
<x:Name>Sheet3</x:Name>
<x:WorksheetOptions>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>8070</x:WindowHeight>
<x:WindowWidth>19020</x:WindowWidth>
<x:WindowTopX>120</x:WindowTopX>
<x:WindowTopY>90</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=512 style='border-collapse:
collapse;table-layout:fixed;width:384pt'>
<col width=512 style='mso-width-source:userset;mso-width-alt:18724;width:384pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl24 width=512 style='height:12.75pt;width:384pt'> </td>
</tr>
<tr height=310 style='mso-height-source:userset;height:232.5pt'>
<td height=310 class=xl25 width=512 style='height:232.5pt;width:384pt'>The
presence of an enlarged spleen is easily determined by ultrasonography and is
less costly than CT. However, CT does offer the advantage of visualising
intra-abdominal lymph nodes, which will be important where lymphoma is
suspected. In differential diagnosis, if the patient has associated
lymphadenopathy, a lymphoma (or leukaemia, etc.) is likely. Causes of
splenomegaly such as the following must be distinguished:<br>
- reticulo-endothelial hypoplasia<br>
- immune hyperplasia<br>
- portal hypertension<br>
- infiltrative disease of spleen (metabolic or benign or malignant cellular
infiltrate), and<br>
- extramedullary haemopoiesis<br>
A significantly enlarged spleen, for example, greater than 8 cm below the
left costal margin, is usually due to a malignant haematological cause
(excluding malaria or kala-azar in the tropics).<br>
Investigation may be more specifically directed after a full blood count
and assessment of any apparent underlying systemic illness. Bone marrow
biopsy and/or biopsy of any lymphadenopathy may be indicated.<br>
Rarely, splenectomy will be performed for diagnostic purposes where no
other site of disease is detected.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=512 style='width:384pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
Biopsy request and report
Initial patient evaluation
Involves the entire body and are not confined to a specific hour during the night. Note the differnce between light sweating vs having to change the sheets.
In the elderly, common causes of weight loss are depression,
malignant disease and benign gastrointestinal disease. By
contrast, in younger individuals, diabetes, hyperthyroidism,
psychiatric disturbance, infection and/or lymphoma need to
be considered. Patients with fever and night sweats may have
either malignancy or chronic infection. Objective confirmation
that weight loss has occurred is important, with a focus on
signs or symptoms that are associated with systemic disease
that may cause weight loss. Weight loss in this context is more
than 10% body weight and unintentional. Apart from general
routine physical examination, a search for lymphadenopathy
and/or splenomegaly should be made. Key laboratory investigations
will be a full blood count, serum LDH, ESR, chest xray and, where
appropriate, CT examination of the abdomen and bone marrow biopsy.
Fever is taken to mean more than 38.5 degrees more than two times with no cause found.
This may include CT scan of abdomen and chest, and bone marrow biopsy. The role of PET
scanning is undergoing investigation in this setting.
Initial patient evaluation
Careful history taking is necessary in terms of the potential for systemic disease, such as infection,
inflammatory disease or malignancy, as well as drug reactions. The physical examination should
compliment the history taking.
Investigations will depend on clinical manifestations, but should include a full blood count with
examination of the film with appropriate biochemistry and cultures. The course of the illness is
critical, and either the patient recovers spontaneously or the initial examination leads to a diagnosis.
Takes you to initial medical examination
Initial investigation
Biopsy request and report
Initial medical history
Back to Top Level view
Top Level Guideline
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.9.1_files/filelist.xml">
<link rel=Edit-Time-Data href="12.9.1_files/editdata.mso">
<link rel=OLE-Object-Data href="12.9.1_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T02:52:13Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:#99CCFF;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>12</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>9009</x:Id>
<x:DivID>12.9.1_9009</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.9.1.htm"/>
<x:Title>Prognostic features</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=486 style='border-collapse:
collapse;table-layout:fixed;width:365pt'>
<col width=486 style='mso-width-source:userset;mso-width-alt:17773;width:365pt'>
<col width=256 style='mso-width-source:userset;mso-width-alt:9362;width:192pt'>
<col width=190 style='mso-width-source:userset;mso-width-alt:6948;width:143pt'>
<col width=192 style='mso-width-source:userset;mso-width-alt:7021;width:144pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=486 style='height:12.75pt;width:365pt'> </td>
</tr>
<tr height=74 style='mso-height-source:userset;height:55.5pt'>
<td height=74 class=xl24 width=486 style='height:55.5pt;width:365pt'>The
five-year actuarial survival rates for patients with 0 risk factors is 90%,
2 risk factors 67% and 3 risk factors 37%. Patients who are asymptomatic
and without<br>
evidence of progressive disease may be managed expectantly without therapy.
There are no randomised studies evaluating immediate versus delayed therapy.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=486 style='width:365pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.9.3.3_files/filelist.xml">
<link rel=Edit-Time-Data href="12.9.3.3_files/editdata.mso">
<link rel=OLE-Object-Data href="12.9.3.3_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T02:52:59Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl27
{mso-style-parent:style0;
background:#99CCFF;
mso-pattern:auto none;}
.xl28
{mso-style-parent:style0;
text-align:center;
background:#99CCFF;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>13</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>32641</x:Id>
<x:DivID>12.9.3.3_32641</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.9.3.3.htm"/>
<x:Title>Low-grade lymphoma Waldenstrom lymphoma therapeutic options (2)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=774 style='border-collapse:
collapse;table-layout:fixed;width:581pt'>
<col width=338 style='mso-width-source:userset;mso-width-alt:12361;width:254pt'>
<col class=xl24 width=91 style='mso-width-source:userset;mso-width-alt:3328;
width:68pt'>
<col width=345 style='mso-width-source:userset;mso-width-alt:12617;width:259pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl27 width=338 style='height:12.75pt;width:254pt'>Text</td>
<td class=xl28 width=91 style='width:68pt'>Evidence level</td>
<td class=xl27 width=345 style='width:259pt'>References</td>
</tr>
<tr height=10 style='mso-height-source:userset;height:7.5pt'>
<td height=10 style='height:7.5pt'></td>
<td class=xl24></td>
<td></td>
</tr>
<tr height=188 style='mso-height-source:userset;height:141.0pt'>
<td height=188 class=xl25 width=338 style='height:141.0pt;width:254pt'>Patients
with symptomatic or progressive Waldenstrom macroglobulinemia may be
treated with plasmapheresis.</td>
<td class=xl26 x:num>3</td>
<td class=xl25 width=345 style='width:259pt'>1. SCHWAB PJ, FAHEY JL.
Treatment of Waldenstrom macroglobulinemia by plasmapheresis. N Engl J Med
1960; 263: 574.<br>
2. Buskard NA, Galton DA, Goldman JM, et al. Plasma exchange in the
long-term management of Waldenstrom macroglobulinemia. Can Med Assoc J
1977; 117: 135.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=338 style='width:254pt'></td>
<td width=91 style='width:68pt'></td>
<td width=345 style='width:259pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.9.2_files/filelist.xml">
<link rel=Edit-Time-Data href="12.9.2_files/editdata.mso">
<link rel=OLE-Object-Data href="12.9.2_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T02:52:33Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:#99CCFF;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>8</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>12323</x:Id>
<x:DivID>12.9.2_12323</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.9.2.htm"/>
<x:Title>Hyperviscosity</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=443 style='border-collapse:
collapse;table-layout:fixed;width:332pt'>
<col width=443 style='mso-width-source:userset;mso-width-alt:16201;width:332pt'>
<col width=256 style='mso-width-source:userset;mso-width-alt:9362;width:192pt'>
<col width=190 style='mso-width-source:userset;mso-width-alt:6948;width:143pt'>
<col width=192 style='mso-width-source:userset;mso-width-alt:7021;width:144pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=443 style='height:12.75pt;width:332pt'> </td>
</tr>
<tr height=133 style='mso-height-source:userset;height:99.75pt'>
<td height=133 class=xl24 width=443 style='height:99.75pt;width:332pt'>For
patients who present with hyperviscosity, plasmapheresis is an effective form
of management, allowing systemic treatments time to control the disease. As
well, plasmapheresis may be used in a palliative context in patients with
advanced drug-resistant disease. The required frequency of plasmapheresis
depends on the production rate of the IgM and the threshold at which the
individual patient becomes symptomatic, but is usually every three to eight
weeks.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=443 style='width:332pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
3
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.9.3.2_files/filelist.xml">
<link rel=Edit-Time-Data href="12.9.3.2_files/editdata.mso">
<link rel=OLE-Object-Data href="12.9.3.2_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T02:53:23Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl27
{mso-style-parent:style0;
background:#99CCFF;
mso-pattern:auto none;}
.xl28
{mso-style-parent:style0;
text-align:center;
background:#99CCFF;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>8</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>26217</x:Id>
<x:DivID>12.9.3.2_26217</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.9.3.2.htm"/>
<x:Title>Low-grade lymphoma Waldenstrom lymphoma therapeutic options (1)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=825 style='border-collapse:
collapse;table-layout:fixed;width:620pt'>
<col width=366 style='mso-width-source:userset;mso-width-alt:13385;width:275pt'>
<col class=xl24 width=109 style='mso-width-source:userset;mso-width-alt:3986;
width:82pt'>
<col width=350 style='mso-width-source:userset;mso-width-alt:12800;width:263pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl27 width=366 style='height:12.75pt;width:275pt'>Text</td>
<td class=xl28 width=109 style='width:82pt'>Evidence level</td>
<td class=xl27 width=350 style='width:263pt'>References</td>
</tr>
<tr height=7 style='mso-height-source:userset;height:5.25pt'>
<td height=7 style='height:5.25pt'></td>
<td class=xl24></td>
<td></td>
</tr>
<tr height=81 style='mso-height-source:userset;height:60.75pt'>
<td height=81 class=xl25 width=366 style='height:60.75pt;width:275pt'>Patients
with asymptomatic Waldenstrom macroglobulinemia may be observed without
initial therapy.</td>
<td class=xl26 x:num>4</td>
<td class=xl25 width=350 style='width:263pt'>Dimopoulos MA, Panayiotidis P,
Moulopoulos LA, Sfikakis P, Dalakas M. Waldenstrom macroglobulinemia:
clinical features, complications, and management. J Clin Oncol 2000;
18:2146.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=366 style='width:275pt'></td>
<td width=109 style='width:82pt'></td>
<td width=350 style='width:263pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.9.3.1_files/filelist.xml">
<link rel=Edit-Time-Data href="12.9.3.1_files/editdata.mso">
<link rel=OLE-Object-Data href="12.9.3.1_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T02:53:43Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:#99CCFF;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>3</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>18517</x:Id>
<x:DivID>12.9.3.1_18517</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.9.3.1.htm"/>
<x:Title>Nucleoside analogues</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=499 style='border-collapse:
collapse;table-layout:fixed;width:374pt'>
<col width=499 style='mso-width-source:userset;mso-width-alt:18249;width:374pt'>
<col width=256 style='mso-width-source:userset;mso-width-alt:9362;width:192pt'>
<col width=190 style='mso-width-source:userset;mso-width-alt:6948;width:143pt'>
<col width=192 style='mso-width-source:userset;mso-width-alt:7021;width:144pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=499 style='height:12.75pt;width:374pt'> </td>
</tr>
<tr height=74 style='mso-height-source:userset;height:55.5pt'>
<td height=74 class=xl24 width=499 style='height:55.5pt;width:374pt'>Either
single-agent oral alkylating agents (continuous or intermittent chlorambucil)
or a nucleoside analogue (2-CdA or fludarabine) are recommended for the
initial therapy of symptomatic patients.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=499 style='width:374pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.9.3.5_files/filelist.xml">
<link rel=Edit-Time-Data href="12.9.3.5_files/editdata.mso">
<link rel=OLE-Object-Data href="12.9.3.5_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T02:54:26Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl27
{mso-style-parent:style0;
background:#99CCFF;
mso-pattern:auto none;}
.xl28
{mso-style-parent:style0;
text-align:center;
background:#99CCFF;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>6</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>12286</x:Id>
<x:DivID>12.9.3.5_12286</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.9.3.5.htm"/>
<x:Title>Low-grade lymphoma Waldenstrom lymphoma response to therapy (2)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=919 style='border-collapse:
collapse;table-layout:fixed;width:690pt'>
<col width=395 style='mso-width-source:userset;mso-width-alt:14445;width:296pt'>
<col class=xl24 width=86 style='mso-width-source:userset;mso-width-alt:3145;
width:65pt'>
<col width=438 style='mso-width-source:userset;mso-width-alt:16018;width:329pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl27 width=395 style='height:12.75pt;width:296pt'>Text</td>
<td class=xl28 width=86 style='width:65pt'>Evidence level</td>
<td class=xl27 width=438 style='width:329pt'>References</td>
</tr>
<tr height=10 style='mso-height-source:userset;height:7.5pt'>
<td height=10 style='height:7.5pt'></td>
<td class=xl24></td>
<td></td>
</tr>
<tr height=283 style='mso-height-source:userset;height:212.25pt'>
<td height=283 class=xl25 width=395 style='height:212.25pt;width:296pt'>Rituximab
has useful activity as a single-agent in relapsed/refractory Waldenstrom
macroglobulinemia. The combination of fludarabine and rituximab has high
levels of activity in elapsed/refractory Waldenstrom macroglobulinemia.</td>
<td class=xl26 x:num>2</td>
<td class=xl25 width=438 style='width:329pt'>1. Dimopoulos MA, Zervas C,
Zomas A, et al. Treatment of Waldenstrom macroglobulinemia with rituximab.
J Clin Oncol 2002; 20: 23273.<br>
2. Byrd JC, White CA, Link B, et al. Rituximab therapy in Waldenstrom
macroglobulinemia: preliminary evidence of clinical activity. Ann Oncol 1999;
10: 1525.<br>
3. Dimopoulos MA, Zervas C, Zomas A, et al. Extended rituximab therapy for
previously untreated patients with Waldenstrom macroglobulinemia. Clin
Lymphoma 2002; 3: 163.<br>
4. Treon SP, Wasi P, Emmanouilides CA, Frankel SR, Kimby E, Lister A, Morel
P, Kelliher A, Branagan A, Preffer F, Anderson K. Combination therapy with
rituximab and fludarabine is highly active in Waldenstrom
macroglobulinemia. Blood 100(Suppl. 1), 211a. 2002.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=395 style='width:296pt'></td>
<td width=86 style='width:65pt'></td>
<td width=438 style='width:329pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.9.3.4_files/filelist.xml">
<link rel=Edit-Time-Data href="12.9.3.4_files/editdata.mso">
<link rel=OLE-Object-Data href="12.9.3.4_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T02:54:03Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl27
{mso-style-parent:style0;
background:#99CCFF;
mso-pattern:auto none;}
.xl28
{mso-style-parent:style0;
text-align:center;
background:#99CCFF;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>8</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>7094</x:Id>
<x:DivID>12.9.3.4_7094</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.9.3.4.htm"/>
<x:Title>Low-grade lymphoma Waldenstrom lymphoma response to therapy (1)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=789 style='border-collapse:
collapse;table-layout:fixed;width:592pt'>
<col width=362 style='mso-width-source:userset;mso-width-alt:13238;width:272pt'>
<col class=xl24 width=96 style='mso-width-source:userset;mso-width-alt:3510;
width:72pt'>
<col width=331 style='mso-width-source:userset;mso-width-alt:12105;width:248pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl27 width=362 style='height:12.75pt;width:272pt'>Text</td>
<td class=xl28 width=96 style='width:72pt'>Evidence level</td>
<td class=xl27 width=331 style='width:248pt'>References</td>
</tr>
<tr height=10 style='mso-height-source:userset;height:7.5pt'>
<td height=10 style='height:7.5pt'></td>
<td class=xl24></td>
<td></td>
</tr>
<tr height=163 style='mso-height-source:userset;height:122.25pt'>
<td height=163 class=xl25 width=362 style='height:122.25pt;width:272pt'>In
patients with relapsed Waldenstrom macroglobulinemia, a nucleoside analogue
(2-CdA or fludarabine) is associated with a higher response rate and more
durable disease control than alkylating agent/anthracycline therapy.</td>
<td class=xl26 x:num>2</td>
<td class=xl25 width=331 style='width:248pt'>Leblond V, Levy V, Maloisel F,
et al. Multicenter, randomized comparative trial of fludarabine and the
combination of cyclophosphamide-doxorubicin-prednisone in 92 patients with
Waldenstrom macroglobulinemia in first relapse or with primary refractory disease.
Blood 2001; 98: 2640.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=362 style='width:272pt'></td>
<td width=96 style='width:72pt'></td>
<td width=331 style='width:248pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.9.3.6_files/filelist.xml">
<link rel=Edit-Time-Data href="12.9.3.6_files/editdata.mso">
<link rel=OLE-Object-Data href="12.9.3.6_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T02:54:45Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:#99CCFF;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>10</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>17563</x:Id>
<x:DivID>12.9.3.6_17563</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.9.3.6.htm"/>
<x:Title>Other management issues</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=485 style='border-collapse:
collapse;table-layout:fixed;width:364pt'>
<col width=485 style='mso-width-source:userset;mso-width-alt:17737;width:364pt'>
<col width=256 style='mso-width-source:userset;mso-width-alt:9362;width:192pt'>
<col width=190 style='mso-width-source:userset;mso-width-alt:6948;width:143pt'>
<col width=192 style='mso-width-source:userset;mso-width-alt:7021;width:144pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=485 style='height:12.75pt;width:364pt'> </td>
</tr>
<tr height=245 style='mso-height-source:userset;height:183.75pt'>
<td height=245 class=xl24 width=485 style='height:183.75pt;width:364pt'>Splenectomy
can be effective in ameliorating symptomatic splenomegaly and can improve
peripheral blood cytopenias due to splenic sequestration or autoimmune
phenomena. For patients with recurrent severe proven infections in the
context of established hypogammaglobulinemia, regular replacement therapy
with a pooled intravenous immunoglobulin preparation, such as Intragam, is
recommended. In the rare cases where it has been applied, high-dose therapy
and either autologous stem-cell transplantation or allogeneic stem-cell
transplantation have been able to achieve durable disease control, but with
substantial morbidity and some mortality risk in this generally elderly
patient group. There are insufficient data to determine whether allogeneic
stem-cell transplantation can Clinical practice guidelines for the diagnosis
and management of lymphoma offer the prospect of cure for these patients, as
is achievable in other ow-gradelymphoproliferative disorders.
Approximately 10% of patients ultimately develop a variety of forms of
histologic transformation, with a poor outcome with conventional therapies.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=485 style='width:364pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
Treatment planning
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="16.2.1_files/filelist.xml">
<link rel=Edit-Time-Data href="16.2.1_files/editdata.mso">
<link rel=OLE-Object-Data href="16.2.1_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T03:35:22Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
background:#99CC00;
mso-pattern:auto none;}
.xl26
{mso-style-parent:style0;
text-align:center;
background:#99CC00;
mso-pattern:auto none;}
.xl27
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl28
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>6</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>9116</x:Id>
<x:DivID>16.2.1_9116</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\16.2.1.htm"/>
<x:Title>Predisposing conditions</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=544 style='border-collapse:
collapse;table-layout:fixed;width:409pt'>
<col width=446 style='mso-width-source:userset;mso-width-alt:16310;width:335pt'>
<col class=xl24 width=98 style='mso-width-source:userset;mso-width-alt:3584;
width:74pt'>
<col width=191 style='mso-width-source:userset;mso-width-alt:6985;width:143pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=446 style='height:12.75pt;width:335pt'>Text</td>
<td class=xl26 width=98 style='width:74pt'>Evidence level</td>
</tr>
<tr height=8 style='mso-height-source:userset;height:6.0pt'>
<td height=8 style='height:6.0pt'></td>
<td class=xl24></td>
</tr>
<tr height=166 style='mso-height-source:userset;height:124.5pt'>
<td height=166 class=xl28 width=446 style='height:124.5pt;width:335pt'>The
predisposing conditions are:<br>
ataxia telangiectasia (AT)<br>
Wiskott-Aldrich syndrome (WAS)<br>
common variable immune deficiency (CVID)<br>
severe combined immune deficiency (SCID)<br>
x-linked lymphoproliferative disorder (XLP or Duncan syndrome)<br>
Nijmegen breakage syndrome (NBS)<br>
hyper-IgM syndrome (HIM)<br>
autoimmune lymphoproliferative syndrome (ALPS)</td>
<td class=xl27 x:num>3</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=446 style='width:335pt'></td>
<td width=98 style='width:74pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="16.2.3.1_files/filelist.xml">
<link rel=Edit-Time-Data href="16.2.3.1_files/editdata.mso">
<link rel=OLE-Object-Data href="16.2.3.1_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T03:35:45Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
text-align:center;}
.xl26
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl29
{mso-style-parent:style0;
background:#99CC00;
mso-pattern:auto none;
white-space:normal;}
.xl30
{mso-style-parent:style0;
text-align:center;
background:#99CC00;
mso-pattern:auto none;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>9</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>16804</x:Id>
<x:DivID>16.2.3.1_16804</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\16.2.3.1.htm"/>
<x:Title>Immune deficiency treatment (1)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=800 style='border-collapse:
collapse;table-layout:fixed;width:600pt'>
<col width=362 style='mso-width-source:userset;mso-width-alt:13238;width:272pt'>
<col class=xl25 width=63 style='mso-width-source:userset;mso-width-alt:2304;
width:47pt'>
<col width=375 style='mso-width-source:userset;mso-width-alt:13714;width:281pt'>
<col width=273 style='mso-width-source:userset;mso-width-alt:9984;width:205pt'>
<tr class=xl24 height=34 style='mso-height-source:userset;height:25.5pt'>
<td height=34 class=xl29 width=362 style='height:25.5pt;width:272pt'>Text</td>
<td class=xl30 width=63 style='width:47pt'>Evidence level</td>
<td class=xl29 width=375 style='width:281pt'>References</td>
</tr>
<tr class=xl24 height=10 style='mso-height-source:userset;height:7.5pt'>
<td height=10 class=xl24 style='height:7.5pt'></td>
<td class=xl26></td>
<td class=xl24></td>
</tr>
<tr height=133 style='mso-height-source:userset;height:99.75pt'>
<td height=133 class=xl27 width=362 style='height:99.75pt;width:272pt'>Patients
with primary immune deficiency (PID) should be under close clinical
surveillance for the development of lymphoproliferative disease. Maintain a
high index of suspicion with prolonged symptoms of unidentified infection;
symptoms referrable to common sites of extranodal lymphoma; and precursor
lesions such as lymphoid hyperplasia and monoclonal gammopathy.</td>
<td class=xl28 x:num>4</td>
<td class=xl27 width=375 style='width:281pt'>1. Knowles DM.
Immunodeficiency-associated lymphoproliferative disorders. Mod Pathol 1999;
12: 2007.<br>
2. Elenitoba-Johnson KS, Jaffe ES. Lymphoproliferative disorders associated
with congenital immunodeficiencies. Semin Diagn Pathol 1997; 14: 357.</td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl24 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=362 style='width:272pt'></td>
<td width=63 style='width:47pt'></td>
<td width=375 style='width:281pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="16.2.3.2_files/filelist.xml">
<link rel=Edit-Time-Data href="16.2.3.2_files/editdata.mso">
<link rel=OLE-Object-Data href="16.2.3.2_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T03:36:07Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
text-align:center;}
.xl26
{mso-style-parent:style0;
font-size:11.0pt;
font-family:"Times New Roman", serif;
mso-font-charset:0;}
.xl27
{mso-style-parent:style0;
background:#99CC00;
mso-pattern:auto none;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
background:#99CC00;
mso-pattern:auto none;
white-space:normal;}
.xl29
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl30
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl31
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl32
{mso-style-parent:style0;
font-family:Arial, sans-serif;
mso-font-charset:0;
vertical-align:top;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Print>
<x:ValidPrinterInfo/>
<x:HorizontalResolution>600</x:HorizontalResolution>
<x:VerticalResolution>600</x:VerticalResolution>
</x:Print>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>10</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>24193</x:Id>
<x:DivID>16.2.3.2_24193</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\16.2.3.2.htm"/>
<x:Title>Immune deficiency treatment (2)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=787 style='border-collapse:
collapse;table-layout:fixed;width:590pt'>
<col width=356 style='mso-width-source:userset;mso-width-alt:13019;width:267pt'>
<col class=xl25 width=79 style='mso-width-source:userset;mso-width-alt:2889;
width:59pt'>
<col width=352 style='mso-width-source:userset;mso-width-alt:12873;width:264pt'>
<col width=273 style='mso-width-source:userset;mso-width-alt:9984;width:205pt'>
<tr class=xl24 height=33 style='mso-height-source:userset;height:24.75pt'>
<td height=33 class=xl27 width=356 style='height:24.75pt;width:267pt'>Text</td>
<td class=xl28 width=79 style='width:59pt'>Evidence level</td>
<td class=xl27 width=352 style='width:264pt'>References</td>
</tr>
<tr class=xl24 height=11 style='mso-height-source:userset;height:8.25pt'>
<td height=11 class=xl24 style='height:8.25pt'></td>
<td class=xl29></td>
<td class=xl24></td>
</tr>
<tr height=139 style='mso-height-source:userset;height:104.25pt'>
<td height=139 class=xl30 width=356 style='height:104.25pt;width:267pt'>Standard
curative intent therapy appropriate for the specific lymphoma should be
administered, with special attention to supportive care for expected
treatment-related toxicity.</td>
<td class=xl31 x:num>4</td>
<td class=xl32 width=352 style='width:264pt'>Seidemann K, Tiemann M, Henze G,
Sauerbrey A, Muller S, Reiter A. Therapy for non-Hodgkin lymphoma in children
with primary immunodeficiency: analysis of 19 patients from the BFM trials.
Med Pediatr Oncol 1999; 33: 5364.</td>
</tr>
<tr height=20 style='height:15.0pt'>
<td height=20 style='height:15.0pt'></td>
<td class=xl25></td>
<td class=xl26></td>
</tr>
<tr height=20 style='height:15.0pt'>
<td height=20 style='height:15.0pt'></td>
<td class=xl25></td>
<td class=xl26></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl24 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=356 style='width:267pt'></td>
<td width=79 style='width:59pt'></td>
<td width=352 style='width:264pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="16.2.3.3_files/filelist.xml">
<link rel=Edit-Time-Data href="16.2.3.3_files/editdata.mso">
<link rel=OLE-Object-Data href="16.2.3.3_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T03:36:41Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
text-align:center;}
.xl26
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl27
{mso-style-parent:style0;
background:#99CC00;
mso-pattern:auto none;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
background:#99CC00;
mso-pattern:auto none;
white-space:normal;}
.xl29
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl30
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>5</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>29806</x:Id>
<x:DivID>16.2.3.3_29806</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\16.2.3.3.htm"/>
<x:Title>Immune deficiency treatment (3)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=815 style='border-collapse:
collapse;table-layout:fixed;width:612pt'>
<col width=365 style='mso-width-source:userset;mso-width-alt:13348;width:274pt'>
<col class=xl25 width=69 style='mso-width-source:userset;mso-width-alt:2523;
width:52pt'>
<col width=381 style='mso-width-source:userset;mso-width-alt:13933;width:286pt'>
<col width=273 style='mso-width-source:userset;mso-width-alt:9984;width:205pt'>
<tr class=xl24 height=40 style='mso-height-source:userset;height:30.0pt'>
<td height=40 class=xl27 width=365 style='height:30.0pt;width:274pt'>Text</td>
<td class=xl28 width=69 style='width:52pt'>Evidence level</td>
<td class=xl27 width=381 style='width:286pt'>References</td>
</tr>
<tr class=xl24 height=11 style='mso-height-source:userset;height:8.25pt'>
<td height=11 class=xl24 style='height:8.25pt'></td>
<td class=xl26></td>
<td class=xl24></td>
</tr>
<tr height=170 style='height:127.5pt'>
<td height=170 class=xl29 width=365 style='height:127.5pt;width:274pt'>Primary
immune deficiency (PID) patients with lymphoma should be assessed for
potential allogeneic bone marrow transplant.</td>
<td class=xl30>opinion</td>
<td class=xl29 width=381 style='width:286pt'>1. Duplantier JE, Seyama K, Day
NK, et al. Immunologic reconstitution following bone marrow transplantation
for X-linked hyper IgM syndrome. Clin Immunol 2001; 98: 313.<br>
2. Neudorf SML, Filipovich AH, Kersey JH. Successful immunoreconstitution
following bone marrow transplantation decreases the risk of developing
lymphoreticular tumours in Wiskott-Aldrich syndrome and severe combined
immune deficiency: A retrospective analysis. In: Purtilo,D.T. (ed) Immune
Deficiency and Cancer: Epstein Barr Virus and Lymphoproliferative
Malignancies. New York 1984: 471-80.</td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl24 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=365 style='width:274pt'></td>
<td width=69 style='width:52pt'></td>
<td width=381 style='width:286pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
Treatment planning
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="13.7.1.1_files/filelist.xml">
<link rel=Edit-Time-Data href="13.7.1.1_files/editdata.mso">
<link rel=OLE-Object-Data href="13.7.1.1_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T04:01:58Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
text-align:center;}
.xl26
{mso-style-parent:style0;
background:#FFCC99;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>10</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>6908</x:Id>
<x:DivID>13.7.1.1_6908</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\13.7.1.1.htm"/>
<x:Title>Mantle cell lymphoma - identification of indolent subgroups</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=493 style='border-collapse:
collapse;table-layout:fixed;width:370pt'>
<col width=384 style='mso-width-source:userset;mso-width-alt:14043;width:288pt'>
<col class=xl25 width=109 style='mso-width-source:userset;mso-width-alt:3986;
width:82pt'>
<col width=143 style='mso-width-source:userset;mso-width-alt:5229;width:107pt'>
<col width=80 style='mso-width-source:userset;mso-width-alt:2925;width:60pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl26 width=384 style='height:12.75pt;width:288pt'> </td>
<td width=109 style='width:82pt'></td>
</tr>
<tr height=70 style='mso-height-source:userset;height:52.5pt'>
<td height=70 class=xl24 width=384 style='height:52.5pt;width:288pt'>Identification
of indolent subgroups of mantle cell lymphoma using appropriate indices and
markers is emerging as an important issue.</td>
<td class=xl25></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=384 style='width:288pt'></td>
<td width=109 style='width:82pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="13.7.1.2_files/filelist.xml">
<link rel=Edit-Time-Data href="13.7.1.2_files/editdata.mso">
<link rel=OLE-Object-Data href="13.7.1.2_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T04:02:14Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
text-align:center;}
.xl26
{mso-style-parent:style0;
background:#FFCC99;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>8</x:ActiveRow>
<x:RangeSelection>$A$8:$A$9</x:RangeSelection>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>10020</x:Id>
<x:DivID>13.7.1.2_10020</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\13.7.1.2.htm"/>
<x:Title>Mantle cell lymphoma - management</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=694 style='border-collapse:
collapse;table-layout:fixed;width:521pt'>
<col width=585 style='mso-width-source:userset;mso-width-alt:21394;width:439pt'>
<col class=xl25 width=109 style='mso-width-source:userset;mso-width-alt:3986;
width:82pt'>
<col width=143 style='mso-width-source:userset;mso-width-alt:5229;width:107pt'>
<col width=80 style='mso-width-source:userset;mso-width-alt:2925;width:60pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl26 width=585 style='height:12.75pt;width:439pt'> </td>
<td width=109 style='width:82pt'></td>
</tr>
<tr height=68 style='height:51.0pt'>
<td height=68 class=xl24 width=585 style='height:51.0pt;width:439pt'>The
optimal therapy of patients with mantle cell lymphoma is unclear at present.
Given the poor outcomes with conventional therapy, novel approaches should be
considered and implemented preferably in the context of clinical trials. Such
patients should optimally be managed in specialised centres.</td>
<td class=xl25></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=585 style='width:439pt'></td>
<td width=109 style='width:82pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
Treatment planning
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="13.8.1_files/filelist.xml">
<link rel=Edit-Time-Data href="13.8.1_files/editdata.mso">
<link rel=OLE-Object-Data href="13.8.1_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T04:05:00Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:#FFCC99;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>7</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>14810</x:Id>
<x:DivID>13.8.1_14810</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\13.8.1.htm"/>
<x:Title>Mediastinal (thymic) large B-cell lymphoma management</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=550 style='border-collapse:
collapse;table-layout:fixed;width:413pt'>
<col width=550 style='mso-width-source:userset;mso-width-alt:20114;width:413pt'>
<col width=256 style='mso-width-source:userset;mso-width-alt:9362;width:192pt'>
<col width=190 style='mso-width-source:userset;mso-width-alt:6948;width:143pt'>
<col width=192 style='mso-width-source:userset;mso-width-alt:7021;width:144pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=550 style='height:12.75pt;width:413pt'> </td>
</tr>
<tr height=156 style='mso-height-source:userset;height:117.0pt'>
<td height=156 class=xl24 width=550 style='height:117.0pt;width:413pt'>In a
large retrospective review by the International Extranodal Lymphoma Study
Group of 426 patients from 20 institutions with PMLCL, the authors found that
MACOP-B appeared superior to other chemotherapy programs, including CHOP.
This retrospective study strongly suggests that MACOP-B (or similar
third-generation chemotherapy regimens such as VACOP-B) plus radiation
therapy represents the best therapeutic option for most of these patients.
The long-term overall survival is as high as 705%. On the other hand,
patients with predictive factors of poor outcome are likely candidates for
high-dose sequential chemotherapy plus autologous stem cell transplantation.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=550 style='width:413pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
Treatment planning
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="16.5.2.1_files/filelist.xml">
<link rel=Edit-Time-Data href="16.5.2.1_files/editdata.mso">
<link rel=OLE-Object-Data href="16.5.2.1_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T04:12:28Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
text-align:center;}
.xl26
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl29
{mso-style-parent:style0;
background:#99CC00;
mso-pattern:auto none;
white-space:normal;}
.xl30
{mso-style-parent:style0;
text-align:center;
background:#99CC00;
mso-pattern:auto none;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>2</x:ActiveRow>
<x:ActiveCol>3</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>23649</x:Id>
<x:DivID>16.5.2.1_23649</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\16.5.2.1.htm"/>
<x:Title>Methotrexate and lymphoproliferative disorders</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=766 style='border-collapse:
collapse;table-layout:fixed;width:575pt'>
<col width=361 style='mso-width-source:userset;mso-width-alt:13202;width:271pt'>
<col class=xl25 width=99 style='mso-width-source:userset;mso-width-alt:3620;
width:74pt'>
<col width=306 style='mso-width-source:userset;mso-width-alt:11190;width:230pt'>
<col width=273 style='mso-width-source:userset;mso-width-alt:9984;width:205pt'>
<tr class=xl24 height=20 style='mso-height-source:userset;height:15.0pt'>
<td height=20 class=xl29 width=361 style='height:15.0pt;width:271pt'>Text</td>
<td class=xl30 width=99 style='width:74pt'>Evidence level</td>
<td class=xl29 width=306 style='width:230pt'>References</td>
</tr>
<tr class=xl24 height=9 style='mso-height-source:userset;height:6.75pt'>
<td height=9 class=xl24 style='height:6.75pt'></td>
<td class=xl26></td>
<td class=xl24></td>
</tr>
<tr height=356 style='mso-height-source:userset;height:267.0pt'>
<td height=356 class=xl27 width=361 style='height:267.0pt;width:271pt'>Methotrexate
should be ceased in patients who develop lymphoma and observed for regression
before administration of the appropriate lymphoma therapy, if clinically
feasible. Methotrexate should not be reintroduced in such patients.</td>
<td class=xl28 x:num>4</td>
<td class=xl27 width=306 style='width:230pt'>1. Kamel OW, van de RM, Weiss
LM, et al. Brief report: reversible lymphomas associated with Epstein-Barr
virus occurring during methotrexate therapy for rheumatoid arthritis and
dermatomyositis. N Engl J Med 1993; 328: 13171.<br>
2. Salloum E, Cooper DL, Howe G, et al. Spontaneous regression of
lymphoproliferative disorders in patients treated with methotrexate for
rheumatoid arthritis and other rheumatic diseases. J Clin Oncol 1996; 14:
1943.<br>
3. Kamel OW, Weiss LM, van de RM, Colby TV, Kingma DW, Jaffe ES. Hodgkin
disease and lymphoproliferations resembling Hodgkin disease in patients
receiving long-term lowdose methotrexate therapy. Am J Surg Pathol 1996; 20:
12797.</td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl24 style='height:12.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=361 style='width:271pt'></td>
<td width=99 style='width:74pt'></td>
<td width=306 style='width:230pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
Treatment planning
/*
Sample Gello for GLIF decision.
A GLIF decision condition returns a structured result of GELLO type GLIFDecisionResult.
The result has several parts..
1. Question.
This is the question being asked or assertion being made.
It should be stated in such a way as to return a true or false answer.
For example
"Is age is 18 years or older?"
True: patient is 18 or more
False: patient is younger than 18
2. Answer.
This is what the GELLO program will determine in response to the question
or condition being determined, or assertion being made.
A "true" answer means that the condition passed. (yes to question)
A "false" answer means that the condition failed. (no to question)
A "unknown" answer typically means there was insufficient data to
give a definite yes or no to the question.
3. Reason.
This is an informative message stating the reason for the decision being made.
It is not used in used in determining the overall result of the condition, however
it will be used to present an informative message to the GLIF when reviewing a decision
that was evaluated.
4. Weight.
When a decision cannot be determined (e.g. unknown) a weight may be returned
between 0 and 100. it represents how close to yes or no the answer is,
with 0 meaning "no" and 100 meaning "yes". 50 is equivalent to "don't know"
*/
// define our assertion or question
let question:string = 'Is this Follicular Lymphoma'
// now evaluate an answer.
//See if we have diagnosis data
let path: String = '1.1.1'
let OBS : Observation = Model.find_observation('Lymphoma_Wizard_Core', path)
let answer:Boolean =
if OBS.isUndefined() then
unknown
else
if OBS.value.equals(Factory.Codedvalue('at0023', 'MO_LymphomaType')) then
true
else
false
endif
endif
// note - due to GELLO language constraints, we are not allowed to assign a
// variable value more than once, so alternative reasons have to be specified
// with sepearate return results.
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'Follicular Lymphoma',50)
else
factory.GLIFDecisionResult(question,answer,'Not Follicular',50)
endif
else
factory.GLIFDecisionResult(question,answer,'Diagnosis uncertain',50)
endif
/*
Sample Gello for GLIF decision.
A GLIF decision condition returns a structured result of GELLO type GLIFDecisionResult.
The result has several parts..
1. Question.
This is the question being asked or assertion being made.
It should be stated in such a way as to return a true or false answer.
For example
"Is age is 18 years or older?"
True: patient is 18 or more
False: patient is younger than 18
2. Answer.
This is what the GELLO program will determine in response to the question
or condition being determined, or assertion being made.
A "true" answer means that the condition passed. (yes to question)
A "false" answer means that the condition failed. (no to question)
A "unknown" answer typically means there was insufficient data to
give a definite yes or no to the question.
3. Reason.
This is an informative message stating the reason for the decision being made.
It is not used in used in determining the overall result of the condition, however
it will be used to present an informative message to the GLIF when reviewing a decision
that was evaluated.
4. Weight.
When a decision cannot be determined (e.g. unknown) a weight may be returned
between 0 and 100. it represents how close to yes or no the answer is,
with 0 meaning "no" and 100 meaning "yes". 50 is equivalent to "don't know"
*/
// define our assertion or question
let question:string = 'Is this small lymphocyctic Lymphoma'
Let IDL : Set(CodedValue) = Set{
Factory.Codedvalue('at0013^r^MO_LymphomaType'),
Factory.CodedValue('at0013^^MO_LymphomaType'),
Factory.CodedValue('at0013^^MO_LymphomaType')
}
// now evaluate an answer.
//See if we have diagnosis data
let path: String = '1.1.1'
let OBS : Observation = Model.find_observation('Lymphoma_Wizard_Core', path)
let answer:Boolean =
if OBS.isUndefined() then
unknown
else
if IDL-> includes(OBS.value) then
true
else
false
endif
endif
// note - due to GELLO language constraints, we are not allowed to assign a
// variable value more than once, so alternative reasons have to be specified
// with sepearate return results.
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'Small Lymphocytic Lymphoma',50)
else
factory.GLIFDecisionResult(question,answer,'Not Correct type',50)
endif
else
factory.GLIFDecisionResult(question,answer,'Diagnosis uncertain',50)
endif
/*
Sample Gello for GLIF decision.
A GLIF decision condition returns a structured result of GELLO type GLIFDecisionResult.
The result has several parts..
1. Question.
This is the question being asked or assertion being made.
It should be stated in such a way as to return a true or false answer.
For example
"Is age is 18 years or older?"
True: patient is 18 or more
False: patient is younger than 18
2. Answer.
This is what the GELLO program will determine in response to the question
or condition being determined, or assertion being made.
A "true" answer means that the condition passed. (yes to question)
A "false" answer means that the condition failed. (no to question)
A "unknown" answer typically means there was insufficient data to
give a definite yes or no to the question.
3. Reason.
This is an informative message stating the reason for the decision being made.
It is not used in used in determining the overall result of the condition, however
it will be used to present an informative message to the GLIF when reviewing a decision
that was evaluated.
4. Weight.
When a decision cannot be determined (e.g. unknown) a weight may be returned
between 0 and 100. it represents how close to yes or no the answer is,
with 0 meaning "no" and 100 meaning "yes". 50 is equivalent to "don't know"
*/
// define our assertion or question
let question:string = 'Is this MALT Lymphoma'
// now evaluate an answer.
//See if we have diagnosis data
let path: String = '1.1.1'
let OBS : Observation = Model.find_observation('Lymphoma_Wizard_Core', path)
let answer:Boolean =
if OBS.isUndefined() then
unknown
else
if OBS.value.equals(Factory.Codedvalue('at0021', 'MO_LymphomaType')) then
true
else
false
endif
endif
// note - due to GELLO language constraints, we are not allowed to assign a
// variable value more than once, so alternative reasons have to be specified
// with sepearate return results.
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'MALT Lymphoma',50)
else
factory.GLIFDecisionResult(question,answer,'Not MALT ',50)
endif
else
factory.GLIFDecisionResult(question,answer,'Diagnosis uncertain',50)
endif
/*
Sample Gello for GLIF decision.
A GLIF decision condition returns a structured result of GELLO type GLIFDecisionResult.
The result has several parts..
1. Question.
This is the question being asked or assertion being made.
It should be stated in such a way as to return a true or false answer.
For example
"Is age is 18 years or older?"
True: patient is 18 or more
False: patient is younger than 18
2. Answer.
This is what the GELLO program will determine in response to the question
or condition being determined, or assertion being made.
A "true" answer means that the condition passed. (yes to question)
A "false" answer means that the condition failed. (no to question)
A "unknown" answer typically means there was insufficient data to
give a definite yes or no to the question.
3. Reason.
This is an informative message stating the reason for the decision being made.
It is not used in used in determining the overall result of the condition, however
it will be used to present an informative message to the GLIF when reviewing a decision
that was evaluated.
4. Weight.
When a decision cannot be determined (e.g. unknown) a weight may be returned
between 0 and 100. it represents how close to yes or no the answer is,
with 0 meaning "no" and 100 meaning "yes". 50 is equivalent to "don't know"
*/
// define our assertion or question
let question:string = 'Is this Waldenstroms Lymphoma'
Let IDL : Set(CodedValue) = Set{
Factory.Codedvalue('at0015^^MO_LymphomaType'),
Factory.CodedValue('at0015^^MO_LymphomaType'),
Factory.CodedValue('at0015^^MO_LymphomaType')
}
// now evaluate an answer.
//See if we have diagnosis data
let path: String = '1.1.1'
let OBS : Observation = Model.find_observation('Lymphoma_Wizard_Core', path)
let answer:Boolean =
if OBS.isUndefined() then
unknown
else
if IDL-> includes(OBS.value) then
true
else
false
endif
endif
// note - due to GELLO language constraints, we are not allowed to assign a
// variable value more than once, so alternative reasons have to be specified
// with sepearate return results.
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'Waldenstroms Lymphoma',50)
else
factory.GLIFDecisionResult(question,answer,'Not Correct type',50)
endif
else
factory.GLIFDecisionResult(question,answer,'Diagnosis uncertain',50)
endif
/*
Sample Gello for GLIF decision.
A GLIF decision condition returns a structured result of GELLO type GLIFDecisionResult.
The result has several parts..
1. Question.
This is the question being asked or assertion being made.
It should be stated in such a way as to return a true or false answer.
For example
"Is age is 18 years or older?"
True: patient is 18 or more
False: patient is younger than 18
2. Answer.
This is what the GELLO program will determine in response to the question
or condition being determined, or assertion being made.
A "true" answer means that the condition passed. (yes to question)
A "false" answer means that the condition failed. (no to question)
A "unknown" answer typically means there was insufficient data to
give a definite yes or no to the question.
3. Reason.
This is an informative message stating the reason for the decision being made.
It is not used in used in determining the overall result of the condition, however
it will be used to present an informative message to the GLIF when reviewing a decision
that was evaluated.
4. Weight.
When a decision cannot be determined (e.g. unknown) a weight may be returned
between 0 and 100. it represents how close to yes or no the answer is,
with 0 meaning "no" and 100 meaning "yes". 50 is equivalent to "don't know"
*/
// define our assertion or question
let question:string = 'Is this Splenic marginal Zone Lymphoma'
// now evaluate an answer.
//See if we have diagnosis data
let path: String = '1.1.1'
let OBS : Observation = Model.find_observation('Lymphoma_Wizard_Core', path)
let answer:Boolean =
if OBS.isUndefined() then
unknown
else
if OBS.value.equals(Factory.Codedvalue('at0016', 'MO_LymphomaType')) then
true
else
false
endif
endif
// note - due to GELLO language constraints, we are not allowed to assign a
// variable value more than once, so alternative reasons have to be specified
// with sepearate return results.
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'SMZ Lymphoma',50)
else
factory.GLIFDecisionResult(question,answer,'Not Follicular',50)
endif
else
factory.GLIFDecisionResult(question,answer,'Diagnosis uncertain',50)
endif
/*
Sample Gello for GLIF decision.
A GLIF decision condition returns a structured result of GELLO type GLIFDecisionResult.
The result has several parts..
1. Question.
This is the question being asked or assertion being made.
It should be stated in such a way as to return a true or false answer.
For example
"Is age is 18 years or older?"
True: patient is 18 or more
False: patient is younger than 18
2. Answer.
This is what the GELLO program will determine in response to the question
or condition being determined, or assertion being made.
A "true" answer means that the condition passed. (yes to question)
A "false" answer means that the condition failed. (no to question)
A "unknown" answer typically means there was insufficient data to
give a definite yes or no to the question.
3. Reason.
This is an informative message stating the reason for the decision being made.
It is not used in used in determining the overall result of the condition, however
it will be used to present an informative message to the GLIF when reviewing a decision
that was evaluated.
4. Weight.
When a decision cannot be determined (e.g. unknown) a weight may be returned
between 0 and 100. it represents how close to yes or no the answer is,
with 0 meaning "no" and 100 meaning "yes". 50 is equivalent to "don't know"
*/
// define our assertion or question
let question:string = 'Is this High Grade Lymphoma'
Let IDL : Set(CodedValue) = Set{
Factory.Codedvalue('at0029^^MO_LymphomaType'),
Factory.CodedValue('at0032^^MO_LymphomaType'),
Factory.CodedValue('at0011^^MO_LymphomaType')
}
// now evaluate an answer.
//See if we have diagnosis data
let path: String = '1.1.1'
let OBS : Observation = Model.find_observation('Lymphoma_Wizard_Core', path)
let answer:Boolean =
if OBS.isUndefined() then
unknown
else
if IDL-> includes(OBS.value) then
true
else
false
endif
endif
// note - due to GELLO language constraints, we are not allowed to assign a
// variable value more than once, so alternative reasons have to be specified
// with sepearate return results.
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'High Grade Lymphoma',50)
else
factory.GLIFDecisionResult(question,answer,'Not Correct type',50)
endif
else
factory.GLIFDecisionResult(question,answer,'Diagnosis uncertain',50)
endif
/*
Sample Gello for GLIF decision.
A GLIF decision condition returns a structured result of GELLO type GLIFDecisionResult.
The result has several parts..
1. Question.
This is the question being asked or assertion being made.
It should be stated in such a way as to return a true or false answer.
For example
"Is age is 18 years or older?"
True: patient is 18 or more
False: patient is younger than 18
2. Answer.
This is what the GELLO program will determine in response to the question
or condition being determined, or assertion being made.
A "true" answer means that the condition passed. (yes to question)
A "false" answer means that the condition failed. (no to question)
A "unknown" answer typically means there was insufficient data to
give a definite yes or no to the question.
3. Reason.
This is an informative message stating the reason for the decision being made.
It is not used in used in determining the overall result of the condition, however
it will be used to present an informative message to the GLIF when reviewing a decision
that was evaluated.
4. Weight.
When a decision cannot be determined (e.g. unknown) a weight may be returned
between 0 and 100. it represents how close to yes or no the answer is,
with 0 meaning "no" and 100 meaning "yes". 50 is equivalent to "don't know"
*/
// define our assertion or question
let question:string = 'Is this Aggressive Lymphoma'
Let IDL : Set(CodedValue) = Set{
Factory.Codedvalue('at0025^^MO_LymphomaType'),
Factory.CodedValue('at0024^^MO_LymphomaType'),
Factory.CodedValue('at0026^^MO_LymphomaType'),
Factory.CodedValue('at0044^^MO_LymphomaType')
}
// now evaluate an answer.
//See if we have diagnosis data
let path: String = '1.1.1'
let OBS : Observation = Model.find_observation('Lymphoma_Wizard_Core', path)
let answer:Boolean =
if OBS.isUndefined() then
unknown
else
if IDL-> includes(OBS.value) then
true
else
false
endif
endif
// note - due to GELLO language constraints, we are not allowed to assign a
// variable value more than once, so alternative reasons have to be specified
// with sepearate return results.
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'Aggressive Lymphoma',50)
else
factory.GLIFDecisionResult(question,answer,'Not Correct type',50)
endif
else
factory.GLIFDecisionResult(question,answer,'Diagnosis uncertain',50)
endif
/*
Sample Gello for GLIF decision.
A GLIF decision condition returns a structured result of GELLO type GLIFDecisionResult.
The result has several parts..
1. Question.
This is the question being asked or assertion being made.
It should be stated in such a way as to return a true or false answer.
For example
"Is age is 18 years or older?"
True: patient is 18 or more
False: patient is younger than 18
2. Answer.
This is what the GELLO program will determine in response to the question
or condition being determined, or assertion being made.
A "true" answer means that the condition passed. (yes to question)
A "false" answer means that the condition failed. (no to question)
A "unknown" answer typically means there was insufficient data to
give a definite yes or no to the question.
3. Reason.
This is an informative message stating the reason for the decision being made.
It is not used in used in determining the overall result of the condition, however
it will be used to present an informative message to the GLIF when reviewing a decision
that was evaluated.
4. Weight.
When a decision cannot be determined (e.g. unknown) a weight may be returned
between 0 and 100. it represents how close to yes or no the answer is,
with 0 meaning "no" and 100 meaning "yes". 50 is equivalent to "don't know"
*/
// define our assertion or question
let question:string = 'Is this Immune deficiency Lymphoma'
Let IDL : Set(CodedValue) = Set{
Factory.Codedvalue('at0056^Immune deficiency LP Disorder^MO_LymphomaType'),
Factory.CodedValue('at0057^Primary immun def^MO_LymphomaType'),
Factory.CodedValue('at0058^HIV related lymphoma^MO_LymphomaType'),
Factory.CodedValue('at0059^Post Transplant^MO_LymphomaType'),
Factory.CodedValue('at0060^Methotrexate associated^MO_LymphomaType')
}
// now evaluate an answer.
//See if we have diagnosis data
let path: String = '1.1.1'
let OBS : Observation = Model.find_observation('Lymphoma_Wizard_Core', path)
let answer:Boolean =
if OBS.isUndefined() then
unknown
else
if IDL-> includes(OBS.value) then
true
else
false
endif
endif
// note - due to GELLO language constraints, we are not allowed to assign a
// variable value more than once, so alternative reasons have to be specified
// with sepearate return results.
if answer <> unknown then
if answer then
factory.GLIFDecisionResult(question,answer,'Immune Deficiency Lymphoma',50)
else
factory.GLIFDecisionResult(question,answer,'Not Correct type',50)
endif
else
factory.GLIFDecisionResult(question,answer,'Diagnosis uncertain',50)
endif
Follicular lymphoma management A
Small lymphocytic lymphoma management
MALT
Lymphoplasmalytic lymphoma (Waldenstrs macroglobulinaemia) management
Splenic marginal zone lymphoma management
High grade lymphoma management A
Aggressive lymphoma management
Immune deficiency associated lymphoma management
Treatment planning
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="13.9.1_files/filelist.xml">
<link rel=Edit-Time-Data href="13.9.1_files/editdata.mso">
<link rel=OLE-Object-Data href="13.9.1_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T04:22:17Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
text-align:center;}
.xl26
{mso-style-parent:style0;
background:#FFCC99;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>8</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>19943</x:Id>
<x:DivID>13.9.1_19943</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\13.9.1.htm"/>
<x:Title>Aggressive T-cell lymphoma management</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=549 style='border-collapse:
collapse;table-layout:fixed;width:412pt'>
<col width=440 style='mso-width-source:userset;mso-width-alt:16091;width:330pt'>
<col class=xl25 width=109 style='mso-width-source:userset;mso-width-alt:3986;
width:82pt'>
<col width=143 style='mso-width-source:userset;mso-width-alt:5229;width:107pt'>
<col width=80 style='mso-width-source:userset;mso-width-alt:2925;width:60pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl26 width=440 style='height:12.75pt;width:330pt'> </td>
<td width=109 style='width:82pt'></td>
</tr>
<tr height=128 style='mso-height-source:userset;height:96.0pt'>
<td height=128 class=xl24 width=440 style='height:96.0pt;width:330pt'>There
are no standard treatment protocols for aggressive T-cell lymphomas. In
general, treatment approaches similar to those used for aggressive B-cell
lymphomas have been used. Several studies have reported inferior outcome for
patients with aggressive T-cell lymphomas when compared to B-cell lymphomas
when stratified for IPI. However, other studies have found that, stage for
stage, the outcome of T-cell and B-cell diffuse large-cell lymphomas was
similar. More intensive therapies are under investigation.</td>
<td class=xl25></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=440 style='width:330pt'></td>
<td width=109 style='width:82pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
Treatment planning
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="16.4.3_files/filelist.xml">
<link rel=Edit-Time-Data href="16.4.3_files/editdata.mso">
<link rel=OLE-Object-Data href="16.4.3_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T04:26:35Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:#99CC00;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>7</x:ActiveRow>
<x:RangeSelection>$A$7:$A$8</x:RangeSelection>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>24672</x:Id>
<x:DivID>16.4.3_24672</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\16.4.3.htm"/>
<x:Title>Post transplant lymphoproliferative disorder</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=445 style='border-collapse:
collapse;table-layout:fixed;width:334pt'>
<col width=445 style='mso-width-source:userset;mso-width-alt:16274;width:334pt'>
<col width=256 style='mso-width-source:userset;mso-width-alt:9362;width:192pt'>
<col width=190 style='mso-width-source:userset;mso-width-alt:6948;width:143pt'>
<col width=192 style='mso-width-source:userset;mso-width-alt:7021;width:144pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=445 style='height:12.75pt;width:334pt'> </td>
</tr>
<tr height=77 style='mso-height-source:userset;height:57.75pt'>
<td height=77 class=xl24 width=445 style='height:57.75pt;width:334pt'>Patients
with post-transplant lymphoproliferative disorder (PTLD) should undergo
standard diagnostic and staging procedures with special attention to
extranodal sites including the allografted organ and/or gut, lung, central
nervous system, kidney.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=445 style='width:334pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="16.4.4.2_files/filelist.xml">
<link rel=Edit-Time-Data href="16.4.4.2_files/editdata.mso">
<link rel=OLE-Object-Data href="16.4.4.2_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T04:27:19Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
.xl26
{mso-style-parent:style0;
background:#99CC00;
mso-pattern:auto none;}
.xl27
{mso-style-parent:style0;
text-align:center;
background:#99CC00;
mso-pattern:auto none;
white-space:normal;}
.xl28
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl29
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>7</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>3653</x:Id>
<x:DivID>16.4.4.2_3653</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\16.4.4.2.htm"/>
<x:Title>Post-transplant lymphoproliferative disorder (PTLD) risk factors (2)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=776 style='border-collapse:
collapse;table-layout:fixed;width:582pt'>
<col width=360 style='mso-width-source:userset;mso-width-alt:13165;width:270pt'>
<col class=xl24 width=64 style='width:48pt'>
<col width=352 style='mso-width-source:userset;mso-width-alt:12873;width:264pt'>
<tr height=38 style='mso-height-source:userset;height:28.5pt'>
<td height=38 class=xl26 width=360 style='height:28.5pt;width:270pt'>Text</td>
<td class=xl27 width=64 style='width:48pt'>Evidence level</td>
<td class=xl26 width=352 style='width:264pt'>References</td>
</tr>
<tr height=9 style='mso-height-source:userset;height:6.75pt'>
<td height=9 style='height:6.75pt'></td>
<td class=xl25></td>
<td></td>
</tr>
<tr height=101 style='mso-height-source:userset;height:75.75pt'>
<td height=101 class=xl28 width=360 style='height:75.75pt;width:270pt'>Use of
OKT3 is the third powerful known risk factor for PTLD.</td>
<td class=xl29 x:num>3</td>
<td class=xl28 width=352 style='width:264pt'>Swinnen LJ, Costanzo-Nordin MR,
Fisher SG, et al. Increased incidence of lymphoproliferative disorder after
immunosuppression with the monoclonal antibody OKT3 in cardiac-transplant
recipients. N Engl J Med 1990; 20;323: 1723.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=360 style='width:270pt'></td>
<td width=64 style='width:48pt'></td>
<td width=352 style='width:264pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="16.4.4.1_files/filelist.xml">
<link rel=Edit-Time-Data href="16.4.4.1_files/editdata.mso">
<link rel=OLE-Object-Data href="16.4.4.1_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T04:27:01Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
background:#99CC00;
mso-pattern:auto none;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
background:#99CC00;
mso-pattern:auto none;
white-space:normal;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl29
{mso-style-parent:style0;
white-space:normal;}
.xl30
{mso-style-parent:style0;
text-align:center;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>5</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>31527</x:Id>
<x:DivID>16.4.4.1_31527</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\16.4.4.1.htm"/>
<x:Title>Post-transplant lymphoproliferative disorder (PTLD) risk factors</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=783 style='border-collapse:
collapse;table-layout:fixed;width:588pt'>
<col width=389 style='mso-width-source:userset;mso-width-alt:14226;width:292pt'>
<col class=xl24 width=60 style='mso-width-source:userset;mso-width-alt:2194;
width:45pt'>
<col width=334 style='mso-width-source:userset;mso-width-alt:12214;width:251pt'>
<tr height=39 style='mso-height-source:userset;height:29.25pt'>
<td height=39 class=xl25 width=389 style='height:29.25pt;width:292pt'>Text</td>
<td class=xl26 width=60 style='width:45pt'>Evidence level</td>
<td class=xl25 width=334 style='width:251pt'>References</td>
</tr>
<tr height=10 style='mso-height-source:userset;height:7.5pt'>
<td height=10 class=xl29 style='height:7.5pt'></td>
<td class=xl30></td>
<td class=xl29></td>
</tr>
<tr height=205 style='mso-height-source:userset;height:153.75pt'>
<td height=205 class=xl27 width=389 style='height:153.75pt;width:292pt'>Two
of the major known risk factors for the development of PTLD are Epstein-Barr
virus (EBV) sero-mismatch and cytomegalovirus (CMV) sero-mismatch (R-, D+).</td>
<td class=xl28 x:num>3</td>
<td class=xl27 width=334 style='width:251pt'>1. Walker RC, Paya CV, Marshall
WF, et al. Pretransplantation seronegative Epstein-Barr virus status is the
primary risk factor for posttransplantation lymphoproliferative disorder in
adult heart, lung, and other solid organ transplantations. J Heart Lung
Transplant 1995; 14: 2141.<br>
2. Manez R, Breinig MC, Linden P, et al. Posttransplant lymphoproliferative
disease in primary Epstein-Barr virus infection after liver transplantation:
the role of cytomegalovirus disease. J Infect Dis 1997; 176: 1462.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=389 style='width:292pt'></td>
<td width=60 style='width:45pt'></td>
<td width=334 style='width:251pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="16.4.5.1_files/filelist.xml">
<link rel=Edit-Time-Data href="16.4.5.1_files/editdata.mso">
<link rel=OLE-Object-Data href="16.4.5.1_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T04:27:38Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl27
{mso-style-parent:style0;
background:#99CC00;
mso-pattern:auto none;}
.xl28
{mso-style-parent:style0;
text-align:center;
background:#99CC00;
mso-pattern:auto none;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>4</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>9718</x:Id>
<x:DivID>16.4.5.1_9718</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\16.4.5.1.htm"/>
<x:Title>Surveillance of post-transplant lymphoproliferative disorder (PTLD) patients</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=810 style='border-collapse:
collapse;table-layout:fixed;width:608pt'>
<col width=365 style='mso-width-source:userset;mso-width-alt:13348;width:274pt'>
<col class=xl24 width=65 style='mso-width-source:userset;mso-width-alt:2377;
width:49pt'>
<col width=380 style='mso-width-source:userset;mso-width-alt:13897;width:285pt'>
<tr height=35 style='mso-height-source:userset;height:26.25pt'>
<td height=35 class=xl27 width=365 style='height:26.25pt;width:274pt'>Text</td>
<td class=xl28 width=65 style='width:49pt'>Evidence level</td>
<td class=xl27 width=380 style='width:285pt'>References</td>
</tr>
<tr height=8 style='mso-height-source:userset;height:6.0pt'>
<td height=8 style='height:6.0pt'></td>
<td class=xl24></td>
<td></td>
</tr>
<tr height=363 style='mso-height-source:userset;height:272.25pt'>
<td height=363 class=xl25 width=365 style='height:272.25pt;width:274pt'>Monitor
EBV viral load serially by quantitative real-time PCR in plasma (preferably
in the context of ongoing research). Monitor for the development of
monoclonal gammopathy.</td>
<td class=xl26 x:num>4</td>
<td class=xl25 width=380 style='width:285pt'>1. Gartner BC, Fischinger J,
Schafer H, Einsele H, Roemer K, Muller-Lantzsch N. Epstein-Barr viral load as
a tool to diagnose and monitor post-transplant lymphoproliferative disease.
Recent Results Cancer Res 2002; 159:494.<br>
2. Wagner HJ, Wessel M, Jabs W, et al. Patients at risk for development of
posttransplant lymphoproliferative disorder: plasma versus peripheral blood
mononuclear cells as material for quantification of Epstein-Barr viral load
by using real-time quantitative polymerase chain reaction. Transplantation
2001; 72: 1012.<br>
3. Orii T, Ohkohchi N, Kikuchi H, et al. Usefulness of quantitative
real-time polymerase chain reaction in following up patients with
Epstein-Barr virus infection after liver transplantation. Clin Transplant
2000; 14: 3087.<br>
4. Badley AD, Portela DF, Patel R, et al. Development of monoclonal
gammopathy precedes the development of Epstein-Barr virus-induced
posttransplant lymphoproliferative disorder. Liver Transpl Surg 1996; 2:
3752.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=365 style='width:274pt'></td>
<td width=65 style='width:49pt'></td>
<td width=380 style='width:285pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="16.4.6.4_files/filelist.xml">
<link rel=Edit-Time-Data href="16.4.6.4_files/editdata.mso">
<link rel=OLE-Object-Data href="16.4.6.4_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T04:29:34Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl27
{mso-style-parent:style0;
background:#99CC00;
mso-pattern:auto none;}
.xl28
{mso-style-parent:style0;
text-align:center;
background:#99CC00;
mso-pattern:auto none;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>7</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>6749</x:Id>
<x:DivID>16.4.6.4_6749</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\16.4.6.4.htm"/>
<x:Title>Management of post-transplant lymphoproliferative disorder (PTLD) patients (4)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=769 style='border-collapse:
collapse;table-layout:fixed;width:577pt'>
<col width=364 style='mso-width-source:userset;mso-width-alt:13312;width:273pt'>
<col class=xl24 width=59 style='mso-width-source:userset;mso-width-alt:2157;
width:44pt'>
<col width=346 style='mso-width-source:userset;mso-width-alt:12653;width:260pt'>
<tr height=34 style='mso-height-source:userset;height:25.5pt'>
<td height=34 class=xl27 width=364 style='height:25.5pt;width:273pt'>Text</td>
<td class=xl28 width=59 style='width:44pt'>Evidence level</td>
<td class=xl27 width=346 style='width:260pt'>References</td>
</tr>
<tr height=11 style='mso-height-source:userset;height:8.25pt'>
<td height=11 style='height:8.25pt'></td>
<td class=xl24></td>
<td></td>
</tr>
<tr height=151 style='mso-height-source:userset;height:113.25pt'>
<td height=151 class=xl25 width=364 style='height:113.25pt;width:273pt'>Standard
combination chemotherapy for aggressive lymphoma should not be delayed in
patients who are not responding to initial strategies.</td>
<td class=xl26 x:num>4</td>
<td class=xl25 width=346 style='width:260pt'>1. Swinnen LJ, Mullen GM, Carr
TJ, Costanzo MR, Fisher RI. Aggressive treatment for postcardiac transplant
lymphoproliferation. Blood 1995; 86: 33330.<br>
2. Mamzer-Bruneel MF, Lome C, Morelon E, et al. Durable remission after
aggressive chemotherapy for very late post-kidney transplant
lymphoproliferation: A report of 16 cases<br>
observed in a single center. J Clin Oncol 2000; 18: 36222.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=364 style='width:273pt'></td>
<td width=59 style='width:44pt'></td>
<td width=346 style='width:260pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="16.4.6.3_files/filelist.xml">
<link rel=Edit-Time-Data href="16.4.6.3_files/editdata.mso">
<link rel=OLE-Object-Data href="16.4.6.3_files/oledata.mso">
<title>Management of post-transplant lymphoproliferative disorder (PTLD)
patients (3)</title>
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T04:29:17Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
background:#99CC00;
mso-pattern:auto none;}
.xl26
{mso-style-parent:style0;
text-align:center;
background:#99CC00;
mso-pattern:auto none;
white-space:normal;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>2</x:ActiveRow>
<x:ActiveCol>5</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=829 style='border-collapse:
collapse;table-layout:fixed;width:623pt'>
<col width=381 style='mso-width-source:userset;mso-width-alt:13933;width:286pt'>
<col class=xl24 width=62 style='mso-width-source:userset;mso-width-alt:2267;
width:47pt'>
<col width=386 style='mso-width-source:userset;mso-width-alt:14116;width:290pt'>
<tr height=33 style='mso-height-source:userset;height:24.75pt'>
<td height=33 class=xl25 width=381 style='height:24.75pt;width:286pt'>Text</td>
<td class=xl26 width=62 style='width:47pt'>Evidence level</td>
<td class=xl25 width=386 style='width:290pt'>References</td>
</tr>
<tr height=7 style='mso-height-source:userset;height:5.25pt'>
<td height=7 style='height:5.25pt'></td>
<td class=xl24></td>
<td></td>
</tr>
<tr height=461 style='mso-height-source:userset;height:345.75pt'>
<td height=461 class=xl27 width=381 style='height:345.75pt;width:286pt'>Additional
therapies that should be considered but the roles of which have not been
clearly defined include systemic antivirals (ganciclovir, acyclovir)1020505
and alpha interferon.</td>
<td class=xl28 x:num>4</td>
<td class=xl27 width=386 style='width:290pt'>1. Boubenider S, Hiesse C, Goupy
C, Kriaa F, Marchand S, Charpentier B. Incidence and consequences of
post-transplantation lymphoproliferative disorders. J Nephrol 1997; 10:
1365.<br>
2. Morrison VA, Dunn DL, Manivel JC, Gajl-Peczalska KJ, Peterson BA.
Clinical characteristics of post-transplant lymphoproliferative disorders. Am
J Med 1994; 97: 144.<br>
3. Pedagogos E, Dowling J, Rockman S, Nicholls K, Fraser I, Walker R.
Lymphoproliferative disorder post renal transplantation: recent experience at
a single centre. Nephrology 1996; 2:1331.<br>
4. Hanto DW, Frizzera G, Gajl-Peczalska KJ, et al. Epstein-Barr
virus-induced B-cell lymphoma after renal transplantation: acyclovir therapy
and transition from polyclonal to monoclonal Bcell proliferation. N Engl J
Med 1982; 306: 913.<br>
5. Orien S, Bernert RA, Logan JL, Lien YH. Remission of posttransplant
lymphoproliferative disorder after interferon alfa therapy. J Am Soc Nephrol
1997; 8: 1483.<br>
6. Shapiro RS, Chauvenet A, McGuire W, et al. Treatment of B-cell
lymphoproliferative disorders with interferon alfa and intravenous gamma
globulin. N Engl J Med 1988; 19;318:1334.<br>
7. Faro A. Interferon-alpha and its effects on post-transplant
lymphoproliferative disorders. Springer Semin Immunopathol 1998; 20:
4256.<br>
8. Davis CL. Interferon and cytotoxic chemotherapy for the treatment of
post-transplant lymphoproliferative disorder. Transpl Infect Dis 2001; 3:
1088.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=381 style='width:286pt'></td>
<td width=62 style='width:47pt'></td>
<td width=386 style='width:290pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="16.4.6.2_files/filelist.xml">
<link rel=Edit-Time-Data href="16.4.6.2_files/editdata.mso">
<link rel=OLE-Object-Data href="16.4.6.2_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T04:28:49Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl26
{mso-style-parent:style0;
text-align:center;
vertical-align:top;
white-space:normal;
mso-text-control:shrinktofit;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
background:#99CC00;
mso-pattern:auto none;}
.xl29
{mso-style-parent:style0;
text-align:center;
vertical-align:top;
background:#99CC00;
mso-pattern:auto none;
white-space:normal;
mso-text-control:shrinktofit;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>10</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>22991</x:Id>
<x:DivID>16.4.6.2_22991</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\16.4.6.2.htm"/>
<x:Title>Management of post-transplant lymphoproliferative disorder (PTLD) patients (2)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=817 style='border-collapse:
collapse;table-layout:fixed;width:613pt'>
<col width=379 style='mso-width-source:userset;mso-width-alt:13860;width:284pt'>
<col class=xl24 width=64 style='width:48pt'>
<col width=374 style='mso-width-source:userset;mso-width-alt:13677;width:281pt'>
<tr height=34 style='height:25.5pt'>
<td height=34 class=xl28 width=379 style='height:25.5pt;width:284pt'>Text</td>
<td class=xl29 width=64 style='width:48pt'>Evidence level</td>
<td class=xl28 width=374 style='width:281pt'>References</td>
</tr>
<tr height=11 style='mso-height-source:userset;height:8.25pt'>
<td height=11 style='height:8.25pt'></td>
<td class=xl26></td>
<td></td>
</tr>
<tr height=245 style='mso-height-source:userset;height:183.75pt'>
<td height=245 class=xl27 width=379 style='height:183.75pt;width:284pt'>Consider
early additional therapy in patients with risk factors for non-response to
reduced immunosuppression (elevated LDH, end organ dysfunction, multi-organ
involvement, late onset PTLD, rapidly progressive disease).</td>
<td class=xl25 x:num>4</td>
<td class=xl27 width=374 style='width:281pt'>1. Herzig KA, Juffs HG, Norris
D, et al. A single-centre experience of post-renal transplant
lymphoproliferative disorder. Transpl Int 2003; 16: 5296.<br>
2. Armitage JM, Kormos RL, Stuart RS, et al. Posttransplant
lymphoproliferative disease in thoracic organ transplant patients: ten years
of cyclosporine-based immunosuppression. J Heart Lung Transplant 1991; 10:
8776.<br>
3. Tsai DE, Hardy CL, Tomaszewski JE, et al. Reduction in immunosuppression
as initial therapy for posttransplant lymphoproliferative disorder: analysis
of prognostic variables and long-term follow-up of 42 adult patients.
Transplantation 2001; 71: 10768.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=379 style='width:284pt'></td>
<td width=64 style='width:48pt'></td>
<td width=374 style='width:281pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="16.4.6.1_files/filelist.xml">
<link rel=Edit-Time-Data href="16.4.6.1_files/editdata.mso">
<link rel=OLE-Object-Data href="16.4.6.1_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T04:28:29Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
background:#99CC00;
mso-pattern:auto none;}
.xl26
{mso-style-parent:style0;
text-align:center;
background:#99CC00;
mso-pattern:auto none;
white-space:normal;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>6</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>18631</x:Id>
<x:DivID>16.4.6.1_18631</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\16.4.6.1.htm"/>
<x:Title>Management of post-transplant lymphoproliferative disorder (PTLD) patients (1)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=819 style='border-collapse:
collapse;table-layout:fixed;width:614pt'>
<col width=380 style='mso-width-source:userset;mso-width-alt:13897;width:285pt'>
<col class=xl24 width=67 style='mso-width-source:userset;mso-width-alt:2450;
width:50pt'>
<col width=372 style='mso-width-source:userset;mso-width-alt:13604;width:279pt'>
<tr height=34 style='mso-height-source:userset;height:25.5pt'>
<td height=34 class=xl25 width=380 style='height:25.5pt;width:285pt'>Text</td>
<td class=xl26 width=67 style='width:50pt'>Evidence level</td>
<td class=xl25 width=372 style='width:279pt'>References</td>
</tr>
<tr height=9 style='mso-height-source:userset;height:6.75pt'>
<td height=9 style='height:6.75pt'></td>
<td class=xl24></td>
<td></td>
</tr>
<tr height=294 style='mso-height-source:userset;height:220.5pt'>
<td height=294 class=xl27 width=380 style='height:220.5pt;width:285pt'>All
patients with PTLD should have baseline immunosuppression substantially
reduced or ceased as the initial therapeutic strategy.</td>
<td class=xl28 x:num>4</td>
<td class=xl27 width=372 style='width:279pt'>1. Cockfield SM. Identifying the
patient at risk for post-transplant lymphoproliferative disorder. Transpl
Infect Dis 2001; 3: 70.<br>
2. Paya CV, Fung JJ, Nalesnik MA, et al. Epstein-Barr virus-induced
posttransplant lymphoproliferative disorders. ASTS/ASTP EBV-PTLD Task Force
and The Mayo Clinic Organized International Consensus Development Meeting.
Transplantation 1999; 68: 151725.<br>
3. Hanson MN, Morrison VA, Peterson BA, et al. Posttransplant T-cell
lymphoproliferative disorders an aggressive, late complication of
solid-organ transplantation. Blood 1996; 88: 36263.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=380 style='width:285pt'></td>
<td width=67 style='width:50pt'></td>
<td width=372 style='width:279pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="16.4.6_files/filelist.xml">
<link rel=Edit-Time-Data href="16.4.6_files/editdata.mso">
<link rel=OLE-Object-Data href="16.4.6_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T04:28:07Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:#99CC00;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>6</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>15789</x:Id>
<x:DivID>16.4.6_15789</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\16.4.6.htm"/>
<x:Title>Therapy of PTLD</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=572 style='border-collapse:
collapse;table-layout:fixed;width:429pt'>
<col width=572 style='mso-width-source:userset;mso-width-alt:20918;width:429pt'>
<col width=256 style='mso-width-source:userset;mso-width-alt:9362;width:192pt'>
<col width=190 style='mso-width-source:userset;mso-width-alt:6948;width:143pt'>
<col width=192 style='mso-width-source:userset;mso-width-alt:7021;width:144pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=572 style='height:12.75pt;width:429pt'> </td>
</tr>
<tr height=243 style='mso-height-source:userset;height:182.25pt'>
<td height=243 class=xl24 width=572 style='height:182.25pt;width:429pt'>There
is no standard approach. Early diagnosis and use of appropriate therapies is
essential to the successful treatment and management of PTLDs. Treatment
should be tailored to the<span style='mso-spacerun:yes'></span>specific
form of disease in the individual patient. Most centres follow a step-wise
approach, with the initial intervention influenced by the extent of disease
and the degree of acute illness of the patient. This results in a diversity
of modifications and makes it difficult to compare therapies. Therapy for
PTLD includes:<br>
reduction of immunosuppression<br>
antiviral therapy<br>
cytokine therapy, for example, interferon<br>
conventional chemotherapy<br>
monoclonal antibody<br>
surgical excision<br>
radiotherapy<br>
cellular immunotherapy</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=572 style='width:429pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="16.4.6.8_files/filelist.xml">
<link rel=Edit-Time-Data href="16.4.6.8_files/editdata.mso">
<link rel=OLE-Object-Data href="16.4.6.8_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T04:30:53Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
background:#99CC00;
mso-pattern:auto none;}
.xl26
{mso-style-parent:style0;
text-align:center;
background:#99CC00;
mso-pattern:auto none;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>6</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>12435</x:Id>
<x:DivID>16.4.6.8_12435</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\16.4.6.8.htm"/>
<x:Title>Management of post-transplant lymphoproliferative disorder (PTLD) patients (8)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=804 style='border-collapse:
collapse;table-layout:fixed;width:603pt'>
<col width=362 style='mso-width-source:userset;mso-width-alt:13238;width:272pt'>
<col class=xl24 width=95 style='mso-width-source:userset;mso-width-alt:3474;
width:71pt'>
<col width=347 style='mso-width-source:userset;mso-width-alt:12690;width:260pt'>
<tr height=20 style='mso-height-source:userset;height:15.0pt'>
<td height=20 class=xl25 width=362 style='height:15.0pt;width:272pt'>Text</td>
<td class=xl26 width=95 style='width:71pt'>Evidence level</td>
<td class=xl25 width=347 style='width:260pt'>References</td>
</tr>
<tr height=10 style='mso-height-source:userset;height:7.5pt'>
<td height=10 style='height:7.5pt'></td>
<td class=xl24></td>
<td></td>
</tr>
<tr height=183 style='mso-height-source:userset;height:137.25pt'>
<td height=183 class=xl27 width=362 style='height:137.25pt;width:272pt'>Adoptive
immunotherapy with autologous EBV-specific CTL should be considered for solid
organ PTLD patients in the context of continuing clinical research.</td>
<td class=xl28 x:num>4</td>
<td class=xl27 width=347 style='width:260pt'>1. Haque T, Amlot PL, Helling N,
et al. Reconstitution of EBV-specific T cell immunity in solid organ
transplant recipients. J Immunol 1998; 160: 6204.<br>
2. Khanna R, Bell S, Sherritt M, et al. Activation and adoptive transfer of
Epstein-Barr virusspecific cytotoxic T cells in solid organ transplant
patients with posttransplant lymphoproliferative disease. Proc Natl Acad Sci
U S A 1999; 96: 10391.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=362 style='width:272pt'></td>
<td width=95 style='width:71pt'></td>
<td width=347 style='width:260pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="16.4.6.7_files/filelist.xml">
<link rel=Edit-Time-Data href="16.4.6.7_files/editdata.mso">
<link rel=OLE-Object-Data href="16.4.6.7_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T04:30:29Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
background:#99CC00;
mso-pattern:auto none;}
.xl26
{mso-style-parent:style0;
text-align:center;
background:#99CC00;
mso-pattern:auto none;}
.xl27
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl28
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>12</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>7601</x:Id>
<x:DivID>16.4.6.7_7601</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\16.4.6.7.htm"/>
<x:Title>Management of post-transplant lymphoproliferative disorder (PTLD) patients (7)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=865 style='border-collapse:
collapse;table-layout:fixed;width:649pt'>
<col width=367 style='mso-width-source:userset;mso-width-alt:13421;width:275pt'>
<col class=xl24 width=94 style='mso-width-source:userset;mso-width-alt:3437;
width:71pt'>
<col width=404 style='mso-width-source:userset;mso-width-alt:14774;width:303pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=367 style='height:12.75pt;width:275pt'>Text</td>
<td class=xl26 width=94 style='width:71pt'>Evidence level</td>
<td class=xl25 width=404 style='width:303pt'>References</td>
</tr>
<tr height=12 style='mso-height-source:userset;height:9.0pt'>
<td height=12 style='height:9.0pt'></td>
<td class=xl24></td>
<td></td>
</tr>
<tr height=137 style='mso-height-source:userset;height:102.75pt'>
<td height=137 class=xl27 width=367 style='height:102.75pt;width:275pt'>Adoptive
immunotherapy with allogeneic EBV-specific CTL should be considered in
post-BMT PTLD.</td>
<td class=xl28 x:num>4</td>
<td class=xl27 width=404 style='width:303pt'>Rooney CM, Smith CA, Ng CY, et
al. Use of gene-modified virus-specific T lymphocytes to control
Epstein-Barr-virus-related lymphoproliferation. Lancet 1995; 345: 93.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=367 style='width:275pt'></td>
<td width=94 style='width:71pt'></td>
<td width=404 style='width:303pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="16.4.6.6_files/filelist.xml">
<link rel=Edit-Time-Data href="16.4.6.6_files/editdata.mso">
<link rel=OLE-Object-Data href="16.4.6.6_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T04:30:10Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl27
{mso-style-parent:style0;
background:#99CC00;
mso-pattern:auto none;}
.xl28
{mso-style-parent:style0;
text-align:center;
background:#99CC00;
mso-pattern:auto none;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>6</x:ActiveRow>
<x:ActiveCol>5</x:ActiveCol>
<x:RangeSelection>$E$7:$F$7</x:RangeSelection>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>21598</x:Id>
<x:DivID>16.4.6.6_21598</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\16.4.6.6.htm"/>
<x:Title>Management of post-transplant lymphoproliferative disorder (PTLD) patients (6)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=751 style='border-collapse:
collapse;table-layout:fixed;width:564pt'>
<col width=354 style='mso-width-source:userset;mso-width-alt:12946;width:266pt'>
<col class=xl24 width=64 style='width:48pt'>
<col width=333 style='mso-width-source:userset;mso-width-alt:12178;width:250pt'>
<tr height=37 style='mso-height-source:userset;height:27.75pt'>
<td height=37 class=xl27 width=354 style='height:27.75pt;width:266pt'>Text</td>
<td class=xl28 width=64 style='width:48pt'>Evidence level</td>
<td class=xl27 width=333 style='width:250pt'>References</td>
</tr>
<tr height=11 style='mso-height-source:userset;height:8.25pt'>
<td height=11 style='height:8.25pt'></td>
<td class=xl24></td>
<td></td>
</tr>
<tr height=194 style='mso-height-source:userset;height:145.5pt'>
<td height=194 class=xl25 width=354 style='height:145.5pt;width:266pt'>Radiation
may contribute to the management of PTLD and should be considered in the same
settings as non-PTLD lymphomas.</td>
<td class=xl26 x:num>4</td>
<td class=xl25 width=333 style='width:250pt'>1. Hanto DW, Frizzera G,
Gajl-Peczalska KJ, et al. Acyclovir therapy of Epstein-Barr virus induced
posttransplant lymphoproliferative disease. Transplant Proc 1985; 17:
892.<br>
2. Swinnen LJ, Mullen GM, Carr TJ, Costanzo MR, Fisher RI. Aggressive treatment
for postcardiac transplant lymphoproliferation. Blood 1995; 86: 33330.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=354 style='width:266pt'></td>
<td width=64 style='width:48pt'></td>
<td width=333 style='width:250pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="16.4.6.5_files/filelist.xml">
<link rel=Edit-Time-Data href="16.4.6.5_files/editdata.mso">
<link rel=OLE-Object-Data href="16.4.6.5_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T04:29:51Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
text-align:center;}
.xl25
{mso-style-parent:style0;
vertical-align:top;
white-space:normal;}
.xl26
{mso-style-parent:style0;
text-align:center;
vertical-align:top;}
.xl27
{mso-style-parent:style0;
background:#99CC00;
mso-pattern:auto none;}
.xl28
{mso-style-parent:style0;
text-align:center;
background:#99CC00;
mso-pattern:auto none;
white-space:normal;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>7</x:ActiveRow>
<x:ActiveCol>2</x:ActiveCol>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>17219</x:Id>
<x:DivID>16.4.6.5_17219</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\16.4.6.5.htm"/>
<x:Title>Management of post-transplant lymphoproliferative disorder (PTLD) patients (5)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=770 style='border-collapse:
collapse;table-layout:fixed;width:578pt'>
<col width=365 style='mso-width-source:userset;mso-width-alt:13348;width:274pt'>
<col class=xl24 width=65 style='mso-width-source:userset;mso-width-alt:2377;
width:49pt'>
<col width=340 style='mso-width-source:userset;mso-width-alt:12434;width:255pt'>
<tr height=36 style='mso-height-source:userset;height:27.0pt'>
<td height=36 class=xl27 width=365 style='height:27.0pt;width:274pt'>Text</td>
<td class=xl28 width=65 style='width:49pt'>Evidence level</td>
<td class=xl27 width=340 style='width:255pt'>References</td>
</tr>
<tr height=10 style='mso-height-source:userset;height:7.5pt'>
<td height=10 style='height:7.5pt'></td>
<td class=xl24></td>
<td></td>
</tr>
<tr height=348 style='mso-height-source:userset;height:261.0pt'>
<td height=348 class=xl25 width=365 style='height:261.0pt;width:274pt'>Rituximab
is an active agent and should be considered as an additional therapeutic
modality.</td>
<td class=xl26 x:num>4</td>
<td class=xl25 width=340 style='width:255pt'>1. Grillo-Lopez AJ, Lynch J,
Coiffier B, et al. Rituximab therapy of lymphoproliferative disorders in
imunosuppressed patients. Ann Oncol 1999; 10: 179.<br>
2. Milpied N, Vasseur B, Parquet N, et al. Humanized anti-CD20 monoclonal
antibody (rituximab) in post transplant B-lymphoproliferative disorder: a
retrospective analysis on 32 patients. Ann Oncol 2000; 11 Suppl
1:113.<br>
3. Faye A, Quartier P, Reguerre Y, et al. Chimaeric anti-CD20 monoclonal
antibody (rituximab) in post-transplant B-lymphoproliferative disorder
following stem cell transplantation in children. Br J Haematol 2001; 115:
112.<br>
4. Serinet MO, Jacquemin E, Habes D, Debray D, Fabre M, Bernard O.
Anti-CD20 monoclonal antibody (rituximab) treatment for Epstein-Barr virus-associated,
B-cell lymphoproliferative disease in pediatric liver transplant recipients.
J Pediatr Gastroenterol Nutr 2002; 34: 3893.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=365 style='width:274pt'></td>
<td width=65 style='width:49pt'></td>
<td width=340 style='width:255pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
Treatment planning
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="13.4.0.1_files/filelist.xml">
<link rel=Edit-Time-Data href="13.4.0.1_files/editdata.mso">
<link rel=OLE-Object-Data href="13.4.0.1_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T05:43:00Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:#FFCC99;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>4</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>24437</x:Id>
<x:DivID>13.4.0.1_24437</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\13.4.0.1.htm"/>
<x:Title>Aggressive lymphoma - staging (1)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=470 style='border-collapse:
collapse;table-layout:fixed;width:353pt'>
<col width=470 style='mso-width-source:userset;mso-width-alt:17188;width:353pt'>
<col width=126 style='mso-width-source:userset;mso-width-alt:4608;width:95pt'>
<col width=110 style='mso-width-source:userset;mso-width-alt:4022;width:83pt'>
<col width=273 style='mso-width-source:userset;mso-width-alt:9984;width:205pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=470 style='height:12.75pt;width:353pt'> </td>
</tr>
<tr height=30 style='mso-height-source:userset;height:22.5pt'>
<td height=30 class=xl24 width=470 style='height:22.5pt;width:353pt'>Radiology:
chest x-ray, CT scan of chest, abdomen and pelvis.</td>
</tr>
<tr height=238 style='height:178.5pt;mso-xlrowspan:14'>
<td height=238 style='height:178.5pt'></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl24 style='height:12.75pt'></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=470 style='width:353pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="13.4.0.2_files/filelist.xml">
<link rel=Edit-Time-Data href="13.4.0.2_files/editdata.mso">
<link rel=OLE-Object-Data href="13.4.0.2_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T05:43:27Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:#FFCC99;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>6</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>26979</x:Id>
<x:DivID>13.4.0.2_26979</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\13.4.0.2.htm"/>
<x:Title>Aggressive lymphoma - staging (2)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=456 style='border-collapse:
collapse;table-layout:fixed;width:342pt'>
<col width=456 style='mso-width-source:userset;mso-width-alt:16676;width:342pt'>
<col width=126 style='mso-width-source:userset;mso-width-alt:4608;width:95pt'>
<col width=110 style='mso-width-source:userset;mso-width-alt:4022;width:83pt'>
<col width=273 style='mso-width-source:userset;mso-width-alt:9984;width:205pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=456 style='height:12.75pt;width:342pt'> </td>
</tr>
<tr height=24 style='mso-height-source:userset;height:18.0pt'>
<td height=24 class=xl24 width=456 style='height:18.0pt;width:342pt'>Pathology:
full blood count, routine biochemistry including LDH and uric acid.</td>
</tr>
<tr height=238 style='height:178.5pt;mso-xlrowspan:14'>
<td height=238 style='height:178.5pt'></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl24 style='height:12.75pt'></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=456 style='width:342pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="13.4.0.3_files/filelist.xml">
<link rel=Edit-Time-Data href="13.4.0.3_files/editdata.mso">
<link rel=OLE-Object-Data href="13.4.0.3_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T05:44:56Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:#FFCC99;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>11</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>29064</x:Id>
<x:DivID>13.4.0.3_29064</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\13.4.0.3.htm"/>
<x:Title>Aggressive lymphoma - staging (3)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=506 style='border-collapse:
collapse;table-layout:fixed;width:380pt'>
<col width=506 style='mso-width-source:userset;mso-width-alt:18505;width:380pt'>
<col width=126 style='mso-width-source:userset;mso-width-alt:4608;width:95pt'>
<col width=110 style='mso-width-source:userset;mso-width-alt:4022;width:83pt'>
<col width=273 style='mso-width-source:userset;mso-width-alt:9984;width:205pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=506 style='height:12.75pt;width:380pt'> </td>
</tr>
<tr height=67 style='mso-height-source:userset;height:50.25pt'>
<td height=67 class=xl24 width=506 style='height:50.25pt;width:380pt'>Diagnostic
lumbar puncture in certain circumstances (paranasal sinus presentation,
testicular lymphoma, involvement of bone marrow, more than two adverse
parameters according to IPI).</td>
</tr>
<tr height=238 style='height:178.5pt;mso-xlrowspan:14'>
<td height=238 style='height:178.5pt'></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl24 style='height:12.75pt'></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=506 style='width:380pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="13.4.0.4_files/filelist.xml">
<link rel=Edit-Time-Data href="13.4.0.4_files/editdata.mso">
<link rel=OLE-Object-Data href="13.4.0.4_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T05:45:15Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:#FFCC99;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>5</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>31162</x:Id>
<x:DivID>13.4.0.4_31162</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\13.4.0.4.htm"/>
<x:Title>Aggressive lymphoma - staging (4)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=542 style='border-collapse:
collapse;table-layout:fixed;width:407pt'>
<col width=542 style='mso-width-source:userset;mso-width-alt:19821;width:407pt'>
<col width=126 style='mso-width-source:userset;mso-width-alt:4608;width:95pt'>
<col width=110 style='mso-width-source:userset;mso-width-alt:4022;width:83pt'>
<col width=273 style='mso-width-source:userset;mso-width-alt:9984;width:205pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=542 style='height:12.75pt;width:407pt'> </td>
</tr>
<tr height=67 style='mso-height-source:userset;height:50.25pt'>
<td height=67 class=xl24 width=542 style='height:50.25pt;width:407pt'>Functional
imaging gallium and/or PET scanning. Evolving data suggest that PET
scanning may be more sensitive than gallium scanning for the staging of
patients with lymphoma.</td>
</tr>
<tr height=238 style='height:178.5pt;mso-xlrowspan:14'>
<td height=238 style='height:178.5pt'></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl24 style='height:12.75pt'></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=542 style='width:407pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
Aggressive lymphoma management
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.5.1_files/filelist.xml">
<link rel=Edit-Time-Data href="12.5.1_files/editdata.mso">
<link rel=OLE-Object-Data href="12.5.1_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T05:51:02Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:#99CCFF;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>8</x:ActiveRow>
<x:RangeSelection>$A$8:$A$9</x:RangeSelection>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>21281</x:Id>
<x:DivID>12.5.1_21281</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.5.1.htm"/>
<x:Title>Reconsider diagnosis</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=465 style='border-collapse:
collapse;table-layout:fixed;width:349pt'>
<col width=465 style='mso-width-source:userset;mso-width-alt:17005;width:349pt'>
<col width=273 style='mso-width-source:userset;mso-width-alt:9984;width:205pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=465 style='height:12.75pt;width:349pt'> </td>
</tr>
<tr height=108 style='mso-height-source:userset;height:81.0pt'>
<td height=108 class=xl24 width=465 style='height:81.0pt;width:349pt'>The
major issue with patients considered to have small lymphocytic lymphoma is
the establishment of an accurate definitive diagnosis, as distinction from
other diffuse mature B-cell lymphoproliferative disorders (lymphoplasmacytic
lymphoma, marginal zone B-cell lymphoma, and mantle-cell lymphoma) is
critical.</td>
</tr>
<tr height=238 style='height:178.5pt;mso-xlrowspan:14'>
<td height=238 style='height:178.5pt'></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl24 style='height:12.75pt'></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=465 style='width:349pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.5.2_files/filelist.xml">
<link rel=Edit-Time-Data href="12.5.2_files/editdata.mso">
<link rel=OLE-Object-Data href="12.5.2_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T05:51:19Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:#99CCFF;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>4</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>27150</x:Id>
<x:DivID>12.5.2_27150</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.5.2.htm"/>
<x:Title>Small lymphocytic lymphoma management (1)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=461 style='border-collapse:
collapse;table-layout:fixed;width:346pt'>
<col width=461 style='mso-width-source:userset;mso-width-alt:16859;width:346pt'>
<col width=126 style='mso-width-source:userset;mso-width-alt:4608;width:95pt'>
<col width=110 style='mso-width-source:userset;mso-width-alt:4022;width:83pt'>
<col width=273 style='mso-width-source:userset;mso-width-alt:9984;width:205pt'>
<tr height=24 style='mso-height-source:userset;height:18.0pt'>
<td height=24 class=xl25 width=461 style='height:18.0pt;width:346pt'> </td>
</tr>
<tr height=58 style='mso-height-source:userset;height:43.5pt'>
<td height=58 class=xl24 width=461 style='height:43.5pt;width:346pt'>Those
rare patients who present with truly localised disease after complete staging
should be managed as described for localised nodal marginal zone B-cell
lymphoma, if isolated nodal involvement is present.</td>
</tr>
<tr height=238 style='height:178.5pt;mso-xlrowspan:14'>
<td height=238 style='height:178.5pt'></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl24 style='height:12.75pt'></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=461 style='width:346pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.5.3_files/filelist.xml">
<link rel=Edit-Time-Data href="12.5.3_files/editdata.mso">
<link rel=OLE-Object-Data href="12.5.3_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T05:51:39Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:#99CCFF;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>8</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>29426</x:Id>
<x:DivID>12.5.3_29426</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.5.3.htm"/>
<x:Title>Small lymphocytic lymphoma management (2)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=459 style='border-collapse:
collapse;table-layout:fixed;width:344pt'>
<col width=459 style='mso-width-source:userset;mso-width-alt:16786;width:344pt'>
<col width=126 style='mso-width-source:userset;mso-width-alt:4608;width:95pt'>
<col width=110 style='mso-width-source:userset;mso-width-alt:4022;width:83pt'>
<col width=273 style='mso-width-source:userset;mso-width-alt:9984;width:205pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=459 style='height:12.75pt;width:344pt'> </td>
</tr>
<tr height=76 style='mso-height-source:userset;height:57.0pt'>
<td height=76 class=xl24 width=459 style='height:57.0pt;width:344pt'>Those
rare patients who present with truly localised disease after complete staging
should be managed as described for localised extranodal marginal zone B-cell
lymphoma of mucosa-associated lymphoid tissue if isolated mucosal involvement
is present.</td>
</tr>
<tr height=238 style='height:178.5pt;mso-xlrowspan:14'>
<td height=238 style='height:178.5pt'></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl24 style='height:12.75pt'></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=459 style='width:344pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.5.4_files/filelist.xml">
<link rel=Edit-Time-Data href="12.5.4_files/editdata.mso">
<link rel=OLE-Object-Data href="12.5.4_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T05:51:54Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:#99CCFF;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>4</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>3630</x:Id>
<x:DivID>12.5.4_3630</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.5.4.htm"/>
<x:Title>Small lymphocytic lymphoma management (3)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=411 style='border-collapse:
collapse;table-layout:fixed;width:308pt'>
<col width=411 style='mso-width-source:userset;mso-width-alt:15030;width:308pt'>
<col width=126 style='mso-width-source:userset;mso-width-alt:4608;width:95pt'>
<col width=110 style='mso-width-source:userset;mso-width-alt:4022;width:83pt'>
<col width=273 style='mso-width-source:userset;mso-width-alt:9984;width:205pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=411 style='height:12.75pt;width:308pt'> </td>
</tr>
<tr height=69 style='mso-height-source:userset;height:51.75pt'>
<td height=69 class=xl24 width=411 style='height:51.75pt;width:308pt'>Those
with advanced-stage disease (stage IV, whether or not leukaemic involvement
is present) should be managed according to guidelines for CLL.</td>
</tr>
<tr height=238 style='height:178.5pt;mso-xlrowspan:14'>
<td height=238 style='height:178.5pt'></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl24 style='height:12.75pt'></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=411 style='width:308pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
Treatment planning
Treatment planning
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.10.1_files/filelist.xml">
<link rel=Edit-Time-Data href="12.10.1_files/editdata.mso">
<link rel=OLE-Object-Data href="12.10.1_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T05:58:33Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:#99CCFF;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>6</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>22394</x:Id>
<x:DivID>12.10.1_22394</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.10.1.htm"/>
<x:Title>Survival and prognostic factors</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=408 style='border-collapse:
collapse;table-layout:fixed;width:306pt'>
<col width=408 style='mso-width-source:userset;mso-width-alt:14921;width:306pt'>
<col width=126 style='mso-width-source:userset;mso-width-alt:4608;width:95pt'>
<col width=110 style='mso-width-source:userset;mso-width-alt:4022;width:83pt'>
<col width=273 style='mso-width-source:userset;mso-width-alt:9984;width:205pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=408 style='height:12.75pt;width:306pt'> </td>
</tr>
<tr height=57 style='mso-height-source:userset;height:42.75pt'>
<td height=57 class=xl24 width=408 style='height:42.75pt;width:306pt'>The
median survival of patients is reported to be about thirteen years. Adverse
prognostic factors include: older age, anaemia, thrombocytopenia, and
lymphocytosis.</td>
</tr>
<tr height=238 style='height:178.5pt;mso-xlrowspan:14'>
<td height=238 style='height:178.5pt'></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl24 style='height:12.75pt'></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=408 style='width:306pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.10.3_files/filelist.xml">
<link rel=Edit-Time-Data href="12.10.3_files/editdata.mso">
<link rel=OLE-Object-Data href="12.10.3_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T05:59:09Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:#99CCFF;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>5</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>32009</x:Id>
<x:DivID>12.10.3_32009</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.10.3.htm"/>
<x:Title>Splenic marginal zone lymphoma - key points (2)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=499 style='border-collapse:
collapse;table-layout:fixed;width:374pt'>
<col width=499 style='mso-width-source:userset;mso-width-alt:18249;width:374pt'>
<col width=126 style='mso-width-source:userset;mso-width-alt:4608;width:95pt'>
<col width=110 style='mso-width-source:userset;mso-width-alt:4022;width:83pt'>
<col width=273 style='mso-width-source:userset;mso-width-alt:9984;width:205pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=499 style='height:12.75pt;width:374pt'> </td>
</tr>
<tr height=63 style='mso-height-source:userset;height:47.25pt'>
<td height=63 class=xl24 width=499 style='height:47.25pt;width:374pt'>It is
recommended that patients be screened for hepatitis C. Where active hepatitis
C is the underlying immunological precipitant for their lymphoma, specific
treatment of the hepatitis C can be associated with significant regression of
the lymphoma.</td>
</tr>
<tr height=238 style='height:178.5pt;mso-xlrowspan:14'>
<td height=238 style='height:178.5pt'></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl24 style='height:12.75pt'></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=499 style='width:374pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.10.2_files/filelist.xml">
<link rel=Edit-Time-Data href="12.10.2_files/editdata.mso">
<link rel=OLE-Object-Data href="12.10.2_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T05:58:54Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:#99CCFF;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>4</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>29323</x:Id>
<x:DivID>12.10.2_29323</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.10.2.htm"/>
<x:Title>Splenic marginal zone lymphoma - key points (1)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=404 style='border-collapse:
collapse;table-layout:fixed;width:303pt'>
<col width=404 style='mso-width-source:userset;mso-width-alt:14774;width:303pt'>
<col width=126 style='mso-width-source:userset;mso-width-alt:4608;width:95pt'>
<col width=110 style='mso-width-source:userset;mso-width-alt:4022;width:83pt'>
<col width=273 style='mso-width-source:userset;mso-width-alt:9984;width:205pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=404 style='height:12.75pt;width:303pt'> </td>
</tr>
<tr height=58 style='mso-height-source:userset;height:43.5pt'>
<td height=58 class=xl24 width=404 style='height:43.5pt;width:303pt'>It is
reasonable to follow, without active intervention, patients who are
asymptomatic with stable lymphocytosis and minor, stable and asymptomatic
cytopenias.</td>
</tr>
<tr height=238 style='height:178.5pt;mso-xlrowspan:14'>
<td height=238 style='height:178.5pt'></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl24 style='height:12.75pt'></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=404 style='width:303pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.10.4_files/filelist.xml">
<link rel=Edit-Time-Data href="12.10.4_files/editdata.mso">
<link rel=OLE-Object-Data href="12.10.4_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T05:59:25Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:#99CCFF;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>11</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>1662</x:Id>
<x:DivID>12.10.4_1662</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.10.4.htm"/>
<x:Title>Splenic marginal zone lymphoma - key points (3)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=469 style='border-collapse:
collapse;table-layout:fixed;width:352pt'>
<col width=469 style='mso-width-source:userset;mso-width-alt:17152;width:352pt'>
<col width=126 style='mso-width-source:userset;mso-width-alt:4608;width:95pt'>
<col width=110 style='mso-width-source:userset;mso-width-alt:4022;width:83pt'>
<col width=273 style='mso-width-source:userset;mso-width-alt:9984;width:205pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=469 style='height:12.75pt;width:352pt'> </td>
</tr>
<tr height=123 style='mso-height-source:userset;height:92.25pt'>
<td height=123 class=xl24 width=469 style='height:92.25pt;width:352pt'>Where
patients have progressive or symptomatic splenomegaly, even in the context of
significant marrow infiltration, splenectomy is the preferred therapy, where
this can be performed safely. Splenectomy results in favourable clinical
response in ~90% of patients. About 50% will never require any further
therapy. Patients who are initially treated with splenectomy are reported to
have a superior likelihood of survival than those initially treated with
chemotherapy, although selection bias cannot be excluded in these
retrospective comparisons.</td>
</tr>
<tr height=238 style='height:178.5pt;mso-xlrowspan:14'>
<td height=238 style='height:178.5pt'></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl24 style='height:12.75pt'></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=469 style='width:352pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="12.10.5_files/filelist.xml">
<link rel=Edit-Time-Data href="12.10.5_files/editdata.mso">
<link rel=OLE-Object-Data href="12.10.5_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T05:59:40Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:#99CCFF;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
<x:PublishObjects>
<x:PublishObject>
<x:Id>3802</x:Id>
<x:DivID>12.10.5_3802</x:DivID>
<x:SourceType>SourceSheet</x:SourceType>
<x:HtmlType>HtmlStatic</x:HtmlType>
<x:Location
HRef="C:\Documents and Settings\Peter Scott\My Documents\MO work\Lymphoma\ITOL\HTML\Guidelines\12.10.5.htm"/>
<x:Title>Splenic marginal zone lymphoma - key points (3)</x:Title>
</x:PublishObject>
</x:PublishObjects>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=527 style='border-collapse:
collapse;table-layout:fixed;width:395pt'>
<col width=527 style='mso-width-source:userset;mso-width-alt:19273;width:395pt'>
<col width=126 style='mso-width-source:userset;mso-width-alt:4608;width:95pt'>
<col width=110 style='mso-width-source:userset;mso-width-alt:4022;width:83pt'>
<col width=273 style='mso-width-source:userset;mso-width-alt:9984;width:205pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=527 style='height:12.75pt;width:395pt'> </td>
</tr>
<tr height=76 style='mso-height-source:userset;height:57.0pt'>
<td height=76 class=xl24 width=527 style='height:57.0pt;width:395pt'>Where
systemic chemotherapy is required for disease progression following
splenectomy, or for symptomatic extra-splenic disease, either single-agent
alkylating agents such as chlorambucil or fludarabine are reasonable choices,
based on limited non-comparative data. CHOP does not appear superior to
simpler alkylating agent therapy.</td>
</tr>
<tr height=238 style='height:178.5pt;mso-xlrowspan:14'>
<td height=238 style='height:178.5pt'></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl24 style='height:12.75pt'></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=527 style='width:395pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
Treatment planning
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="9.5_files/filelist.xml">
<link rel=Edit-Time-Data href="9.5_files/editdata.mso">
<link rel=OLE-Object-Data href="9.5_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T06:05:32Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:yellow;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Print>
<x:ValidPrinterInfo/>
<x:PaperSizeIndex>9</x:PaperSizeIndex>
<x:HorizontalResolution>-3</x:HorizontalResolution>
<x:VerticalResolution>0</x:VerticalResolution>
</x:Print>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>5</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=698 style='border-collapse:
collapse;table-layout:fixed;width:524pt'>
<col width=698 style='mso-width-source:userset;mso-width-alt:25526;width:524pt'>
<col width=256 style='mso-width-source:userset;mso-width-alt:9362;width:192pt'>
<col width=190 style='mso-width-source:userset;mso-width-alt:6948;width:143pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=698 style='height:12.75pt;width:524pt'> </td>
</tr>
<tr height=162 style='mso-height-source:userset;height:121.5pt'>
<td height=162 class=xl24 width=698 style='height:121.5pt;width:524pt'>In the
elderly, common causes of weight loss are depression, malignant disease and
benign<br>
gastrointestinal disease. By contrast, in younger individuals, diabetes,
hyperthyroidism, psychiatric<br>
disturbance, infection and/or lymphoma need to be considered. Patients with
fever and night sweats<br>
may have either malignancy or chronic infection. Objective confirmation
that weight loss has<br>
occurred is important, with a focus on signs or symptoms that are
associated with systemic disease<br>
that may cause weight loss.<br>
Apart from general routine physical examination, a search for
lymphadenopathy and/or splenomegaly<br>
should be made. Key laboratory investigations will be a full blood count,
serum LDH, ESR, chest xray<br>
and, where appropriate, CT examination of the abdomen and bone marrow
biopsy.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=698 style='width:524pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="9.6_files/filelist.xml">
<link rel=Edit-Time-Data href="9.6_files/editdata.mso">
<link rel=OLE-Object-Data href="9.6_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T06:06:57Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:yellow;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Print>
<x:ValidPrinterInfo/>
<x:PaperSizeIndex>9</x:PaperSizeIndex>
<x:HorizontalResolution>-3</x:HorizontalResolution>
<x:VerticalResolution>0</x:VerticalResolution>
</x:Print>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>3</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=698 style='border-collapse:
collapse;table-layout:fixed;width:524pt'>
<col width=698 style='mso-width-source:userset;mso-width-alt:25526;width:524pt'>
<col width=256 style='mso-width-source:userset;mso-width-alt:9362;width:192pt'>
<col width=190 style='mso-width-source:userset;mso-width-alt:6948;width:143pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=698 style='height:12.75pt;width:524pt'> </td>
</tr>
<tr height=163 style='mso-height-source:userset;height:122.25pt'>
<td height=163 class=xl24 width=698 style='height:122.25pt;width:524pt'>Careful
history taking is necessary in terms of the potential for systemic disease,
such as infection,<br>
inflammatory disease or malignancy, as well as drug reactions. The physical
examination should<br>
compliment the history taking.<br>
Investigations will depend on clinical manifestations, but should include a
full blood count with<br>
examination of the film with appropriate biochemistry and cultures. The
course of the illness is<br>
critical, and either the patient recovers spontaneously or the initial
examination leads to a diagnosis.<br>
For continued fever, the patient is diagnosed with fever of unknown origin,
which requires more<br>
intensive investigation. This may include CT scan of abdomen and chest, and
bone marrow biopsy.<br>
The role of PET scanning is undergoing investigation in this setting.</td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=698 style='width:524pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
Initial medical history
Top Level Guideline
<html>
<head></head><body>
<div><font face="Arial">A notification will be sent to the blood cancer registry every time you order investigations electronically</font></div>
</body></html>
<html xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
<meta name=ProgId content=Excel.Sheet>
<meta name=Generator content="Microsoft Excel 11">
<link rel=File-List href="11.14.1.1_files/filelist.xml">
<link rel=Edit-Time-Data href="11.14.1.1_files/editdata.mso">
<link rel=OLE-Object-Data href="11.14.1.1_files/oledata.mso">
<!--[if gte mso 9]><xml>
<o:DocumentProperties>
<o:Author>Peter Scott</o:Author>
<o:LastAuthor>Peter Scott</o:LastAuthor>
<o:Created>2006-10-11T11:48:10Z</o:Created>
<o:LastSaved>2007-02-06T06:14:47Z</o:LastSaved>
<o:Company>Medical Objects</o:Company>
<o:Version>11.8107</o:Version>
</o:DocumentProperties>
</xml><![endif]-->
<style>
<!--table
{mso-displayed-decimal-separator:"\,";
mso-displayed-thousand-separator:"\.";}
@page
{margin:1.0in .75in 1.0in .75in;
mso-header-margin:.5in;
mso-footer-margin:.5in;}
tr
{mso-height-source:auto;}
col
{mso-width-source:auto;}
br
{mso-data-placement:same-cell;}
.style0
{mso-number-format:General;
text-align:general;
vertical-align:bottom;
white-space:nowrap;
mso-rotate:0;
mso-background-source:auto;
mso-pattern:auto;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
border:none;
mso-protection:locked visible;
mso-style-name:Normal;
mso-style-id:0;}
td
{mso-style-parent:style0;
padding-top:1px;
padding-right:1px;
padding-left:1px;
mso-ignore:padding;
color:windowtext;
font-size:10.0pt;
font-weight:400;
font-style:normal;
text-decoration:none;
font-family:Arial;
mso-generic-font-family:auto;
mso-font-charset:0;
mso-number-format:General;
text-align:general;
vertical-align:bottom;
border:none;
mso-background-source:auto;
mso-pattern:auto;
mso-protection:locked visible;
white-space:nowrap;
mso-rotate:0;}
.xl24
{mso-style-parent:style0;
white-space:normal;}
.xl25
{mso-style-parent:style0;
background:silver;
mso-pattern:auto none;}
-->
</style>
<!--[if gte mso 9]><xml>
<x:ExcelWorkbook>
<x:ExcelWorksheets>
<x:ExcelWorksheet>
<x:Name>Sheet1</x:Name>
<x:WorksheetOptions>
<x:Selected/>
<x:FreezePanes/>
<x:FrozenNoSplit/>
<x:SplitHorizontal>1</x:SplitHorizontal>
<x:TopRowBottomPane>1</x:TopRowBottomPane>
<x:ActivePane>2</x:ActivePane>
<x:Panes>
<x:Pane>
<x:Number>3</x:Number>
</x:Pane>
<x:Pane>
<x:Number>2</x:Number>
<x:ActiveRow>0</x:ActiveRow>
</x:Pane>
</x:Panes>
<x:ProtectContents>False</x:ProtectContents>
<x:ProtectObjects>False</x:ProtectObjects>
<x:ProtectScenarios>False</x:ProtectScenarios>
</x:WorksheetOptions>
</x:ExcelWorksheet>
</x:ExcelWorksheets>
<x:WindowHeight>7815</x:WindowHeight>
<x:WindowWidth>18060</x:WindowWidth>
<x:WindowTopX>480</x:WindowTopX>
<x:WindowTopY>105</x:WindowTopY>
<x:ProtectStructure>False</x:ProtectStructure>
<x:ProtectWindows>False</x:ProtectWindows>
</x:ExcelWorkbook>
</xml><![endif]-->
</head>
<body link=blue vlink=purple>
<table x:str border=0 cellpadding=0 cellspacing=0 width=579 style='border-collapse:
collapse;table-layout:fixed;width:434pt'>
<col width=579 style='mso-width-source:userset;mso-width-alt:21174;width:434pt'>
<col width=126 style='mso-width-source:userset;mso-width-alt:4608;width:95pt'>
<col width=110 style='mso-width-source:userset;mso-width-alt:4022;width:83pt'>
<col width=273 style='mso-width-source:userset;mso-width-alt:9984;width:205pt'>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl25 width=579 style='height:12.75pt;width:434pt'> </td>
</tr>
<tr height=136 style='height:102.0pt'>
<td height=136 class=xl24 width=579 style='height:102.0pt;width:434pt'>Treatment
with chemotherapy or pelvic irradiation may lead to infertility and, given
the long life expectancy following successful treatment and young age at
which many patients present, it is crucial to address reproductive issues
before treatment planning commences, except in cases where emergency
treatment is required. Where relevant, that is, when treatment carries a
significant risk of affecting reproductive function, referral for harvesting
and storage of sperm should be made and appropriate specialist consultations
arranged to discuss preservation of fertility in female patients. Ovarian
transposition may be considered if pelvic radiotherapy is planned, but
results of this procedure are variable.</td>
</tr>
<tr height=238 style='height:178.5pt;mso-xlrowspan:14'>
<td height=238 style='height:178.5pt'></td>
</tr>
<tr height=17 style='height:12.75pt'>
<td height=17 class=xl24 style='height:12.75pt'></td>
</tr>
<![if supportMisalignedColumns]>
<tr height=0 style='display:none'>
<td width=579 style='width:434pt'></td>
</tr>
<![endif]>
</table>
</body>
</html>
Follow this to get to Diagnosis specific plans
Curative intent management plan
Palliative management plan
Semi-automated trial eligibility paths
Determine trial suitability
Top Level Guideline
Record The chemotherapy details here
Top Level Guideline
LymphomaWizard
Medical-Objects
2007-04-17T21:05:57.000Z
1
Draft
1
0.9
TS
YYYMMXX
TS
YYYYMMDD
ANY
Lymphoma_specific_symptoms
ANY
Lymphoma_finding
ST FT
*
ST FT
*
ANY
MO_LymphomaType
ST
ANY
Radiology_Findings
ST FT
*
INT
0
7
INT
0
3
ST FT
*
INT
0
5
INT
0
2147483647
ST FT
*
ST FT
*
ST
false
false
ST FT
*
ST FT
*
ST FT
*
ST FT
*
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
-
Lymphoma Wizard
Data storage for Lymphoma wizard
-
Date of Onset
Date of onset
-
Registration date
Registration date
-
Tumour observable
Tumour observable
-
Initial Performance Status
Initial Performance Status
-
Lymphoma Specific Symptoms
Lymphoma Specific Symptoms
-
Radiology Findings
Radiology Findings
-
Histology Findings
Histology Findings
-
Prognostic Score Values
Prognostic Score Values
-
Patient Status Assessments
Patient Status Assessments
-
Chemotherapy Given
Chemotherapy Given
-
Radiotherapy Given
Radiotherapy Given
-
Prognostic score value
Prognostic score value
-
Date of calculation
Date of calculation
-
Prognostic score
Prognostic score
-
Hasenclever index
Hasenclever index
-
International Prognostic Index Score
International Prognostic Index Score
-
Prognostic Score Data
Prognostic Score Data
-
BNLI Data
BNLI Data
-
Absence of rapid generalised disease progression
Absence of rapid generalised disease progression
-
Absence of life endangering organ involvment
Absence of life endangering organ involvment
-
Absence of bone lesions
Absence of bone lesions
-
Absence of renal infiltration
Absence of renal infiltration
-
Absence of macroscopic liver involvement
Absence of macroscopic liver involvement
-
BNLI index
BNLI index
-
Early stage HL favourable characteristics
Early stage HL favourable characteristics
-
Initial patient evaluation
Initial patient evaluation
-
Initial Clinical Examination
Initial Clinical Examination
-
Lymphoma Stage
Lymphoma Stage
-
Ann Arbor lymphoma staging system
Ann Arbor lymphoma staging system (tumor staging)
-
Follicular Lymphoma International Prognostic Score
Follicular Lymphoma International Prognostic Score
-
GELF
GELF
-
Initial History
Initial History
-
GELF Data
GELF Data
-
Fewer than 3 nodal sites with a diameter > 3 cm
Fewer than 3 nodal sites with a diameter > 3 cm
-
Spleen < 16cm on CT Scan
Spleen < 16cm on CT Scan
-
No significant serous effusions evident clinically of on CXR
No significant serous effusions evident clinically of on CXR
-
Absence of risk of local compressive symptoms (epidural, ureteral ect)
Absence of risk of local compressive symptoms (epidural, ureteral ect)
-
No circulating Lymphoma cells
No circulating Lymphoma cells
-
Demographics
Demographics
-
Waldenstroms Macroglobulinaemia Prognostic Tool
Waldenstroms Macroglobulinaemia Prognostic Tool
-
Country of Birth
Country of Birth
-
Place of Residence
Place of Residence
-
Radiology Findings
Radiology Findings
-
Any Lymphoma Prognostic score
Any score caculated by
Gello
MO_LymphomaType
Lymphoproliferative disease diagnosis
L
Scott
Peter
Dr.
Medical-Objects
5F07E0B7-0DAF-48AF-8A1A-FEEEA5824384
GUID
2007-04-17T21:05:57.000Z
1
Draft
1
0.9
CE
- at0010
- at0011
- at0013
- at0014
- at0015
- at0016
- at0017
- at0018
- at0019
- at0020
- at0021
- at0022
- at0023
- at0024
- at0025
- at0026
- at0027
- at0028
- at0029
- at0030
- at0031
- at0032
- at0033
- at0034
- at0035
- at0036
- at0037
- at0038
- at0039
- at0040
- at0041
- at0042
- at0043
- at0044
- at0045
- at0046
- at0047
- at0048
- at0049
- at0050
- at0051
- at0052
- at0053
- at0054
- at0055
- at0056
- at0057
- at0058
- at0059
- at0060
- at0061
- at0062
- at0063
- at0064
- at0065
0
-
Type of Lymphoma Diagnosed
-
Diagnosis
*
-
Precursor B-cell neoplasm
*
-
Precursor B-lymphoblastic leukaemia/lymphoma
*
-
Mature B-cell neoplasms
*
-
Chronic lymphocytic leukaemia/small lymphocytic lymphoma
*
-
B-cell prolymphocytic leukaemia
*
-
Lymphoplasmacytic lymphoma
*
-
Splenic marginal zone B-cell lymphoma
*
-
Hairy cell leukaemia
*
-
Plasma cell myeloma
*
-
Solitary plasmocytoma of bone
*
-
Extraosseous plasmacytoma
*
-
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT)
*
-
Nodal marginal zone B-cell lymphoma
*
-
Follicular lymphoma
*
-
Mantle cell lymphoma
*
-
Diffuse large B-cell lymphoma
*
-
Mediastinal (thymic) large B-cell lymphoma
*
-
Intravascular large B-cell lymphoma
*
-
Primary effusion lymphoma
*
-
Burkitt lymphoma/leukaemia
*
-
Lymphomatoid granulomatosis
*
-
Post-transplant lymphoproliferative disorder, polymorphic
*
-
Precursor T-lymphoblastic lymphoma/leukaemia
*
-
Blastic NK cell lymphoma
*
-
T-cell prolymphocytic leukaemia
*
-
T-cell large granular lymphocytic leukaemia
*
-
Aggressive NK cell leukaemia
*
-
Adult T-cell leukaemia/lymphoma
*
-
Extranodal NK/T-cell lymphoma, nasal type
*
-
Enteropathy-type T-cell lymphoma
*
-
Subcutaneous panniculitis-like T-cell lymphoma
*
-
Mycosis fungoides
*
-
Sézary syndrome
*
-
Primary cutaneous anaplastic large-cell lymphoma
*
-
Peripheral T-cell lymphoma, unspecified
*
-
Angioimmunoblastic T-cell lymphoma
*
-
Anaplastic large cell lymphoma
*
-
T-cell proliferation of uncertain malignant potential
*
-
Lymphomatoid papulosis
*
-
Hodgkin lymphoma
*
-
Nodular lymphocytic-predominant Hodgkin lymphoma
*
-
Classical Hodgkin lymphoma
*
-
Nodular sclerosis Hodgkin lymphoma
*
-
Lymphocyte-rich Hodgkin lymphoma
*
-
Mixed cellularity Hodgkin lymphoma
*
-
Lymphocyte-depleted Hodgkin lymphoma
*
-
Immunodeficiency associated lymphoproliferative disorder
*
-
Lymphoproliferative disease associated with primary immune disorders
*
-
Human immunodeficiency virus-related lymphoma
*
-
Post-transplant lymphoproliferative disorder
*
-
Methotrexate-associated lymphoproliferative disorder
*
-
Lymphoma, unclassified
*
-
Atypical lymphoid hyperplasia
*
-
Haematolymphoid neoplasm, not otherwise stated
*
-
Reactive lymphadenopathy
*
-
Non-lymphoid tumour
*
performance_status
As published in Am. J. Clin. Oncol.: Oken, M.M., Creech,
R.H., Tormey, D.C., Horton, J., Davis, T.E.,
McFadden, E.T., Carbone, P.P.: Toxicity And Response
Criteria Of The Eastern Cooperative Oncology Group.
Am J Clin Oncol 5:649-655, 1982.
OpenEHR
2007-04-17T21:05:57.000Z
1
Draft
0.9
CE
-
ECOG performance status
As published in Am. J. Clin. Oncol.: Oken, M., Creech,
-
Performance Status
*
-
ECOG 0
Fully active, able to carry on all pre-disease performance
-
ECOG 1
Restricted in physically strenuous activity but ambulant
-
ECOG 2
Ambulatory and capable of all selfcare but unable to carry
-
ECOG 3
Capable of only limited selfcare, confined to bed
-
ECOG 4
Completely disabled. Cannot carry on any selfcare.
-
ECOG 5
Dead
Radiology_Findings
Medical-Objects
2007-04-17T21:05:57.000Z
1
Draft
1
0.9
TS
ST
false
false
ST
false
false
/*
Do what you need to do with the observation and set answer as appropriate.
*/
let o: Observation = parameter[1]
//locate target
let o2: Observation =
if o.isdefined() then
// we can look up the target
o.find_observation('1.3.1')
else
// it's already undefined.
o
endif
if o2.isDefined() then
/****************************************
do your testing here
****************************************/
if o2.Value.equals(True) then
true
else
false
endif
else
// could not find the target
unknown
endif
RTO
0
ST
false
false
-
Date of Radiology Procedure
Date of Radiology Procedure
-
Abdominal Lymphadenopathy
Abdominal Lymphadenopathy
-
Mediastinal Mass findings
Mediastinal Mass findings
-
Mediastinal Mass Ratio
Mediastinal Mass Ratio
-
Mediastinal width
Mediastinal width
-
Retroperitoneal Lymphadenopathy
Retroperitoneal Lymphadenopathy
-
Radiology findings
Radiology findings
-
Mediastinal mass present
Mediastinal mass present
-
Mediastinal mass details
Mediastinal mass details
-
error
error
Chemotherapy_Given
Medical-Objects
2007-04-17T21:05:57.000Z
1
Draft
1
0.9
CE
- at0013
- at0018
- at0020
- at0017
- at0016
- at0022
- at0023
- at0024
- at0021
- at0025
- at0026
- at0019
- at0004
- at0027
- at0014
- at0015
0
CE
- at0028
- at0030
- at0029
- at0031
0
INT
0
100
CE
- at0032
- at0033
0
TS
TS
CE
- at0035
- at0034
0
ANY
performance_status
-
Chemotherapy given
Chemotherapy given
-
Protocol Name
Protocol Name
-
MOPP
MOPP
-
Cycle
Cycle
-
Cycle length
Cycle length
-
Number of cycles
Number of cycles
-
First or second line status
First or second line status
-
Date of commencement
Date of commencement
-
Date of completion
Date of completion
-
Completion status
Completion status
-
Response
Response
-
ABVD
ABVD
-
R-CHOP
R-CHOP
-
single agent chlorambucil
single agent chlorambucil
-
CVP
CVP
-
COP
COP
-
CHOP
CHOP
-
MACOP-B
MACOP-B
-
CODOX-M/IVAC
CODOX-M/IVAC
-
Gemcitabine/Navelbine
Gemcitabine/Navelbine
-
DHAP
DHAP
-
ESHAP
ESHAP
-
Etoposide (oral)
Etoposide (oral)
-
HyperCVAD / R-HyperCVAD
HyperCVAD / R-HyperCVAD
-
ICE / R-ICE
ICE / R-ICE
-
Other Protocol
Other Protocol
-
7 Days
7 Days
-
14 Days
14 days
-
21 Days
21 Days
-
Other cycle length
Other cycle length
-
First line
First line
-
Second line
Second line
-
Completed
Completed
-
Ongoing
Ongoing
-
Response
Response
-
Patient status
Patient status
Radiotherapy_Given
Medical-Objects
2007-04-17T21:05:57.000Z
1
Draft
1
0.9
Lymphoma_finding
Medical-Objects
2007-04-17T21:05:57.000Z
1
Draft
1
0.9
ST
false
false
/*
Do what you need to do with the observation and set answer as appropriate.
*/
let o: Observation = parameter[1]
//locate target
let o2: Observation =
if o.isdefined() then
// we can look up the target
o.find_observation('1.1.1')
else
// it's already undefined.
o
endif
//now logic
let answer:boolean =
if o2.isDefined() then
/****************************************
do your testing here
****************************************/
if o2.Value.equals(True) then
true
else
false
endif
else
// could not find the target
unknown
endif
let reason:string =
if answer <> unknown then
if answer then
'Have extranodal sitess'
else
'No record of Extranodal sites'
endif
else
if o.isdefined() then
'Target observation not found'
else
'No Observation passed in'
endif
endif
/* now return our annotated boolean result...
If you aren't interested in the reason, just pass back a boolean (i.e. answer )
*/
factory.annotatedboolean(answer,reason)
// uncomment the following and comment the above to just return a boolean
// answer
INT
1
30
INT
0
100
PQ
0
ST
false
false
ST
false
false
0
0
-
Lymph Node Findings
Lymph Node Findings
-
Organomegaly
Organomegaly
-
Extranodal site
Extranodal site
-
Number of Involved Nodal Sites
Number of Involved Nodal Sites
-
Large liver
Large liver (disorder)
-
Splenomegaly
Splenomegaly (disorder)
-
Maximum Diameter of any Site of Disease
Maximum Diameter of any Site of Disease
-
Body weight
Body weight (observable entity)
-
Body height measure
Body height measure (observable entity)
-
Examination Findings
Examination findings
-
Number of Extranodal Sites
Number of Extranodal Sites
Lymphoma_specific_symptoms
Medical-Objects
2007-04-17T21:05:57.000Z
1
Draft
1
0.9
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
-
Lymphoma Specific Symptoms
Lymphoma related symptoms
-
Important Symptoms
Important Symptoms
-
Relevant Symptoms
Relevant Symptoms
-
B Type Symptoms
B Type Symptoms
-
Pruritis
Pruritis
-
Fever
Fever
-
Weight Loss
Weight Loss
-
Night sweats
Night sweats (finding)
-
abdominal pain
abdominal pain
-
abdominal swelling
abdominal swelling
-
anaemia
anaemia
-
anxiety
anxiety
-
arm swelling
arm swelling
-
Blurred vision
Blurred vision
-
Bruising
Bruising
-
Chest pain
Chest pain
-
Confusion
Confusion
-
Constipation
Constipation
-
Cough
Cough
-
Cramps
Cramps
-
Cyanosis
Cyanosis
-
Deep vein thrombosis
Deep vein thrombosis
-
Dehydration
Dehydration
-
Depression
Depression
-
Diarrhoea
Diarrhoea
-
Difficulty swallowing
Difficulty swallowing
-
Double vision
Double vision
-
Drowsiness
Drowsiness
-
Easy bruising
Easy bruising
-
Erythroderma
Erythroderma
-
Facial swelling
Facial swelling
-
Falls
Falls
-
Fatigue
Fatigue
-
Gout
Gout
-
Hair loss
Hair loss
-
High blood sugar
High blood sugar
-
Hoarseness
Hoarseness
-
Indigestion
Indigestion
-
Irregular pulse
Irregular pulse
-
Jaundice
Jaundice
-
Joint pain
Joint pain
-
Lethargy
Lethargy
-
Lightheadedness
Lightheadedness
-
Loss of appetite
Loss of appetite
-
Lymphadenopathy
Lymphadenopathy
-
Loss of appetite
Loss of appetite
-
Mouth ulcers
Mouth ulcers
-
Nasal congestion
Nasal congestion
-
Orthopnoea
Orthopnoea
-
Pain
Pain
-
Painful lymph glands after alcohol
Painful lymph glands after alcohol
-
Pins and needles
Pins and needles
-
Poor circulation
Poor circulation
-
Pregnant
Pregnant
-
Pressure sore
Pressure sore
-
Seizure
Seizure
-
Shortness of breath
Shortness of breath
-
Skin cancer
Skin cancer
-
Sore throat
Sore throat
-
Stridor
Stridor
-
Ulcer of foot
Ulcer of foot
-
Ulcer of heel
Ulcer of heel
-
Ulcer of foot
Ulcer of foot
-
Ulcer of heel
Ulcer of heel
-
Ulcer of leg
Ulcer of leg
-
Uncoordinated
Uncoordinated
-
Urinary symptoms
Urinary symptoms
-
Vomiting
Vomiting
-
Abdominal pain
Abdominal pain (finding)
-
Abdominal swelling
Abdominal swelling
-
Anaemia
Anaemia
-
Anxiety
Anxiety
-
Arm swelling
Arm swelling
MO_Lymphoma_Stage
Medical-Objects
2007-04-17T21:05:57.000Z
1
Draft
1
0.9
CE
- at0007
- at0018
- at0024
- at0023
- at0022
- at0008
- at0009
- at0019
- at0012
- at0010
- at0013
- at0014
- at0020
- at0026
- at0027
- at0029
- at0028
- at0030
- at0015
- at0016
- at0017
- at0011
- at0021
- at0031
- at0032
0
//See if we have stage data
let path: String = '1.2.1'
let OBS : Observation = Model.find_observation('Lymphoma_Wizard_Core', path)
if OBS.isUndefined() then
Factory.Observation('', Factory.CodedValue('G4Nodes', 'L'), 'ST', '', '', '')
else
OBS
endif
-
Registration Date
Registration Date
-
Onset of Symptoms
Onset of Symptoms
-
Lymphoma Type
Lymphoma Type
-
Lymphoma Stage
Lymphoma Stage
-
Core Data
Core Data
-
Lymphoma stage I
Lymphoma stage I (finding)
-
Lymphoma stage IE
Lymphoma stage IE (finding)
-
Lymphoma stage II
Lymphoma stage II (finding)
-
Lymphoma stage III
Lymphoma stage III (finding)
-
Lymphoma stage IV
Lymphoma stage IV (finding)
-
Lymphoma stage IIE
Lymphoma stage IIE (finding)
-
Lymphoma stage III 1
Lymphoma stage III 1 (finding)
-
Lymphoma stage III 2
Lymphoma stage III 2 (finding)
-
Lymphoma stage IIIE
Lymphoma stage IIIE (finding)
-
Lymphoma stage IIIS
Lymphoma stage IIIS (finding)
-
Lymphoma stage IIISE
Lymphoma stage IIISE (finding)
-
Lymphoma stage IA
Lymphoma stage IA
-
Lymphoma stage IIA
Lymphoma stage IIA
-
Lymphoma stage IIIA
Lymphoma stage IIIA
-
Lymphoma stage IVA
Lymphoma stage IVA
-
Lymphoma stage IB
Lymphoma stage IB
-
Lymphoma stage IAE
Lymphoma stage IAE
-
Lymphoma stage IAB
Lymphoma stage IAB
-
Unknown stage
Unknown stage
-
Lymphoma stage IIIAE
Lymphoma stage IIIAE
-
Lymphoma stage IIIAES
Lymphoma stage IIIAES
-
Lymphoma stage IIIBE
Lymphoma stage IIIBE
-
Lymphoma stage IIIB
Lymphoma stage IIIB
-
Lymphoma stage IIIBES
Lymphoma stage IIIBES
-
Lymphoma stage IVB
Lymphoma stage IVB
-
Lymphoma stage IIB
Lymphoma stage IIB
Registration_Details
Medical-Objects
2007-04-17T21:05:57.000Z
1
Draft
1
0.9
TS
Factory.AbsoluteTime('').now()
TS
CE
- at0008
- at0009
- at0010
- at0011
- at0012
- at0013
- at0014
- at0015
- at0016
- at0017
- at0018
- at0019
- at0020
- at0021
- at0022
- at0023
- at0024
- at0025
- at0026
- at0027
- at0028
- at0029
- at0030
- at0031
- at0032
- at0033
- at0034
- at0035
- at0036
- at0037
- at0038
- at0039
- at0040
- at0041
- at0042
- at0043
- at0044
- at0045
- at0046
- at0047
- at0048
- at0049
- at0050
- at0051
- at0052
- at0053
- at0054
- at0055
- at0056
- at0057
- at0058
- at0059
- at0060
- at0061
- at0062
- at0063
- at0064
- at0065
- at0066
- at0067
- at0068
- at0223
- at0069
- at0070
- at0071
- at0072
- at0073
- at0074
- at0075
- at0076
- at0077
- at0078
- at0079
- at0080
- at0081
- at0082
- at0083
- at0084
- at0085
- at0086
- at0087
- at0088
- at0089
- at0236
- at0090
- at0091
- at0092
- at0093
- at0094
- at0095
- at0096
- at0097
- at0098
- at0099
- at0100
- at0101
- at0102
- at0103
- at0105
- at0106
- at0107
- at0108
- at0109
- at0110
- at0111
- at0112
- at0113
- at0114
- at0115
- at0116
- at0117
- at0118
- at0119
- at0120
- at0121
- at0123
- at0124
- at0125
- at0126
- at0127
- at0128
- at0129
- at0130
- at0131
- at0132
- at0133
- at0134
- at0135
- at0136
- at0137
- at0138
- at0139
- at0140
- at0141
- at0142
- at0143
- at0144
- at0145
- at0146
- at0147
- at0148
- at0149
- at0150
- at0151
- at0152
- at0153
- at0154
- at0155
- at0156
- at0157
- at0158
- at0159
- at0160
- at0161
- at0162
- at0163
- at0164
- at0165
- at0166
- at0167
- at0168
- at0169
- at0122
- at0170
- at0171
- at0172
- at0173
- at0174
- at0175
- at0176
- at0177
- at0178
- at0179
- at0180
- at0181
- at0182
- at0183
- at0184
- at0185
- at0186
- at0187
- at0188
- at0189
- at0190
- at0191
- at0192
- at0193
- at0194
- at0195
- at0196
- at0197
- at0198
- at0199
- at0200
- at0201
- at0202
- at0203
- at0204
- at0205
- at0206
- at0207
- at0208
- at0209
- at0210
- at0211
- at0212
- at0213
- at0214
- at0215
- at0216
- at0217
- at0218
- at0219
- at0220
- at0221
- at0222
- at0224
- at0227
- at0228
- at0229
- at0230
- at0231
- at0232
- at0233
- at0234
- at0235
- at0237
- at0238
- at0239
- at0240
- at0241
- at0242
- at0243
- at0244
- at0245
- at0246
- at0247
- at0248
- at0249
- at0250
- at0251
0
Factory.CodedValue('at0020', 'Registration_Details')
ST FT
*
Model.Patient.patient_id
-
Registration details
Registration details
-
Registration date
Registration date
-
Onset of symptoms
Onset of symptoms
-
Country of Birth
Country of Birth
-
Date diagnosed
Date diagnosed
-
Person ID
Person ID
-
AFGHANISTAN
AFGHANISTAN
-
ALBANIA
ALBANIA
-
ALGERIA
ALGERIA
-
AMERICAN SAMOA
AMERICAN SAMOA
-
ANDORRA
ANDORRA
-
ANGOLA
ANGOLA
-
ANGUILLA
ANGUILLA
-
ANTARCTICA
ANTARCTICA
-
ANTIGUA AND BARBUDA
ANTIGUA AND BARBUDA
-
ARGENTINA
ARGENTINA
-
ARMENIA
ARMENIA
-
ARUBA
ARUBA
-
AUSTRALIA
AUSTRALIA
-
AUSTRIA
AUSTRIA
-
AZERBAIJAN
AZERBAIJAN
-
BAHAMAS
BAHAMAS
-
BAHRAIN
BAHRAIN
-
BANGLADESH
BANGLADESH
-
BARBADOS
BARBADOS
-
BELARUS
BELARUS
-
BELGIUM
BELGIUM
-
BELIZE
BELIZE
-
BENIN
BENIN
-
BERMUDA
BERMUDA
-
BHUTAN
BHUTAN
-
BOLIVIA
BOLIVIA
-
BOSNIA AND HERZEGOVINA
BOSNIA AND HERZEGOVINA
-
BOTSWANA
BOTSWANA
-
BOUVET ISLAND
BOUVET ISLAND
-
BRAZIL
BRAZIL
-
BRITISH INDIAN OCEAN TERRITORY
BRITISH INDIAN OCEAN TERRITORY
-
BRUNEI
BRUNEI
-
BULGARIA
BULGARIA
-
BURKINA FASO
BURKINA FASO
-
BURUNDI
BURUNDI
-
CAMBODIA
CAMBODIA
-
CAMEROON
CAMEROON
-
CANADA
CANADA
-
CAPE VERDE
CAPE VERDE
-
CAYMAN ISLANDS
CAYMAN ISLANDS
-
CENTRAL AFRICAN REPUBLIC
CENTRAL AFRICAN REPUBLIC
-
CHAD
CHAD
-
CHILE
CHILE
-
CHINA
CHINA
-
CHRISTMAS ISLAND
CHRISTMAS ISLAND
-
COCOS (KEELING) ISLANDS
COCOS (KEELING) ISLANDS
-
COLOMBIA
COLOMBIA
-
COMOROS
COMOROS
-
CONGO
CONGO
-
CONGO, THE DEMOCRATIC REPUBLIC OF THE
CONGO, THE DEMOCRATIC REPUBLIC OF THE
-
COOK ISLANDS
COOK ISLANDS
-
COSTA RICA
COSTA RICA
-
CÔTE D'IVOIRE
CÔTE D'IVOIRE
-
CROATIA
CROATIA
-
CUBA
CUBA
-
CYPRUS
CYPRUS
-
CZECH REPUBLIC
CZECH REPUBLIC
-
DENMARK
DENMARK
-
DJIBOUTI
DJIBOUTI
-
DOMINICA
DOMINICA
-
DOMINICAN REPUBLIC
DOMINICAN REPUBLIC
-
ECUADOR
ECUADOR
-
EGYPT
EGYPT
-
EL SALVADOR
EL SALVADOR
-
EQUATORIAL GUINEA
EQUATORIAL GUINEA
-
ERITREA
ERITREA
-
ESTONIA
ESTONIA
-
ETHIOPIA
ETHIOPIA
-
FALKLAND ISLANDS (MALVINAS)
FALKLAND ISLANDS (MALVINAS)
-
FAROE ISLANDS
FAROE ISLANDS
-
FIJI
FIJI
-
FINLAND
FINLAND
-
FRANCE
FRANCE
-
FRENCH GUIANA
FRENCH GUIANA
-
FRENCH POLYNESIA
FRENCH POLYNESIA
-
FRENCH SOUTHERN TERRITORIES
FRENCH SOUTHERN TERRITORIES
-
GABON
GABON
-
GAMBIA
GAMBIA
-
GEORGIA
GEORGIA
-
GERMANY
GERMANY
-
GHANA
GHANA
-
GIBRALTAR
GIBRALTAR
-
GREECE
GREECE
-
GREENLAND
GREENLAND
-
GRENADA
GRENADA
-
GUADELOUPE
GUADELOUPE
-
GUAM
GUAM
-
GUATEMALA
GUATEMALA
-
GUERNSEY
GUERNSEY
-
GUINEA
GUINEA
-
GUINEA-BISSAU
GUINEA-BISSAU
-
GUYANA
GUYANA
-
HAITI
HAITI
-
HEARD ISLAND AND MCDONALD ISLANDS
HEARD ISLAND AND MCDONALD ISLANDS
-
HOLY SEE (VATICAN CITY STATE)
HOLY SEE (VATICAN CITY STATE)
-
HONDURAS
HONDURAS
-
HONG KONG
HONG KONG
-
HUNGARY
HUNGARY
-
ICELAND
ICELAND
-
INDIA
INDIA
-
INDONESIA
INDONESIA
-
IRAN, ISLAMIC REPUBLIC OF
IRAN, ISLAMIC REPUBLIC OF
-
IRAQ
IRAQ
-
IRELAND
IRELAND
-
ISLE OF MAN
ISLE OF MAN
-
ISRAEL
ISRAEL
-
ITALY
ITALY
-
JAMAICA
JAMAICA
-
JAPAN
JAPAN
-
JERSEY
JERSEY
-
JORDAN
JORDAN
-
KAZAKHSTAN
KAZAKHSTAN
-
KENYA
KENYA
-
KIRIBATI
KIRIBATI
-
NORTH KOREA
NORTH KOREA
-
KOREA
KOREA
-
KUWAIT
KUWAIT
-
KYRGYZSTAN
KYRGYZSTAN
-
LAOS
LAOS
-
LATVIA
LATVIA
-
LEBANON
LEBANON
-
LESOTHO
LESOTHO
-
LIBERIA
LIBERIA
-
LIBYA
LIBYA
-
LIECHTENSTEIN
LIECHTENSTEIN
-
LITHUANIA
LITHUANIA
-
LUXEMBOURG
LUXEMBOURG
-
MACAO
MACAO
-
MACEDONIA, THE FORMER YUGOSLAV REPUBLIC OF
MACEDONIA, THE FORMER YUGOSLAV REPUBLIC OF
-
MADAGASCAR
MADAGASCAR
-
MALAWI
MALAWI
-
MALAYSIA
MALAYSIA
-
MALDIVES
MALDIVES
-
MALI
MALI
-
MALTA
MALTA
-
MARSHALL ISLANDS
MARSHALL ISLANDS
-
MARTINIQUE
MARTINIQUE
-
MAURITANIA
MAURITANIA
-
MAURITIUS
MAURITIUS
-
MAYOTTE
MAYOTTE
-
MEXICO
MEXICO
-
MICRONESIA, FEDERATED STATES OF
MICRONESIA, FEDERATED STATES OF
-
MOLDOVA, REPUBLIC OF
MOLDOVA, REPUBLIC OF
-
MONACO
MONACO
-
MONGOLIA
MONGOLIA
-
MONTENEGRO
MONTENEGRO
-
MONTSERRAT
MONTSERRAT
-
MOROCCO
MOROCCO
-
MOZAMBIQUE
MOZAMBIQUE
-
MYANMAR
MYANMAR
-
NAMIBIA
NAMIBIA
-
NAURU
NAURU
-
NEPAL
NEPAL
-
NETHERLANDS
NETHERLANDS
-
NETHERLANDS ANTILLES
NETHERLANDS ANTILLES
-
NEW CALEDONIA
NEW CALEDONIA
-
NEW ZEALAND
NEW ZEALAND
-
NICARAGUA
NICARAGUA
-
NIGER
NIGER
-
NIGERIA
NIGERIA
-
NIUE
NIUE
-
NORFOLK ISLAND
NORFOLK ISLAND
-
NORTHERN MARIANA ISLANDS
NORTHERN MARIANA ISLANDS
-
NORWAY
NORWAY
-
OMAN
OMAN
-
PAKISTAN
PAKISTAN
-
PALAU
PALAU
-
PALESTINIAN TERRITORY
PALESTINIAN TERRITORY
-
PANAMA
PANAMA
-
PAPUA NEW GUINEA
PAPUA NEW GUINEA
-
PARAGUAY
PARAGUAY
-
PERU
PERU
-
PHILIPPINES
PHILIPPINES
-
PITCAIRN
PITCAIRN
-
POLAND
POLAND
-
PORTUGAL
PORTUGAL
-
PUERTO RICO
PUERTO RICO
-
QATAR
QATAR
-
RÉUNION
RÉUNION
-
ROMANIA
ROMANIA
-
RUSSIA
RUSSIA
-
RWANDA
RWANDA
-
SAINT HELENA
SAINT HELENA
-
SAINT KITTS AND NEVIS
SAINT KITTS AND NEVIS
-
SAINT LUCIA
SAINT LUCIA
-
SAINT PIERRE AND MIQUELON
SAINT PIERRE AND MIQUELON
-
SAINT VINCENT AND THE GRENADINES
SAINT VINCENT AND THE GRENADINES
-
SAMOA
SAMOA
-
SAN MARINO
SAN MARINO
-
SAO TOME AND PRINCIPE
SAO TOME AND PRINCIPE
-
SAUDI ARABIA
SAUDI ARABIA
-
SENEGAL
SENEGAL
-
SERBIA
SERBIA
-
SEYCHELLES
SEYCHELLES
-
SIERRA LEONE
SIERRA LEONE
-
SINGAPORE
SINGAPORE
-
SLOVAKIA
SLOVAKIA
-
SLOVENIA
SLOVENIA
-
SOLOMON ISLANDS
SOLOMON ISLANDS
-
SOMALIA
SOMALIA
-
SOUTH AFRICA
SOUTH AFRICA
-
SOUTH GEORGIA AND THE SOUTH SANDWICH ISLANDS
SOUTH GEORGIA AND THE SOUTH SANDWICH ISLANDS
-
SPAIN
SPAIN
-
SRI LANKA
SRI LANKA
-
SUDAN
SUDAN
-
SURINAME
SURINAME
-
SVALBARD AND JAN MAYEN
SVALBARD AND JAN MAYEN
-
SWAZILAND
SWAZILAND
-
SWEDEN
SWEDEN
-
SWITZERLAND
SWITZERLAND
-
SYRIA
SYRIA
-
TAIWAN
TAIWAN
-
TAJIKISTAN
TAJIKISTAN
-
TANZANIA
TANZANIA
-
THAILAND
THAILAND
-
EAST TIMOR
EAST TIMOR
-
TOGO
TOGO
-
TOKELAU
TOKELAU
-
TONGA
TONGA
-
TRINIDAD AND TOBAGO
TRINIDAD AND TOBAGO
-
TUNISIA
TUNISIA
-
TURKEY
TURKEY
-
TURKMENISTAN
TURKMENISTAN
-
TURKS AND CAICOS ISLANDS
TURKS AND CAICOS ISLANDS
-
TUVALU
TUVALU
-
UGANDA
UGANDA
-
UKRAINE
UKRAINE
-
UNITED ARAB EMIRATES
UNITED ARAB EMIRATES
-
GREAT BRITAIN
GREAT BRITAIN
-
UNITED STATES
UNITED STATES
-
UNITED STATES MINOR OUTLYING ISLANDS
UNITED STATES MINOR OUTLYING ISLANDS
-
URUGUAY
URUGUAY
-
UZBEKISTAN
UZBEKISTAN
-
VANUATU
VANUATU
-
VENEZUELA
VENEZUELA
-
VIETNAM
VIETNAM
-
VIRGIN ISLANDS, BRITISH
VIRGIN ISLANDS, BRITISH
-
VIRGIN ISLANDS, U.S.
VIRGIN ISLANDS, U.S.
-
WALLIS AND FUTUNA
WALLIS AND FUTUNA
-
WESTERN SAHARA
WESTERN SAHARA
-
YEMEN
YEMEN
-
ZAMBIA
ZAMBIA
-
ZIMBABWE
ZIMBABWE
-
ÅLAND ISLANDS
ÅLAND ISLANDS
-
Country of Birth
Child_of[223369002]; Search_Phrase['']
Generic_Order_Details
Medical-Objects
2007-04-17T21:05:57.000Z
1
Draft
1
0.9
ST FT
*
-
Generic order details
Generic order details
-
Notes
Notes
Remission_Status
Medical-Objects
2007-04-17T21:05:57.000Z
1
Draft
1
0.9
CE
- at0008
- at0004
- at0006
- at0007
- at0005
0
-
Remission data
Remission data
-
Response
Response
-
Complete Remission
CR
-
Partial Remission
PR
-
Complete remission unconfirmed/uncertain
CR[u]
-
Progression of Disease
PD
-
Complete Molecular Response
CMR
-
Response
Response
Hodgkin_or_NonHodgkin_Lymphoma
Medical-Objects
2007-04-17T21:05:57.000Z
1
Draft
1
0.9
CE
- at0004
- at0005
0
-
HL or NHL
HL or NHL
-
HL or NHL
HL or NHL
-
Hodgkin's disease
Hodgkin's disease (disorder)
-
Non-Hodgkin's lymphoma
Non-Hodgkin's lymphoma (disorder)
-
Hodgkin Lymphoma or Non-Hodgkin Lymphoma?
Hodgkin Lymphoma or Non-Hodgkin Lymphoma?
Initial_Notification
Medical-Objects
2007-04-17T21:05:57.000Z
1
Draft
1
0.9
TS
//See if we have diagnosis data
let path: String = '1.3'
let OBS : Observation = Model.find_observation('Lymphoma_Wizard_Core', path)
if OBS.isUndefined() then
Factory.AbsoluteTime('').now()
else
OBS.value_asAbsoluteTime()
endif
TS
Factory.AbsoluteTime('').now()
CE
- at0024
- at0025
0
//See if we have diagnosis data
let path: String = '1.1.1'
let OBS : Observation = Model.find_observation('Lymphoma_Wizard_Core', path)
//setup all the current diagnoses
//Hodgkins
let Group01: Set(CodedValue) =
Set{
//Hodgkin lymphoma
Factory.CodedValue('at0049^Hodgkin lymphoma^MO_LymphomaType'),
//Nodular lymphocytic-predominant Hodgkin lymphoma
Factory.CodedValue('at0050^Nodular lymphocytic-predominant Hodgkin lymphoma^MO_LymphomaType'),
//Classical Hodgkin lymphoma
Factory.CodedValue('at0051^Classical Hodgkin lymphoma^MO_LymphomaType'),
//Nodular sclerosis Hodgkin lymphoma
Factory.CodedValue('at0052', 'MO_LymphomaType'),
//Lymphocyte-rich Hodgkin lymphoma
Factory.CodedValue('at0053', 'MO_LymphomaType'),
//Mixed cellularity Hodgkin lymphoma
Factory.CodedValue('at0054', 'MO_LymphomaType'),
//Lymphocyte-depleted Hodgkin lymphoma
Factory.CodedValue('at0055', 'MO_LymphomaType')
}
if OBS.isUndefined() then
Factory.Observation('', Factory.CodedValue('G4Nodes', 'L'), 'ST', '', '', '')
else
if Group01->includes(OBS.value) then
Factory.Observation(Factory.CodedValue('at0024^01 Hodgkin Lymphoma^Initial_Notification'), Factory.Codedvalue('ABCRType', 'ABCR'), 'CE', '', '', '')
else
Factory.Observation(Factory.CodedValue('at0025^02 Non Hodgkin Lymphoma^Initial_Notification'), Factory.Codedvalue('ABCRType', 'ABCR'), 'CE', '', '', '')
endif
endif
/*
Gello for Non Hodgkins
*/
/*
1. Get the observation for this node in the archetype tree.
the parameter[1] is defined as Any, but is actually an observation.
*/
let o:observation = parameter[1]
/*
Do what you need to do with the observation and set answer as appropriate.
*/
//locate target
let o2: Observation =
if o.isdefined() then
// we can look up the target
o.find_observation('1.1.3')
else
// it's already undefined.
o
endif
let answer:boolean =
if o2.isDefined() then
if o2.value_asCodedValue().code = '02' then
true
else
false
endif
else
// could not find the target
unknown
endif
let reason:string =
if answer <> unknown then
if answer then
'Enter you reason for acceptance here...'
else
o2.value_asCodedValue().code
endif
else
if o.isdefined() then
'Target observation not found'
else
'No Observation passed in'
endif
endif
/* now return our annotated boolean result...
If you aren't interested in the reason, just pass back a boolean (i.e. answer )
*/
factory.annotatedboolean(answer,reason)
CE
- at0026
- at0027
- at0029
0
//See if we have diagnosis data
let path: String = '1.1.1'
let OBS : Observation = Model.find_observation('Lymphoma_Wizard_Core', path)
//Follicular (nodular) NHL
let Group1: Set(CodedValue) =
Set{
Factory.CodedValue('at0023^Folicular lymphoma^MO_LymphomaType')
}
//Aggressive lymphoma
let Group2: Set(CodedValue) =
Set{
Factory.CodedValue('at0024^Mantle cell lymphoma^MO_LymphomaType'),
Factory.CodedValue('at0025^Diffuse large B-cell lymphoma^MO_LymphomaType'),
Factory.CodedValue('at0026^Mediastinal(Thymic) large B-cell lymphoma^MO_LymphomaType'),
Factory.CodedValue('at0028^Primary effusion lymphoma^MO_LymphomaType'),
Factory.CodedValue('at0038^Extranodal NK/T-cell lymphoma, nasal type^MO_LymphomaType'),
Factory.CodedValue('at0043^Primary cutaneous anaplastic large-cell lymphoma^MO_LymphomaType'),
Factory.CodedValue('at0044^Peripheral T-cell lymphoma, unspecified^MO_LymphomaType'),
Factory.CodedValue('at0045^Angioimmunoblastic T-cell lymphoma^MO_LymphomaType'),
Factory.CodedValue('at0046^Anaplastic large cell lymphoma^MO_LymphomaType')
}
//Other NHL .. all other NHLs not in the above two sets
let Group3:Set(codedValue) =
Set{
// but for completeness
Factory.CodedValue('at0011^Precursor B-lymphoblastic leukaemia/lymphoma^MO_LymphomaType'),
Factory.CodedValue('at0013^Chronic lymphocytic leukaemia/small lymphocytic lymphoma^MO_LymphomaType'),
Factory.CodedValue('at0015^Lymphoplasmacytic lymphoma^MO_LymphomaType'),
Factory.CodedValue('at0016^Splenic marginal zone B-cell lymphoma^MO_LymphomaType'),
Factory.CodedValue('at0018^Plasma cell myeloma^MO_LymphomaType'),
Factory.CodedValue('at0021^Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT)^MO_LymphomaType'),
Factory.CodedValue('at0022^Nodal marginal zone B-cell lymphoma^MO_LymphomaType'),
Factory.CodedValue('at0029^Burkitt lymphoma/leukaemia^MO_LymphomaType'),
Factory.CodedValue('at0032^Precursor T-lymphoblastic lymphoma/leukaemia^MO_LymphomaType'),
Factory.CodedValue('at0034^T-cell prolymphocytic leukaemia^MO_LymphomaType'),
Factory.CodedValue('at0035^T-cell large granular lymphocytic leukaemia^MO_LymphomaType'),
Factory.CodedValue('at0036^Aggressive NK cell leukaemia^MO_LymphomaType'),
Factory.CodedValue('at0037^Adult T-cell leukaemia/lymphoma^MO_LymphomaType'),
Factory.CodedValue('at0039^Enteropathy-type T-cell lymphoma^MO_LymphomaType'),
Factory.CodedValue('at0040^Subcutaneous panniculitis-like T-cell lymphoma^MO_LymphomaType'),
Factory.CodedValue('at0041^Mycosis fungoides^MO_LymphomaType'),
Factory.CodedValue('at0042^Sezary syndrome^MO_LymphomaType')
}
if OBS.isUndefined() then
Factory.CodedValue('', '')
else
if Group1->includes(OBS.value) then
Factory.CodedValue('at0026^Follicular NHL^Initial_Notification')
else
if Group2->includes(OBS.value) then
Factory.CodedValue('at0027^Aggressive NHL^Initial_Notification')
else
Factory.CodedValue('at0029^Other NHL^Initial_Notification')
endif
endif
endif
CE
- at0030
- at0031
- at0032
- at0033
- at0034
- at0035
- at0037
- at0038
- at0039
- at0040
- at0041
- at0042
- at0043
- at0082
- at0083
- at0084
- at0085
- at0086
- at0087
- at0088
- at0089
- at0090
- at0091
- at0092
- at0093
- at0094
- at0095
- at0096
- at0097
- at0098
- at0099
- at0100
- at0101
0
//See if we have diagnosis data
let path: String = '1.1.1'
let OBS : Observation = Model.find_observation('Lymphoma_Wizard_Core', path)
if OBS.isUndefined() then
Factory.CodedValue('^^')
else
if OBS.value.equals(Factory.CodedValue('at0017^Hairy Cell Leukenia^MO_LymphomaType')) then
Factory.CodedValue('at0102^C91.4^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0023^Follicular Lymphoma^MO_LymphomaType')) then
Factory.CodedValue('at0093^C82.9^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0024^Mantle cell lymphoma^MO_LymphomaType')) then
Factory.CodedValue('at0092^C83.8^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0025^Diffuse large B Cell Lymphoma^MO_LymphomaType')) then
Factory.Codedvalue('at0089^C83.3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0029^Burkitt lymphoma/leukemia^MO_LymphomaType')) then
Factory.Codedvalue('at0038^C83.7^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0041^Mycosis Fungoides^MO_LymphomaType')) then
Factory.Codedvalue('at0039^C84.0^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0042^Sezary syndrome^MO_LymphomaType')) then
Factory.Codedvalue('at0040^C84.1^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0049^Hodgkin Lymphoma^MO_LymphomaType')) then
Factory.Codedvalue('at0035^C81.9^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0050^Nodular Lymphocyte-predominant Hodgkins^MO_LymphomaType')) then
Factory.Codedvalue('at0034^C81.7^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0051^Classical Hodgkins^MO_LymphomaType')) then
Factory.Codedvalue('at0035^C81.9^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0052^Nodular Sclerosing Hodgkins^MO_LymphomaType')) then
Factory.Codedvalue('at0031^C81.1^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0053^Lymphocyte rich Hodgkins^MO_LymphomaType')) then
Factory.Codedvalue('at0030^C81.0^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0054^Mixed Cellularity Hodgkins^MO_LymphomaType')) then
Factory.Codedvalue('at0032^C81.2^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0055^Lymphocyte Depleted Hodgkins^MO_LymphomaType')) then
Factory.Codedvalue('at0033^C81.3^Initial_Notification')
else
Factory.CodedValue('', 'Initial_Notification')
endif
endif
endif
endif
endif
endif
endif
endif
endif
endif
endif
endif
endif
endif
endif
/*
Factory.CodedValue('at0030^C81.0^Initial_Notification')
Factory.CodedValue('at0031^C81.1^Initial_Notification')
Factory.CodedValue('at0032^C81.2^Initial_Notification')
Factory.CodedValue('at0033^C81.3^Initial_Notification')
Factory.CodedValue('at0034^C81.7^Initial_Notification')
Factory.CodedValue('at0035^C81.9^Initial_Notification')
Factory.CodedValue('at0036^C82.9^Initial_Notification')
Factory.CodedValue('at0037^C83.4^Initial_Notification')
Factory.CodedValue('at0038^C83.7^Initial_Notification')
Factory.CodedValue('at0039^C84.0^Initial_Notification')
Factory.CodedValue('at0040^C84.1^Initial_Notification')
Factory.CodedValue('at0041^C85.1^Initial_Notification')
Factory.CodedValue('at0042^C90.2^Initial_Notification')
Factory.CodedValue('at0043^C91.4^Initial_Notification')
Factory.CodedValue('at0082^C82.0^Initial_Notification')
Factory.CodedValue('at0083^C82.1^Initial_Notification')
Factory.CodedValue('at0084^C82.2^Initial_Notification')
Factory.CodedValue('at0085^C82.7^Initial_Notification')
Factory.CodedValue('at0086^C83.0^Initial_Notification')
Factory.CodedValue('at0087^C83.1^Initial_Notification')
Factory.CodedValue('at0088^C83.2^Initial_Notification')
Factory.CodedValue('at0089^C83.3^Initial_Notification')
Factory.CodedValue('at0090^C83.5^Initial_Notification')
Factory.CodedValue('at0091^C83.6^Initial_Notification')
Factory.CodedValue('at0092^C83.8^Initial_Notification')
Factory.CodedValue('at0093^C83.9^Initial_Notification')
Factory.CodedValue('at0094^C84.2^Initial_Notification')
Factory.CodedValue('at0095^C84.3^Initial_Notification')
Factory.CodedValue('at0096^C84.4^Initial_Notification')
Factory.CodedValue('at0097^C84.5^Initial_Notification')
Factory.CodedValue('at0098^C85.0^Initial_Notification')
Factory.CodedValue('at0099^C85.7^Initial_Notification')
Factory.CodedValue('at0100^C85.9^Initial_Notification')
Factory.CodedValue('at0101^C88^Initial_Notification')
*/
CE
- at0046
- at0047
- at0048
- at0049
- at0050
- at0051
- at0052
- at0053
- at0054
- at0055
- at0056
- at0057
- at0058
- at0059
- at0060
- at0061
- at0062
- at0063
- at0063
- at0064
- at0065
- at0066
- at0067
- at0068
- at0069
- at0070
- at0071
- at0072
- at0073
- at0074
- at0075
- at0076
- at0077
- at0078
- at0079
0
//See if we have diagnosis data
let path: String = '1.1.1'
let OBS : Observation = Model.find_observation('Lymphoma_Wizard_Core', path)
if OBS.isUndefined() then
Factory.CodedValue('^^')
else
if OBS.value.equals(Factory.CodedValue('at0011^Precursor B-lymphoblastic lymphoma/leukemia^MO_LymphomaType')) then
Factory.CodedValue('at0071^9728/3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0013^CLL/SLL^MO_LymphomaType')) then
Factory.CodedValue('at0052^9670/3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0015^Lymphoplasmacytic lymphoma^MO_LymphomaType')) then
Factory.CodedValue('at0053^9671/3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0016^Splenic Marginal zone B Lymphoma^MO_LymphomaType')) then
Factory.Codedvalue('at0059^9689/3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0017^Hairy cell leukemia^MO_LymphomaType')) then
Factory.Codedvalue('at0079^9940/3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0018^Plasma cell myeloma^MO_LymphomaType')) then
Factory.Codedvalue('at0074^9732/3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0019^Solitary plasmacytoma of bone^MO_LymphomaType')) then
Factory.Codedvalue('at0073^9731/3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0020^Extraosseeous plasmacytoma^MO_LymphomaType')) then
Factory.Codedvalue('at0075^9734/3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0021^MALT Lymphoma^MO_LymphomaType')) then
Factory.Codedvalue('at0061^9699/3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0022^Nodal Marginal zone B-cell lymphoma^MO_LymphomaType')) then
Factory.Codedvalue('at0061^9699/3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0023^Follicular lymphoma^MO_LymphomaType')) then
Factory.Codedvalue('at0060^9690/3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0024^Mantle Cell Lymphoma^MO_LymphomaType')) then
Factory.Codedvalue('at0054^9673/3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0025^Diffuse Large B-cell lymphoma^MO_LymphomaType')) then
Factory.Codedvalue('at0057^9680/3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0026^Mediastinal (thymic) B-cell lymphoma^MO_LymphomaType')) then
Factory.Codedvalue('at0056^9679/3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0028^Primary effusion lymphoma^MO_LymphomaType')) then
Factory.Codedvalue('at0055^9678/3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0029^Burkitt Lymphoma/leukaemia^MO_LymphomaType')) then
Factory.Codedvalue('at0058^9687/3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0032^Precursor T-lymphoblastic lymphoma/leukemia^MO_LymphomaType')) then
Factory.Codedvalue('at0072^9729/3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0034^T-cell prolymphocytic leukaemia^MO_LymphomaType')) then
Factory.Codedvalue('at0078^9834/3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0035^T-cell large granular lymphocytic leukemia^MO_LymphomaType')) then
Factory.Codedvalue('at0077^9831/3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0036^Aggressive NK cell leukemia^MO_LymphomaType')) then
Factory.Codedvalue('at0103^9948/3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0037^Adult T-cell leukaemia/lymphoma^MO_LymphomaType')) then
Factory.Codedvalue('at0076^9827/3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0038^Extranodal NK/T-cell lymphoma, nasal type^MO_LymphomaType')) then
Factory.Codedvalue('at0070^9719/3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0039^Enteropathy-type T-cell lymphoma^MO_LymphomaType')) then
Factory.Codedvalue('at0068^9717/3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0040^Subcutaneous panniculitis=like T-cell lymphoma^MO_LymphomaType')) then
Factory.Codedvalue('at0066^9708/3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0041^Mycosis fungoides^MO_LymphomaType')) then
Factory.Codedvalue('at0062^9700/3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0042^Sezary Syndrome^MO_LymphomaType')) then
Factory.Codedvalue('at0063^9701/3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0043^Primary cutaneous anaplastic large-cell lymphoma^MO_LymphomaType')) then
Factory.Codedvalue('at0067^9714/3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0044^Peripheral T-cell lymphoma^MO_LymphomaType')) then
Factory.Codedvalue('at0064^9702/3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0045^Angioimmunoblastic T-cell lymphoma^MO_LymphomaType')) then
Factory.Codedvalue('at0065^9705/3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0046^Anaplastic large cell lymphoma^MO_LymphomaType')) then
Factory.Codedvalue('at0067^9714/3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0048^Lymphomatoid papulosis^MO_LymphomaType')) then
Factory.Codedvalue('at0069^9718/3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0049^Hodgkin Lymphoma^MO_LymphomaType')) then
Factory.Codedvalue('at0046^9650/3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0050^Nodular Lymphocyte-predominant Hodgkin^MO_LymphomaType')) then
Factory.Codedvalue('at0050^9659/3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0051^Classical Hodgkin^MO_LymphomaType')) then
Factory.Codedvalue('at0046^9650/3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0052^Nodular sclerosis Hodgkin^MO_LymphomaType')) then
Factory.Codedvalue('at0051^9663/3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0053^Lymphocyte Rich Hodgkin^MO_LymphomaType')) then
Factory.Codedvalue('at0047^9651/3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0054^Mixed Cellularity Hodgkin lymphoma^MO_LymphomaType')) then
Factory.Codedvalue('at0048^9652/3^Initial_Notification')
else
if OBS.value.equals(Factory.CodedValue('at0055^Lymphocyte Depleted Hodgkin^MO_LymphomaType')) then
Factory.Codedvalue('at0049^9653/3^Initial_Notification')
else
Factory.CodedValue('', 'Initial_Notification')
endif
endif
endif
endif
endif
endif
endif
endif
endif
endif
endif
endif
endif
endif
endif
endif
endif
endif
endif
endif
endif
endif
endif
endif
endif
endif
endif
endif
endif
endif
endif
endif
endif
endif
endif
endif
endif
endif
endif
ANY
MO_Lymphoma_Stage
/*
Gello forHodgkins
*/
/*
1. Get the observation for this node in the archetype tree.
the parameter[1] is defined as Any, but is actually an observation.
*/
let o:observation = parameter[1]
/*
Do what you need to do with the observation and set answer as appropriate.
*/
//locate target
let o2: Observation =
if o.isdefined() then
// we can look up the target
o.find_observation('1.1.3')
else
// it's already undefined.
o
endif
let answer:boolean =
if o2.isDefined() then
if o2.value_asCodedValue().code = '01' then
true
else
false
endif
else
// could not find the target
unknown
endif
let reason:string =
if answer <> unknown then
if answer then
'Enter you reason for acceptance here...'
else
o2.value_asCodedValue().code
endif
else
if o.isdefined() then
'Target observation not found'
else
'No Observation passed in'
endif
endif
/* now return our annotated boolean result...
If you aren't interested in the reason, just pass back a boolean (i.e. answer )
*/
factory.annotatedboolean(answer,reason)
// uncomment the following and comment the above to just return a boolean
// answer
ANY
Hasenclever_index
/*
Gello for Non Hodgkins
*/
/*
1. Get the observation for this node in the archetype tree.
the parameter[1] is defined as Any, but is actually an observation.
*/
let o:observation = parameter[1]
/*
Do what you need to do with the observation and set answer as appropriate.
*/
//locate target
let o2: Observation =
if o.isdefined() then
// we can look up the target
o.find_observation('1.1.3')
else
// it's already undefined.
o
endif
let o3: Observation =
if o.isdefined() then
// we can look up the target
o.find_observation('1.1.4')
else
// it's already undefined.
o
endif
let isaggressive : boolean =
if o3.isdefined () then
if o3.value_asCodedValue().code = 'at0027' then
false
else
true
endif
else
false
endif
let answer:boolean =
if o2.isDefined() then
if o2.value_asCodedValue().code = '02' then
true
else
false
endif
else
// could not find the target
unknown
endif
let reason:string =
if answer <> unknown then
if answer then
'Enter you reason for acceptance here...'
else
o2.value_asCodedValue().code
endif
else
if o.isdefined() then
'Target observation not found'
else
'No Observation passed in'
endif
endif
/* now return our annotated boolean result...
If you aren't interested in the reason, just pass back a boolean (i.e. answer )
*/
factory.annotatedboolean(isaggressive,reason)
// uncomment the following and comment the above to just return a boolean
// answer
ANY
FLIPI
/*
Gello for Non Hodgkins
*/
/*
1. Get the observation for this node in the archetype tree.
the parameter[1] is defined as Any, but is actually an observation.
*/
let o:observation = parameter[1]
/*
Do what you need to do with the observation and set answer as appropriate.
*/
//locate target
let o2: Observation =
if o.isdefined() then
// we can look up the target
o.find_observation('1.1.4')
else
// it's already undefined.
o
endif
let answer:boolean =
if o2.isDefined() then
if o2.value_asCodedValue().code = '2' then
true
else
false
endif
else
// could not find the target
unknown
endif
let reason:string =
if answer <> unknown then
if answer then
'Enter you reason for acceptance here...'
else
o2.value_asCodedValue().code
endif
else
if o.isdefined() then
'Target observation not found'
else
'No Observation passed in'
endif
endif
/* now return our annotated boolean result...
If you aren't interested in the reason, just pass back a boolean (i.e. answer )
*/
factory.annotatedboolean(answer,reason)
// uncomment the following and comment the above to just return a boolean
// answer
ANY
IPI
ST FT
*
'Cytogenetic Markers' + '&nl;' + 'none found'
ST FT
*
let Code : CodedValue = Factory.CodedValue('PBSCM', '1964')
let OBS = Model.Observations->select(code.equals(Code))->last()
if OBS.isdefined() then
OBS.value_asString()
else
'Modecular Markers' + '&nl;' + 'none found'
endif
-
Initial Notification
-
Person
Person
-
ID
ID
-
Country of birth
Country of birth
-
Cancer diagnosis
Cancer diagnosis
-
Date diagnosed
Date diagnosed
-
Date of report
Date of report
-
Haematological Cancer Group
Haematological Cancer Group
-
Haematological Cancer Sub-group
Haematological Cancer Sub-group
-
Primary Site of Cancer
Primary Site of Cancer
-
Morphology
Morphology
-
Stage of Disease
Stage of Disease
-
Morphology (ICD-10-AM 'C'codes)
Morphology (ICD-10-AM 'C'codes)
-
Morphology (ICD-10-AM 'C' code)
Morphology (ICD-10-AM 'C' code)
-
Relevant Prognostic Score
Relevant Prognostic Score
-
Hasenclever Index (If Hodkin Lymphoma)
Hasenclever Index (If Hodkin Lymphoma)
-
Hasenclever Index (If Hodgkin Lymphoma)
Hasenclever Index (If Hodgkin Lymphoma)
-
FLIPI (If Follicular lymphoma)
FLIPI (If Follicular lymphoma)
-
IPI (If Aggressive lymphoma)
IPI (If Aggressive lymphoma)
-
Markers (If available)
Markers (If available)
-
Cytogenic markers - names and values
Cytogenic markers - names and values
-
Molecular markers - names and values
Molecular markers - names and values
-
Details
Details
-
01 Hodgkin Lymphoma
01
-
02 Non Hodgkin Lymphoma
02
-
1 - Follicular (nodular) NHL
1
-
2 - Aggressive NHL
2
-
3
3
-
8 - Other NHL
8
-
C81.0 - Lymphocytic predominance
C81.0
-
C81.1 - Nodular sclerosis
C81.1
-
C81.2 - Mixed cellularity
C81.2
-
C81.3 - Lymphocytic depletion
C81.3
-
C81.7 - other HL
C81.7
-
C81.9 - Hodgkin Disease, unspecified
C81.9
-
C82.9 - Follicular NHL, unspecified
C82.9
-
C83.4 - Immunoblastic (diffuse)
C83.4
-
C83.7 - Burkitt tumour
C83.7
-
C84.0 - Mycosis fungoides
C84.0
-
C84.1 - Sezary disease
C84.1
-
C85.1 - B-cell lymphoma, unspecified
C85.1
-
C90.2 - Plasmacytoma, extramedullary
C90.2
-
C91.4 - Hairy-cell leukaemia
C91.4
-
Morphology code from ICD-10-AM
Morphology code from ICD-10-AM
-
9560/3
9560/3
-
9650/3 - Hodgkin lymphoma NOS
9650/3
-
9651/3 - Hodgkin lymphoma, lymphocyte-rich
9651/3
-
9652/3 - Hodgkin disease, mixed cellularity NOS
9652/3
-
9653/3 - Hodgkin lymphoma, lymphocyte depletion NOS
9653/3
-
9659/3 - Hodgkin lymphoma, nodular lymphocyte predominance
9659/3
-
9663/3 - Hodgkin lymphoma, nodular sclerosis NOS
9663/3
-
9670/3 - Lymphoma, small B lymphocytic NOS
9670/3
-
9671/3 - Lymphoma, lymphoplasmacytic
9671/3
-
9673/3 - Mantle cell lymphoma
9673/3
-
9678/3 - Primary effusion lymphoma
9678/3
-
9679/3 - Mediastinal large B-cell lymphoma
9679/3
-
9680/3 - Lymphoma, large B-cell, diffuse NOS
9680/3
-
9687/3 - Burkitt lymphoma NOS
9687/3
-
9689/3 - Splenic marginal zone B-cell lymphoma
9689/3
-
9690/3 - Follicular lymphoma NOS
9690/3
-
9699/3 - Marginal zone B-cell lymphoma NOS
9699/3
-
9700/3 - Mycosis fungoides
9700/3
-
9701/3 - Sezary syndrome
9701/3
-
9702/3 - Mature T-cell lymphoma NOS
9702/3
-
9705/3 - Angioimmunoblastic T-cell lymphoma
9705/3
-
9708/3 - Subcutaneous panniculitis-like T-cell lymphoma
9708/3
-
9714/3 - Anaplastic large cell lymphoma, T cell and Null cell type
9714/3
-
9717/3 - Intestinal T-cell lymphoma
9717/3
-
9718/3 - Primary cutaneous CD30+ T-cell lymphoproliferative disorder
9718/3
-
9719/3 - NK/T-cell lymphoma, nasal and nasal-type
9719/3
-
9728/3 - Precursor B-cell lymphoblastic lymphoma
9728/3
-
9729/3 - Precursor T-cell lymphoblastic lymphoma
9729/3
-
9731/3 - Plasmacytoma NOS
9731/3
-
9732/3 - Multiple myeloma
9732/3
-
9734/3 - Plasmacytoma, extramedullary
9734/3
-
9827/3 - Adult T-cell leukaemia/lymphoma
9827/3
-
9831/3 - T-cell large granular lymphocytic leukaemia
9831/3
-
9834/3 - Prolymphocytic leukaemia, T-cell type
9834/3
-
9940/3 - Hairy cell leukaemia
9940/3
-
9948/3
9948/3
-
Haematological Cancer Sub-group (if NHL)
Haematological Cancer Sub-group (if NHL)
-
C82.0 - Small cleaved cell, follicular
C82.0
-
C82.1 - Mixed small cleaved and large cell, follicular
C82.1
-
C82.2 - Large cell, follicular
C82.2
-
C82.7 - Other types of follicular non-Hodgkin lymphoma
C82.7
-
C83.0 - Small cell (diffuse)
C83.0
-
C83.1 - Small cleaved cell (diffuse)
C83.1
-
C83.2 - Mixed small and large cell (diffuse)
C83.2
-
C83.3 - Large cell (diffuse)
C83.3
-
C83.5 - Lymphoblastic (diffuse)
C83.5
-
C83.6 - Undifferentiated (diffuse)
C83.6
-
C83.8 - Other types of diffuse non-Hodgkin lymphoma
C83.8
-
C83.9 - Diffuse non-Hodgkin lymphoma, unspecified
C83.9
-
C84.2 - T-zone lymphoma
C84.2
-
C84.3 - Lymphoepithelioid lymphoma
C84.3
-
C84.4 - Peripheral T-cell lymphoma
C84.4
-
C84.5 - Other and unspecified T-cell lymphomas
C84.5
-
C85.0 - Lymphosarcoma
C85.0
-
C85.7 - Other specified types of non-Hodgkin lymphoma
C85.7
-
C85.9 - Non-Hodgkin lymphoma, unspecified type
C85.9
-
C88 - Waldenström macroglobulinaemia
C88
-
C91.4 - Hairy Cell Leukemia
C91.4
Updated_Notification
Medical-Objects
2007-04-17T21:05:57.000Z
1
Draft
1
0.9
ANY
Registration_Details
ANY
Remission_Status
ST FT
*
ANY
LW_Clinical_Trial.V1
ST FT
*
let Code : CodedValue = Factory.CodedValue('PBSCM', '1964')
let OBS = Model.Observations->select(code.equals(Code))->last()
if OBS.isdefined() then
OBS.value_asString()
else
'Modecular Markers' + '&nl;' + 'none found'
endif
-
Previous notification details
Previous notification details
-
Previous details
Previous details
-
Person details
Person details
-
Person details
Person details
-
Response
Response
-
Response
Response
-
Treatment
Treatment
-
Clinical trial
Clinical trial
-
Marker information
Marker information (If available)
Hasenclever_index
Medical-Objects
2007-04-17T21:05:57.000Z
1
Draft
1
0.9
ST
false
false
let ALB_LN : CodedValue = Factory.CodedValue('1751-7', 'LN')
let albumin_threshold = factory.physicalquantity(40,'g/dL')
let ALB = Model.Observations->select(code.equals(ALB_LN))->last()
if ALB.isdefined() then
let ALB_Low = ALB.value < albumin_threshold
if ALB_Low then
conclude Factory.Observation(False, Factory.CodedValue('123', 'L'), 'CE', '','', '20070404')
else
conclude Factory.Observation(True, Factory.CodedValue('123', 'L'), 'CE', '','', '')
endif
else
conclude Factory.Observation(Unknown, Factory.CodedValue('123', 'L'), 'CE', '' ,'', '')
endif
ST
false
false
let HB_LN : CodedValue = Factory.CodedValue('718-7', 'LN')
let haemoglobin_threshold = factory.physicalquantity(10.5,'g/L')
let HB = Model.Observations->select(code.equals(HB_LN))->last()
if HB.isdefined() then
let HB_Low = HB.value < haemoglobin_threshold
if HB_Low then
conclude Factory.Observation(False, Factory.CodedValue('123', 'L'), 'CE', '','', '20070404')
else
conclude Factory.Observation(True, Factory.CodedValue('123', 'L'), 'CE', '','', '')
endif
else
conclude Factory.Observation(Unknown, Factory.CodedValue('123', 'L'), 'CE', '' ,'', '')
endif
ST
false
false
if Model.Patient.gender = 'M' then
Factory.Observation(True, Factory.CodedValue('123', 'L'), 'CE', '','', '')
else
if Model.Patient.gender = 'F' then
Factory.Observation(False, Factory.CodedValue('123', 'L'), 'CE', '','', '')
else
Factory.Observation(Unknown, Factory.CodedValue('123', 'L'), 'CE', '','', '')
endif
endif
ST
false
false
//See if we have stage data
let path: String = '1.2.1'
let OBS : Observation = Model.find_observation('Lymphoma_Wizard_Core', path)
let S1: Codedvalue = Factory.CodedValue('at0011', 'MO_Lymphoma_Stage')
let S2: Codedvalue = Factory.CodedValue('at0021', 'MO_Lymphoma_Stage')
let S3: Codedvalue = Factory.CodedValue('at0031', 'MO_Lymphoma_Stage')
Let Stages: Set(CodedValue) = Set{S1, S2, S3}
let answer: Boolean =
if OBS.isUndefined() then
unknown
else
if Stages->includes(OBS.value) then
true
else
false
endif
endif
Factory.Observation(Answer, Factory.CodedValue('G4Nodes', 'L'), 'CE', '', '', '')
ST
false
false
let WCC_LN : CodedValue = Factory.CodedValue('6690-2', 'LN')
let WCC_threshold = factory.physicalquantity(15,'10^9/L')
let WCC = Model.Observations->select(code.equals(WCC_LN))->last()
if WCC.isdefined() then
let WCC_Low = WCC.value < WCC_threshold
if WCC_Low then
conclude Factory.Observation(False, Factory.CodedValue('123', 'L'), 'CE', '','', '20070404')
else
conclude Factory.Observation(True, Factory.CodedValue('123', 'L'), 'CE', '','', '')
endif
else
conclude Factory.Observation(Unknown, Factory.CodedValue('123', 'L'), 'CE', '' ,'', '')
endif
ST
false
false
let LYMPC_LN : CodedValue = Factory.CodedValue('736-9', 'LN')
let LYM_LN : CodedValue = Factory.Codedvalue('731-0', 'LN')
let LYMP_threshold = factory.physicalquantity(0.6,'10^9/L')
let LYMPC_Threshold = factory.Physicalquantity(8, '%')
let LYM = Model.Observations->select(code.equals(LYM_LN))->last()
let LYMPC = Model.Observations->select(code.equals(LYMPC_LN))->last()
Let LYM_High : Boolean =
if LYM.isdefined() then
LYM.value > LYMP_threshold
else
Unknown
endif
Let LYMPC_High : Boolean =
if LYMPC.isdefined() then
LYMPC.value > LYMPC_Threshold
else
Unknown
endif
if (LYM_High = True) or (LYMPC_High = True) then
Factory.Observation(False, Factory.CodedValue('123', 'L'), 'CE', '','', '')
else
if (LYM_High = Unknown) and (LYMPC_High = Unknown) then
Factory.Observation(Unknown, Factory.CodedValue('123', 'L'), 'CE', '','', '')
else
Factory.Observation(False, Factory.CodedValue('123', 'L'), 'CE', '','', '')
endif
endif
ST
false
false
if Model.Patient.age_at(Factory.AbsoluteTime('20070101')) > 45 then
Factory.Observation(True, Factory.CodedValue('123', 'L'), 'CE', '','', '20070405')
else
Factory.Observation(False, Factory.CodedValue('123', 'L'), 'CE', '','', '20070405')
endif
/*
Gello for Calculating Hasenclever
*/
/*
1. Get the observation for this node in the archetype tree.
the parameter[1] is defined as Any, but is actually an observation.
*/
let o:observation = parameter[1]
//locate targets
let Albumin: Integer =
if o.isdefined() then
// we can look up the target
if o.find_observation('1.1').value.equals(True) then
1
else
0
endif
else
0
endif
Let Hb: Integer =
if o.isdefined() then
if o.find_observation('1.2').value.equals(True) then
1
else
0
endif
else
0
endif
Let Male: Integer =
if o.isdefined() then
if o.find_observation('1.3').value.equals(True) then
1
else
0
endif
else
0
endif
Let StageIV: Integer =
if o.isdefined() then
if o.find_observation('1.4').value.equals(True) then
1
else
0
endif
else
0
endif
Let WCCLow: Integer =
if o.isdefined() then
if o.find_observation('1.5').value.equals(True) then
1
else
0
endif
else
0
endif
Let LympH: Integer =
if o.isdefined() then
if o.find_observation('1.6').value.equals(True) then
1
else
0
endif
else
0
endif
Let Age45: Integer =
if o.isdefined() then
if o.find_observation('1.7').value.equals(True) then
1
else
0
endif
else
0
endif
//the result is the sum of the values
Albumin + Hb + Male + StageIV + WCCLow + LympH + Age45
INT
0
7
-
Hasenclever Index
-
Hasenclever Index score
Hasenclever Index score - sums the other elements
-
Serum albumin < 40 g/dL
Serum albumin < 40 g/dL
-
Haemoglobin < 10.5 g/dL
Haemoglobin < 10.5 g/dL
-
Male gender
Male gender
-
Age >= 45 yrs
Age >= 45 yrs
-
Lymphoma stage IV disease
Lymphoma stage IV disease
-
WCC < 15
WCC < 15
-
Lymphocytes > 0.6 or > 8% of WCC
Lymphocytes > 0.6 or > 8% of WCC
-
Total
Total
-
Hasenclever index score
Hasenclever index score
FLIPI
Medical-Objects
2007-04-17T21:05:57.000Z
1
Draft
1
0.9
ST
false
false
if Model.Patient.age_at(Factory.AbsoluteTime('20070101')) > 60 then
True
else
False
endif
ST
false
false
//See if we have stage data
let path: String = '1.2.1'
let OBS : Observation = Model.find_observation('Lymphoma_Wizard_Core', path)
let S1: Codedvalue = Factory.CodedValue('at0010', 'MO_Lymphoma_Stage')
let S2: Codedvalue = Factory.CodedValue('at0011', 'MO_Lymphoma_Stage')
let S3: Codedvalue = Factory.CodedValue('at0013', 'MO_Lymphoma_Stage')
let S4: Codedvalue = Factory.CodedValue('at0014', 'MO_Lymphoma_Stage')
let S5: Codedvalue = Factory.CodedValue('at0015', 'MO_Lymphoma_Stage')
let S6: Codedvalue = Factory.CodedValue('at0016', 'MO_Lymphoma_Stage')
let S7: Codedvalue = Factory.CodedValue('at0017', 'MO_Lymphoma_Stage')
let S8: Codedvalue = Factory.CodedValue('at0020', 'MO_Lymphoma_Stage')
let S9: Codedvalue = Factory.CodedValue('at0021', 'MO_Lymphoma_Stage')
let S10: Codedvalue = Factory.CodedValue('at0026', 'MO_Lymphoma_Stage')
let S11: Codedvalue = Factory.CodedValue('at0027', 'MO_Lymphoma_Stage')
let S12: Codedvalue = Factory.CodedValue('at0028', 'MO_Lymphoma_Stage')
let S13: Codedvalue = Factory.CodedValue('at0029', 'MO_Lymphoma_Stage')
let S14: Codedvalue = Factory.CodedValue('at0030', 'MO_Lymphoma_Stage')
let S15: Codedvalue = Factory.CodedValue('at0031', 'MO_Lymphoma_Stage')
Let Stages: Set(CodedValue) = Set{S1, S2, S3, S4, S5, S6, S7, S8, S9, S10, S11, S12, S13, S14, S15}
if OBS.isUndefined() then
unknown
else
if Stages->includes(OBS.value) then
true
else
false
endif
endif
ST
false
false
//See how many node groups we have
let path: String = '1.1.3'
let OBS : Observation = Model.find_observation('Lymphoma_finding', path)
let answer: Boolean =
if OBS.isUndefined() then
unknown
else
//we have an Observation
if OBS.value_type = 'NM' then
//see if matches value
if OBS.Value_asReal() > 4 then
true
else
false
endif
else
unknown
endif
endif
Factory.Observation(Answer, Factory.CodedValue('G4Nodes', 'L'), 'CE', '', '', '')
ST
false
false
let LDH_LN : CodedValue = Factory.CodedValue('2532-0', 'LN')
let LDH = Model.Observations->select(code.equals(LDH_LN))->last()
if LDH.isdefined() then
if LDH.value <= LDH.reference_range.upper_limit then
False
else
True
endif
else
Unknown
endif
ST
false
false
let HB_LN : CodedValue = Factory.CodedValue('718-7', 'LN')
let haemoglobin_threshold = factory.physicalquantity(12.5,'g/L')
let HB = Model.Observations->select(code.equals(HB_LN))->last()
if HB.isdefined() then
if HB.value < haemoglobin_threshold then
False
else
True
endif
else
Unknown
endif
/*
Gello for Calculating FLIPI score
*/
/*
1. Get the observation for this node in the archetype tree.
the parameter[1] is defined as Any, but is actually an observation.
*/
let o:observation = parameter[1]
//locate targets
let AgeOver60: Integer =
if o.isdefined() then
// we can look up the target
if o.find_observation('1.1').value.equals(True) then
1
else
0
endif
else
0
endif
Let AnnArbour: Integer =
if o.isdefined() then
if o.find_observation('1.2').value.equals(True) then
1
else
0
endif
else
0
endif
Let NumberNodalAreas: Integer =
if o.isdefined() then
if o.find_observation('1.3').value.equals(True) then
1
else
0
endif
else
0
endif
Let ElevatedLDH: Integer =
if o.isdefined() then
if o.find_observation('1.4').value.equals(True) then
1
else
0
endif
else
0
endif
Let NormalHB: Integer =
if o.isdefined() then
if o.find_observation('1.5').value.equals(True) then
1
else
0
endif
else
0
endif
//result is sum of values
AgeOver60 + AnnArbour + NumberNodalAreas + ElevatedLDH + NormalHB
INT
0
5
-
FLIPI score
FLIPI score
-
FLIPI components
FLIPI components
-
Age > 60 yrs
Age > 60 yrs
-
Ann Arbor Stage III or IV
Ann Arbor Stage III or IV
-
FLIPI score
FLIPI score
-
Number of nodal areas > 4
Number of nodal areas > 4
-
Serum LDH above normal
Serum LDH above normal
-
HB >= 120 g/L
HB >= 120 g/L
-
FLIPI score
FLIPI score
IPI
Medical-Objects
2007-04-17T21:05:57.000Z
1
Draft
1
0.9
ST
false
false
//See if we have stage data
let path: String = '1.2.1'
let OBS : Observation = Model.find_observation('Lymphoma_Wizard_Core', path)
let S1: Codedvalue = Factory.CodedValue('at0010', 'MO_Lymphoma_Stage')
let S2: Codedvalue = Factory.CodedValue('at0011', 'MO_Lymphoma_Stage')
let S3: Codedvalue = Factory.CodedValue('at0013', 'MO_Lymphoma_Stage')
let S4: Codedvalue = Factory.CodedValue('at0014', 'MO_Lymphoma_Stage')
let S5: Codedvalue = Factory.CodedValue('at0015', 'MO_Lymphoma_Stage')
let S6: Codedvalue = Factory.CodedValue('at0016', 'MO_Lymphoma_Stage')
let S7: Codedvalue = Factory.CodedValue('at0017', 'MO_Lymphoma_Stage')
let S8: Codedvalue = Factory.CodedValue('at0020', 'MO_Lymphoma_Stage')
let S9: Codedvalue = Factory.CodedValue('at0021', 'MO_Lymphoma_Stage')
let S10: Codedvalue = Factory.CodedValue('at0026', 'MO_Lymphoma_Stage')
let S11: Codedvalue = Factory.CodedValue('at0027', 'MO_Lymphoma_Stage')
let S12: Codedvalue = Factory.CodedValue('at0028', 'MO_Lymphoma_Stage')
let S13: Codedvalue = Factory.CodedValue('at0029', 'MO_Lymphoma_Stage')
let S14: Codedvalue = Factory.CodedValue('at0030', 'MO_Lymphoma_Stage')
let S15: Codedvalue = Factory.CodedValue('at0031', 'MO_Lymphoma_Stage')
Let Stages: Set(CodedValue) = Set{S1, S2, S3, S4, S5, S6, S7, S8, S9, S10, S11, S12, S13, S14, S15}
let answer: Boolean =
if OBS.isUndefined() then
unknown
else
if Stages->includes(OBS.value) then
true
else
false
endif
endif
Factory.Observation(Answer, Factory.CodedValue('G4Nodes', 'L'), 'CE', '', '', '')
ST
false
false
Model.run('LDH_above_normal')
/*
let LDH_LN : CodedValue = Factory.CodedValue('2532-0', 'LN')
let LDH = Model.Observations->select(code.equals(LDH_LN))->last()
if LDH.isdefined() then
let LDH_Not_High = LDH.value <= LDH.reference_range.upper_limit
if LDH_Not_High then
conclude Factory.Observation(False, Factory.CodedValue('LDH_UP', 'L'), 'CE', '','', '')
else
conclude Factory.Observation(True, Factory.CodedValue('LDH_UP', 'L'), 'CE', '','', '')
endif
else
conclude Factory.Observation(Unknown, Factory.CodedValue('LDH_UP', 'L'), 'CE', '' ,'', '')
endif
*/
ST
false
false
Model.run('ECOG2_or_greater')
/*
//See if we have stage data
let path: String = '1.1'
let OBS : Observation = Model.find_observation('performance_status', path)
Let Stages: Set(Codedvalue) = Set{
Factory.Codedvalue('373805004^2^SNOMED-CT'),
Factory.Codedvalue('373806003^3^SNOMED-CT'),
Factory.Codedvalue('373807007^4^SNOMED-CT'),
Factory.Codedvalue('419099009^5^SNOMED-CT')
}
if OBS.isUndefined() then
unknown
else
if Stages->includes(OBS.value) then
true
else
false
endif
endif
*/
ST
false
false
if Model.Patient.age_at(Factory.AbsoluteTime('20070101')) > 60 then
Factory.Observation(True, Factory.CodedValue('123', 'L'), 'CE', '','', '20070405')
else
Factory.Observation(False, Factory.CodedValue('123', 'L'), 'CE', '','', '20070405')
endif
ST
false
false
//See how many node groups we have
let IsExtraNodalPath: String = '1.1.1'
let path: String = '1.1.2'
let O2 : Observation = Model.find_observation('Lymphoma_Finding', path)
let Extranodal : Observation = Model.find_observation('Lymphoma_Finding', IsExtranodalPath)
let SnomedTrue: CodedValue = Factory.CodedValue('31874001', 'SNOMED-CT')
let answer: Boolean =
if O2.isUndefined() then
if ExtraNodal.isUndefined() then
unknown
else
if Extranodal.value.equals(SnomedTrue) then
unknown
else
false
endif
endif
else
//we have an Observation
if O2.value_type = 'NM' then
//see if matches value
if O2.Value_asReal() > 1 then
true
else
false
endif
else
false
endif
endif
Factory.Observation(Answer, Factory.CodedValue('G1eNodal', 'L'), 'CE', '', '', '')
/*
Gello for Calculating IPI score
*/
/*
1. Get the observation for this node in the archetype tree.
the parameter[1] is defined as Any, but is actually an observation.
*/
let o:observation = parameter[1]
//locate targets
let T1: Integer =
if o.isdefined() then
// we can look up the target
if o.find_observation('1.1').value.equals(True) then
1
else
0
endif
else
0
endif
Let T2: Integer =
if o.isdefined() then
if o.find_observation('1.2').value.equals(True) then
1
else
0
endif
else
0
endif
Let T3: Integer =
if o.isdefined() then
if o.find_observation('1.3').value.equals(True) then
1
else
0
endif
else
0
endif
Let T4: Integer =
if o.isdefined() then
if o.find_observation('1.4').value.equals(True) then
1
else
0
endif
else
0
endif
Let T5: Integer =
if o.isdefined() then
if o.find_observation('1.5').value.equals(True) then
1
else
0
endif
else
0
endif
//The result is sum of values
T1 + T2 + T3 + T4 + T5
INT
0
5
-
International Prognostic Score components
International Prognostic Score components
-
Ann Arbor clinical stage III or IV
Ann Arbor clinical stage III or IV
-
Serum LDH above normal
Serum LDH above normal
-
ECOG >= 2 (Less than 50% time in bed)
ECOG >= 2 (Less than 50% time in bed)
-
Age >60 yrs
Age >60 yrs
-
Number of extranodal sites > 1
Number of extranodal sites > 1
-
FLIPI score
FLIPI score
-
IPI Score
IPI Score
-
International prognostic index score
International prognostic index score
GELF
Medical-Objects
2007-04-17T21:05:57.000Z
1
Draft
1
0.9
ST FT
*
-
GELF
GELF
BNLI
Medical-Objects
2007-04-17T21:05:57.000Z
1
Draft
1
0.9
ST FT
*
-
BNLI
BNLI
Waldenstroms_macroglobulinaemia prognosis tool
Medical-Objects
2007-04-17T21:05:57.000Z
1
Draft
1
0.9
ST
false
false
ST
false
false
ST
false
false
ST
false
false
ST
false
false
INT
0
5
-
Waldenstroms macroglobulinaemia prognosis tool
Waldenstroms macroglobulinaemia prognosis tool
-
Waldenstroms macroglobulinaemia prognosis tool components
Waldenstroms macroglobulinaemia prognosis tool components
-
Age >65
Age >65
-
Serum albumin < 40 g/L
Serum albumin < 40 g/L
-
One or two of the following
One or two of the following
-
Hb < 120g/L
Hb < 120g/L
-
Neutrophils < 1.5 * 10 to the ninth/L
Neutrophils < 1.5 * 10 to the ninth/L
-
Platelets < 150 * 10 to the ninth / L
Platelets < 150 * 10 to the ninth / L
-
Number of adverse prognostic features - Waldenstroms macroglobulinaemia
Number of adverse prognostic features - Waldenstroms macroglobulinaemia
-
Total
Total
-
Total
Total
-
Total
Total
-
Total adverse features
Total adverse features
Biopsy_request_Full
Medical-Objects
2007-04-17T21:05:57.000Z
1
Draft
1
0.9
ST
ST
CE
- at0008
- at0009
- at0010
- at0011
0
ANY
Lymphoma_finding
CE
- at0017
- at0018
- at0019
0
ANY
Lymphoma_Wizard_Core
CE
- at0026
- at0028
0
ST
CE
- at0027
- at0035
- at0036
- at0033
- at0034
- at0037
0
ST
false
false
ST
TS
-
Current illness
Current illness
-
Disease duration
Disease duration
-
Presenting complaint
Presenting complaint
-
Disease extent
Disease extent
-
Disease extent
Disease extent
-
Current illness
Current illness
-
Generalised
Generalised disease extent
-
Localised
Localised disease extent
-
Solitary
Solitary
-
Unknown
Unknown
-
Known sites of disease
Known sites of disease
-
Nodal sites
Nodal sites
-
Extranodal sites
Extranodal sites
-
Findings
Findings
-
Constitutional symptoms
Constitutional symptoms
-
Constitutional symptoms present
Yes
-
Constitutional symptoms not present
No
-
Unknown as to constitutional symptoms
Unknown
-
Provisional clinical diagnosis
Provisional clinical diagnosis
-
Clinical stage
Clinical stage
-
Current working diagnosis
Current working diagnosis
-
Relevant past history
Relevant past history
-
On methotrexate?
On methotrexate?
-
Immunosupressed?
Immunosupressed?
-
Medication
Medication
-
Methotrexate
Methotrexate
-
Autoimmune disease
Autoimmune disease
-
Medication
Medication
-
Details
Details
-
Relevant past history
Relevant past history
-
Immunosuppression
Immunosuppression
-
Congenital
Congenital cause for imunosupression
-
Other immunosuppression
Other imunosupression
-
Transplantation
Transplant cause for immunosupression
-
Viral
Viral cause for immunosupression
-
Unknown immunosuppresson status
Unkown immunosupresison status
-
Previous lymphoid disease
Previous lymphoid disease
-
Previous lymphoid disease
Previous lymphoid disease
-
Date
Date
-
Previous diagnosis
Previous diagnosis
Lymphoma_Wizard_Core
Medical-Objects
2007-04-17T21:05:57.000Z
1
Draft
1
0.9
ANY
MO_LymphomaType
ANY
MO_Lymphoma_Stage
TS
Factory.AbsoluteTime('').now()
/*
Do what you need to do with the observation and set answer as appropriate.
*/
let o: Observation = parameter[1]
//locate target
let o2: Observation =
if o.isdefined() then
// we can look up the target
o.find_observation('1.1.1')
else
// it's already undefined.
o
endif
if o2.isDefined() then
/****************************************
do your testing here
****************************************/
if o2.value.equals(Factory.CodedValue('','')) then
false
else
true
endif
else
// could not find the target
unknown
endif
ANY
LW_Clinical_Trial.V1
-
Core Data
Core Data
-
Lymphoma Stage
Lymphoma Stage
-
Date of Diagnosis
Date of Diagnosis
-
Trial enrollment
Trial enrollment
LW_Clinical_Trial.V1
Medical-Objects
2007-04-17T21:05:57.000Z
1
Draft
1
0.9
CE
- at0012
- at0007
- at0011
- at0010
- at0008
- at0009
- at0005
- at0004
- at0013
0
-
Lymphoma Trial
Lymphoma Trial
-
Lymphoma Trial Patient Enrolled in
Lymphoma Trial Patient Enrolled in
-
No Trial
No Trial
-
PRIMA - Primary Rituximab and Maintenance Trial
PRIMA - Primary Rituximab and Maintenance Trial
-
NHLLOW-5 TROG 99.03
NHLLOW-5 TROG 99.03
-
ALLG LY02 TROG 99.04
ALLG LY02 TROG 99.04
-
LY03 /WM1
LY03 /WM1
-
LY07
LY07
-
ALLG NHL11 PROTOCOL
ALLG NHL11 PROTOCOL
-
ALLG NHL 13 / GELA CORAL: 50-03B
ALLG NHL 13 / GELA CORAL: 50-03B
-
ALLG HD4 / Intergroup
ALLG HD4 / Intergroup
-
Unspecified Trial
Unspecified Trial